LOCUS       NM_011299               5394 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus ribosomal protein S6 kinase, polypeptide 2 (Rps6ka2),
            mRNA.
ACCESSION   NM_011299 XM_112492
VERSION     NM_011299.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5394)
  AUTHORS   Zhang,J., Liao,J.Q., Wen,L.R., Padhiar,A.A., Li,Z., He,Z.Y.,
            Wu,H.C., Li,J.F., Zhang,S., Zhou,Y., Pan,X.H., Yang,J.H. and
            Zhou,G.Q.
  TITLE     Rps6ka2 enhances iMSC chondrogenic differentiation to attenuate
            knee osteoarthritis through articular cartilage regeneration in
            mice
  JOURNAL   Biochem Biophys Res Commun 663, 61-70 (2023)
   PUBMED   37119767
  REMARK    GeneRIF: Rps6ka2 enhances iMSC chondrogenic differentiation to
            attenuate knee osteoarthritis through articular cartilage
            regeneration in mice.
REFERENCE   2  (bases 1 to 5394)
  AUTHORS   Decourt,C., Schaeffer,J., Blot,B., Paccard,A., Excoffier,B.,
            Pende,M., Nawabi,H. and Belin,S.
  TITLE     The RSK2-RPS6 axis promotes axonal regeneration in the peripheral
            and central nervous systems
  JOURNAL   PLoS Biol 21 (4), e3002044 (2023)
   PUBMED   37068088
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5394)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5394)
  AUTHORS   Lee,W.S., Lavery,L., Rousseaux,M.W.C., Rutledge,E.B., Jang,Y.,
            Wan,Y.W., Wu,S.R., Kim,W., Al-Ramahi,I., Rath,S., Adamski,C.J.,
            Bondar,V.V., Tewari,A., Soleimani,S., Mota,S., Yalamanchili,H.K.,
            Orr,H.T., Liu,Z., Botas,J. and Zoghbi,H.Y.
  TITLE     Dual targeting of brain region-specific kinases potentiates
            neurological rescue in Spinocerebellar ataxia type 1
  JOURNAL   EMBO J 40 (7), e106106 (2021)
   PUBMED   33709453
  REMARK    GeneRIF: Dual targeting of brain region-specific kinases
            potentiates neurological rescue in Spinocerebellar ataxia type 1.
REFERENCE   5  (bases 1 to 5394)
  AUTHORS   Madogwe,E., Schuermann,Y., Siddappa,D., Bordignon,V., Roux,P.P. and
            Duggavathi,R.
  TITLE     Sustained ERK1/2 signaling is necessary for follicular rupture
            during ovulation in mice
  JOURNAL   Reproduction 161 (2), 183-193 (2021)
   PUBMED   33434153
REFERENCE   6  (bases 1 to 5394)
  AUTHORS   Schimenti,J.C.
  TITLE     ORFless, intronless, and mutant transcription units in the mouse t
            complex responder (Tcr) locus
  JOURNAL   Mamm Genome 10 (10), 969-976 (1999)
   PUBMED   10501965
REFERENCE   7  (bases 1 to 5394)
  AUTHORS   Kispert,A., Stoger,R.J., Caparros,M. and Herrmann,B.G.
  TITLE     The mouse Rsk3 gene maps to the Leh66 elements carrying the
            t-complex responder Tcr
  JOURNAL   Mamm Genome 10 (8), 794-802 (1999)
   PUBMED   10430666
REFERENCE   8  (bases 1 to 5394)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   9  (bases 1 to 5394)
  AUTHORS   Yin,T. and Yang,Y.C.
  TITLE     Mitogen-activated protein kinases and ribosomal S6 protein kinases
            are involved in signaling pathways shared by interleukin-11,
            interleukin-6, leukemia inhibitory factor, and oncostatin M in
            mouse 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (5), 3731-3738 (1994)
   PUBMED   7508917
REFERENCE   10 (bases 1 to 5394)
  AUTHORS   Gilardi-Hebenstreit,P., Nieto,M.A., Frain,M., Mattei,M.G.,
            Chestier,A., Wilkinson,D.G. and Charnay,P.
  TITLE     An Eph-related receptor protein tyrosine kinase gene segmentally
            expressed in the developing mouse hindbrain
  JOURNAL   Oncogene 7 (12), 2499-2506 (1992)
   PUBMED   1281307
  REMARK    Erratum:[Oncogene. 1993 Apr;8(4):1103.. PMID: 8455939]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126433.3 and AC117241.4.
            
            On Nov 30, 2022 this sequence version replaced NM_011299.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043064.1, AJ131021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AC126433.3         56641-56957         c
            318-434             AC117241.4         163491-163607       c
            435-516             AC117241.4         155393-155474       c
            517-597             AC117241.4         144738-144818       c
            598-677             AC117241.4         142149-142228       c
            678-784             AC117241.4         139874-139980       c
            785-822             AC117241.4         137071-137108       c
            823-965             AC117241.4         135547-135689       c
            966-1036            AC117241.4         130446-130516       c
            1037-1125           AC117241.4         129304-129392       c
            1126-1190           AC117241.4         119864-119928       c
            1191-1293           AC117241.4         113955-114057       c
            1294-1424           AC117241.4         109621-109751       c
            1425-1550           AC117241.4         108651-108776       c
            1551-1640           AC117241.4         102516-102605       c
            1641-1799           AC117241.4         100732-100890       c
            1800-1961           AC117241.4         98613-98774         c
            1962-2038           AC117241.4         96241-96317         c
            2039-2156           AC117241.4         95388-95505         c
            2157-2294           AC117241.4         92100-92237         c
            2295-5394           AC117241.4         88205-91304         c
FEATURES             Location/Qualifiers
     source          1..5394
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 4.7 cM"
     gene            1..5394
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /note="ribosomal protein S6 kinase, polypeptide 2"
                     /db_xref="GeneID:20112"
                     /db_xref="MGI:MGI:1342290"
     exon            1..317
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..2420
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /EC_number="2.7.11.1"
                     /note="S6K-alpha 2; p90-RSK 2; RSK-3; p90RSK2; pp90RSK3;
                     MAPKAPK-1c; MAPKAP kinase 1c; ribosomal S6 kinase 3;
                     protein-tyrosine kinase Mpk-9; MAPK-activated protein
                     kinase 1c; 90 kDa ribosomal protein S6 kinase 2; MAP
                     kinase-activated protein kinase 1c; ribosomal protein S6
                     kinase, 90kD, polypeptide 2"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase alpha-2"
                     /protein_id="NP_035429.1"
                     /db_xref="CCDS:CCDS28376.1"
                     /db_xref="GeneID:20112"
                     /db_xref="MGI:MGI:1342290"
                     /translation="MELSMKKFTVRRFFSVYLRKKSRSKSSSLSRLEEEGIVKEIDIS
                     NHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRD
                     RVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEED
                     VKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRAYS
                     FCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKL
                     GMPQFLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFFVTIDWNKLYRKEIKPP
                     FKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLVQEPSQQDV
                     PKAPIHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSK
                     RDPSEEIEILLRYGQHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSERE
                     ASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENG
                     LLMTPCYTANFVAPEVLKRQGYDAACDVWSLGILLYTMLAGFTPFANGPDDTPEEILA
                     RIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPQQRLTAVQVLKHPWIVNREYLSQNQ
                     LSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSSLAQRRGMKRLTSTRL"
     exon            318..434
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            435..516
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            517..597
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            598..677
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            678..784
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            785..822
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..965
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1036
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1125
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1190
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1293
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1424
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1550
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1640
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1799
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1961
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2038
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2156
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2294
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..5394
                     /gene="Rps6ka2"
                     /gene_synonym="90kDa; D17Wsu134e; p90rsk; pp90rsk;
                     Rps6ka-rs1; Rsk3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcctggcc ggaggcaaag gcgccgcggg agtgatccag ggacccgggc ccggtggccg
       61 gtgcggcctg ccctttgtgc ttgcagcccg catccgcgcc gagggccgcc gcgtcgggct
      121 ccccggcgcg cgtgcccgcc agcgcgctgc ctagcctggg atgtgccggg gatgcgcgcc
      181 cgccggccct gcggctcctg gcagctgggc gcggggcgat ggagctgagc atgaagaagt
      241 tcacggtgcg caggttcttc tccgtgtacc tgcgcaagaa gtcgcgctcc aagagctcca
      301 gtctgagtcg cctcgaggaa gaaggcattg tgaaggagat tgacattagc aaccatgtga
      361 aggaaggctt tgagaaggca gacccctccc agttcgagct actaaaggtt ttaggacaag
      421 ggtcgtatgg aaaggtgttc ttggtgagga aggttacagg atcagacgct ggtcagctct
      481 acgccatgaa ggtcctgaag aaagccacct tgaaagtgcg agaccgggtc agatctaaga
      541 tggagagaga catcctggca gaggtgaatc accctttcat tgtcaagctg cattatgcct
      601 ttcagaccga aggcaagctc tacctgatcc tggacttcct gcggggaggt gacctcttca
      661 ccaggctttc caaagaggtg atgttcacgg aggaggatgt caagttctac ctggctgagc
      721 tggccttggc tctagaccac ctccatggcc tggggatcat ctacagggat ctgaagccag
      781 agaatatcct cctggatgaa gagggacaca ttaagatcac agattttggc ttgagcaagg
      841 aggccaccga ccatgacaag agagcctatt cattctgtgg gactattgaa tacatggcgc
      901 ccgaggtggt gaaccggcgt ggacacacac agagtgccga ctggtggtcc ttcggtgtgc
      961 tcatgttcga gatgctcaca gggtccctgc cattccaggg gaaggacagg aaggaaacaa
     1021 tggccctcat cctcaaagcc aagctgggta tgcctcagtt cctcagtgcg gaggctcaga
     1081 gcctgctcag ggcccttttc aagcggaacc cctgcaacag gctaggtgct ggtgttgatg
     1141 gagtggagga aattaaacgt cacccgttct ttgtcaccat agactggaat aagctgtacc
     1201 gcaaggagat caagccaccc ttcaagccag cagtgggcag gcctgaggac accttccact
     1261 ttgaccccga gtttactgca aggaccccca cagattctcc tggtgtcccc ccaagtgcaa
     1321 acgcccacca cctcttcaga ggattcagct ttgtggcctc cagcctggtc caggagccct
     1381 cacagcaaga cgtgcccaag gcccccattc acccaattgt gcagcagcta catgggaaca
     1441 acatccactt cactgacggc tatgagatca aggaggacat cggggtgggc tcctactcag
     1501 tgtgcaagcg gtgtgtacac aaagccacgg atgctgagta tgctgtgaag atcatcgata
     1561 agagcaaaag ggacccctcg gaggagattg agatcctcct gcgctatggc cagcacccca
     1621 acatcatcac cctaaaagat gtctatgatg atggcaagta cgtctacctg gtgatggagc
     1681 tcatgcgagg cggggagctg ctggaccgta tcctccgtca gcggtgcttc tcagagcgtg
     1741 aggccagtga tgtgctctat accatcgcca ggaccatgga ctacctgcac tcccaagggg
     1801 ttgtccatcg ggacctgaaa ccaagtaaca ttctgtacat ggatgagtct ggaaaccccg
     1861 aatctatccg catctgtgac tttgggtttg ccaaacagct tcgagcggag aatgggctgc
     1921 tcatgacccc ctgctatact gcaaactttg tagctcccga ggtcttgaag cggcaaggct
     1981 acgatgcagc gtgtgatgtc tggagcttgg gaatcctgct gtacaccatg ctggctgggt
     2041 tcactccgtt tgccaatggc ccagacgata cccctgagga gattctggct aggatcggca
     2101 gtgggaagta cgccctttct gggggaaact gggactccat atctgatgca gcaaaagatg
     2161 tcgtgtccaa gatgctccac gtggaccctc agcaacgcct aacagcagtt caagtgttga
     2221 agcacccgtg gatcgtgaac agagagtacc tatcccaaaa ccagctgagc agacaggatg
     2281 tccatctagt gaagggtgcc atggcggcca cctactttgc tctgaacagg accccacagg
     2341 caccgaggct agagcctgtg ctctcatcta gcttggccca acgcagaggc atgaagagac
     2401 tcacgtctac caggttgtag tggccagcca agtctccagc ctcagtcgcc ctgcccaacg
     2461 tcctctcagc ctcacagaca ccagacatag gtcctgttca tgggcacttg agtgcccatg
     2521 agtccagcac aaagatggat ctggccttgg ctgtctctct gtttcctttg cagccctgga
     2581 aagggtcctg cccaggatgt ctgagccttg ctgcaccgac ctcgccgccc gctctctctc
     2641 ctcctgagtg aaaccaaatg aatctgtcac ctcatagcac cctgctgggg cctccctggg
     2701 ctcactcagg gctctcagtg tctccatgtc atggcttatg cccaaagcag agctctttta
     2761 ccatcctgat gtcacctacg tgtcccactg tctctctgag agtgttagtg cacagtccct
     2821 gcctggagac agcagagcca cagcagagct ggatgttcct ggatgttctg gcaatgccag
     2881 tggccatgtg aaagcatcca gcttagatgc ctggctctgt ccacaatcac ccaaagagtg
     2941 ctcctcacca ccctcctgct ctcaagcaag atgctgggta gcctctccct gactctgtct
     3001 ctgacttggc aggatgaaag caaccaaccc aagagtctag atggctagag tctatttgag
     3061 agcgtgattc ctgttggttg agacaggagc cccaggaaat tgccgggcag agccagtacc
     3121 cactacactg ctgccccctt aaccctgtgg ccccagggac actggagaga gtggggctct
     3181 gccattgctg ggtgtgttgg catctctgct catatttgcc tgctgtggta tagcatattc
     3241 actctctctc tgctttcctg ggccacagag aatgtcttct cctctatccc tctatccctt
     3301 cttgactgag gacaggagag acacctgagc cccttgcctt agacaggcag aaggtgcctg
     3361 gacaagttgt cagtgggagt gatgctcttc ttagaagctg tggtcctatg ttgcatcttg
     3421 tgtttctgtt gtctagcctg ttttcaggct gtagtctgcg cagggagcag tagttacacg
     3481 gaccaggcta tctgtggcat actcttcatg cagagtaacc gagtgagacc cttcccccgt
     3541 ggcgtgctcc actcctcctg gtcggagagg agggacttgt gtgtcctgaa gtctctctgg
     3601 aggctgctga ggatagtgga ctcaggtcag aagacactcc actgtggctc agaacctgcc
     3661 agtctgagaa gcagcccctc tgcccagtag aggcacctgt aggaggcgcc tgttggtcac
     3721 agcaggctta cactaggaag accacaggtg gaccacggct gcttctgcaa tgcctgcccc
     3781 agtggaatgt tcagaacata attcctttgc tcagtctaat tatttcagac ctcaaaacgt
     3841 aaacgtattt ctgaagcttt aattactcca ctggactctg ttctgtttga gaattataaa
     3901 atacagagtg gggatagact gtgtgccatt tccagtgtcc ctggggatgg tctcctgctt
     3961 tctcagtgga tgctctgccc aaggctgaga tcatctccca gttaatgttc tgggcccgaa
     4021 tccttgcgat tcttgataga aatccagagg gaaagtatag tgggtagtct tagtgacgga
     4081 ttctgtcctc tgggaaatga acaggagctc tggcaccctc cgagggcctc tctggcatgc
     4141 acccttgctc cagctgctca cggctcaggc tgggtttgct tgcagcttca agtgtacatg
     4201 ttccaatgaa aagaaagaac aacagaacac agaaggcatg gctgaggagg cgagcatagc
     4261 ctgtccctct catggtcacg tggccgcatc acctctttca gtaatgtgag gttacctgct
     4321 ttacactcag cctactctcg ccaaatagat ggaggagacc atcagtcaaa acaaacgcat
     4381 ccttgaagtg tctggaagga tgctcagcct tgccctgcag agagtggagt accccacatt
     4441 cccacctcac ccagtacttg atacttgaaa tctctcgtgg agtcagccag aggagcacgt
     4501 gacaggatcg ttttaatccc tgttctttaa agtcttcagt gccacagcag tctgctgtgg
     4561 catgtaaccc cgtgtcccca gtgtttacct ggcctgtgac cctttaccca acatgaggaa
     4621 aggctctgta ttctctacac aaatgactac ttgtgtagct acagaatttg tcatgggaaa
     4681 gcccagccta catcctggga ctcctttacc catcccccag agctactttt gggctatccc
     4741 actgcagctc ctgccctgtt tgggctgaga acatgatgag cgctccactg aaggaggtgg
     4801 ggatggggtg cttgtcagat tctgtacccc agagtcaatg gcaggcaagc cgtgaacgtc
     4861 ccctgtccta tggttggaac gtgtgtgatt ttgaactacc tgtgtgcact ggtctttgga
     4921 tattgtttgg ctttttaagt gaggatcgtc ctgatggtat ctaatgtcag cagtattcct
     4981 gattaaatgg tgttcttcct taagatgccc tttgggattt cccctgcatt gtaccgcttc
     5041 tctcaagcac aggaggagat acaccgtgac tcttcattct ctctggcaca ttttgccgcc
     5101 cttcaccacc cgcaagactg tgagacacct agagtgggaa aggtctctgg ggtccctctg
     5161 tggcagggac aggtggaagg ggaagccagc atggctcatc ggtgcaggtg aaaggcacca
     5221 ccccactccc agcccgcgct gcgtttacat gatcagcagt tccgtttaca gctcactcca
     5281 tgttcacact ttctggctgt gtgttgagac ggcggccact gtacagatat ttattatgct
     5341 ttccaaactt tcccatgaga ttttttgaat aaacatggat tttatgaagt gtaa
//
