LOCUS       NM_009097               3151 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ribosomal protein S6 kinase polypeptide 1 (Rps6ka1),
            transcript variant 1, mRNA.
ACCESSION   NM_009097
VERSION     NM_009097.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3151)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3151)
  AUTHORS   Decourt,C., Schaeffer,J., Blot,B., Paccard,A., Excoffier,B.,
            Pende,M., Nawabi,H. and Belin,S.
  TITLE     The RSK2-RPS6 axis promotes axonal regeneration in the peripheral
            and central nervous systems
  JOURNAL   PLoS Biol 21 (4), e3002044 (2023)
   PUBMED   37068088
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3151)
  AUTHORS   Bonucci,M., Kuperwasser,N., Barbe,S., Koka,V., de Villeneuve,D.,
            Zhang,C., Srivastava,N., Jia,X., Stokes,M.P., Bienaime,F.,
            Verkarre,V., Lopez,J.B., Jaulin,F., Pontoglio,M., Terzi,F.,
            Delaval,B., Piel,M. and Pende,M.
  TITLE     mTOR and S6K1 drive polycystic kidney by the control of
            Afadin-dependent oriented cell division
  JOURNAL   Nat Commun 11 (1), 3200 (2020)
   PUBMED   32581239
  REMARK    GeneRIF: mTOR and S6K1 drive polycystic kidney by the control of
            Afadin-dependent oriented cell division.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3151)
  AUTHORS   Singh,M.V., Kotla,S., Le,N.T., Ae Ko,K., Heo,K.S., Wang,Y.,
            Fujii,Y., Thi Vu,H., McBeath,E., Thomas,T.N., Jin Gi,Y., Tao,Y.,
            Medina,J.L., Taunton,J., Carson,N., Dogra,V., Doyley,M.M.,
            Tyrell,A., Lu,W., Qiu,X., Stirpe,N.E., Gates,K.J., Hurley,C.,
            Fujiwara,K., Maggirwar,S.B., Schifitto,G. and Abe,J.I.
  TITLE     Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes
            Monocytes and Macrophages to Oxidative Stress in HIV-Positive
            Individuals
  JOURNAL   Circulation 139 (9), 1199-1216 (2019)
   PUBMED   30586719
  REMARK    GeneRIF: combination antiretroviral therapy increased
            monocyte/macrophage sensitivity to reactive oxygen species- in
            HIV(+) individuals by suppressing NRF2-ARE activity via
            p90RSK-mediated ERK5 S496 phosphorylation, which coordinately
            elicited senescent phenotypes and proinflammatory responses
REFERENCE   5  (bases 1 to 3151)
  AUTHORS   Abdulrahman,N., Jaspard-Vinassa,B., Fliegel,L., Jabeen,A., Riaz,S.,
            Gadeau,A.P. and Mraiche,F.
  TITLE     Na+/H+ exchanger isoform 1-induced osteopontin expression
            facilitates cardiac hypertrophy through p90 ribosomal S6 kinase
  JOURNAL   Physiol Genomics 50 (5), 332-342 (2018)
   PUBMED   29473817
  REMARK    GeneRIF: Data show that osteopontin (OPN) mediates Na(+)/H(+)
            exchanger isoform 1 (NHE1)-induced cardiac hypertrophy through p90
            ribosomal S6 kinase (p90 RSK).
REFERENCE   6  (bases 1 to 3151)
  AUTHORS   Spring,D.J. and Krebs,E.G.
  TITLE     Deletion of 11 amino acids in p90(rsk-mo-1) abolishes kinase
            activity
  JOURNAL   Mol Cell Biol 19 (1), 317-320 (1999)
   PUBMED   9858555
REFERENCE   7  (bases 1 to 3151)
  AUTHORS   Kawasome,H., Papst,P., Webb,S., Keller,G.M., Johnson,G.L.,
            Gelfand,E.W. and Terada,N.
  TITLE     Targeted disruption of p70(s6k) defines its role in protein
            synthesis and rapamycin sensitivity
  JOURNAL   Proc Natl Acad Sci U S A 95 (9), 5033-5038 (1998)
   PUBMED   9560223
REFERENCE   8  (bases 1 to 3151)
  AUTHORS   Cheatham,L., Monfar,M., Chou,M.M. and Blenis,J.
  TITLE     Structural and functional analysis of pp70S6k
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11696-11700 (1995)
   PUBMED   8524831
REFERENCE   9  (bases 1 to 3151)
  AUTHORS   Engel,K., Plath,K. and Gaestel,M.
  TITLE     The MAP kinase-activated protein kinase 2 contains a proline-rich
            SH3-binding domain
  JOURNAL   FEBS Lett 336 (1), 143-147 (1993)
   PUBMED   8262198
REFERENCE   10 (bases 1 to 3151)
  AUTHORS   Alcorta,D.A., Crews,C.M., Sweet,L.J., Bankston,L., Jones,S.W. and
            Erikson,R.L.
  TITLE     Sequence and expression of chicken and mouse rsk: homologs of
            Xenopus laevis ribosomal S6 kinase
  JOURNAL   Mol Cell Biol 9 (9), 3850-3859 (1989)
   PUBMED   2779569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL837508.21, BY737295.1 and BC049076.1.
            
            On Oct 22, 2013 this sequence version replaced NM_009097.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049076.1, AK148208.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AL837508.21        64545-64565         c
            22-49               BY737295.1         7-34
            50-3151             BC049076.1         1-3102
FEATURES             Location/Qualifiers
     source          1..3151
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.37 cM"
     gene            1..3151
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /note="ribosomal protein S6 kinase polypeptide 1"
                     /db_xref="GeneID:20111"
                     /db_xref="MGI:MGI:104558"
     exon            1..228
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..2373
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1;
                     ribosomal protein S6 kinase alpha-1; MAPKAP kinase 1a;
                     MAPK-activated protein kinase 1a; 90 kDa ribosomal protein
                     S6 kinase 1; MAP kinase-activated protein kinase 1a;
                     ribosomal protein S6 kinase, 90kD, polypeptide 1;
                     Ribosomal protein S6 kinase, 90kD, 1"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase alpha-1 isoform a"
                     /protein_id="NP_033123.2"
                     /db_xref="CCDS:CCDS18758.2"
                     /db_xref="GeneID:20111"
                     /db_xref="MGI:MGI:104558"
                     /translation="MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQPSKDEAILKEI
                     SITHHVKAGSEKADPSQFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK
                     VRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFT
                     EEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKK
                     AYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILK
                     AKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFYSTIDWNKLYRREI
                     KPPFKPAVAQPDDTFYFDTEFTSRTPRDSPGIPPSAGAHQLFRGFSFVATGLMEDDGK
                     PRTTQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSVCKRCVHKATNMEYAVKVID
                     KSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFS
                     EREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRA
                     ENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEE
                     ILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWITQKDKLP
                     QSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTTL"
     exon            229..273
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..390
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..472
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..553
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..633
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..740
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            741..778
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..921
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..992
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1081
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1146
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1249
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1380
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1506
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1596
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1755
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1917
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..1994
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2112
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2250
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..3135
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3113..3118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /note="hexamer: AATAAA"
     polyA_site      3135
                     /gene="Rps6ka1"
                     /gene_synonym="Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1;
                     p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1"
                     /note="major polyA site"
ORIGIN      
        1 agcgagccga agtgcgagtg ccgcggcggc ggcggacggc ccatccagag cgcgaggggc
       61 tcaggggcgt gcgggggtct cggtgtagca gcagggaccc cgtggcccag aggcagcgct
      121 gcccggggcc gccgggagga gcgcgggcgg tccggcagcg gcgcgatgcc gctcgcccag
      181 ctcaaggagc cctggccgct catggagctg gtgccgctgg acccggagaa tggccagact
      241 tcaggggaag aagctggact tcagccatcc aaggatgagg ccatcctcaa ggagatctcc
      301 atcacacacc acgtcaaggc tggctctgag aaggccgatc catcccagtt tgagctcctc
      361 aaggttctgg gccaaggatc ctttggcaaa gtcttcctgg tacgcaaggt cacccggcct
      421 gacagtgggc acttgtatgc catgaaagta ttaaagaagg ccacgctgaa agtgcgtgac
      481 cgtgttcgga ccaagatgga gagagacatc ctcgctgacg tgaaccaccc gttcgtggtg
      541 aagctacatt atgccttcca gaccgagggc aagctctatc ttattctgga cttcctgcgt
      601 ggtggagacc tgttcacacg gctctcaaag gaggtcatgt ttacagagga ggatgtgaag
      661 ttttacctgg ctgagctggc actgggcctg gaccacctgc acagcttggg cattatttac
      721 agagacctca agcctgagaa tatccttttg gatgaggagg gccacatcaa actcactgac
      781 tttggcctga gcaaggaggc catagaccat gagaagaagg cttactcctt ctgcgggaca
      841 gtggagtaca tggcgcccga ggttgtcaac cgccagggtc acacccacag tgcagactgg
      901 tggtcctatg gggtgctgat gtttgagatg ctgacgggct ccctgccctt ccaggggaag
      961 gaccggaagg agaccatgac cttgattttg aaggcgaagc taggcatgcc ccagtttctg
     1021 agcacggaag cccagagcct cctgcgggcc ctgttcaaga ggaatcctgc caatcggctt
     1081 ggctcgggcc ctgatggggc agaggaaatt aagagacata tcttctactc caccattgac
     1141 tggaataagc tctaccggcg tgagatcaag ccccctttca agccggctgt ggcccagccc
     1201 gacgacacct tctactttga taccgagttc acgtcacgca cacccaggga ttcgccaggc
     1261 atccctccca gtgctggtgc ccatcagctg ttccgtggct tcagcttcgt ggccactggt
     1321 ctgatggagg acgacggcaa gcctcggacc actcaggccc ccctacactc ggtggtacag
     1381 caactccacg ggaagaactt ggttttcagt gacggctacg tagtaaagga gacgatcggc
     1441 gtgggctcct actctgtgtg taagcgttgt gtccacaagg ccaccaacat ggagtatgct
     1501 gtcaaggtca tcgacaagag caaaagagat ccctcagaag agattgagat tcttctgcgg
     1561 tatggccagc accccaacat catcaccctg aaagatgtgt acgatgatgg taagcacgtg
     1621 tacctggtga cagagctgat gaggggcggc gagctgctgg ataagatcct acggcagaaa
     1681 ttcttctcag agcgggaggc cagcttcgtc ctgcacacga tcagcaagac tgtggaatac
     1741 ttgcactctc aaggggttgt ccacagagat ctcaaaccca gtaacatcct ctatgtggat
     1801 gagtctggga accccgagtg cctgcgcatc tgcgactttg gctttgccaa gcagctacgg
     1861 gccgagaacg gactcctcat gacaccttgc tacacagcca actttgtggc acctgaggtg
     1921 ctgaagcgcc agggctacga tgaaggctgt gacatatgga gcctgggcat tctgctgtac
     1981 acgatgctgg caggatacac tccatttgcc aatgggccca gtgacacccc agaggagatc
     2041 ctcacccgga tcggcagcgg gaagttcacc ctcagtgggg gaaactggaa cacggtttca
     2101 gagacagcca aggacttggt atctaagatg ctgcatgtgg acccccacca gcgcctcaca
     2161 gccaagcagg tcctgcagca cccatggatc acccagaaag acaagcttcc ccagagccag
     2221 ttgtcccacc aagacctgca gctcgtgaag ggagccatgg cggctacata ctctgctctc
     2281 aatagctcca aacccacccc tcagctcaag ccaattgagt cgtctatcct ggcccagcgg
     2341 cgggtgagga agctgccatc caccaccctg tgagccgcag acgaactcct cagaggcaga
     2401 gtccttccca gagacagcaa gcctgggtca caggaccaag tggaatggag ttctaaagga
     2461 agtaaccagc ccagatcacc cgtgagggtg tgacgtgcct tcctccccgg gacgggctct
     2521 tctgggctca ggctccaccg tgtgaaagcc actcactgta caaactattt tttaaggaaa
     2581 aaaaaatggc gtcatctccc atgaattttt tacaagatcc atttgccttc ttggccatcg
     2641 cagtcccagc agtcccagga ggaacgacga gtcacatgtg tggccgagac tcccttggta
     2701 gctttggggc cctctccgct gttggccgtg gggccatctg cacatgactt cgagcaggtc
     2761 cagcgtcgcc tctcagagct gtctcctggc tcctcagcag aacttggtcc ccagccatct
     2821 ctttttccgt tctgttctgg ggttctagaa ccactttctg ctagagcaag ggaccccacc
     2881 ctgtcagctc ttggctccag gcaccagcat ccacaacgcc catcctcggt gggtccctgc
     2941 ggtgggatcg gacaacccca tggagaggaa gcagaaagca cttttgggga aacctgctgt
     3001 ctgccgctag acagagttca caggagacca gggaggcggt ccccgggcga tgagggcttt
     3061 ttcatttcct cctcagctgg taactcaggg ttcatctgtc caaggccttt ctaataaact
     3121 tacaatccag ttaaaaaaaa aaaaaaaaaa a
//
