LOCUS       NM_009096               1394 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus ribosomal protein S6 (Rps6), mRNA.
ACCESSION   NM_009096
VERSION     NM_009096.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1394)
  AUTHORS   Kawase,K., Nakamura,Y., Wolbeck,L., Takemura,S., Zaitsu,K.,
            Ando,T., Jinnou,H., Sawada,M., Nakajima,C., Rydbirk,R., Gokenya,S.,
            Ito,A., Fujiyama,H., Saito,A., Iguchi,A., Kratimenos,P.,
            Ishibashi,N., Gallo,V., Iwata,O., Saitoh,S., Khodosevich,K. and
            Sawamoto,K.
  TITLE     Significance of birth in the maintenance of quiescent neural stem
            cells
  JOURNAL   Sci Adv 11 (4), eadn6377 (2025)
   PUBMED   39841848
REFERENCE   2  (bases 1 to 1394)
  AUTHORS   Geiselmann,A., Micouin,A., Vandormael-Pournin,S., Laville,V.,
            Chervova,A., Mella,S., Navarro,P. and Cohen-Tannoudji,M.
  TITLE     PI3K/AKT signaling controls ICM maturation and proper epiblast and
            primitive endoderm specification in mice
  JOURNAL   Dev Cell 60 (2), 204-219 (2025)
   PUBMED   39461340
REFERENCE   3  (bases 1 to 1394)
  AUTHORS   Tang,I., Nisal,A., Reed,A., Ware,T.B., Johansen,A., Zaki,M.S.,
            Cravatt,B.F. and Gleeson,J.G.
  TITLE     Lipidomic profiling of mouse brain and human neuron cultures
            reveals a role for Mboat7 in mTOR-dependent neuronal migration
  JOURNAL   Sci Transl Med 17 (779), eadp5247 (2025)
   PUBMED   39742503
REFERENCE   4  (bases 1 to 1394)
  AUTHORS   Iyer,D.P., Khoei,H.H., van der Weijden,V.A., Kagawa,H.,
            Pradhan,S.J., Novatchkova,M., McCarthy,A., Rayon,T., Simon,C.S.,
            Dunkel,I., Wamaitha,S.E., Elder,K., Snell,P., Christie,L.,
            Schulz,E.G., Niakan,K.K., Rivron,N. and Bulut-Karslioglu,A.
  TITLE     mTOR activity paces human blastocyst stage developmental
            progression
  JOURNAL   Cell 187 (23), 6566-6583 (2024)
   PUBMED   39332412
REFERENCE   5  (bases 1 to 1394)
  AUTHORS   Li,Q., Jiang,S., Lei,K., Han,H., Chen,Y., Lin,W., Xiong,Q., Qi,X.,
            Gan,X., Sheng,R., Wang,Y., Zhang,Y., Ma,J., Li,T., Lin,S., Zhou,C.,
            Chen,D. and Yuan,Q.
  TITLE     Metabolic rewiring during bone development underlies tRNA
            m7G-associated primordial dwarfism
  JOURNAL   J Clin Invest 134 (20), e177220 (2024)
   PUBMED   39255038
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1394)
  AUTHORS   Pata,I. and Metspalu,A.
  TITLE     Structural characterization of the mouse ribosomal protein
            S6-encoding gene
  JOURNAL   Gene 175 (1-2), 241-245 (1996)
   PUBMED   8917105
REFERENCE   7  (bases 1 to 1394)
  AUTHORS   Lecomte,F., Champagne,B., Dasnoy,J.F., Szpirer,J. and Szpirer,C.
  TITLE     The mammalian RPS6 gene, homolog of the Drosophila air8 tumor
            suppressor gene: is it an oncosuppressor gene?
  JOURNAL   Somat Cell Mol Genet 21 (6), 443-450 (1995)
   PUBMED   8600571
REFERENCE   8  (bases 1 to 1394)
  AUTHORS   Bandi,H.R., Ferrari,S., Krieg,J., Meyer,H.E. and Thomas,G.
  TITLE     Identification of 40 S ribosomal protein S6 phosphorylation sites
            in Swiss mouse 3T3 fibroblasts stimulated with serum
  JOURNAL   J Biol Chem 268 (6), 4530-4533 (1993)
   PUBMED   8440735
REFERENCE   9  (bases 1 to 1394)
  AUTHORS   Ferrari,S., Bandi,H.R., Hofsteenge,J., Bussian,B.M. and Thomas,G.
  TITLE     Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S
            ribosomal S6 phosphorylation sites
  JOURNAL   J Biol Chem 266 (33), 22770-22775 (1991)
   PUBMED   1939282
REFERENCE   10 (bases 1 to 1394)
  AUTHORS   Lalanne,J.L., Lucero,M. and le Moullec,J.M.
  TITLE     Complete sequence of mouse S6 ribosomal protein
  JOURNAL   Nucleic Acids Res 15 (12), 4990 (1987)
   PUBMED   3601662
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK146952.1.
            
            On Apr 6, 2007 this sequence version replaced NM_009096.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146952.1, SRR1660815.195258.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142, SAMN02415133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1394              AK146952.1         2-1395
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 40.69 cM"
     gene            1..1394
                     /gene="Rps6"
                     /gene_synonym="S6R"
                     /note="ribosomal protein S6"
                     /db_xref="GeneID:20104"
                     /db_xref="MGI:MGI:98159"
     exon            1..47
                     /gene="Rps6"
                     /gene_synonym="S6R"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..791
                     /gene="Rps6"
                     /gene_synonym="S6R"
                     /note="40S ribosomal protein S6; phosphoprotein NP33"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS6"
                     /protein_id="NP_033122.1"
                     /db_xref="CCDS:CCDS18310.1"
                     /db_xref="GeneID:20104"
                     /db_xref="MGI:MGI:98159"
                     /translation="MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEE
                     WKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIV
                     DANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRK
                     PLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMK
                     EAKEKRQEQIAKRRRLSSLRASTSKSESSQK"
     exon            48..179
                     /gene="Rps6"
                     /gene_synonym="S6R"
                     /inference="alignment:Splign:2.1.0"
     exon            180..390
                     /gene="Rps6"
                     /gene_synonym="S6R"
                     /inference="alignment:Splign:2.1.0"
     exon            391..537
                     /gene="Rps6"
                     /gene_synonym="S6R"
                     /inference="alignment:Splign:2.1.0"
     exon            538..1394
                     /gene="Rps6"
                     /gene_synonym="S6R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctttttcg tgacgcctcc caggcgctcg gctgtgtcaa gatgaagctg aacatctcct
       61 tccccgccac cggctgtcag aagctcatcg aggtggatga cgagcgcaag ctccgcacct
      121 tctatgagaa gcgcatggcc acggaagtag ccgctgatgc tcttggtgaa gagtggaagg
      181 gttatgtggt ccggatcagc ggtgggaatg acaagcaagg ttttcccatg aagcaaggtg
      241 ttctgaccca tggcagagtg cgcctgctgt tgagtaaggg gcattcctgt tacaggccaa
      301 ggagaactgg agagaggaag cgcaagtctg ttcgtggatg cattgtggac gctaatctca
      361 gtgttctcaa cttggtcatt gtaaagaaag gagagaagga tattcctgga ctgacagaca
      421 ctactgtgcc tcgtcggttg ggacctaaaa gggctagtag aatccgcaag ctttttaatc
      481 tctccaaaga agatgatgtc cgccagtatg ttgtcaggaa gcccttaaac aaagaaggta
      541 agaagcccag gaccaaagca cccaagattc agcgacttgt tactcctcgt gtcctgcaac
      601 acaaacgccg acgtattgct ctgaagaagc aacgcactaa gaagaacaag gaggaggctg
      661 cagaatacgc taaacttttg gccaagagaa tgaaggaagc caaagaaaag cgccaggaac
      721 agattgccaa gagacgtagg ctgtcctcac tgagagcttc tacttctaag tctgagtcca
      781 gtcaaaaatg agtctttaag agcaacaaat aaataatgac cttgaatctt tcattggctt
      841 tcattaatag tgtaactaga taaatgatgg gaaagatgag acagaagaag gaatacatct
      901 ataggactgc tagaatatgg ggagagtgat tattttcaaa ttaatatgta tcgagcttct
      961 accccaaggt aaataaataa catttggaga ccattaaaat gtaggatggc atagaagagg
     1021 cctttactaa gattaataat taaagaaaca cagcctttaa agtaaaaaac acactgtgcc
     1081 tttgaaactt gctaaaaaga ttaacttctg tcccaaaagg tatcagccat gcgctaccag
     1141 cctccctgcc cctacagtgg cagtggctgc attcttggtg aatggtagtg gaagggatta
     1201 aacctaggcc tcagtcatgc ttcccagtca ctggtactga tttgtatgca cccgcttagg
     1261 tgtgaaggta gttttggtgt gtatcacaag ttagcctgtg tagcgaagac aggttttctc
     1321 caccgtgttt tttgttacac atgactattc acaaatgtgc tgcagacagt aaaatgagaa
     1381 atacccttcc aagg
//
