LOCUS       NM_001004154            2308 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus Ras-related GTP binding B (Rragb), mRNA.
ACCESSION   NM_001004154 XM_142239
VERSION     NM_001004154.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2308)
  AUTHORS   Zhu,X., Wu,Y., Li,Y., Zhou,X., Watzlawik,J.O., Chen,Y.M.,
            Raybuck,A.L., Billadeau,D.D., Shapiro,V.S., Springer,W., Sun,J.,
            Boothby,M.R. and Zeng,H.
  TITLE     The nutrient-sensing Rag-GTPase complex in B cells controls humoral
            immunity via TFEB/TFE3-dependent mitochondrial fitness
  JOURNAL   Nat Commun 15 (1), 10163 (2024)
   PUBMED   39580479
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2308)
  AUTHORS   Zhang,X., Li,S., Malik,I., Do,M.H., Ji,L., Chou,C., Shi,W.,
            Capistrano,K.J., Zhang,J., Hsu,T.W., Nixon,B.G., Xu,K., Wang,X.,
            Ballabio,A., Schmidt,L.S., Linehan,W.M. and Li,M.O.
  TITLE     Reprogramming tumour-associated macrophages to outcompete cancer
            cells
  JOURNAL   Nature 619 (7970), 616-623 (2023)
   PUBMED   37380769
REFERENCE   3  (bases 1 to 2308)
  AUTHORS   Ikeda,S., Nah,J., Shirakabe,A., Zhai,P., Oka,S.I., Sciarretta,S.,
            Guan,K.L., Shimokawa,H. and Sadoshima,J.
  TITLE     YAP plays a crucial role in the development of cardiomyopathy in
            lysosomal storage diseases
  JOURNAL   J Clin Invest 131 (5) (2021)
   PUBMED   33373332
REFERENCE   4  (bases 1 to 2308)
  AUTHORS   Do,M.H., Wang,X., Zhang,X., Chou,C., Nixon,B.G., Capistrano,K.J.,
            Peng,M., Efeyan,A., Sabatini,D.M. and Li,M.O.
  TITLE     Nutrient mTORC1 signaling underpins regulatory T cell control of
            immune tolerance
  JOURNAL   J Exp Med 217 (1) (2020)
   PUBMED   31649036
REFERENCE   5  (bases 1 to 2308)
  AUTHORS   Shi,H., Chapman,N.M., Wen,J., Guy,C., Long,L., Dhungana,Y.,
            Rankin,S., Pelletier,S., Vogel,P., Wang,H., Peng,J., Guan,K.L. and
            Chi,H.
  TITLE     Amino Acids License Kinase mTORC1 Activity and Treg Cell Function
            via Small G Proteins Rag and Rheb
  JOURNAL   Immunity 51 (6), 1012-1027 (2019)
   PUBMED   31668641
REFERENCE   6  (bases 1 to 2308)
  AUTHORS   Jewell,J.L., Kim,Y.C., Russell,R.C., Yu,F.X., Park,H.W.,
            Plouffe,S.W., Tagliabracci,V.S. and Guan,K.L.
  TITLE     Metabolism. Differential regulation of mTORC1 by leucine and
            glutamine
  JOURNAL   Science 347 (6218), 194-198 (2015)
   PUBMED   25567907
REFERENCE   7  (bases 1 to 2308)
  AUTHORS   Kim,Y.C., Park,H.W., Sciarretta,S., Mo,J.S., Jewell,J.L.,
            Russell,R.C., Wu,X., Sadoshima,J. and Guan,K.L.
  TITLE     Rag GTPases are cardioprotective by regulating lysosomal function
  JOURNAL   Nat Commun 5, 4241 (2014)
   PUBMED   24980141
  REMARK    GeneRIF: RagA and RagB are key regulators of lysosomal function and
            cardiac protection.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2308)
  AUTHORS   Efeyan,A., Schweitzer,L.D., Bilate,A.M., Chang,S., Kirak,O.,
            Lamming,D.W. and Sabatini,D.M.
  TITLE     RagA, but not RagB, is essential for embryonic development and
            adult mice
  JOURNAL   Dev Cell 29 (3), 321-329 (2014)
   PUBMED   24768164
REFERENCE   9  (bases 1 to 2308)
  AUTHORS   Sekiguchi,T., Todaka,Y., Wang,Y., Hirose,E., Nakashima,N. and
            Nishimoto,T.
  TITLE     A novel human nucleolar protein, Nop132, binds to the G proteins,
            RRAG A/C/D
  JOURNAL   J Biol Chem 279 (9), 8343-8350 (2004)
   PUBMED   14660641
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY123210.1, BC069180.1 and BC070407.1.
            
            On Nov 5, 2008 this sequence version replaced NM_001004154.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069180.1, SRR14777531.238187.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BY123210.1         1-42
            43-2232             BC069180.1         1-2190
            2233-2238           BC070407.1         2210-2215
            2239-2308           BC069180.1         2191-2260
FEATURES             Location/Qualifiers
     source          1..2308
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..2308
                     /gene="Rragb"
                     /note="Ras-related GTP binding B"
                     /db_xref="GeneID:245670"
                     /db_xref="MGI:MGI:3038613"
     exon            1..618
                     /gene="Rragb"
                     /inference="alignment:Splign:2.1.0"
     CDS             527..1651
                     /gene="Rragb"
                     /note="ragB; rag B"
                     /codon_start=1
                     /product="ras-related GTP-binding protein B"
                     /protein_id="NP_001004154.1"
                     /db_xref="CCDS:CCDS30480.1"
                     /db_xref="GeneID:245670"
                     /db_xref="MGI:MGI:3038613"
                     /translation="MEESDSEKKTEKENVGPKVEPPLGEPEGSLGWAMPNAAMKKKVL
                     LMGKSGSGKTSMRSIIFANYIARDTRRLGATILDRIHSLQINSSLSTYSLVDSVGNTK
                     TFDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESREL
                     EKDMHYYQSCLEAILQNSPEAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLEC
                     SCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFERATFLVIS
                     HYQCKEQRDAHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVM
                     VVMSDPSIPSAATLINIRNARKHFEKLERVDGPKQCLLMR"
     exon            619..652
                     /gene="Rragb"
                     /inference="alignment:Splign:2.1.0"
     exon            653..752
                     /gene="Rragb"
                     /inference="alignment:Splign:2.1.0"
     exon            753..836
                     /gene="Rragb"
                     /inference="alignment:Splign:2.1.0"
     exon            837..903
                     /gene="Rragb"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1126
                     /gene="Rragb"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1222
                     /gene="Rragb"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1345
                     /gene="Rragb"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1437
                     /gene="Rragb"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1553
                     /gene="Rragb"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..2281
                     /gene="Rragb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2260..2265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rragb"
                     /note="hexamer: AATAAA"
     polyA_site      2281
                     /gene="Rragb"
                     /note="major polyA site"
ORIGIN      
        1 gtgatcctgg cctgcagtag cgtggttgcg gtgaggttct tgcgctcctg aagggcgggc
       61 gcggaagtaa gagcatcctc aggcggaccg tgactggcag cgaggtcggg aggagccacc
      121 aggcagtgac cgctttgctt ctgcagctcc gctccgctca ttccgttatc tcagcctttg
      181 cagtctgtac agaagctgac caagttacct ttgggtcttg agaccttggc gagtgaggcc
      241 caaactcggg accaactcct catccacctt gccctccctc tcctccatct cttcctttgc
      301 acgcaccgaa tcgaatcgct tgctcctttg ggctggcctg ctcggctgtg cctggagact
      361 aagttcgggt cggtaaaggt aactgtggga aaagcggccc cccagtggac aaaggcggag
      421 gcagggatag atcaggcccc gcgggccctg ggtgctgagc gtaggcaggt gagccagaag
      481 aacggtactg cggatttaga aggcactgtg aaggacttgt tgcacgatgg aagaatctga
      541 ctccgagaaa aagacagaga aagagaatgt gggcccaaaa gtggagcctc ctctagggga
      601 gccggaagga tcgcttgggt gggcaatgcc aaatgcagcc atgaagaaaa aggtcctgtt
      661 gatgggtaaa agtggatctg gtaagaccag catgaggtct attatctttg caaattatat
      721 tgccagagac acacgtcgtc ttggtgcaac aatactagac cgtatacata gtcttcaaat
      781 taatagcagt ttgagcacct actctctcgt agactctgtt ggaaatacaa agacatttga
      841 tgtagaacat tctcatgttc gatttctggg aaacctggtt ttgaacctgt gggattgtgg
      901 tggacaagat accttcatgg aaaattattt cactagccag cgtgacaaca tcttccgaaa
      961 tgtggaggtt ctgatttatg tctttgatgt ggagagccgt gaacttgaaa aggacatgca
     1021 ctactatcag tcatgccttg aggctattct gcagaattct ccagaagcca aaatcttttg
     1081 cttggtacac aaaatggatt tggtacagga agatcagcga gacttgatat ttaaagaacg
     1141 agaagaggac ttaaggcgtt tatcgcgtcc gctagaatgt tcttgtttcc gaacatctat
     1201 ctgggatgaa actctgtata aggcatggtc cagcattgtt tatcagctga ttcccaatgt
     1261 tcagcaactg gaaatgaacc tgcggaattt tgctgaaatt attgaggctg atgaagttct
     1321 tctgtttgaa agagctacct ttctggtgat ttctcattat cagtgtaaag aacagcgaga
     1381 tgcccaccga tttgagaaaa tcagcaacat tattaagcaa ttcaagctga gctgtagcaa
     1441 gctggctgcc tctttccaga gtatggaagt gaggaactct aactttgctg ctttcattga
     1501 catattcaca tccaacactt acgtcatggt cgtgatgtct gatccatcca ttccttctgc
     1561 agctactctg atcaacatcc gcaatgccag aaaacacttt gaaaagctgg agagagtgga
     1621 tggaccaaaa cagtgtcttc tcatgcgcta aacattgctg aatattgttt cacacaaaaa
     1681 ttgaaacact gtttcttaat tttattgttg tattcatata tgtaggattt gaaatattgt
     1741 gatgcccacc acgtctgtat ttcttctcta ctccccagtc ttaacgttta tctttgaatg
     1801 ctatttattc aaatagcgtg aggagttaga agatgaggtg tctatgatgt tgatgtaatg
     1861 tatacgtagg cgatatatgt aagtgttctg ataacatgac tctaatggtg tttaagtgtt
     1921 ctgataacct gcttttaata gttgtgtatg ccaaagtctt tcccagcacc tcttgtattc
     1981 attatcaaat atatacatgt aagtttgaag tattactgtt ttctcagcat gaattaaaaa
     2041 tattctgtaa ctcagccagg caaggtagct catgcctgtg atcccagcat ttgggaaaca
     2101 gaggcaagag gattgctgca agtttaaggc cagcctgtct acatagggag gtccaggcca
     2161 gggatgtata tcaagatctt gtttcaaaaa attatatata tatatatata tatatatata
     2221 tatatatata tatatatacc ttaacttcac ttcaatgtaa ataaacttct gctgttaggg
     2281 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
