LOCUS       NM_001407441             639 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus ribosomal protein S12 (Rps12), transcript variant 2,
            mRNA.
ACCESSION   NM_001407441
VERSION     NM_001407441.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 639)
  AUTHORS   Folgado-Marco,V., Ames,K., Chuen,J., Gritsman,K. and Baker,N.E.
  TITLE     Haploinsufficiency of the essential gene Rps12 causes defects in
            erythropoiesis and hematopoietic stem cell maintenance
  JOURNAL   Elife 12, e69322 (2023)
   PUBMED   37272618
  REMARK    GeneRIF: Haploinsufficiency of the essential gene Rps12 causes
            defects in erythropoiesis and hematopoietic stem cell maintenance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 639)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   3  (bases 1 to 639)
  AUTHORS   Distler,U., Schmeisser,M.J., Pelosi,A., Reim,D., Kuharev,J.,
            Weiczner,R., Baumgart,J., Boeckers,T.M., Nitsch,R., Vogt,J. and
            Tenzer,S.
  TITLE     In-depth protein profiling of the postsynaptic density from mouse
            hippocampus using data-independent acquisition proteomics
  JOURNAL   Proteomics 14 (21-22), 2607-2613 (2014)
   PUBMED   25211037
REFERENCE   4  (bases 1 to 639)
  AUTHORS   Raines,A.M., Adam,M., Magella,B., Meyer,S.E., Grimes,H.L., Dey,S.K.
            and Potter,S.S.
  TITLE     Recombineering-based dissection of flanking and paralogous Hox gene
            functions in mouse reproductive tracts
  JOURNAL   Development 140 (14), 2942-2952 (2013)
   PUBMED   23760953
REFERENCE   5  (bases 1 to 639)
  AUTHORS   Kondrashov,N., Pusic,A., Stumpf,C.R., Shimizu,K., Hsieh,A.C.,
            Ishijima,J., Shiroishi,T. and Barna,M.
  TITLE     Ribosome-mediated specificity in Hox mRNA translation and
            vertebrate tissue patterning
  JOURNAL   Cell 145 (3), 383-397 (2011)
   PUBMED   21529712
REFERENCE   6  (bases 1 to 639)
  AUTHORS   Huttenhofer,A., Kiefmann,M., Meier-Ewert,S., O'Brien,J.,
            Lehrach,H., Bachellerie,J.P. and Brosius,J.
  TITLE     RNomics: an experimental approach that identifies 201 candidates
            for novel, small, non-messenger RNAs in mouse
  JOURNAL   EMBO J 20 (11), 2943-2953 (2001)
   PUBMED   11387227
REFERENCE   7  (bases 1 to 639)
  AUTHORS   Ayane,M., Nielsen,P. and Kohler,G.
  TITLE     Cloning and sequencing of mouse ribosomal protein S12 cDNA
  JOURNAL   Nucleic Acids Res 17 (16), 6722 (1989)
   PUBMED   2780296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160147.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.842920.1,
                                           SRR17253011.9531413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415136 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC160147.6         127056-127191       c
            137-187             AC160147.6         125786-125836       c
            188-304             AC160147.6         125556-125672       c
            305-407             AC160147.6         124694-124796       c
            408-509             AC160147.6         124368-124469       c
            510-639             AC160147.6         123936-124065       c
FEATURES             Location/Qualifiers
     source          1..639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 11.1 cM"
     gene            1..639
                     /gene="Rps12"
                     /note="ribosomal protein S12"
                     /db_xref="GeneID:20042"
                     /db_xref="MGI:MGI:98105"
     exon            1..136
                     /gene="Rps12"
                     /inference="alignment:Splign:2.1.0"
     exon            137..187
                     /gene="Rps12"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..572
                     /gene="Rps12"
                     /note="isoform a is encoded by transcript variant 2; 40S
                     ribosomal protein S12; small ribosomal subunit protein
                     eS12"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS12 isoform a"
                     /protein_id="NP_001394370.1"
                     /db_xref="GeneID:20042"
                     /db_xref="MGI:MGI:98105"
                     /translation="MAEEGIAAGGVMDVNTALQEVLKTALIHDGLARGIREAAKALDK
                     RQAHLCVLASNCDEPMYVKLVEALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRK
                     VVGCSCVVVKDYGKESQAKDVIEEYFKCKK"
     exon            188..304
                     /gene="Rps12"
                     /inference="alignment:Splign:2.1.0"
     exon            305..407
                     /gene="Rps12"
                     /inference="alignment:Splign:2.1.0"
     exon            408..509
                     /gene="Rps12"
                     /inference="alignment:Splign:2.1.0"
     exon            510..639
                     /gene="Rps12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      572..577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rps12"
                     /note="hexamer: AATAAA"
     polyA_site      601
                     /gene="Rps12"
                     /note="major polyA site"
     regulatory      616..621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rps12"
                     /note="hexamer: TATAAA"
     polyA_site      639
                     /gene="Rps12"
                     /note="major polyA site"
ORIGIN      
        1 ctctcttcct gtctgaatat tcttcctgca cttacctggc tggaactcta gttaaaacct
       61 cttttaaatg ctgccataaa ctccaaatcc cctgcgttcc cacatcatct ccactcccca
      121 gcaccgtggc attctgtgcg ttcaagattc ggcgtcaccc gtgattcacc gccatggccg
      181 aggaaggcat agctgctgga ggtgtaatgg acgtcaacac tgctctacaa gaggtgctga
      241 agaccgccct catccacgat ggcctagcac gtggcatacg cgaagctgcc aaagccttag
      301 acaagcgcca agcccatctg tgtgtgctcg catccaactg tgatgagccc atgtatgtca
      361 agctggtgga ggcactttgt gctgagcacc aaatcaacct gataaaggtt gatgacaaca
      421 agaaactagg ggaatgggta ggcctctgta aaatcgatcg agagggcaaa ccacggaagg
      481 tggttggttg cagttgcgta gtggttaagg actatggcaa agaatctcag gccaaggatg
      541 tcatcgagga atacttcaag tgcaagaaat aaataaattt tggctgattt ttctcttgta
      601 tttcttgttt gctggtataa aatgggatgt gcttactca
//
