LOCUS       NM_028898               7046 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus regulatory associated protein of MTOR, complex 1
            (Rptor), transcript variant 1, mRNA.
ACCESSION   NM_028898
VERSION     NM_028898.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7046)
  AUTHORS   Zhu,X., Wu,Y., Li,Y., Zhou,X., Watzlawik,J.O., Chen,Y.M.,
            Raybuck,A.L., Billadeau,D.D., Shapiro,V.S., Springer,W., Sun,J.,
            Boothby,M.R. and Zeng,H.
  TITLE     The nutrient-sensing Rag-GTPase complex in B cells controls humoral
            immunity via TFEB/TFE3-dependent mitochondrial fitness
  JOURNAL   Nat Commun 15 (1), 10163 (2024)
   PUBMED   39580479
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7046)
  AUTHORS   Rosenlehner,T., Pennavaria,S., Akcabozan,B., Jahani,S.,
            O'Neill,T.J., Krappmann,D., Straub,T., Kranich,J. and Obst,R.
  TITLE     Reciprocal regulation of mTORC1 signaling and ribosomal
            biosynthesis determines cell cycle progression in activated T cells
  JOURNAL   Sci Signal 17 (859), eadi8753 (2024)
   PUBMED   39436996
  REMARK    Erratum:[Sci Signal. 2024 Dec 17;17(867):eadu7437. doi:
            10.1126/scisignal.adu7437.. PMID: 39689184]
REFERENCE   3  (bases 1 to 7046)
  AUTHORS   Imada,S., Khawaled,S., Shin,H., Meckelmann,S.W., Whittaker,C.A.,
            Correa,R.O., Alquati,C., Lu,Y., Tie,G., Pradhan,D.,
            Calibasi-Kocal,G., Nascentes Melo,L.M., Allies,G., Rosler,J.,
            Wittenhofer,P., Krystkiewicz,J., Schmitz,O.J., Roper,J.,
            Vinolo,M.A.R., Ricciardiello,L., Lien,E.C., Vander Heiden,M.G.,
            Shivdasani,R.A., Cheng,C.W., Tasdogan,A. and Yilmaz,O.H.
  TITLE     Short-term post-fast refeeding enhances intestinal stemness via
            polyamines
  JOURNAL   Nature 633 (8031), 895-904 (2024)
   PUBMED   39169180
REFERENCE   4  (bases 1 to 7046)
  AUTHORS   Deng,D., Liu,X., Huang,W., Yuan,S., Liu,G., Ai,S., Fu,Y., Xu,H.,
            Zhang,X., Li,S., Xu,S., Bai,X. and Zhang,Y.
  TITLE     Osteoclasts control endochondral ossification via regulating
            acetyl-CoA availability
  JOURNAL   Bone Res 12 (1), 49 (2024)
   PUBMED   39198395
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7046)
  AUTHORS   Laplante,M. and Sabatini,D.M.
  TITLE     mTOR signaling in growth control and disease
  JOURNAL   Cell 149 (2), 274-293 (2012)
   PUBMED   22500797
  REMARK    Review article
REFERENCE   6  (bases 1 to 7046)
  AUTHORS   Guertin,D.A., Stevens,D.M., Thoreen,C.C., Burds,A.A., Kalaany,N.Y.,
            Moffat,J., Brown,M., Fitzgerald,K.J. and Sabatini,D.M.
  TITLE     Ablation in mice of the mTORC components raptor, rictor, or mLST8
            reveals that mTORC2 is required for signaling to Akt-FOXO and
            PKCalpha, but not S6K1
  JOURNAL   Dev Cell 11 (6), 859-871 (2006)
   PUBMED   17141160
REFERENCE   7  (bases 1 to 7046)
  AUTHORS   Reiling,J.H. and Sabatini,D.M.
  TITLE     Stress and mTORture signaling
  JOURNAL   Oncogene 25 (48), 6373-6383 (2006)
   PUBMED   17041623
  REMARK    Review article
REFERENCE   8  (bases 1 to 7046)
  AUTHORS   Shah,O.J. and Hunter,T.
  TITLE     Turnover of the active fraction of IRS1 involves raptor-mTOR- and
            S6K1-dependent serine phosphorylation in cell culture models of
            tuberous sclerosis
  JOURNAL   Mol Cell Biol 26 (17), 6425-6434 (2006)
   PUBMED   16914728
REFERENCE   9  (bases 1 to 7046)
  AUTHORS   Jacinto,E., Loewith,R., Schmidt,A., Lin,S., Ruegg,M.A., Hall,A. and
            Hall,M.N.
  TITLE     Mammalian TOR complex 2 controls the actin cytoskeleton and is
            rapamycin insensitive
  JOURNAL   Nat Cell Biol 6 (11), 1122-1128 (2004)
   PUBMED   15467718
REFERENCE   10 (bases 1 to 7046)
  AUTHORS   Hara,K., Maruki,Y., Long,X., Yoshino,K., Oshiro,N., Hidayat,S.,
            Tokunaga,C., Avruch,J. and Yonezawa,K.
  TITLE     Raptor, a binding partner of target of rapamycin (TOR), mediates
            TOR action
  JOURNAL   Cell 110 (2), 177-189 (2002)
   PUBMED   12150926
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK161011.1, AK144082.1,
            BC118971.1 and BC060140.1.
            
            On Apr 14, 2015 this sequence version replaced NM_028898.2.
            
            Summary: This gene encodes a subunit of mammalian target of
            rapamycin complex 1 (mTORC1), a component of the mTOR signaling
            pathway, which regulates cell growth in response to nutrient and
            energy levels. The encoded protein may regulate the assembly,
            localization, and substrate binding of the mTORC1 complex.
            Homozygous knockout mice for this gene exhibit embryonic lethality.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB082952.1, BC118971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AK161011.1         2-111
            111-910             AK144082.1         1-800
            911-4913            BC118971.1         1-4003
            4914-7046           BC060140.1         4045-6177
FEATURES             Location/Qualifiers
     source          1..7046
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.96 cM"
     gene            1..7046
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /note="regulatory associated protein of MTOR, complex 1"
                     /db_xref="GeneID:74370"
                     /db_xref="MGI:MGI:1921620"
     exon            1..1067
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     CDS             906..4913
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /note="isoform 1 is encoded by transcript variant 1;
                     regulatory-associated protein of mTOR; p150 target of
                     rapamycin (TOR)-scaffold protein"
                     /codon_start=1
                     /product="regulatory-associated protein of mTOR isoform 1"
                     /protein_id="NP_083174.2"
                     /db_xref="CCDS:CCDS25720.1"
                     /db_xref="GeneID:74370"
                     /db_xref="MGI:MGI:1921620"
                     /translation="MESEMLQSPLMGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKS
                     LAQSWRMKDRMKTVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETI
                     GANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTV
                     NGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELE
                     VAAINPNHPLAQMPLPPSMKNCIQLAACEAHELLPMIPDLPADLFTSCLTTPIKIALR
                     WFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQ
                     KLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQ
                     LPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRSPPEQLPIVLQVLLSQVHRLRAL
                     DLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSSARELRPLLVFIWAKILAVDSSCQAD
                     LVKDNGHKYFLSVLADPYMPAEHRTMTAFILAVIVNSYTTGQEACLQGNLIAICLEQL
                     SDPHPLLRQWVAICLGRIWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALG
                     TFVGNSAERTDHSTTIDHNVAMMLAQLINDGSPMVRKELVVALSHLVVQYESNFCTVA
                     LQFMEEEKNYPLPSPAATEGGSLTPVRDSPCTPRLRSVSSYGNIRAVTTARNLNKSLQ
                     NLSLTEESGSSVAFSPGNLSTSSSASSTLGSPENEEYILSFETIDKMRRVSSYSALNS
                     LIGVSFNSVYTQIWRVLLHLAADPYPDVSDLAMKVLNSIAYKATVNARPQRILDTSSL
                     TQSAPASPTNKGMHMHQVGGSPPASSTSSCSLTNDVAKQTVSRDLPSSRPGTAGPTGA
                     QYTPHSHQFPRTRKMFDKGPDQTTDDADDAAGHKSFICASMQTGFCDWSARYFAQPVM
                     KIPEEHDLESQIRKEREWRFLRNTRVRKQAQQVIQKGITRLDDQIFLNRNPGVPSVVK
                     FHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNGQDCSLLLTAT
                     DDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRI
                     VRIWDTDRETKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRV
                     MTYREHTAWVVKAYLQKHPEGHIVSVSVNGDVRFFDPRMPESVNVMQIVKGLTALDIH
                     PQANLIACGSMNQFTAIYNGNGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAVGS
                     NDYYISVYSVEKRVR"
     exon            1068..1170
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1253
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1412
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1559
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1735
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1795
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1896
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2041
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2117
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2219
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2303
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2414
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2489
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2555
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2747
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2888
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3006
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            3007..3147
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3306
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..3425
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            3426..3529
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..3713
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            3714..3824
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..3930
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            3931..4045
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            4046..4170
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            4171..4275
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            4276..4382
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            4383..4510
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..4597
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            4598..4714
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            4715..4844
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     exon            4845..7022
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6819..6824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /note="hexamer: AATAAA"
     polyA_site      6838
                     /gene="Rptor"
                     /gene_synonym="4932417H02Rik; mKIAA1303; Rap; Raptor"
                     /note="major polyA site"
ORIGIN      
        1 aggacggaac accgagctct acgccctagc aggggtagag cggtgagaac gctcgaagag
       61 gtttggctta ttggacgcgc cgtagatagc ggtgcatgct gggccttggc aatatggcgt
      121 cctccttgat gtgctgatga gaggagtttt cactgtggct ccagagcaga gggcaaaact
      181 cccctgacct aataagccca gtgtccctgt gctgtccgcg ggcccgtgtc gcgtgtgtat
      241 cgggactcgt tcctgggtag gagagagcca cgaagcagaa ggccagcacg ggcctggccg
      301 cgcggcccgg tggctgagga gcccggctgc ggacgggcac gatgggccgg tcctggctca
      361 ggttgcagcc cctcaggcga gtgcgggacc cgcagggctg agagccgctg ggcgagcccc
      421 gaagcccccc gatcccgatc ccttgaggcc tcagccgggc cagcacagtc ggagaagccg
      481 ccctgcgagc gggccggcct gcccgccggg agccactgag gcgttggagg ccgagagccg
      541 ggtcatcgcc gggcctgaag tctctcccgc ctccgccagt cccgcttgcc gccctcctga
      601 cggcctgcag agctgcgggg gccggcgacc gggcgcgcgt gtcgccgctc gtccgggtcc
      661 tgcgggcttg ggtacccacg ggctcgccac ccaccccgcc ccctccaact tcgcgctcag
      721 agttcgagat aaagatctcc gaggtttagc ctcaataagg atcttcgaac gctctgccgc
      781 cgtctctatt cccagcttcc cgttttcccg tattttattt taccagttct ggtccacact
      841 agtttttaag gctggaggtt ctcgagcgcc tgctgccaag gactccccct ccccctcctc
      901 ccctgatgga gtcggagatg ctgcagtcgc ctcttatggg actcggggag gaagatgagg
      961 cggaccttac agattggaac ttgcctttgg cttttatgaa gaaaagacat tgtgagaaaa
     1021 tcgaaggctc caaatcttta gcgcagagct ggagaatgaa ggatcggatg aagacggtga
     1081 gtgtggcctt ggtcctgtgc ctgaatgtgg gtgtggatcc tccggatgtg gtgaagacca
     1141 caccctgtgc tcggctggaa tgctggatcg atcctctgtc tatgggccct cagaaagctc
     1201 tggaaaccat cggtgcaaac ctacagaagc agtatgagaa ctggcagcca agggctcggt
     1261 acaagcagag cctcgaccct actgtggatg aagtcaagaa actttgcaca tctctgcgcc
     1321 ggaacgccaa ggaggaacgg gtccttttcc actacaatgg ccacggggtg cccaggccta
     1381 cagtgaatgg agaggtctgg gtcttcaaca agaactacac tcagtacatc cctctgtcca
     1441 tatacgacct gcagacgtgg atgggcagcc catccatctt tgtctacgac tgttccaatg
     1501 ctggcctcat cgtcaagtcc ttcaaacagt ttgcactgca gagggagcag gaactagagg
     1561 tagctgcgat taacccaaac catccacttg cccagatgcc cttgcctccc tcaatgaaaa
     1621 actgcatcca gttggcagcg tgtgaggcac acgagctgct gcccatgatc cctgacctcc
     1681 cagccgacct gttcacatcc tgcctcacca ctcccatcaa gattgctctg cgctggtttt
     1741 gcatgcagaa gtgcgtgagt ctggtgcctg gagtcacact ggatttgata gaaaagatcc
     1801 ctggccggct gaatgaccgg aggacccctc tgggagagct gaactggatc ttcacagcca
     1861 tcacagatac catcgcctgg aatgtgctcc ctcgggatct cttccaaaag cttttccgac
     1921 aggacctgct cgtggcaagt ttgtttagaa attttttatt ggcagaaaga atcatgaggt
     1981 catataactg caccccagta agcagcccgc ggctcccccc gacatacatg catgccatgt
     2041 ggcaggcctg ggaccttgct gtggacattt gcctctctca gctgccaacc atcatcgaag
     2101 agggtactgc cttcaggcac agcccattct ttgccgagca gctgacagca ttccaggtgt
     2161 ggctcacaat gggtgtggaa aacaggagcc ccccagagca gctgcccatc gtcctgcagg
     2221 tgctgctaag ccaggtgcac cggctgagag cattggactt gctgggacgg tttttggact
     2281 tgggcccttg ggcggtgagc ttggccctgt cggtgggcat cttcccctat gtactgaagc
     2341 tgcttcagag ctcagcccga gagcttcggc cactccttgt cttcatctgg gccaaaatcc
     2401 tcgctgtcga cagttcgtgc caagctgacc tcgtgaagga caacggtcac aagtacttcc
     2461 tatccgtctt ggcagaccca tacatgccag ctgaacatag gaccatgaca gccttcattc
     2521 ttgctgtaat cgtcaacagc tacacaacag ggcaagaggc ctgcctccag ggaaacctga
     2581 ttgccatctg tctggagcag ctcagcgacc cacacccctt gctacgccag tgggtggcca
     2641 tttgcctggg aaggatctgg cagaacttcg actctgcaag atggtgtggg gtgagagaca
     2701 gtgcccacga aaagctctat agcctcctct ctgaccccat ccctgaggtc cgatgtgcag
     2761 ctgtatttgc cctgggcacc tttgtgggaa attctgctga gaggacagac cactctacca
     2821 ccattgacca caatgtggcc atgatgctgg ctcagctgat caatgatgga agccccatgg
     2881 tccggaagga gctggtggtg gctctgagtc accttgtagt ccaatatgaa agcaatttct
     2941 gcactgtggc cctgcagttc atggaggaag aaaagaacta ccctttgcct tctccagcag
     3001 ccacagaggg agggagcttg accccagttc gagacagccc atgcaccccc agactccgtt
     3061 cagtgagctc ctatgggaac atccgagccg tcacgacagc taggaacctg aacaaatctt
     3121 tgcagaatct gagcttgacg gaagaatcgg gcagctcagt ggccttctct cccgggaacc
     3181 tcagcaccag cagcagtgcc agcagcacct tggggagccc tgagaacgag gagtacatcc
     3241 tgtccttcga gaccatcgac aagatgcggc gtgtgagctc ctactcagcg ctcaactccc
     3301 tcataggagt ttcttttaat agtgtttaca ctcaaatttg gagagtctta ctgcatctgg
     3361 ctgctgatcc ctatccagat gtttctgatt tagccatgaa agtcctcaac agcattgctt
     3421 acaaggccac agtgaacgcc cggccccaac gaatccttga cacatcctct ctcacacagt
     3481 cggccccagc cagcccaacc aacaagggca tgcacatgca ccaggtggga ggctccccgc
     3541 cagcatctag caccagcagc tgcagcctga ccaatgatgt ggccaagcag actgtcagcc
     3601 gtgacctgcc ttccagccgc ccgggtactg ccggccccac aggggcacag tacacccctc
     3661 actcccacca gttccctcga acacgaaaga tgtttgacaa aggccctgat cagaccacag
     3721 atgatgcaga tgatgctgcc ggacacaaga gcttcatttg tgcctctatg cagacagggt
     3781 tctgtgactg gagtgcccgc tactttgccc agccagtcat gaagatcccc gaggagcatg
     3841 acctagagag tcagatccgc aaggagcgtg agtggcggtt cctgaggaac actcgagtca
     3901 ggaagcaggc tcagcaggtc atccagaagg gcatcaccag actggacgat cagatctttc
     3961 tgaacaggaa ccccggcgtt ccttctgtgg tcaaattcca tccctttaca ccatgcatag
     4021 ctgtcgccga caaggacagc atctgttttt gggactggga gaaaggagag aagctggact
     4081 atttccacaa tggcaaccct cggtacacca gggtcaccgc catggagtac ctgaatggtc
     4141 aggactgttc cttgctgctg acagccacag atgatggtgc catcagggtc tggaagaatt
     4201 ttgctgattt ggaaaagaat ccagagatgg tgactgcgtg gcaagggctc tcagacatgc
     4261 ttccaacaac acgaggagct gggatggtgg tagactggga acaagaaact ggccttctca
     4321 tgagctcagg ggacgtgcgc attgtcagga tctgggatac tgaccgggag acgaaggtgc
     4381 aggacatccc cacgggtgct gacagctgtg tgacaagtct gtcttgtgat tcgcaccgtt
     4441 cgctcattgt ggctggcctg ggtgatggct cgatccgtgt ctacgacagg aggatggcac
     4501 tcagtgaatg ccgggtcatg acttaccgag agcacacagc gtgggtggta aaggcctacc
     4561 tgcagaagca ccctgagggc cacatcgtga gtgtgagtgt caatggagat gtgcgcttct
     4621 tcgaccctcg gatgcccgag tctgtgaatg taatgcagat tgtgaagggg ctgacagccc
     4681 tggacatcca cccccaggca aacctgatcg cctgtggctc catgaaccag ttcacagcca
     4741 tctacaacgg aaatggagag ctgatcaaca acatcaaata ctatgatggc ttcatgggcc
     4801 agcgagtcgg ggccatcagc tgcctggctt tccacccaca ctggcctcat ctggccgtag
     4861 gaagcaatga ctactacatt tccgtgtatt cggtggagaa gcgtgtcaga tagcggcacc
     4921 taggaccact gccaggccgc agccacctct gctgtacata gtgagccagc ctgcactgct
     4981 cggatgcagt gcccacctac ccacccacct gcaaaccccg gctcctgact tggccgtggc
     5041 cagctgagga ggggcttgca catccttcct tctgtcttca ctataacagc gtacaggtcc
     5101 agagcagggg aggggttggc ctggcttccc atcaagaacc agcacccagg caccaaggac
     5161 ctcctcagtg cagcatggtc ctttcctgcc ctgttttctt ctgaggtttt acaaagggac
     5221 acatttgatt tttccatgtg atcaaagcat tagttacaga gcagacagcg ccctgtagaa
     5281 tagccgtgct ggggctccta agggccatgg cccagcccca ctgtcctctc agagtgtgct
     5341 gccagtcctg ggaaatggat aagagcaatt gggggaagag agagggtaga agagagggaa
     5401 ggcctctcct gctacaaggt atggaagtct gagcctggcc ctcctggagc accgaggcag
     5461 tccagcacat tgtgtatgtc atggtgctat gaggaaagct agacctctga ggtccagcct
     5521 ggcgggcgcc ctcaagtgag ctagctgcag gagagggtct ggttcagggc agatgaggca
     5581 gatctgtagt tagcggctgc ctccatctat caggcatatt ctgaagtgct tctctcccat
     5641 agggcagtaa cagtggccac aggcctgtct cctgcttgtg ccacacacag gtacacacgc
     5701 atgcaggcac gcagcctccc catccataat tacatggatg ccctggtctt cctgcccatg
     5761 tacacttagg tgtgcattca tgcaggccca tagtttcccc tcctgcacat atatgggcac
     5821 tgtggccggc cacatgcacg cacatgctgg cctcaccatg catagggctc agacacttca
     5881 ctgaactcag aggctggagg gcagcatcag ctctgttgat ggtggaactg aggttacatg
     5941 atgcagtatg tgctgagcac gagttccaca gtgtcctggt gtgcctgaca cgtgtctgcg
     6001 tgcacaggca agagaggacc atggacactg tagccctaga tgtcagcact gtccccgtgt
     6061 gtccgacatg tgtctgtgtg cacaggcaag tgaggacctt aggcactgca gccctggatg
     6121 gacccagcat tgcagagcag ttgcacacaa acaggacaca acacaatgat gttttgaaaa
     6181 gcattttccg ttttccctgg gaatcaggat ctttcagagg acaagtgcca acaggagccc
     6241 agggacacgg gttgggacat ctgtggcaga ggctgggtcc ctgtgctgtg ttcagtggac
     6301 ctgttttagc caagagcatc ttccctgtga gaggatccta caggctgagc tgtcctgggc
     6361 aagcagaaca ggagaccctg gcacggcccc tggaaatgca ttctcccaac cgggtggggc
     6421 tcaaggaagc cagccccttg gttgggccat agagcagtgt ggcgacagga aggccctaga
     6481 gccacctgac ttacccctgc tcagttctgc agagagcttc aggggctgag tgtgcgtcag
     6541 ctcagtcctt gtccaactgg tgactcagtt ttggccgcac agggccgcct gatgggctgg
     6601 gctgcttccc tgccctggtg gaaccagtgt ttgcatcttg cccacaggct gggcctcaca
     6661 agtctgatgc ggaaattcaa tcatgaagct aagcaaagct cgagagagcg ctgacctaga
     6721 gcgcatttct ctatttattt taccaaaatg agagttgaaa ggactgacag gacacggaac
     6781 tgcagtggcg tccagagcag tgacagcaac agagtgttaa taaagaataa agccgtgaga
     6841 tgtcgctgcc cttgccagat gagaatggtg gggtggggtg gcccaaaggg ctgtgccctt
     6901 gtggcttctg cagtccccgg gtccctgggg tgagacagtc ttggccagag acaaggctac
     6961 tctatctacc cctccaggcc tgggtggaag tgaagacatg ctggttgcca tggagatctt
     7021 gaaaaaaaaa aaaaaaaaaa aaaaaa
//
