LOCUS       NM_148945               7320 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ribosomal protein S6 kinase polypeptide 3 (Rps6ka3),
            transcript variant 1, mRNA.
ACCESSION   NM_148945
VERSION     NM_148945.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7320)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7320)
  AUTHORS   Kalra,J., Artamonov,M., Wang,H., Franke,A., Markowska,Z., Jin,L.,
            Derewenda,Z.S., Ayon,R.J. and Somlyo,A.
  TITLE     p90RSK2, a new MLCK mediates contractility in myosin light chain
            kinase null smooth muscle
  JOURNAL   Front Physiol 14, 1228488 (2023)
   PUBMED   37781225
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7320)
  AUTHORS   Schaeffer,S., Gupta,B., Calatayud,A.L., Calderaro,J., Caruso,S.,
            Hirsch,T.Z., Pelletier,L., Zucman-Rossi,J. and Rebouissou,S.
  TITLE     RSK2 inactivation cooperates with AXIN1 inactivation or
            beta-catenin activation to promote hepatocarcinogenesis
  JOURNAL   J Hepatol 79 (3), 704-716 (2023)
   PUBMED   37201672
  REMARK    GeneRIF: RSK2 inactivation cooperates with AXIN1 inactivation or
            beta-catenin activation to promote hepatocarcinogenesis.
REFERENCE   4  (bases 1 to 7320)
  AUTHORS   Decourt,C., Schaeffer,J., Blot,B., Paccard,A., Excoffier,B.,
            Pende,M., Nawabi,H. and Belin,S.
  TITLE     The RSK2-RPS6 axis promotes axonal regeneration in the peripheral
            and central nervous systems
  JOURNAL   PLoS Biol 21 (4), e3002044 (2023)
   PUBMED   37068088
  REMARK    GeneRIF: The RSK2-RPS6 axis promotes axonal regeneration in the
            peripheral and central nervous systems.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7320)
  AUTHORS   Jiang,M., Wang,J., Shen,Y., Zhu,J., Liu,Z., Gong,W., Yu,Y.,
            Zhang,S., Zhou,X., He,S., Song,Y., Zhu,Z., Jin,L. and Cong,W.
  TITLE     Ribosomal S6 Protein Kinase 2 Aggravates the Process of Systemic
            Scleroderma
  JOURNAL   J Invest Dermatol 142 (12), 3175-3183 (2022)
   PUBMED   35853487
  REMARK    GeneRIF: Ribosomal S6 Protein Kinase 2 Aggravates the Process of
            Systemic Scleroderma.
REFERENCE   6  (bases 1 to 7320)
  AUTHORS   Dufresne,S.D., Bjorbaek,C., El-Haschimi,K., Zhao,Y.,
            Aschenbach,W.G., Moller,D.E. and Goodyear,L.J.
  TITLE     Altered extracellular signal-regulated kinase signaling and
            glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase
            2 knockout mice
  JOURNAL   Mol Cell Biol 21 (1), 81-87 (2001)
   PUBMED   11113183
REFERENCE   7  (bases 1 to 7320)
  AUTHORS   Bruning,J.C., Gillette,J.A., Zhao,Y., Bjorbaeck,C., Kotzka,J.,
            Knebel,B., Avci,H., Hanstein,B., Lingohr,P., Moller,D.E., Krone,W.,
            Kahn,C.R. and Muller-Wieland,D.
  TITLE     Ribosomal subunit kinase-2 is required for growth factor-stimulated
            transcription of the c-Fos gene
  JOURNAL   Proc Natl Acad Sci U S A 97 (6), 2462-2467 (2000)
   PUBMED   10716983
REFERENCE   8  (bases 1 to 7320)
  AUTHORS   Jensen,C.J., Buch,M.B., Krag,T.O., Hemmings,B.A., Gammeltoft,S. and
            Frodin,M.
  TITLE     90-kDa ribosomal S6 kinase is phosphorylated and activated by
            3-phosphoinositide-dependent protein kinase-1
  JOURNAL   J Biol Chem 274 (38), 27168-27176 (1999)
   PUBMED   10480933
REFERENCE   9  (bases 1 to 7320)
  AUTHORS   Blair,H.J., Gormally,E., Uwechue,I.C. and Boyd,Y.
  TITLE     Mouse mutants carrying deletions that remove the genes mutated in
            Coffin-Lowry syndrome and lactic acidosis
  JOURNAL   Hum Mol Genet 7 (3), 549-555 (1998)
   PUBMED   9467016
REFERENCE   10 (bases 1 to 7320)
  AUTHORS   Alcorta,D.A., Crews,C.M., Sweet,L.J., Bankston,L., Jones,S.W. and
            Erikson,R.L.
  TITLE     Sequence and expression of chicken and mouse rsk: homologs of
            Xenopus laevis ribosomal S6 kinase
  JOURNAL   Mol Cell Biol 9 (9), 3850-3859 (1989)
   PUBMED   2779569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ123041.1, AY083469.1, BC038683.1 and AL808146.3.
            
            On Mar 15, 2014 this sequence version replaced NM_148945.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154778.1, AY083469.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               CJ123041.1         1-338
            339-2561            AY083469.1         1-2223
            2562-3114           BC038683.1         648-1200
            3115-7320           AL808146.3         118756-122961
FEATURES             Location/Qualifiers
     source          1..7320
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 73.27 cM"
     gene            1..7320
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /note="ribosomal protein S6 kinase polypeptide 3"
                     /db_xref="GeneID:110651"
                     /db_xref="MGI:MGI:104557"
     exon            1..407
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            408..464
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            465..581
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..663
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            664..744
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            745..824
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            825..931
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            932..969
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1112
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1183
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1272
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1337
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1440
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1565
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1691
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1781
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1940
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2102
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2179
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2297
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2438
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..7320
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3094..3099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /note="hexamer: ATTAAA"
     polyA_site      3116
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /note="major polyA site"
     regulatory      7300..7305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /note="hexamer: AATAAA"
     polyA_site      7320
                     /gene="Rps6ka3"
                     /gene_synonym="MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2;
                     S6K-alpha3"
                     /note="major polyA site"
ORIGIN      
        1 tgggatcggg cgcgggaagc ggcggggagg ggaggcgggg ggcggagccg tagtccgggc
       61 ggcggaagga ggagaggaag aaaggggcga gccctggtgc ctggcggcgg cgcaaggctc
      121 tcgcttggag tgcgggcggc tgtggctagg cgctgggcgt tcgggtggtc ggcgtcggcg
      181 tcggcgtcga gctcgctctc gggggagccg cggctgcccg gctgctgctt ctcggctctg
      241 ccttggagct cgagtggcta aggagccgag ccggctgtgg ggcgggtggg gagggaggag
      301 gcggtgaagg cggcggcggg ccggggaggg ggggaaagat gccgctggcg cagctggcgg
      361 acccgtggca gaagatggct gtggagagcc cttccgacag cgcggagaat ggacagcaaa
      421 ttatggatga acctatggga gaggaggaga ttaacccaca aactgaagaa ggcagtatca
      481 aagaaattgc aatcacacat catgtgaagg aaggacatga aaaggcagat ccttcccagt
      541 ttgaactttt aaaagtatta gggcagggat catttggaaa ggttttctta gttaaaaaaa
      601 tctcaggctc tgatgctaga cagctttatg ccatgaaagt attaaagaag gccacgctga
      661 aagttcgaga ccgtgttcgg acaaaaatgg aacgtgatat cttggtagaa gtcaatcacc
      721 ctttcattgt caaattgcat tacgcttttc aaacggaagg gaagttgtat cttattttgg
      781 attttctcag gggcggagac ttgtttacac gcttatccaa agaggtgatg ttcacagagg
      841 aagatgtcaa attctacttg gctgaacttg cacttgcttt agaccatctt catagcctgg
      901 gaataatcta tagagactta aaaccagaaa acatacttct tgatgaagaa ggtcacatca
      961 agttaactga ttttggctta agtaaggaat ctattgatca tgagaagaag gcttattctt
     1021 tttgtggcac tgtggaatac atggctccag aagtagttaa ccgcagaggt cacactcaga
     1081 gtgcggactg gtggtccttt ggtgtgttga tgtttgaaat gctcactggt acactacctt
     1141 tccaaggaaa agatcgtaaa gaaacaatga ctatgattct taaagccaaa ctcgggatgc
     1201 cacagtttct gagtcctgaa gcccagagtc ttttacgaat gcttttcaaa cggaatcctg
     1261 caaacagatt aggtgctgga ccagatggag ttgaagaaat taaaagacat tcatttttct
     1321 caacaataga ctggaataaa ctatatagaa gagagattca cccacctttt aagcctgcaa
     1381 ctggcagacc tgaagataca ttttattttg atcctgagtt tactgcaaaa actcccaaag
     1441 attcaccggg cattccacct agtgctaacg cacatcagct ttttcggggg tttagttttg
     1501 ttgctattac ctcagatgat gaaagccaag ctatgcagac agttggtgtg cattcaattg
     1561 ttcagcaatt acacagaaac agtattcagt ttactgatgg atatgaagta aaagaggata
     1621 ttggcgttgg ctcatactcc gtttgtaaga gatgtataca taaagctaca aacatggagt
     1681 ttgccgtgaa gattattgat aaaagcaaga gagacccaac agaagagatt gaaattcttc
     1741 ttcgctatgg acagcatcca aacatcatta ccctaaagga tgtgtatgat gatggaaaat
     1801 atgtgtatgt agtaacagaa cttatgaaag gaggtgaatt gctggataag attcttagac
     1861 agaagttttt ctcagagcga gaggccagcg ctgtcctgtt tactataacc aaaactgttg
     1921 agtatcttca tgcacaaggg gtggttcaca gagacttgaa acctagcaac attctttatg
     1981 tggatgagtc tggtaatcca gaatctattc gaatttgtga ttttggcttt gcaaaacaac
     2041 tgagagcaga aaatggtctt ctcatgactc cttgttatac tgcaaatttt gttgcaccag
     2101 aggttttaaa acggcaaggt tatgatgctg cctgtgatat atggagtctt ggcgtcctcc
     2161 tttatacaat gcttactggt tacactccat ttgcaaatgg ccctgatgat actccagagg
     2221 aaatactggc acgaataggt agtggaaaat tctcactcag tggtggttac tggaattctg
     2281 tttcagacac agcaaaggac ctggtgtcaa agatgcttca tgtagatcct catcagagac
     2341 tgacggctgc tctggtgctc agacatcctt ggattgtcca ctgggaccaa ctaccacaat
     2401 accaactaaa cagacaggat gcgccgcatc tcgtaaaggg tgccatggca gctacgtact
     2461 ctgctttaaa ccgcaatcag tccccagtct tggaaccagt gggccgctcc actcttgctc
     2521 agcggagagg gattaaaaaa atcacctcaa cagccctgtg aagtgacctc agtgagatgt
     2581 ttggtaccat gatgtcagct gatagcacaa gctctggcga caggtagcac gtacctgaga
     2641 gacacctgca agcacacact gtcccagctg gtacccataa cgctgctgct cctgcttcct
     2701 ctcttctcgc ttccagtgat tgttagcaag ttcgatttcc ctggagctcc gaaacgaaaa
     2761 tggaaacatg atgaagatct attcactgaa tcaataaaaa taatgaacac atgaatacca
     2821 cctaaaatac actgaataaa agtactctac accatatagc attattttta taggaaatat
     2881 ttcatgtccc ctaaatattc tttgtagtta tagggatgga cagtttatgt tgagcactta
     2941 gcttaaacag ttcatttata ttagcactgt atcccttgtg ccatccaaca ttttgtatgt
     3001 ttttgtaaac agttcatata cagtacattt ctgtactgct ttctttaatg tatacatgcc
     3061 ttgtttaact tagagtctac taatcaattg actattaaat ctggataaat agttcacctg
     3121 gattaacagt attgtcggca aaccttagag atggccagat tgagtgaaca gctattgaat
     3181 gtaattcttt caaattgtac atatcgcccc atctgtttca caggttggtc catttgttct
     3241 caagtcaggt gctctgtcag actaactaga gagctgttaa caggacagga agttggtgtg
     3301 tgtgtgtgtg tgtgcacggc atgaaatcag gaacacacct atgaagtcag tccatagact
     3361 ttgtggtttg ttagggtttc tttcccttaa gtaaccttac atagccctca tacttagtat
     3421 ttggcatata atttgaaatt ttgcctgtat acatcaaaga cctttaaaag aatcatagta
     3481 aagaaattag aaaaggaaat tttagcaatt ggtaattaaa gccttactgg atatttcatg
     3541 tttaaataga cattctatat taaacactaa tttgaatgta ataaaggcca caggcctcca
     3601 tataaaattg gatttaaact ttcttattct agggaatgaa atgtccttct accaatatct
     3661 gatctaacct aaagtcctag ctgcagacgg ccgagtgatc agcgctgact gttttctgga
     3721 tccctgatga tgatttatag ccatatgatg tcccctttga cttcagtagt caccagattt
     3781 cacaatggcc cctggctgca cttcaagtgc agtattcagt attcacatct aacttggtag
     3841 tttctagttt catttaacaa caacaacaaa accatcccta tccatcatta cccatatctt
     3901 tgtcacacta cccagtatac attaatatgt gatgtgatga acaagagcaa ggaaaaagta
     3961 atttaacttc cctcagcagg catgtgcccc aatacatgag gcccttactg ctttttgcag
     4021 ttcataaaaa cactatcatt ccttattttc tctgctacta aagagaaaga gaaaatctct
     4081 gataccccct ttgcccaagc aacacaaaat gatgactgca tagaaatgaa atgtatgctt
     4141 atcttctaac tgaaaagaag ttctatatac atctattgaa gttcttgatg ctaactattc
     4201 aaagttgctt tccatcgcct agcaagaaag ccgttccccc tcctctagtc agtgtgtccg
     4261 attcttccat ttattgtatc ccccatttaa tttttcctca taacaccatg atgcctttcc
     4321 ttcttattat cacccaacca ggagctaaag tcatatattt cttcctggca gtcctctact
     4381 atagaatatt gccaagttta tttcctttaa gaagaattgc cttctttatc tagttaaact
     4441 gccagtttta ttggagaaaa gcaatagatt cataaatcta aaggcttcct actgataaag
     4501 caggttagga gcataaatga ttgcatctgt ggctttagtg ttcacattgt cgttgggcag
     4561 atgtagccga tgatgtagcg cttgtgctgg gttagccttt ccattccctt cacaaagaac
     4621 atctctcaca ggccactgta cttaatggct cctcaagtct tccacctttc acccatccct
     4681 gccagtttct aggacttatc ccagagttgt tggtccagct tttatgtttc actgaaggaa
     4741 ggaactaaac tggcaggcct ctgtacagac atctcttggt ttacaatgca aaataatatc
     4801 ccagacaata gaaatgcatt ctgacatagt caagcacaca ctggaaacta tgatttacaa
     4861 tactgtgtgt tttgcatctt ccctttcaag ttatgatatt aaattaaggt aagttgggtt
     4921 ttgttggggc tttgttgttt tttatgaatc atttcagctc cttctgttta aaagggtatc
     4981 ttctaagtgc attactccct taaatttaac agctgtgaag taaatctttt ttcacaaacc
     5041 accctaaaag tctaaaaata aatgtagcaa gacccaaagt caacatgctg tgaggctggc
     5101 atatggaaga gtcagttcga gtgtctggag ggaggatggt gggtatttac agtagtttcc
     5161 acgtttcacg tgcattgcac tccaaagaat agggtggggg tcaacgattt tccaactgtt
     5221 ctttagatgt ggcttttgtt gggatcggaa aacatcaaga gaagtggggg ttgtcctcta
     5281 agctatgcac atactcgcag cctagaaagg atttgaacag agagtaggtg cagaagcgtc
     5341 taaagaaggc atgtatttga tagggaaagg accagagtag gctaatcctg gggtgatagt
     5401 tgcaaaaggc tttctagact ttggggcctt ggtataagat gtccttaatt attgtggggg
     5461 ccagtaacac acaattcaac atgactttga tagtctccat tccctggctt tatgaattac
     5521 ctacactttc aggttgtttt gctgtatttt ataaaaatag gttctatctt actatggtgt
     5581 tgaaaatttg agacttggga aagcagacag agagctctgg aatgcaaagg atcaaaaaca
     5641 gccagctctc ttctgtgact cacaaaaaac aatggatttc atggctgatc ttggtgctta
     5701 aaccaggaag gtccagtcta actctatctg ttcctctgca agacccaact cctgtgacta
     5761 acctggatgt atactttgag ccttatttaa ttcacagaga agttgactta aatcagtgtt
     5821 tttatttcaa ttaatgaaaa cagtcctctt tcaaccccag gttacttaac attttgctga
     5881 tctcccccaa gagatcattg gtggagacca attaatgaag gagtgaattc agtttcttga
     5941 gactgtggta ttctacagag ccacacctaa ccactttttc cagtgaagaa tctacacaat
     6001 aatacccaaa tatggatggc caagaagaat ctgtatctac agtgtgcttt gtgtgttttt
     6061 gacactgctg tattttgtgt tgccaagtga cttgtaactg gttccaacgt gacagttctt
     6121 taaaagttct agtaattaag tcaacttaaa tttttgtaaa acctggtgtc actataggtc
     6181 tcacaagtac cacttttatt ccagtcttta actgttcata atgggcatag caagggttgg
     6241 agtgagagcc tacttcctac ctcttaaggc actttcctca ttgttttgcc atataacctt
     6301 ggactgcatg ataagctgat gaaatatcca tgacttttcc cagagcaact agcaaggtat
     6361 atgacatttt ggctagagat tagtgggaag gaaaatttag aggtttaagt ccggatgtat
     6421 gaacctcaaa aaaaagtctt ctaaacacat atcatttaag tacaatatat ggaaatgtat
     6481 ctgagcagag agtcactata acagttctct ctaagtagat tagttcaatg tccaatgaaa
     6541 gtgaacatct ttattcctat attactatag tactggatga actgtatact gagtttttca
     6601 aacaagtatt taaagtagaa cttttaagta cgagcaaggg catgaggata aagactttgg
     6661 gttgtgtttc tgtaagtgta gtttaccata tagagctttg tttcttaatt ttaaaaaagg
     6721 tttcaaagta ttgccattca ttagcatcct taatgattat gagcgatgag tgtgtaactc
     6781 gaaatcatat acatgtatta gtttatctta actttttacc ctaaataaaa gggaaggtgt
     6841 acacctaaaa gatgtaatta ttttgcattt ttggccatgg gtgggaatgg ggtgggcatc
     6901 tacttgagca gtttttaaaa aagaaaaaaa aaatcagaaa tatttttcta ctattatata
     6961 tgatcttcct ttatactagt ttatccctag taaggcatgc cagaagccca agcaaggtac
     7021 catatcaagg gttcttacgt gctgtacctt tcgttggtgg gtaatcgaat cagatgcttg
     7081 gcactgtggt catagttatg aagtgcttgt gaggatcaga tttcactgaa tactaatttg
     7141 ttttacttaa gagtctaatc tgggaagttt gcaaatcata ctattaatgt gtaatctaag
     7201 ctctttccaa tgtatccatg aataatcctg gaacaatatt gcttgtattc ctgtcacaga
     7261 acaggttttg taatctttaa aagaaatgga aatttatata ataaagtttc aagtaaagca
//
