LOCUS       NM_001024728            1621 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus ribosomal protein S23, retrogene 1 (Rps23rg1), mRNA.
ACCESSION   NM_001024728 XM_620639 XM_911413
VERSION     NM_001024728.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1621)
  AUTHORS   Zhao D, Zhou Y, Huo Y, Meng J, Xiao X, Han L, Zhang X, Luo H, Can
            D, Sun H, Huang TY, Wang X, Zhang J, Liu FR, Xu H and Zhang YW.
  TITLE     RPS23RG1 modulates tau phosphorylation and axon outgrowth through
            regulating p35 proteasomal degradation
  JOURNAL   Cell Death Differ 28 (1), 337-348 (2021)
   PUBMED   32908202
  REMARK    GeneRIF: RPS23RG1 modulates tau phosphorylation and axon outgrowth
            through regulating p35 proteasomal degradation.
REFERENCE   2  (bases 1 to 1621)
  AUTHORS   Zhao D, Meng J, Zhao Y, Huo Y, Liu Y, Zheng N, Zhang M, Gao Y, Chen
            Z, Sun H, Wang X, Jing C, Zhang T, Zhang X, Luo H, Wang X, Zhang J,
            Liu FR, Li Y, Bu G, Wen L, Huang TY, Xu H and Zhang YW.
  TITLE     RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's
            Disease-Associated Cognitive Deficits
  JOURNAL   Biol Psychiatry 86 (3), 171-184 (2019)
   PUBMED   30292394
  REMARK    GeneRIF: The study results reveal a role for RPS23RG1 in
            maintaining synaptic integrity and function and provide a new
            mechanism for synaptic dysfunction in Alzheimer's disease (AD)
            pathogenesis.
REFERENCE   3  (bases 1 to 1621)
  AUTHORS   Yan L, Chen Y, Li W, Huang X, Badie H, Jian F, Huang T, Zhao Y,
            Cohen SN, Li L, Zhang YW, Luo H, Tu S and Xu H.
  TITLE     RPS23RG1 reduces Abeta oligomer-induced synaptic and cognitive
            deficits
  JOURNAL   Sci Rep 6, 18668 (2016)
   PUBMED   26733416
  REMARK    GeneRIF: Our study demonstrates that RPS23RG1 may reduce the
            occurrence of key elements of AD pathology and enhance synaptic
            functions to counteract oAbeta-induced synaptic and cognitive
            deficits in AD
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1621)
  AUTHORS   Huang X, Chen Y, Li WB, Cohen SN, Liao FF, Li L, Xu H and Zhang YW.
  TITLE     The Rps23rg gene family originated through retroposition of the
            ribosomal protein s23 mRNA and encodes proteins that decrease
            Alzheimer's beta-amyloid level and tau phosphorylation
  JOURNAL   Hum Mol Genet 19 (19), 3835-3843 (2010)
   PUBMED   20650958
REFERENCE   5  (bases 1 to 1621)
  AUTHORS   Zhang YW, Liu S, Zhang X, Li WB, Chen Y, Huang X, Sun L, Luo W,
            Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen SN, Greengard P,
            Liao FF, Li L and Xu H.
  TITLE     A functional mouse retroposed gene Rps23r1 reduces Alzheimer's
            beta-amyloid levels and tau phosphorylation
  JOURNAL   Neuron 64 (3), 328-340 (2009)
   PUBMED   19914182
  REMARK    GeneRIF: We provide compelling evidence to show that RPS23R1
            overexpression can reduce both beta-amyloid levels and tau
            phosphorylation, two major pathological hallmarks of Alzheimer's
            disease
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK049309.1.
            
            On Apr 5, 2007 this sequence version replaced NM_001024728.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049309.1, SRR11927937.1378719.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1621              AK049309.1         4-1624
FEATURES             Location/Qualifiers
     source          1..1621
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.92 cM"
     gene            1..1621
                     /gene="Rps23rg1"
                     /gene_synonym="2610027C06Rik; C330021F23Rik; Rps23r1"
                     /note="ribosomal protein S23, retrogene 1"
                     /db_xref="GeneID:546049"
                     /db_xref="MGI:MGI:3612471"
     exon            1..99
                     /gene="Rps23rg1"
                     /gene_synonym="2610027C06Rik; C330021F23Rik; Rps23r1"
                     /inference="alignment:Splign:2.1.0"
     exon            100..200
                     /gene="Rps23rg1"
                     /gene_synonym="2610027C06Rik; C330021F23Rik; Rps23r1"
                     /inference="alignment:Splign:2.1.0"
     exon            201..405
                     /gene="Rps23rg1"
                     /gene_synonym="2610027C06Rik; C330021F23Rik; Rps23r1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..604
                     /gene="Rps23rg1"
                     /gene_synonym="2610027C06Rik; C330021F23Rik; Rps23r1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..679
                     /gene="Rps23rg1"
                     /gene_synonym="2610027C06Rik; C330021F23Rik; Rps23r1"
                     /inference="alignment:Splign:2.1.0"
     CDS             674..1099
                     /gene="Rps23rg1"
                     /gene_synonym="2610027C06Rik; C330021F23Rik; Rps23r1"
                     /note="ribosomal protein S23 like protein"
                     /codon_start=1
                     /product="ribosomal protein S23, retrogene 1"
                     /protein_id="NP_001019899.1"
                     /db_xref="CCDS:CCDS52468.1"
                     /db_xref="GeneID:546049"
                     /db_xref="MGI:MGI:3612471"
                     /translation="MQSQQRNIGYFNHLKADSRNITYSMTFSTKSSNQNFIIFLNEVQ
                     AAIIGHERCDLLPVLNELHPDALPDGRIWLFGLNPYFFQHNSLCMRGTPKRIGLQGCA
                     QVGFLVLFVMPLLIPSVTAELPGSSETTTLAHLAGATGP"
     exon            680..1621
                     /gene="Rps23rg1"
                     /gene_synonym="2610027C06Rik; C330021F23Rik; Rps23r1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttctctcac cccagataaa tgcctgtcct caactgccga ttctctctgc tgctgtcagc
       61 agactggaga tttctccact gccacctgtc gtgcttgagg gtctcacgta ccccaggttg
      121 acctcaaact tgctgtgcac tggaggatga ccttgaacta cctgtgttcc ggcctccaac
      181 tctgagtgct aggataacag gtctagctcg ttatgctgcc caagcttgtc tggctgtctg
      241 gaactcctac ctcaagtgat tcgctttctc ggctccctca ccatgcctga cagacagatg
      301 cattggcttg tgtctcatcc gtgagagaaa gactgagcag gatcctggag acagtgggag
      361 atttatcaga cataggaaat gccggcagct ccttttttgc ccatgatgcc cattgtcctt
      421 ccaacccagt atgggtgagg gcctgcagct gtcttctagg aaaacaagtg cctacactac
      481 acatctgcct tgtgtctctt gagtgtttgc agcaagctgc aggtgcagtg gcttatccgg
      541 gattgtcctt ggggtccaca gagttcaaga gaacattctc aggaaaagca aacaagtggg
      601 caaggtccag ggggttttgt tgccttttcc agcctccgtt ggctccaggc atgattatgt
      661 tgcatacaca tacatgcaga gccaacagag aaacattggc tactttaacc accttaaagc
      721 ggactccagg aatatcacct acagcatgac cttttcgacg aaatccagca accagaactt
      781 catcattttc ctcaatgaag ttcaggcagc catcattggg cacgaacgct gtgatcttct
      841 tcccgttctt aatgagctgc accctgacgc acttcctgat ggcagaattt ggctgtttgg
      901 cctcaacccc tactttttcc agcacaattc cctttgcatg agaggcaccc ccaaacggat
      961 tggccttcag ggctgtgccc aagtgggctt tcttgtactg tttgtcatgc cacttctgat
     1021 cccgtcggtg actgcggagc ttccgggcag ttcggagacc acgacacttg cccatcttgc
     1081 cggcgccacg ggcccctaat aactatattt taaagatgac ctggccttga tctgttcctc
     1141 agcatctccc cccagccccc acctccttgt ctgggaggga gacacaggta gctgagagct
     1201 gaatctgatc ctgagccagc tgcagccact gagtaatgct gcatggtgca aggggctggg
     1261 tcaacagaag agaaatgtgt gaatctgagc atgaaggtcc cctccagggg cttcccttct
     1321 gcaaacttac agagtaactt ctgcacggtc ctctgcctaa gagacactgg gaggcactga
     1381 taaaatactc tcaccagcca cagcagctgc catagtgaac actgaccaag ctgtgtcttg
     1441 tgccacatca gacaatcaag tcacctctca acaacctagt cccaaaagta ctgggggttt
     1501 caggctagca agatggctca gcagagaaag gtgcttgcca gcaagtctaa caatctgaga
     1561 ttgaccccca gggcccatgc tgttctctga cctccacata ggtgcccccc acacacacac
     1621 c
//
