LOCUS       NM_026467                509 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus ribosomal protein S27-like (Rps27l), transcript
            variant 2, mRNA.
ACCESSION   NM_026467
VERSION     NM_026467.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Xu,A.F., Molinuevo,R., Fazzari,E., Tom,H., Zhang,Z., Menendez,J.,
            Casey,K.M., Ruggero,D., Hinck,L., Pritchard,J.K. and Barna,M.
  TITLE     Subfunctionalized expression drives evolutionary retention of
            ribosomal protein paralogs Rps27 and Rps27l in vertebrates
  JOURNAL   Elife 12, e78695 (2023)
   PUBMED   37306301
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Zhao,Y., Tan,M., Liu,X., Xiong,X. and Sun,Y.
  TITLE     Inactivation of ribosomal protein S27-like confers radiosensitivity
            via the Mdm2-p53 and Mdm2-MRN-ATM axes
  JOURNAL   Cell Death Dis 9 (2), 145 (2018)
   PUBMED   29396424
  REMARK    GeneRIF: This study revealed a physiological condition under which
            Rps27l regulates the Mdm2/p53 and MRN/Atm axes to maintain DNA
            damage response and to confer radioprotection in vivo.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 509)
  AUTHORS   Xiong,X., Zhao,Y., Tang,F., Wei,D., Thomas,D., Wang,X., Liu,Y.,
            Zheng,P. and Sun,Y.
  TITLE     Ribosomal protein S27-like is a physiological regulator of p53 that
            suppresses genomic instability and tumorigenesis
  JOURNAL   Elife 3, e02236 (2014)
   PUBMED   25144937
  REMARK    GeneRIF: Data suggest that ribosomal protein S27-like (Rps27l) is
            an essential gene for postnatal development by modulating tumor
            suppressor protein p53.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 509)
  AUTHORS   Easterday,M.C., Dougherty,J.D., Jackson,R.L., Ou,J., Nakano,I.,
            Paucar,A.A., Roobini,B., Dianati,M., Irvin,D.K., Weissman,I.L.,
            Terskikh,A.V., Geschwind,D.H. and Kornblum,H.I.
  TITLE     Neural progenitor genes. Germinal zone expression and analysis of
            genetic overlap in stem cell populations
  JOURNAL   Dev Biol 264 (2), 309-322 (2003)
   PUBMED   14651920
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159741.2, BY088997.1, AK007689.1 and AV040832.2.
            
            On Mar 1, 2018 this sequence version replaced NM_026467.4.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            3' coding region that results in a frame-shift compared to variant
            1. It encodes isoform 2, which is shorter than and has a distinct
            C-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU962967.1, AI156863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC159741.2         164981-164983
            4-32                BY088997.1         1-29
            33-496              AK007689.1         2-465
            497-505             AV040832.2         289-297
            506-509             AC159741.2         168414-168417
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 36.23 cM"
     gene            1..509
                     /gene="Rps27l"
                     /gene_synonym="1810034D23Rik"
                     /note="ribosomal protein S27-like"
                     /db_xref="GeneID:67941"
                     /db_xref="MGI:MGI:1915191"
     exon            1..95
                     /gene="Rps27l"
                     /gene_synonym="1810034D23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            96..204
                     /gene="Rps27l"
                     /gene_synonym="1810034D23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            205..315
                     /gene="Rps27l"
                     /gene_synonym="1810034D23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            316..509
                     /gene="Rps27l"
                     /gene_synonym="1810034D23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      436..441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rps27l"
                     /gene_synonym="1810034D23Rik"
                     /note="hexamer: TATAAA"
     polyA_site      462
                     /gene="Rps27l"
                     /gene_synonym="1810034D23Rik"
                     /note="major polyA site"
     regulatory      481..486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rps27l"
                     /gene_synonym="1810034D23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      500
                     /gene="Rps27l"
                     /gene_synonym="1810034D23Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcctctatcc cggaagttgc tgaggggcgc tcgaaagcga gcagttcgtc tcggcgacct
       61 ggagcggccg cgcttgcgga gccgtcacca tgcccctggc tagagatctg ttacaccctt
      121 ccttggagga ggagaagaaa aaacataaga agaaacggct ggttcagagc ccaaattctt
      181 acttcatgga tgtgaaatgt ccaggttgct acaagattac tacagttttc agccatgcac
      241 agactgtggt tctttgtgtg ggttgttcaa ctgtgttgtg ccagcccaca ggaggaaaag
      301 ccaggctcac agaaggctgt tcatttagaa gaaagcaaca ctaatgagct atgaagttcc
      361 ggaatttgtg tttttcacag aaagccttac caacttcagt tactttacca agacaatgta
      421 attattgttt gattttataa agtctacaac aatgatctcc tattttggtg tcagtttttc
      481 aataaagttt taattatgga caagttcct
//
