LOCUS       NM_178376               1653 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus Ras-related GTP binding A (Rraga), mRNA.
ACCESSION   NM_178376
VERSION     NM_178376.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1653)
  AUTHORS   Zhu,X., Wu,Y., Li,Y., Zhou,X., Watzlawik,J.O., Chen,Y.M.,
            Raybuck,A.L., Billadeau,D.D., Shapiro,V.S., Springer,W., Sun,J.,
            Boothby,M.R. and Zeng,H.
  TITLE     The nutrient-sensing Rag-GTPase complex in B cells controls humoral
            immunity via TFEB/TFE3-dependent mitochondrial fitness
  JOURNAL   Nat Commun 15 (1), 10163 (2024)
   PUBMED   39580479
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1653)
  AUTHORS   Samson,N., Bosoi,C.R., Roy,C., Turcotte,L., Tribouillard,L.,
            Mouchiroud,M., Berthiaume,L., Trottier,J., Silva,H.C.G.,
            Guerbette,T., Plata-Gomez,A.B., Besse-Patin,A., Montoni,A.,
            Ilacqua,N., Lamothe,J., Citron,Y.R., Gelinas,Y., Gobeil,S.,
            Zoncu,R., Caron,A., Morissette,M., Pellegrini,L., Rochette,P.J.,
            Estall,J.L., Efeyan,A., Shum,M., Audet-Walsh,E., Barbier,O.,
            Marette,A. and Laplante,M.
  TITLE     HSDL2 links nutritional cues to bile acid and cholesterol
            homeostasis
  JOURNAL   Sci Adv 10 (22), eadk9681 (2024)
   PUBMED   38820148
REFERENCE   3  (bases 1 to 1653)
  AUTHORS   Plata-Gomez,A.B., de Prado-Rivas,L., Sanz,A., Deleyto-Seldas,N.,
            Garcia,F., de la Calle Arregui,C., Silva,C., Caleiras,E.,
            Grana-Castro,O., Pineiro-Yanez,E., Krebs,J., Leiva-Vega,L.,
            Munoz,J., Jain,A., Sabio,G. and Efeyan,A.
  TITLE     Hepatic nutrient and hormone signaling to mTORC1 instructs the
            postnatal metabolic zonation of the liver
  JOURNAL   Nat Commun 15 (1), 1878 (2024)
   PUBMED   38499523
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1653)
  AUTHORS   Zhang,X., Li,S., Malik,I., Do,M.H., Ji,L., Chou,C., Shi,W.,
            Capistrano,K.J., Zhang,J., Hsu,T.W., Nixon,B.G., Xu,K., Wang,X.,
            Ballabio,A., Schmidt,L.S., Linehan,W.M. and Li,M.O.
  TITLE     Reprogramming tumour-associated macrophages to outcompete cancer
            cells
  JOURNAL   Nature 619 (7970), 616-623 (2023)
   PUBMED   37380769
REFERENCE   5  (bases 1 to 1653)
  AUTHORS   Di Lorenzo,G., Iavarone,F., Maddaluno,M., Plata-Gomez,A.B.,
            Aureli,S., Quezada Meza,C.P., Cinque,L., Palma,A., Reggio,A.,
            Cirillo,C., Sacco,F., Stolz,A., Napolitano,G., Marin,O.,
            Pinna,L.A., Ruzzene,M., Limongelli,V., Efeyan,A., Grumati,P. and
            Settembre,C.
  TITLE     Phosphorylation of FAM134C by CK2 controls starvation-induced
            ER-phagy
  JOURNAL   Sci Adv 8 (35), eabo1215 (2022)
   PUBMED   36044577
REFERENCE   6  (bases 1 to 1653)
  AUTHORS   Efeyan,A., Zoncu,R., Chang,S., Gumper,I., Snitkin,H., Wolfson,R.L.,
            Kirak,O., Sabatini,D.D. and Sabatini,D.M.
  TITLE     Regulation of mTORC1 by the Rag GTPases is necessary for neonatal
            autophagy and survival
  JOURNAL   Nature 493 (7434), 679-683 (2013)
   PUBMED   23263183
REFERENCE   7  (bases 1 to 1653)
  AUTHORS   Hong-Brown,L.Q., Brown,C.R., Kazi,A.A., Navaratnarajah,M. and
            Lang,C.H.
  TITLE     Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation
            of mTORC1 signaling in response to alcohol and leucine
  JOURNAL   Am J Physiol Cell Physiol 302 (10), C1557-C1565 (2012)
   PUBMED   22442136
  REMARK    GeneRIF: Overexpression of constitutively active (ca)RagA and
            caRagC increased mTORC1 activity, as determined by increased S6K1
            phosphorylation.
REFERENCE   8  (bases 1 to 1653)
  AUTHORS   Zoncu,R., Bar-Peled,L., Efeyan,A., Wang,S., Sancak,Y. and
            Sabatini,D.M.
  TITLE     mTORC1 senses lysosomal amino acids through an inside-out mechanism
            that requires the vacuolar H(+)-ATPase
  JOURNAL   Science 334 (6056), 678-683 (2011)
   PUBMED   22053050
REFERENCE   9  (bases 1 to 1653)
  AUTHORS   Stylianou,I.M., Korstanje,R., Li,R., Sheehan,S., Paigen,B. and
            Churchill,G.A.
  TITLE     Quantitative trait locus analysis for obesity reveals multiple
            networks of interacting loci
  JOURNAL   Mamm Genome 17 (1), 22-36 (2006)
   PUBMED   16416088
REFERENCE   10 (bases 1 to 1653)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY128554.1 and BC048245.1.
            
            On May 9, 2009 this sequence version replaced NM_178376.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC048245.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               BY128554.1         1-302
            303-1244            BC048245.1         290-1231
            1245-1653           BC048245.1         1235-1643
FEATURES             Location/Qualifiers
     source          1..1653
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 40.69 cM"
     gene            1..1653
                     /gene="Rraga"
                     /gene_synonym="1300010C19Rik; FIP-1; RAGA"
                     /note="Ras-related GTP binding A"
                     /db_xref="GeneID:68441"
                     /db_xref="MGI:MGI:1915691"
     exon            1..1613
                     /gene="Rraga"
                     /gene_synonym="1300010C19Rik; FIP-1; RAGA"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1188
                     /gene="Rraga"
                     /gene_synonym="1300010C19Rik; FIP-1; RAGA"
                     /note="rag A"
                     /codon_start=1
                     /product="ras-related GTP-binding protein A"
                     /protein_id="NP_848463.1"
                     /db_xref="CCDS:CCDS18306.1"
                     /db_xref="GeneID:68441"
                     /db_xref="MGI:MGI:1915691"
                     /translation="MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATID
                     VEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKD
                     MHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACF
                     RTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQ
                     CKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVM
                     SDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR"
     regulatory      1590..1595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rraga"
                     /gene_synonym="1300010C19Rik; FIP-1; RAGA"
                     /note="hexamer: AATAAA"
     polyA_site      1613
                     /gene="Rraga"
                     /gene_synonym="1300010C19Rik; FIP-1; RAGA"
                     /note="major polyA site"
ORIGIN      
        1 gaagtgggtg gcggccgggc cgaagctgat cacatcactg gtctgctctc gctagctcgg
       61 agcggctgtg gccattgcct cgggcgctgt tttctgagac ctcgcctcgc cgcggtcttt
      121 cctgccccca gctcgcgtgc acggcctccg ctgccggtcg gtgctcggtg tcccgccgtc
      181 cccatccttg gtcggtccgc cgttaggccg tgcctcaggc ccagtccgtg gcgacgccgg
      241 caggtgatgc ccaatacagc catgaagaaa aaggtgctgt tgatgggaaa gagcgggtcg
      301 gggaagacca gcatgaggtc gatcatcttt gcaaattata ttgcgcgcga cactaggcgc
      361 ctgggtgcca ccatcgacgt ggagcactcc cacgtccgat tcttggggaa cctggtgctg
      421 aacctgtggg actgtggcgg ccaggacacc tttatggaaa attacttcac cagccagcgg
      481 gacaacatct tccgtaatgt ggaggttctg atatacgtgt ttgacgtaga gagccgcgaa
      541 ctggaaaaag atatgcatta ttaccaatcg tgtctggaag ccatcctcca gaattcacct
      601 gacgccaaaa tcttctgcct ggtgcacaaa atggatctgg ttcaggaaga tcaacgtgac
      661 ctgattttta aagagcgaga ggaagacctg aggcgtttgt ctcgcccgct ggagtgcgct
      721 tgttttcgaa cgtccatctg ggatgagacg ctctacaaag cctggtccag catcgtctat
      781 cagctgatcc ccaacgttca gcagctggag atgaacctaa ggaattttgc ccagattatt
      841 gaggctgatg aagttctgct gttcgagaga gctacgttct tggtgatttc ccactaccag
      901 tgcaaagagc agcgagatgt gcaccgcttt gagaagatca gcaacatcat caagcagttt
      961 aagctgagct gcagtaaatt ggccgcttct ttccagagca tggaagtgag gaattctaac
     1021 ttcgctgcct tcatcgacat ctttacatca aacacgtacg tgatggtggt catgtcagat
     1081 ccatccatcc cttctgcagc tactctgatc aacattcgta atgccaggaa acactttgag
     1141 aagctagaaa gagtagatgg gcccaagcac agcctcctca tgcgttgaaa taatgccaaa
     1201 tgctctttag taaaatgctg aattacggtg tttttttttt ttttgcatca tttgtcttta
     1261 atattcataa tgtcatgtgc ttaaaagtga gcttgaaacg tgtgcttact atctcatctc
     1321 ttccctagtc ttagtattgg acgctattta ctcagctatc aagtagagat cttcaagacg
     1381 gcctttatga aaagttagtg tggtgttaac actaaagtag gtggggtgtg ggtgggtgtg
     1441 tgtgtatgtg tgtgtgttct ggttacctgg ttataataga gtattaaagc agttatcttc
     1501 tgtattatca gatcacaaag gtggaatgtt actattttat cagcaagata ttaaaatgta
     1561 tttctaaatc ctccttggtt tcaatcatga ataaacttat tagcaattta aaaaaaaaaa
     1621 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
