LOCUS       NM_019924               3152 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus ribosomal protein S6 kinase, polypeptide 4 (Rps6ka4),
            mRNA.
ACCESSION   NM_019924
VERSION     NM_019924.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3152)
  AUTHORS   Jones,M.R., Lingampally,A., Ahmadvand,N., Chong,L., Wu,J.,
            Wilhem,J., Vazquez-Armendariz,A.I., Ansari,M., Herold,S.,
            Ornitz,D.M., Schiller,H.B., Chao,C.M., Zhang,J.S., Carraro,G. and
            Bellusci,S.
  TITLE     FGFR2b signalling restricts lineage-flexible alveolar progenitors
            during mouse lung development and converges in mature alveolar type
            2 cells
  JOURNAL   Cell Mol Life Sci 79 (12), 609 (2022)
   PUBMED   36445537
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3152)
  AUTHORS   Sutavani,R.V., Phair,I.R., Barker,R., McFarlane,A., Shpiro,N.,
            Lang,S., Woodland,A. and Arthur,J.S.C.
  TITLE     Differential control of Toll-like receptor 4-induced interleukin-10
            induction in macrophages and B cells reveals a role for p90
            ribosomal S6 kinases
  JOURNAL   J Biol Chem 293 (7), 2302-2317 (2018)
   PUBMED   29229781
REFERENCE   3  (bases 1 to 3152)
  AUTHORS   Hunter,C.J., Remenyi,J., Correa,S.A., Privitera,L.,
            Reyskens,K.M.S.E., Martin,K.J., Toth,R., Frenguelli,B.G. and
            Arthur,J.S.C.
  TITLE     MSK1 regulates transcriptional induction of Arc/Arg3.1 in response
            to neurotrophins
  JOURNAL   FEBS Open Bio 7 (6), 821-834 (2017)
   PUBMED   28593137
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3152)
  AUTHORS   McGuire,V.A., Rosner,D., Ananieva,O., Ross,E.A., Elcombe,S.E.,
            Naqvi,S., van den Bosch,M.M.W., Monk,C.E., Ruiz-Zorrilla Diez,T.,
            Clark,A.R. and Arthur,J.S.C.
  TITLE     Beta Interferon Production Is Regulated by p38 Mitogen-Activated
            Protein Kinase in Macrophages via both MSK1/2- and
            Tristetraprolin-Dependent Pathways
  JOURNAL   Mol Cell Biol 37 (1), e00454-16 (2016)
   PUBMED   27795299
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3152)
  AUTHORS   Bhat,N., Park,J., Zoghbi,H.Y., Arthur,J.S. and Zaret,K.S.
  TITLE     The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates
            during Mouse Pancreatic Development
  JOURNAL   PLoS One 11 (12), e0166703 (2016)
   PUBMED   27973548
  REMARK    GeneRIF: chromatin modifier, MSK1/2, has a role in suppressing
            endocrine and promoting acinar differentiation during pancreatic
            development
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3152)
  AUTHORS   Soloaga,A., Thomson,S., Wiggin,G.R., Rampersaud,N., Dyson,M.H.,
            Hazzalin,C.A., Mahadevan,L.C. and Arthur,J.S.
  TITLE     MSK2 and MSK1 mediate the mitogen- and stress-induced
            phosphorylation of histone H3 and HMG-14
  JOURNAL   EMBO J 22 (11), 2788-2797 (2003)
   PUBMED   12773393
REFERENCE   7  (bases 1 to 3152)
  AUTHORS   Vermeulen,L., De Wilde,G., Van Damme,P., Vanden Berghe,W. and
            Haegeman,G.
  TITLE     Transcriptional activation of the NF-kappaB p65 subunit by mitogen-
            and stress-activated protein kinase-1 (MSK1)
  JOURNAL   EMBO J 22 (6), 1313-1324 (2003)
   PUBMED   12628924
REFERENCE   8  (bases 1 to 3152)
  AUTHORS   Wiggin,G.R., Soloaga,A., Foster,J.M., Murray-Tait,V., Cohen,P. and
            Arthur,J.S.
  TITLE     MSK1 and MSK2 are required for the mitogen- and stress-induced
            phosphorylation of CREB and ATF1 in fibroblasts
  JOURNAL   Mol Cell Biol 22 (8), 2871-2881 (2002)
   PUBMED   11909979
  REMARK    GeneRIF: MSK1 and MSK2 are required for the mitogen- and
            stress-induced phosphorylation of CREB and ATF1 in fibroblasts.
REFERENCE   9  (bases 1 to 3152)
  AUTHORS   Casanova,E., Fehsenfeld,S., Greiner,E., Stewart,A.F. and Schutz,G.
  TITLE     Construction of a conditional allele of RSK-B/MSK2 in the mouse
  JOURNAL   Genesis 32 (2), 158-160 (2002)
   PUBMED   11857808
REFERENCE   10 (bases 1 to 3152)
  AUTHORS   Deak,M., Clifton,A.D., Lucocq,L.M. and Alessi,D.R.
  TITLE     Mitogen- and stress-activated protein kinase-1 (MSK1) is directly
            activated by MAPK and SAPK2/p38, and may mediate activation of CREB
  JOURNAL   EMBO J 17 (15), 4426-4441 (1998)
   PUBMED   9687510
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120557.12, CJ065157.1, AK089467.1, CF616720.1, BF465098.1 and
            BP759267.1.
            
            On May 2, 2013 this sequence version replaced NM_019924.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012964.1, AF074714.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC120557.12        158351-158356
            7-429               CJ065157.1         2-424
            430-840             AK089467.1         421-831
            841-1768            AK089467.1         833-1760
            1769-2291           CF616720.1         146-668
            2292-2799           BF465098.1         1-508
            2800-3152           BP759267.1         26-378              c
FEATURES             Location/Qualifiers
     source          1..3152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.08 cM"
     gene            1..3152
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /note="ribosomal protein S6 kinase, polypeptide 4"
                     /db_xref="GeneID:56613"
                     /db_xref="MGI:MGI:1930076"
     exon            1..135
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            136..207
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            208..426
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..542
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..650
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            651..731
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            732..835
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            836..986
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1151
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1280
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1414
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1508
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1682
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1877
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2037
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2201
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..3132
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3109..3114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /note="hexamer: AATAAA"
     polyA_site      3132
                     /gene="Rps6ka4"
                     /gene_synonym="1110069D02Rik; 90kDa; mMSK2; Msk2"
                     /note="major polyA site"
ORIGIN      
        1 gcacccgccc cggccggagc cgccatgtaa ccggcgccgc ccgtagcccc agccgcgcgg
       61 gccccagcga cccgcccgcc atgggagacg aggatgagga cgagggctgc gccgtggagc
      121 tgcagatcac cgaagccaac ctcaccgggc atgaggagaa ggtgagcgtg gagaacttcg
      181 cgctgctcaa ggtgctgggc acgggagcct atgggaaggt gttcctggtg cggaagacgg
      241 gtgggcacga cgcgggcaag ctctatgcca tgaaggtgct acgcaaggcg gcgttggtgc
      301 agcgcgcgaa gacacaggag catacccgca ccgaacgctc ggtgctggag ctggttcgcc
      361 aagcaccctt cctggtcaca ctgcactacg ccttccagac ggatgccaag ctgcacctca
      421 tcctggacta cgtgagcggt ggtgagatgt tcactcacct ctaccagcgc cagtacttca
      481 aggaggctga ggttcgagtg tatgggggcg agattgtgct ggccctggaa cacctgcaca
      541 agctgggtat catctaccgg gacctgaagc tggagaacgt cttacttgac tcagaaggtc
      601 acatcgtcct tacagacttt gggctgagca aggagttcct gacggaggag aaagagcgga
      661 ccttctcctt ctgtggcaca atcgagtaca tggctcccga aatcatccga agcaaggctg
      721 gacatggcaa ggctgtggac tggtggagcc tgggtatcct gctcttcgag ctgctgacag
      781 gggcctcacc cttcacactg gagggagaga ggaacactca ggctgaggtg tcccgacgga
      841 tcttgaagtg ctcccctccc ttccctctcc ggattgggcc tgtggcacag gacctgctac
      901 agcggctgct gtgcaaggac cctaagaaga ggttgggcgc aggtccccag ggtgcgcagg
      961 aagtcaagag tcaccccttc ttccagggtc tggactgggt ggctctggct gccagaaaga
     1021 tcccagcccc attccggccc cagatccgct cagagctgga tgtggggaat tttgcggagg
     1081 aattcacccg gctggagccc gtctactccc ctgcaggcag ccctccacct ggggaccctc
     1141 ggatctttca gggatactcc ttcgtggctc cgtccatcct ctttgaccac aacaatgcag
     1201 tgatggctga tgtactgcag gcaccgggtg ccggatacag gcccggcagg gcagcagttg
     1261 ccaggagtgc catgatgcag gactcgcctt tcttccagca gtacgaactg gaccttcggg
     1321 agccagcgct ggggcagggc agcttctctg tgtgtcggag atgtaggcag cgccagagcg
     1381 gccaggagtt tgctgtcaag atcctcagcc gcaggctgga ggagaacact cagcgagagg
     1441 tggctgctct tcgcctgtgc cagtcacacc ccaacgtggt gaatctgcat gaggtgcttc
     1501 atgaccagct acacacttac ctggtcctgg agttgctgcg aggcggagag ctattggaac
     1561 acatccgcaa gaagcggctc ttcagcgagt cggaggccag ccagatcctt cggagcctgg
     1621 tttcggccgt gagcttcatg cacgaggagg caggcgtggt gcaccgcgac ctgaaacccg
     1681 agaacatctt gtacgcggac gacactcccg gggccccggt gaagatcatc gacttcgggt
     1741 tcgcgcgact gcggccccag agcccggcag agcccatgca gactccttgc ttcacactgc
     1801 agtacgctgc acccgagctg ctggcacagc agggctacga tgagtcctgc gatctatgga
     1861 gcctgggtgt cattctgtac atgatgctgt ctggccaggt tcccttccaa ggggcctccg
     1921 gccagggtgg acagagtcag gcagctgaga tcatgtgcaa gatccgtgaa gggcgcttct
     1981 ccctggacgg ggaagcctgg caaggtgtgt cggaggaagc caaggagctg gtccgagggc
     2041 tactgacagt cgaccccgcc aagcggctga agctggaggg gctgcgtagc agctcgtggc
     2101 ttcaggacgg cagcgcgcgc tcctcgcccc cgctccgcac gccggatgtg ctggagtcct
     2161 ctgggccagc tgtgcgttcc gggctcaatg ccactttcat ggcgttcaac cgaggcaagc
     2221 gcgagggctt ctttctcaag agtgtagaga atgcgcctct ggccaagagg cgcaagcaga
     2281 agctccggag cgcggccgcc tcccgccgag gctccccagt gcctgcctcc tccggtcgcc
     2341 taccagcctc tgccgctaag gggacaactc gccgagccaa cggccccttg tccccttcct
     2401 agctcccgcc actgtgaccc ccttaccttt aggagctccg atccgggagc ctggtgctgc
     2461 caccagactt ttgccagcgg ctcccactct gatccctagg aattgccctc ccctccacac
     2521 ccacttccag acagagcaga agtattttta taagcagaga ttttttaaaa gtgtcttact
     2581 agataagagt tggggacaca gagaagcaac tgttgtgagc aaagtggagc ttggggctcc
     2641 ctcgcccgat cccaatgctg ccccatcagg aagagagaag gtcctttcca ggagcaactc
     2701 tgctaagaaa gggcatccta tcctgttcct aagtacccag ttgccatgga gaagaaatca
     2761 ggagcccgta tactgtgctt ccctgggact ttgcccctag gaggggacac ccatcaatgt
     2821 cactttatgg accgtgtgca atgatgtcca ccaaagacct gtgttgggaa tgagagagag
     2881 agagaccctg agggacctct agagcatttc tgagatacat cacttttgtc aacggctccc
     2941 ctagtggggt taaggaagaa ggcaggtgct ccccaggggg agcccctttc tcactcaccc
     3001 attcctcatg ggcacagctg cttctggctg caggtggagc cttagggttc tgggctaggc
     3061 atccacagtc actgcctcag cccctctagg ctgtgccttt gactttaaaa taaaactcca
     3121 cccagtgctg caaaaaaaaa aaaaaaaaaa aa
//
