LOCUS       NM_017475               2621 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus Ras-related GTP binding C (Rragc), mRNA.
ACCESSION   NM_017475
VERSION     NM_017475.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2621)
  AUTHORS   Ortega-Molina,A., Lebrero-Fernandez,C., Sanz,A., Calvo-Rubio,M.,
            Deleyto-Seldas,N., de Prado-Rivas,L., Plata-Gomez,A.B.,
            Fernandez-Florido,E., Gonzalez-Garcia,P., Vivas-Garcia,Y., Sanchez
            Garcia,E., Grana-Castro,O., Price,N.L., Aroca-Crevillen,A.,
            Caleiras,E., Monleon,D., Borras,C., Casanova-Acebes,M., de Cabo,R.
            and Efeyan,A.
  TITLE     A mild increase in nutrient signaling to mTORC1 in mice leads to
            parenchymal damage, myeloid inflammation and shortened lifespan
  JOURNAL   Nat Aging 4 (8), 1102-1120 (2024)
   PUBMED   38849535
REFERENCE   2  (bases 1 to 2621)
  AUTHORS   Ortega-Molina,A., Lebrero-Fernandez,C., Sanz,A., Deleyto-Seldas,N.,
            Plata-Gomez,A.B., Menendez,C., Grana-Castro,O., Caleiras,E. and
            Efeyan,A.
  TITLE     Inhibition of Rag GTPase signaling in mice suppresses B cell
            responses and lymphomagenesis with minimal detrimental trade-offs
  JOURNAL   Cell Rep 36 (2), 109372 (2021)
   PUBMED   34260908
REFERENCE   3  (bases 1 to 2621)
  AUTHORS   Alesi,N., Akl,E.W., Khabibullin,D., Liu,H.J., Nidhiry,A.S.,
            Garner,E.R., Filippakis,H., Lam,H.C., Shi,W., Viswanathan,S.R.,
            Morroni,M., Ferguson,S.M. and Henske,E.P.
  TITLE     TSC2 regulates lysosome biogenesis via a non-canonical RAGC and
            TFEB-dependent mechanism
  JOURNAL   Nat Commun 12 (1), 4245 (2021)
   PUBMED   34253722
  REMARK    GeneRIF: TSC2 regulates lysosome biogenesis via a non-canonical
            RAGC and TFEB-dependent mechanism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2621)
  AUTHORS   Ortega-Molina,A., Deleyto-Seldas,N., Carreras,J., Sanz,A.,
            Lebrero-Fernandez,C., Menendez,C., Vandenberg,A.,
            Fernandez-Ruiz,B., Marin-Arraiza,L., de la Calle Arregui,C., Belen
            Plata-Gomez,A., Caleiras,E., de Martino,A., Martinez-Martin,N.,
            Troule,K., Pineiro-Yanez,E., Nakamura,N., Araf,S., Victora,G.D.,
            Okosun,J., Fitzgibbon,J. and Efeyan,A.
  TITLE     Oncogenic Rag GTPase signaling enhances B cell activation and
            drives follicular lymphoma sensitive to pharmacological inhibition
            of mTOR
  JOURNAL   Nat Metab 1 (8), 775-789 (2019)
   PUBMED   31579886
REFERENCE   5  (bases 1 to 2621)
  AUTHORS   Hashimoto,Y., Shirane,M. and Nakayama,K.I.
  TITLE     TMEM55B contributes to lysosomal homeostasis and amino acid-induced
            mTORC1 activation
  JOURNAL   Genes Cells 23 (6), 418-434 (2018)
   PUBMED   29644770
REFERENCE   6  (bases 1 to 2621)
  AUTHORS   Hong-Brown,L.Q., Brown,C.R., Kazi,A.A., Navaratnarajah,M. and
            Lang,C.H.
  TITLE     Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation
            of mTORC1 signaling in response to alcohol and leucine
  JOURNAL   Am J Physiol Cell Physiol 302 (10), C1557-C1565 (2012)
   PUBMED   22442136
  REMARK    GeneRIF: The constitutively active RagA-RagC heterodimer blocks the
            inhibitory effect of alcohol (EtOH).
REFERENCE   7  (bases 1 to 2621)
  AUTHORS   Nakaji,T., Kataoka,T.R., Watabe,K., Nishiyama,K., Nojima,H.,
            Shimada,Y., Sato,F., Matsushima,H., Endo,Y., Kuroda,Y.,
            Kitamura,Y., Ito,A. and Maeda,S.
  TITLE     A new member of the GTPase superfamily that is upregulated in
            highly metastatic cells
  JOURNAL   Cancer Lett 147 (1-2), 139-147 (1999)
   PUBMED   10660099
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ172014.1, AK159355.1, AL606962.22 and BE628749.1.
            
            On Sep 7, 2006 this sequence version replaced NM_017475.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005417.1, AK159434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                CJ172014.1         2-69
            69-1330             AK159355.1         2-1263
            1331-2509           AL606962.22        45812-46990
            2510-2621           BE628749.1         1-112               c
FEATURES             Location/Qualifiers
     source          1..2621
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.42 cM"
     gene            1..2621
                     /gene="Rragc"
                     /gene_synonym="Gtr2; RAGC; TIB929; YGR163W"
                     /note="Ras-related GTP binding C"
                     /db_xref="GeneID:54170"
                     /db_xref="MGI:MGI:1858751"
     exon            1..335
                     /gene="Rragc"
                     /gene_synonym="Gtr2; RAGC; TIB929; YGR163W"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1298
                     /gene="Rragc"
                     /gene_synonym="Gtr2; RAGC; TIB929; YGR163W"
                     /note="rag C; GTPase-interacting protein 2; small GTPase,
                     homolog"
                     /codon_start=1
                     /product="ras-related GTP-binding protein C"
                     /protein_id="NP_059503.2"
                     /db_xref="CCDS:CCDS18622.1"
                     /db_xref="GeneID:54170"
                     /db_xref="MGI:MGI:1858751"
                     /translation="MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAGGGGG
                     AGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDD
                     ISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITV
                     SKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTS
                     IYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPV
                     DMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFL
                     ALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCSHQTSAPSLKALAHNG
                     TPRNAI"
     exon            336..539
                     /gene="Rragc"
                     /gene_synonym="Gtr2; RAGC; TIB929; YGR163W"
                     /inference="alignment:Splign:2.1.0"
     exon            540..739
                     /gene="Rragc"
                     /gene_synonym="Gtr2; RAGC; TIB929; YGR163W"
                     /inference="alignment:Splign:2.1.0"
     exon            740..854
                     /gene="Rragc"
                     /gene_synonym="Gtr2; RAGC; TIB929; YGR163W"
                     /inference="alignment:Splign:2.1.0"
     exon            855..997
                     /gene="Rragc"
                     /gene_synonym="Gtr2; RAGC; TIB929; YGR163W"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1146
                     /gene="Rragc"
                     /gene_synonym="Gtr2; RAGC; TIB929; YGR163W"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..2606
                     /gene="Rragc"
                     /gene_synonym="Gtr2; RAGC; TIB929; YGR163W"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2582..2587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rragc"
                     /gene_synonym="Gtr2; RAGC; TIB929; YGR163W"
                     /note="hexamer: AATAAA"
     polyA_site      2602
                     /gene="Rragc"
                     /gene_synonym="Gtr2; RAGC; TIB929; YGR163W"
                     /note="major polyA site"
ORIGIN      
        1 ggcggctact gccgggggcg gcggcaacag cggcggcctg gggaggcggc ggcctaacct
       61 ggcctggcct gtcagggcgc gggcggtggt ggtccagcac catgtccctg cagtacgggg
      121 cggaggagac gcccctggcc ggcagttacg gcgcagccga ctcgttcccc aaggacttcg
      181 gctacggcgt ggaggaggag gaagaggagg cagcggcggg tggcggcgga ggcgcggggg
      241 ccggcggcgg ctgcggcccg ggcggcgctg acagctccaa gccgaggatc ctgcttatgg
      301 ggctccggcg cagcggcaaa tcctccatcc agaaggtggt gtttcataag atgtcaccca
      361 atgagactct ctttttggaa agtaccaaca agatttataa agatgacatt tccaacagct
      421 cctttgtgaa cttccagatt tgggattttc ctgggcagat ggacttcttt gatccaacct
      481 ttgactacga aatgatcttc aggggcacag gagcattgat atatgtcatt gatgcacagg
      541 acgactacat ggaggcttta acccgacttc acatcactgt ttctaaggcc tacaaagtta
      601 acccagacat gaattttgag gtttttattc acaaagttga tggactgtct gatgatcaca
      661 aaatagaaac acagagggac attcatcaaa gggccaatga tgaccttgca gatgctgggc
      721 tagaaaagct ccatcttagc ttttatttga ctagcatcta tgaccattca atatttgaag
      781 ccttcagtaa ggtggtacag aaactcattc cacaactgcc cactttggaa aacctattaa
      841 atatctttat atcaaattca ggtattgaaa aagcttttct ctttgatgtt gtcagcaaaa
      901 tctacattgc aacagacagc tcccctgtgg atatgcagtc ttatgaactt tgctgtgaca
      961 tgattgatgt tgtaattgat gtgtcttgta tatatggatt aaaggaagat ggaagtggaa
     1021 gtgcttatga caaagaatcg atggccatta tcaagctgaa taatacaact gtcctttatt
     1081 taaaggaagt cactaaattt ttggcactgg tttgcattct tagggaagag agctttgaac
     1141 gaaaagggtt gatagactac aacttccact gtttccgaaa agctatccat gaggtgtttg
     1201 aggtgggtgt gacttctcac agaagctgca gtcatcagac cagtgctcca agtctgaaag
     1261 ccttggcaca taacggcacg cctcggaatg ccatctagtc tgagtctcag cagcggaggc
     1321 tcagtgctgg cttagtcctc cctccagggt cagatgccat gcactgcagg acatgagcgc
     1381 tgctgcctat ggagtctgga gacgatgacg acggtggagt ttctctgctg acgagagccc
     1441 ctcagccggc tgtgtgcaac tgaagctact ctctaagtac atcgcaaaag aattgcagag
     1501 acctcagaac tcagtgtgtc ttttcttctc tcttgagccc tactttaaat agctgggata
     1561 ttttggacct ggagatgata accagttagc catctttacc agtgaatgtt gctgtcagtc
     1621 ccagcctaaa acagtaggaa actgagtttt atatgcttcc ctaggccttc acttgagtag
     1681 tgtcgaaaga cttgctttgc ttacgttcta acactgcctt tcagagttca gatctcactg
     1741 tacctctaag accttggaag tgcattacct tgctgattca gaagaccaag cgaaggatgt
     1801 ttctgaagag aagaggaagt ttttgtgcgg catcggggag agccaggctc agcaagggca
     1861 gcatcagatc tctggatgtg ttggaaaaac tttgaaacag aagtgatttt ccacagctgt
     1921 ggttcaggta gcagagggcc gtgctctcct cgcctgatca tgaccatgca caatgcaaca
     1981 aagggaattt aagacagaaa gacttcccca cagtcccccc agtgaaggga caaactcatt
     2041 atgtcactga agtacttagc tcacttttct ttaatctcga tgccatggct tttattctat
     2101 gctatgtagg ctctttacga attgtttttg accacagatg accctaaggg ctcctgcgaa
     2161 ccgtcctctg gggattggcg gaagcatgcg gtggtgcagc tgcagcgtgt gcaacttcac
     2221 acactctgcg gtcggttgtc tgacaccaag tgtcagctgt gctactttgc tttgcctgag
     2281 atatgaattc ataattgttc cctgttgttc atggctgata cccttcccac tgatttaggc
     2341 tttcacattt tctttactac acatgcccag tagtcacatt ccaaagccac tgggcccctt
     2401 gagtgcgtca gtgcagctgg tgagtgaaat gtactcaggt ctgtaaccta gcagtgagac
     2461 ttggagcact tcctgcagat gactgactgt tgcgaattta catggaccac ggtgatatcc
     2521 aaaggaaaaa tgcttttata tttatagatt atttcattga actatatgta aaatgggtat
     2581 caataaatgt atttactcca aagtcaaaaa aaaaaaaaaa a
//
