LOCUS       NP_036182                243 aa            linear   ROD 04-JUN-2024
DEFINITION  small ribosomal subunit protein uS3 [Mus musculus].
ACCESSION   NP_036182
VERSION     NP_036182.1
DBSOURCE    REFSEQ: accession NM_012052.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 243)
  AUTHORS   Li,H., Huo,Y., He,X., Yao,L., Zhang,H., Cui,Y., Xiao,H., Xie,W.,
            Zhang,D., Wang,Y., Zhang,S., Tu,H., Cheng,Y., Guo,Y., Cao,X.,
            Zhu,Y., Jiang,T., Guo,X., Qin,Y. and Sha,J.
  TITLE     A male germ-cell-specific ribosome controls male fertility
  JOURNAL   Nature 612 (7941), 725-731 (2022)
   PUBMED   36517592
REFERENCE   2  (residues 1 to 243)
  AUTHORS   Chern,T., Achilleos,A., Tong,X., Hill,M.C., Saltzman,A.B.,
            Reineke,L.C., Chaudhury,A., Dasgupta,S.K., Redhead,Y., Watkins,D.,
            Neilson,J.R., Thiagarajan,P., Green,J.B.A., Malovannaya,A.,
            Martin,J.F., Rosenblatt,D.S. and Poche,R.A.
  TITLE     Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin
            metabolism and ribosomopathy
  JOURNAL   Nat Commun 13 (1), 134 (2022)
   PUBMED   35013307
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 243)
  AUTHORS   Li,Y., Huang,B., Yang,H., Kan,S., Yao,Y., Liu,X., Pu,S., He,G.,
            Khan,T.M., Qi,G., Zhou,Z., Shu,W. and Chen,M.
  TITLE     Latexin deficiency in mice up-regulates inflammation and aggravates
            colitis through HECTD1/Rps3/NF-kappaB pathway
  JOURNAL   Sci Rep 10 (1), 9868 (2020)
   PUBMED   32555320
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 243)
  AUTHORS   Peng,H., Zhao,Y., Chen,J., Huo,J., Zhang,Y. and Xiao,T.
  TITLE     Knockdown of ribosomal protein S3 causes preimplantation
            developmental arrest in mice
  JOURNAL   Theriogenology 129, 77-81 (2019)
   PUBMED   30826720
  REMARK    GeneRIF: RpS3 has a role in early embryonic development in mice.
REFERENCE   5  (residues 1 to 243)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   6  (residues 1 to 243)
  AUTHORS   Kimball,S.R., Horetsky,R.L., Ron,D., Jefferson,L.S. and
            Harding,H.P.
  TITLE     Mammalian stress granules represent sites of accumulation of
            stalled translation initiation complexes
  JOURNAL   Am J Physiol Cell Physiol 284 (2), C273-C284 (2003)
   PUBMED   12388085
REFERENCE   7  (residues 1 to 243)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 243)
  AUTHORS   Lyamouri,M., Enerly,E. and Lambertsson,A.
  TITLE     Organization, sequence, and phylogenetic analysis of the ribosomal
            protein S3 gene from Drosophila virilis
  JOURNAL   Gene 294 (1-2), 147-156 (2002)
   PUBMED   12234676
REFERENCE   9  (residues 1 to 243)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
REFERENCE   10 (residues 1 to 243)
  AUTHORS   Kim,J., Chubatsu,L.S., Admon,A., Stahl,J., Fellous,R. and Linn,S.
  TITLE     Implication of mammalian ribosomal protein S3 in the processing of
            DNA damage
  JOURNAL   J Biol Chem 270 (23), 13620-13629 (1995)
   PUBMED   7775413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ074413.1, AK164077.1 and AC115858.14.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164077.1, SRR1660821.280868.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.07 cM"
     Protein         1..243
                     /product="small ribosomal subunit protein uS3"
                     /EC_number="4.2.99.18"
                     /note="40S ribosomal protein S3"
                     /calculated_mol_wt=26543
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P23396; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     Region          4..216
                     /region_name="PTZ00084"
                     /note="40S ribosomal protein S3; Provisional"
                     /db_xref="CDD:240260"
     Site            6
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC/PRKCD.
                     /evidence=ECO:0000250|UniProtKB:P23396; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     Site            35
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P23396; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     Site            42
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAPK.
                     /evidence=ECO:0000250|UniProtKB:P23396; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     Site            62
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P23396; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     Site            64
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, by PRMT1.
                     /evidence=ECO:0000250|UniProtKB:P23396; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     Site            65
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, by PRMT1.
                     /evidence=ECO:0000250|UniProtKB:P23396; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     Site            67
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, by PRMT1.
                     /evidence=ECO:0000250|UniProtKB:P23396; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     Site            70
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKB.
                     /evidence=ECO:0000250|UniProtKB:P23396; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     Site            104
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P23396; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     Region          200..243
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P62908.1)"
     Site            209
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKB.
                     /evidence=ECO:0000250|UniProtKB:P23396; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     Site            220
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P23396; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     Site            221
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     Site            224
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P23396; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     Site            242
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P62908.1)"
     CDS             1..243
                     /gene="Rps3"
                     /gene_synonym="D7Ertd795e; Rs_3"
                     /coded_by="NM_012052.2:89..820"
                     /db_xref="CCDS:CCDS40031.1"
                     /db_xref="GeneID:27050"
                     /db_xref="MGI:MGI:1350917"
ORIGIN      
        1 mavqiskkrk fvadgifkae lnefltrela edgysgvevr vtptrteiii latrtqnvlg
       61 ekgrrirelt avvqkrfgfp egsvelyaek vatrglcaia qaeslrykll gglavrracy
      121 gvlrfimesg akgcevvvsg klrgqraksm kfvdglmihs gdpvnyyvdt avrhvllrqg
      181 vlgikvkiml pwdpsgkigp kkplpdhvsi vepkdeilpt tpiseqkggk peppampqpv
      241 pta
//
