LOCUS       NM_025587                396 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ribosomal protein S21 (Rps21), transcript variant 2,
            mRNA.
ACCESSION   NM_025587
VERSION     NM_025587.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 396)
  AUTHORS   Li,H., Huo,Y., He,X., Yao,L., Zhang,H., Cui,Y., Xiao,H., Xie,W.,
            Zhang,D., Wang,Y., Zhang,S., Tu,H., Cheng,Y., Guo,Y., Cao,X.,
            Zhu,Y., Jiang,T., Guo,X., Qin,Y. and Sha,J.
  TITLE     A male germ-cell-specific ribosome controls male fertility
  JOURNAL   Nature 612 (7941), 725-731 (2022)
   PUBMED   36517592
REFERENCE   2  (bases 1 to 396)
  AUTHORS   Zhao,Q., Yan,S., Lu,J., Parker,D.J., Wu,H., Sun,Q., Crossman,D.K.,
            Liu,S., Wang,Q., Sesaki,H., Mitra,K., Liu,K. and Jiao,K.
  TITLE     Drp1 regulates transcription of ribosomal protein genes in
            embryonic hearts
  JOURNAL   J Cell Sci 135 (4) (2022)
   PUBMED   35099001
REFERENCE   3  (bases 1 to 396)
  AUTHORS   Dinh,T.T.H., Iseki,H., Mizuno,S., Iijima-Mizuno,S., Tanimoto,Y.,
            Daitoku,Y., Kato,K., Hamada,Y., Hasan,A.S.H., Suzuki,H., Murata,K.,
            Muratani,M., Ema,M., Kim,J.D., Ishida,J., Fukamizu,A., Kato,M.,
            Takahashi,S., Yagami,K.I., Wilson,V., Arkell,R.M. and Sugiyama,F.
  TITLE     Disruption of entire Cables2 locus leads to embryonic lethality by
            diminished Rps21 gene expression and enhanced p53 pathway
  JOURNAL   Elife 10, e50346 (2021)
   PUBMED   33949947
  REMARK    GeneRIF: Disruption of entire Cables2 locus leads to embryonic
            lethality by diminished Rps21 gene expression and enhanced p53
            pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 396)
  AUTHORS   Liu,Y., Zhao,L.W., Shen,J.L., Fan,H.Y. and Jin,Y.
  TITLE     Maternal DCAF13 Regulates Chromatin Tightness to Contribute to
            Embryonic Development
  JOURNAL   Sci Rep 9 (1), 6278 (2019)
   PUBMED   31000741
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 396)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   6  (bases 1 to 396)
  AUTHORS   Kondrashov,N., Pusic,A., Stumpf,C.R., Shimizu,K., Hsieh,A.C.,
            Ishijima,J., Shiroishi,T. and Barna,M.
  TITLE     Ribosome-mediated specificity in Hox mRNA translation and
            vertebrate tissue patterning
  JOURNAL   Cell 145 (3), 383-397 (2011)
   PUBMED   21529712
REFERENCE   7  (bases 1 to 396)
  AUTHORS   Roma,G., Cobellis,G., Claudiani,P., Maione,F., Cruz,P., Tripoli,G.,
            Sardiello,M., Peluso,I. and Stupka,E.
  TITLE     A novel view of the transcriptome revealed from gene trapping in
            mouse embryonic stem cells
  JOURNAL   Genome Res 17 (7), 1051-1060 (2007)
   PUBMED   17540781
REFERENCE   8  (bases 1 to 396)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU534365.1 and AA049954.1.
            
            On Sep 6, 2006 this sequence version replaced NM_025587.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All six variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD241027.1, BU534365.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-384               BU534365.1         4-387
            385-396             AA049954.1         311-322
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 102.78 cM"
     gene            1..396
                     /gene="Rps21"
                     /gene_synonym="1810049N11Rik; 2410030A14Rik"
                     /note="ribosomal protein S21"
                     /db_xref="GeneID:66481"
                     /db_xref="MGI:MGI:1913731"
     exon            1..69
                     /gene="Rps21"
                     /gene_synonym="1810049N11Rik; 2410030A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            70..132
                     /gene="Rps21"
                     /gene_synonym="1810049N11Rik; 2410030A14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..334
                     /gene="Rps21"
                     /gene_synonym="1810049N11Rik; 2410030A14Rik"
                     /note="40S ribosomal protein S21"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS21"
                     /protein_id="NP_079863.1"
                     /db_xref="CCDS:CCDS38376.1"
                     /db_xref="GeneID:66481"
                     /db_xref="MGI:MGI:1913731"
                     /translation="MQNDAGEFVDLYVPRKCSASNRIIAAKDHASIQMNVAEVDRTTG
                     RFNGQFKTYGICGAIRRMGESDDSILRLAKADGIVSKNF"
     exon            133..196
                     /gene="Rps21"
                     /gene_synonym="1810049N11Rik; 2410030A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            197..268
                     /gene="Rps21"
                     /gene_synonym="1810049N11Rik; 2410030A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            269..324
                     /gene="Rps21"
                     /gene_synonym="1810049N11Rik; 2410030A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            325..391
                     /gene="Rps21"
                     /gene_synonym="1810049N11Rik; 2410030A14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      361..366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rps21"
                     /gene_synonym="1810049N11Rik; 2410030A14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      391
                     /gene="Rps21"
                     /gene_synonym="1810049N11Rik; 2410030A14Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctcctgccca atagtgctgc ggaggcacga gctacttcct ttctgcgctc tcgctggaca
       61 agtgagcagg gacggcctca ggatgcagaa cgacgccggc gagtttgtgg acctgtacgt
      121 gccgcggaaa tgctccgcaa gcaaccgcat cattgctgcc aaggaccacg cgtccatcca
      181 gatgaacgtg gccgaggttg ataggaccac aggccggttt aatggccagt ttaaaaccta
      241 tggcatctgc ggggccattc gcaggatggg cgagtcagat gattctattc tccgattggc
      301 taaggctgat ggaattgtct caaagaactt ttgagcagaa gaaatcggga atttgttaca
      361 aataaaagtt ttaagtacct gtgacagtta aaaaaa
//
