LOCUS       NM_025949               4683 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus ribosomal protein S6 kinase polypeptide 6 (Rps6ka6),
            transcript variant 1, mRNA.
ACCESSION   NM_025949
VERSION     NM_025949.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4683)
  AUTHORS   Lekkos,K., Bhuiyan,A.A., Albloshi,A.M.K., Brooks,P.M., Coate,T.M.
            and Lionikas,A.
  TITLE     Validation of positional candidates Rps6ka6 and Pou3f4 for a locus
            associated with skeletal muscle mass variability
  JOURNAL   G3 (Bethesda) 14 (5) (2024)
   PUBMED   38577978
  REMARK    GeneRIF: Validation of positional candidates Rps6ka6 and Pou3f4 for
            a locus associated with skeletal muscle mass variability.
REFERENCE   2  (bases 1 to 4683)
  AUTHORS   Decourt,C., Schaeffer,J., Blot,B., Paccard,A., Excoffier,B.,
            Pende,M., Nawabi,H. and Belin,S.
  TITLE     The RSK2-RPS6 axis promotes axonal regeneration in the peripheral
            and central nervous systems
  JOURNAL   PLoS Biol 21 (4), e3002044 (2023)
   PUBMED   37068088
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4683)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4683)
  AUTHORS   Zhu,L., Zhang,S., Huan,X., Mei,Y. and Yang,H.
  TITLE     Down-regulation of TRAF4 targeting RSK4 inhibits proliferation,
            invasion and metastasis in breast cancer xenografts
  JOURNAL   Biochem Biophys Res Commun 500 (3), 810-816 (2018)
   PUBMED   29684350
  REMARK    GeneRIF: TRAF4 knockdown significantly inhibited proliferation,
            invasion and metastasis in the xenograft nude mouse model, possibly
            involving in the interaction with RSK4.
REFERENCE   5  (bases 1 to 4683)
  AUTHORS   Distler,U., Schmeisser,M.J., Pelosi,A., Reim,D., Kuharev,J.,
            Weiczner,R., Baumgart,J., Boeckers,T.M., Nitsch,R., Vogt,J. and
            Tenzer,S.
  TITLE     In-depth protein profiling of the postsynaptic density from mouse
            hippocampus using data-independent acquisition proteomics
  JOURNAL   Proteomics 14 (21-22), 2607-2613 (2014)
   PUBMED   25211037
REFERENCE   6  (bases 1 to 4683)
  AUTHORS   Laugel-Haushalter,V., Paschaki,M., Marangoni,P., Pilgram,C.,
            Langer,A., Kuntz,T., Demassue,J., Morkmued,S., Choquet,P.,
            Constantinesco,A., Bornert,F., Schmittbuhl,M., Pannetier,S.,
            Viriot,L., Hanauer,A., Dolle,P. and Bloch-Zupan,A.
  TITLE     RSK2 is a modulator of craniofacial development
  JOURNAL   PLoS One 9 (1), e84343 (2014)
   PUBMED   24416220
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4683)
  AUTHORS   Myers,A.P., Corson,L.B., Rossant,J. and Baker,J.C.
  TITLE     Characterization of mouse Rsk4 as an inhibitor of fibroblast growth
            factor-RAS-extracellular signal-regulated kinase signaling
  JOURNAL   Mol Cell Biol 24 (10), 4255-4266 (2004)
   PUBMED   15121846
  REMARK    GeneRIF: Rsk4 inhibits the transcriptional activation of specific
            targets of receptor tyrosine kinase signaling as well as the
            activation of ERK
REFERENCE   8  (bases 1 to 4683)
  AUTHORS   Kohn,M., Hameister,H., Vogel,M. and Kehrer-Sawatzki,H.
  TITLE     Expression pattern of the Rsk2, Rsk4 and Pdk1 genes during murine
            embryogenesis
  JOURNAL   Gene Expr Patterns 3 (2), 173-177 (2003)
   PUBMED   12711546
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY096109.1, AK049349.1, BC054113.1, AK012150.2 and CR392009.5.
            
            On Mar 15, 2014 this sequence version replaced NM_025949.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               BY096109.1         1-385
            386-935             AK049349.1         137-686
            936-1044            BC054113.1         609-717
            1045-2413           AK049349.1         796-2164
            2414-2476           BC054113.1         2087-2149
            2477-2585           AK049349.1         2228-2336
            2586-4110           AK012150.2         1321-2845
            4111-4683           CR392009.5         27494-28066         c
FEATURES             Location/Qualifiers
     source          1..4683
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 48.2 cM"
     gene            1..4683
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /note="ribosomal protein S6 kinase polypeptide 6"
                     /db_xref="GeneID:67071"
                     /db_xref="MGI:MGI:1914321"
     exon            1..139
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            140..271
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..2740
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ribosomal protein S6 kinase alpha-6"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase alpha-6 isoform 1"
                     /protein_id="NP_080225.2"
                     /db_xref="CCDS:CCDS30356.1"
                     /db_xref="GeneID:67071"
                     /db_xref="MGI:MGI:1914321"
                     /translation="MLNFRRTRHTPSGHRSNSNLNLFCCLPFFGCRRRSKSRQRAGTP
                     VVPLLRYPRLARSAVTQRETWSFEDDQEPAQQTGCMLVLGPGSFFSRAPEAAMLPFAP
                     VEDPWDQEDMEVFGSTSSSEPQVVFTMKNAATVMREHERKEVNDLKMVDEPMEEGEPV
                     SCRREELVKEIPITQHVKEGYEKADPAQFDLLKVLGQGSFGKVFLVRKKTGPDAGQLY
                     AMKVLRKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDV
                     FTRLSKEVLFTEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEIGHIKLTDFG
                     LSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGK
                     DRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEVKRHAFFASID
                     WNKLYKREVQPPFRPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVA
                     TSIAEEYKITPVTSSNVLPIVQINGNAAQFSEAYELKEDIGIGSYSVCKRCIHSASNV
                     EFAVKIIDKNKRDPSEEIEILMRYGQHPNIISLKEVFDDGKYVYLVTDLMKGGELLDR
                     ILKKKCFSEQEASNVLYVITKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIKICDF
                     GFAKQLRGENGLLLTPCYTANFVAPEVLTQQGYDAACDIWSLGVLLYTMLAGYTPFSN
                     GPNDTPEEILLRIGNGRFSLSGGIWDNISRGAKDLLSHMLHMDPHQRYTAEQVLKHPW
                     ITQREQLPRHQPNSDEPPQEAVAAPYSVLARNPNRHHPILEPVTASRLAQRRNMKKRT
                     STGL"
     exon            272..523
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            524..586
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            587..646
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            647..763
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            764..845
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            846..926
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1006
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1113
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1151
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1294
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1365
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1454
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1513
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1616
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1747
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1870
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1960
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2119
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2281
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2358
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2476
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2608
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..4683
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4293..4298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /note="hexamer: ATTAAA"
     polyA_site      4328
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /note="major polyA site"
     regulatory      4615..4620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
                     /note="hexamer: AATAAA"
     polyA_site      4644
                     /gene="Rps6ka6"
                     /gene_synonym="2610524K04Rik; RSK4; S6K-alpha-6"
ORIGIN      
        1 tgcttgagcc acttcgctct gggactccaa agggcagaga acgctcagta gcctccggag
       61 tgagaaagtc cggccttagg tgaaagcgcc ctccgtctct gatctgacct cagagctgca
      121 gtttgaagtc tcacttcaga caaacccact ttgaatcatg ctgaatttta gaaggacacg
      181 ccacacgcca tctggccaca ggtccaactc taacttgaac ctgttctgtt gtcttccatt
      241 ttttggatgt cgtcggcgat ccaagagtcg gcagcgggcg gggacccccg tggtccctct
      301 tttgaggtac ccgcggctgg cgaggtcggc agtcacccag cgcgagacct ggtccttcga
      361 agacgaccag gagcccgctc agcagacggg atgcatgctg gtgctggggc caggcagctt
      421 cttctcgaga gcccctgaag cggcgatgct accgttcgcc cctgtggagg atccctggga
      481 ccaagaagac atggaggtgt tcggcagcac gagcagtagc gagccacagg ttgtgtttac
      541 catgaagaac gcagcaacgg ttatgcggga gcatgaacgc aaagaggtaa atgatctgaa
      601 aatggttgat gagccaatgg aagagggaga gccagtttct tgccggcggg aagaattggt
      661 taaggagata cctattacac agcatgttaa agaaggatac gagaaagcag atcccgcaca
      721 gtttgacttg ctcaaggttc ttggtcaggg atcttttgga aaggtttttc ttgttagaaa
      781 gaagactggt cctgatgctg ggcagctcta tgcaatgaag gtgttaagaa aagcttcttt
      841 gaaagttcga gaccgagttc gcacaaagat ggagagggat atcttggtgg aagtaaatca
      901 tccctttatc gtcaaactgc actatgcttt tcagactgaa gggaagctgt acttaatatt
      961 ggatttcctc aggggaggag atgtcttcac aagattatcc aaagaggttc tttttacaga
     1021 ggaagatgtg aaattctacc ttgcagaatt ggccctggct ttggatcatc tacatcgatt
     1081 aggaattgtt tatagagacc tgaaaccaga aaacatctta cttgatgaaa taggacatat
     1141 caagttaaca gattttgggc ttagcaaaga gtcagtggat caagaaaaga aggcctactc
     1201 attttgtggt actgtagaat atatggcccc tgaagtagta aacagacgag gccattctca
     1261 gagtgctgat tggtggtcat atggtgtact tatgtttgaa atgcttactg gcactttgcc
     1321 atttcaaggg aaagacagaa atgagaccat gaatatgata ctgaaagcaa aacttggaat
     1381 gccccaattc cttagtgctg aagcacaaag tctattaagg atgttattca aaaggaatcc
     1441 agcaaataga ttggggtcag aaggagttga agaagtcaaa agacatgctt tttttgcttc
     1501 cattgactgg aataaactat ataaaagaga agtccagcct cctttcagac ctgcttctgg
     1561 aaaaccggat gataccttct gttttgatcc tgaatttact gccaaaacac ctaaagattc
     1621 tcctggtttg ccagccagtg caaacgctca tcaactcttc aaaggattca gttttgttgc
     1681 gacttctatt gccgaagaat ataaaatcac tcctgttaca agttcaaatg tattaccaat
     1741 cgttcagata aatggaaatg ctgctcaatt tagtgaagct tatgaattga aagaggatat
     1801 tggtattggt tcttattctg tttgcaagcg atgcatacac tcagcttcca atgtggaatt
     1861 tgcagtcaag atcattgata aaaataagag agacccctca gaagaaattg aaattttgat
     1921 gcgctatgga caacatccca acattatctc tttaaaggag gtctttgatg atgggaaata
     1981 tgtttacctt gttacggact tgatgaaagg aggagaactt ctggatcgga ttctcaaaaa
     2041 gaaatgtttc tcagagcagg aagctagtaa tgtgctgtat gtaataacca agacagttga
     2101 atgccttcat tctcaaggag tcgttcatcg tgatcttaag cccagtaata ttttatatat
     2161 ggatgagtca gcccatccag attcaatcaa gatctgtgat tttgggtttg caaaacagct
     2221 tcgtggagaa aatggacttc tgttaactcc gtgctacacc gcaaactttg tagcacctga
     2281 ggttctcact caacagggat atgatgctgc ctgtgatatt tggagcttag gagtcctttt
     2341 gtacacaatg ttggctggct acactccatt ttccaacggc cccaatgata ctcctgagga
     2401 aatactgctg cgcataggca acgggaggtt ctctttgagt ggtggaatct gggacaatat
     2461 ttcacgtgga gcaaaggatt tgctttctca tatgcttcac atggacccac atcagcgtta
     2521 tactgctgag caagtattaa agcacccttg gataacccaa agagaacaac tgccgcgcca
     2581 tcagccaaac tcagatgagc caccacagga agcagtggca gcaccatatt ctgtcttggc
     2641 tcggaaccca aacaggcatc atccaatcct ggagcctgtt actgcttcac gtttagctca
     2701 gaggcggaac atgaaaaagc gaacatcaac tggcttgtaa gagtcttgtg ctcttcagtc
     2761 ctcagctaac tggatgaaga gaaaattaaa tgtgtgttgt ggattggctt tgttttcttt
     2821 ttgtctaatc tcatatcaaa ggtattttgt ttcctgccac attacttgaa tattctgttt
     2881 aagcctcttt tggagaggtt ggaattttaa atgaacatac ataggtccat aatattcata
     2941 ctatgtcatt gcagtagtgt ccaaacgttt aactatataa ttgatgtcca caaggtctta
     3001 acttctctgc acattaactt tccaaattcc tttcaaataa agttaacctg tttttttatt
     3061 attttacaca aaaatggttt aggaattcat taatactaat caagatgctt ttcatatgtt
     3121 ataatgataa ataatatcag tattttaaca tcatttccta aaaaggaact tttgttctta
     3181 aaagaacaac agaagtattc taatagcttg tgcatagcca aagcactcca ttcatttgag
     3241 tctgtttaga tactaaatgt agtaaaagta gtttggtgcc tgagcaaaat acattcgtgc
     3301 taatatatga attcctgata tggttggtgc caaagttttg atagattaat taaatcacta
     3361 ataatttgtg cagacagatt tgtatattat ccataagtga cttcaactaa agaaaggttc
     3421 catacagctt ctaatgtttt acagctaata aaattgtagt gaaagtgaaa atgtttttat
     3481 ccaaaggttt catgttggtg ttgtaagctc ctaaaaatgt catagttaag cctttgaata
     3541 tgcacttcat ggtgttgatg cgatcttggt gttacctaag ctgactttga agttaatcaa
     3601 ttgaattcaa ccatcgttgt tcccctttat aagtgaagct actctgttgt attcctgatt
     3661 tccatgtggt ttgagctaca gtgtagcata ttgagctacc ttgaatccta tggcgatgta
     3721 gttgaagttt tattatagtg gacttgtgca cttagcacat atgatacaat ataatgtatt
     3781 tcagtaagca tcagacaatt ctatatactt caagaaaata atttcacatt ttaaaaagga
     3841 aacaatatta atggttgaca cagaaatttg agtacattta aaaatcattt ataataaact
     3901 ggccaaattg gtattattaa atttatgatt cagaaccagt gtgtaatgtg tattattttc
     3961 ttcaaatgct gaaaatttta aaagtcattt tatattgtta aggaaaatat cattagctac
     4021 tactactgac agaatccatg aatgtaagct ggcggatagg agttttgttt agtgtgtgct
     4081 aggtgtactg tgtgcttagt tcagagaact gattactgac tatgtgacgt agactaggag
     4141 acatgtaatg ttggaattta ataaaacgaa ctgtctgtat tctcttcaaa ctgtaagtga
     4201 tccttgtcca tgcacaaata tctgtttcct acatgtgata tataaattct gtattcttac
     4261 ttgaggtgtc ttttttaaaa tgattggaca ttattaaaca acagctgatc tgataccaca
     4321 caacagcatc atttagtctt ggtgtagtat tttgtctttg gtgtttcaat ttggttaatt
     4381 ttcccccttt ctttttgttt tatcgcaata agtacttgca tttaaacagt tgtattccta
     4441 cattcaaatt agtgtgctct tgtcatgatc ttctttgtgc tgttacacat ccttaccagt
     4501 tgatttgttg aagtcaaaaa cattagtttg gttttgactt tttaggacac atactatgtc
     4561 tgtatgtgct ttccagctaa ttagagaaaa tgaacctgga aaatgaaaag tgaaaataaa
     4621 aatacctttt agcctttgtg taaacaatgt gttaaaaaca tcataatttt cagttagttc
     4681 act
//
