LOCUS       NM_012052               1879 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ribosomal protein S3 (Rps3), mRNA.
ACCESSION   NM_012052
VERSION     NM_012052.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1879)
  AUTHORS   Li,H., Huo,Y., He,X., Yao,L., Zhang,H., Cui,Y., Xiao,H., Xie,W.,
            Zhang,D., Wang,Y., Zhang,S., Tu,H., Cheng,Y., Guo,Y., Cao,X.,
            Zhu,Y., Jiang,T., Guo,X., Qin,Y. and Sha,J.
  TITLE     A male germ-cell-specific ribosome controls male fertility
  JOURNAL   Nature 612 (7941), 725-731 (2022)
   PUBMED   36517592
REFERENCE   2  (bases 1 to 1879)
  AUTHORS   Chern,T., Achilleos,A., Tong,X., Hill,M.C., Saltzman,A.B.,
            Reineke,L.C., Chaudhury,A., Dasgupta,S.K., Redhead,Y., Watkins,D.,
            Neilson,J.R., Thiagarajan,P., Green,J.B.A., Malovannaya,A.,
            Martin,J.F., Rosenblatt,D.S. and Poche,R.A.
  TITLE     Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin
            metabolism and ribosomopathy
  JOURNAL   Nat Commun 13 (1), 134 (2022)
   PUBMED   35013307
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1879)
  AUTHORS   Li,Y., Huang,B., Yang,H., Kan,S., Yao,Y., Liu,X., Pu,S., He,G.,
            Khan,T.M., Qi,G., Zhou,Z., Shu,W. and Chen,M.
  TITLE     Latexin deficiency in mice up-regulates inflammation and aggravates
            colitis through HECTD1/Rps3/NF-kappaB pathway
  JOURNAL   Sci Rep 10 (1), 9868 (2020)
   PUBMED   32555320
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1879)
  AUTHORS   Peng,H., Zhao,Y., Chen,J., Huo,J., Zhang,Y. and Xiao,T.
  TITLE     Knockdown of ribosomal protein S3 causes preimplantation
            developmental arrest in mice
  JOURNAL   Theriogenology 129, 77-81 (2019)
   PUBMED   30826720
  REMARK    GeneRIF: RpS3 has a role in early embryonic development in mice.
REFERENCE   5  (bases 1 to 1879)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   6  (bases 1 to 1879)
  AUTHORS   Kimball,S.R., Horetsky,R.L., Ron,D., Jefferson,L.S. and
            Harding,H.P.
  TITLE     Mammalian stress granules represent sites of accumulation of
            stalled translation initiation complexes
  JOURNAL   Am J Physiol Cell Physiol 284 (2), C273-C284 (2003)
   PUBMED   12388085
REFERENCE   7  (bases 1 to 1879)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1879)
  AUTHORS   Lyamouri,M., Enerly,E. and Lambertsson,A.
  TITLE     Organization, sequence, and phylogenetic analysis of the ribosomal
            protein S3 gene from Drosophila virilis
  JOURNAL   Gene 294 (1-2), 147-156 (2002)
   PUBMED   12234676
REFERENCE   9  (bases 1 to 1879)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
REFERENCE   10 (bases 1 to 1879)
  AUTHORS   Kim,J., Chubatsu,L.S., Admon,A., Stahl,J., Fellous,R. and Linn,S.
  TITLE     Implication of mammalian ribosomal protein S3 in the processing of
            DNA damage
  JOURNAL   J Biol Chem 270 (23), 13620-13629 (1995)
   PUBMED   7775413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ074413.1, AK164077.1 and AC115858.14.
            
            On Sep 21, 2006 this sequence version replaced NM_012052.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164077.1, SRR1660821.280868.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                CJ074413.1         31-101
            72-1028             AK164077.1         15-971
            1029-1879           AC115858.14        80800-81650         c
FEATURES             Location/Qualifiers
     source          1..1879
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.07 cM"
     gene            1..1879
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
                     /note="ribosomal protein S3"
                     /db_xref="GeneID:27050"
                     /db_xref="MGI:MGI:1350917"
     exon            1..118
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..820
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
                     /EC_number="4.2.99.18"
                     /note="40S ribosomal protein S3"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS3"
                     /protein_id="NP_036182.1"
                     /db_xref="CCDS:CCDS40031.1"
                     /db_xref="GeneID:27050"
                     /db_xref="MGI:MGI:1350917"
                     /translation="MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPT
                     RTEIIILATRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIAQA
                     ESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHS
                     GDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPSGKIGPKKPLPDHVSIVEPKDEIL
                     PTTPISEQKGGKPEPPAMPQPVPTA"
     exon            119..249
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
                     /inference="alignment:Splign:2.1.0"
     exon            250..343
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
                     /inference="alignment:Splign:2.1.0"
     exon            344..438
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
                     /inference="alignment:Splign:2.1.0"
     exon            439..626
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
                     /inference="alignment:Splign:2.1.0"
     exon            627..823
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1879
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      871..876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
                     /note="hexamer: AATAAA"
     regulatory      883..888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
                     /note="hexamer: AACAAA"
     polyA_site      888
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
                     /note="major polyA site"
     polyA_site      926
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
                     /note="hexamer: AATAAA"
     polyA_site      1879
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
ORIGIN      
        1 gcgctgcgcg gcgtcattgc tcccgcccta tatacctact tccgcccgcg agccacttcc
       61 tttcctttca gcggcgcgcg gctgcaagat ggcggtgcag atttccaaga agaggaagtt
      121 tgtagctgat ggcatcttca aagctgagct gaatgaattt ctcactcggg agctggctga
      181 agatggctac tctggagttg aagtccgagt tacaccaacc aggacagaaa tcattatttt
      241 agccaccagg acacagaatg ttcttgggga gaagggtcgt cggatcagag agttgaccgc
      301 agttgtccag aagcgctttg gcttccctga aggcagcgta gagctttatg cagagaaagt
      361 ggccacaaga ggtctgtgtg ccattgccca ggcagagtct ctacgctaca aactccttgg
      421 agggcttgcg gttcgaaggg cctgctatgg tgtgcttcgg ttcattatgg agagtggggc
      481 caagggctgc gaggttgtgg tgtctgggaa gctccgagga cagagggcca agtccatgaa
      541 gtttgtggat ggtctgatga ttcacagtgg agaccctgtt aactactatg tcgacacagc
      601 tgtgcgccat gtgctcctca gacagggtgt gctgggcatc aaagtgaaga tcatgctgcc
      661 ctgggaccca agtggtaaga ttggtcccaa gaagcctctg cctgatcatg tgagcatcgt
      721 ggaacctaaa gatgaaatcc tgcccacgac ccccatctcc gaacagaagg gtgggaagcc
      781 agagccacca gccatgcccc agccagtgcc tacagcataa cagggtcttg gcagctgcat
      841 ctggaggcat ttaataaaat aaagacattt aataaaatct tgaacaaaga caaggcctga
      901 ctggattgtg tccagtattc aactgagtta tgttgtctat ggagccatgc ttattctgtt
      961 ggtttaagct ggagggcatg agcagagctg accagagaag tcatgaagtt ggtgaccctg
     1021 tgttgaacaa ttgagggtta gaagagcagt ttggttttgg tgctcttgat ggaacccagg
     1081 tgcttggaca tagtaagcac acataagaca gagtaagact gctgtgtctc tggcctggag
     1141 tagtctttct tgcttttttt tttttttttt tttttctcta gaatgaaagc agatggccca
     1201 gcgagttagg tgcttcctat gaaagcatgt gtgctggttt gtcatgcaca cagccctgca
     1261 ggagagagta tggcaacaca gccgctcagc atcccaagat aaaaagggag tttctactgc
     1321 cattttgagc ttgggagttt gaaatgtaaa gcctgtccat atgttttaag gatccatgta
     1381 tttctgtttt gtttgttttt caaaacaggg tttctctgta gccctggctg tcctggaacc
     1441 cactctgtat gtagaccagg ctggccttga actcagaaat ccacctgcct ctggcgatcc
     1501 atatatttct aagtcctgta cttagacgct gttttggaaa attcattttg gaagcattta
     1561 ctgttggtgt gttttgtggg gaatgaatga tagcttggga attcttttct gtttggtgag
     1621 agtgaagctg tcagcccggt tgtagcctgg ctggtgctca aaggctttct ctcattgtct
     1681 tcacctacgt agctttacgt ggggtaagga cttaagttac ttaagttggg tgcacactga
     1741 ccatgtccac aacctgttaa ccaactctac atgatgagta cagatgtacc tttttagaaa
     1801 gtgttaatgt gtagccctgg ctggcctctg cctcagggta ttatgaataa agtgtgcaac
     1861 cttcatctgg ttgattaaa
//
