LOCUS       NM_023396               1460 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus reprimo, TP53 dependent G2 arrest mediator candidate
            (Rprm), mRNA.
ACCESSION   NM_023396
VERSION     NM_023396.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1460)
  AUTHORS   Lin,Y., Tang,W., Huang,P., Wang,Z., Duan,L., Jia,C., Sun,R., Liu,L.
            and Shen,J.
  TITLE     Denticleless E3 ubiquitin protein ligase (DTL) maintains the
            proliferation and differentiation of epidermis and hair follicles
            during skin development
  JOURNAL   Dev Dyn 253 (7), 635-647 (2024)
   PUBMED   38131461
REFERENCE   2  (bases 1 to 1460)
  AUTHORS   Shi,W., Wang,J., Li,Z., Xu,S., Wang,J., Zhang,L. and Yang,H.
  TITLE     Reprimo (RPRM) mediates neuronal ferroptosis via CREB-Nrf2/SCD1
            pathways in radiation-induced brain injury
  JOURNAL   Free Radic Biol Med 213, 343-358 (2024)
   PUBMED   38272326
  REMARK    GeneRIF: Reprimo (RPRM) mediates neuronal ferroptosis via
            CREB-Nrf2/SCD1 pathways in radiation-induced brain injury.
REFERENCE   3  (bases 1 to 1460)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1460)
  AUTHORS   Li,Z., Zhou,Z., Tian,S., Zhang,K., An,G., Zhang,Y., Ma,R.,
            Sheng,B., Wang,T., Yang,H. and Yang,L.
  TITLE     RPRM deletion preserves hematopoietic regeneration by promoting
            EGFR-dependent DNA repair and hematopoietic stem cell proliferation
            post ionizing radiation
  JOURNAL   Cell Biol Int 46 (12), 2158-2172 (2022)
   PUBMED   36041213
  REMARK    GeneRIF: RPRM deletion preserves hematopoietic regeneration by
            promoting EGFR-dependent DNA repair and hematopoietic stem cell
            proliferation post ionizing radiation.
REFERENCE   5  (bases 1 to 1460)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   6  (bases 1 to 1460)
  AUTHORS   Vinall,R.L., Tepper,C.G., Shi,X.B., Xue,L.A., Gandour-Edwards,R.
            and de Vere White,R.W.
  TITLE     The R273H p53 mutation can facilitate the androgen-independent
            growth of LNCaP by a mechanism that involves H2 relaxin and its
            cognate receptor LGR7
  JOURNAL   Oncogene 25 (14), 2082-2093 (2006)
   PUBMED   16434975
  REMARK    GeneRIF: p53(R273H) binds directly to the relaxin promoter, further
            confirming a role for H2 relaxin signaling in p53(R273H)-mediated
            androgen-independent prostate cancer
REFERENCE   7  (bases 1 to 1460)
  AUTHORS   Lu,Y.P., Lou,Y.R., Liao,J., Xie,J.G., Peng,Q.Y., Yang,C.S. and
            Conney,A.H.
  TITLE     Administration of green tea or caffeine enhances the disappearance
            of UVB-induced patches of mutant p53 positive epidermal cells in
            SKH-1 mice
  JOURNAL   Carcinogenesis 26 (8), 1465-1472 (2005)
   PUBMED   15817611
  REMARK    GeneRIF: Oral administration of green tea or topical caffeine
            immediately after discontinuation of UVB treatment enhanced the
            rate and extent of disappearance of the mutant p53-positive patches
            on skin of hairless mice.
REFERENCE   8  (bases 1 to 1460)
  AUTHORS   Grimberg,A., Coleman,C.M., Burns,T.F., Himelstein,B.P., Koch,C.J.,
            Cohen,P. and El-Deiry,W.S.
  TITLE     p53-Dependent and p53-independent induction of insulin-like growth
            factor binding protein-3 by deoxyribonucleic acid damage and
            hypoxia
  JOURNAL   J Clin Endocrinol Metab 90 (6), 3568-3574 (2005)
   PUBMED   15769996
  REMARK    GeneRIF: Induction by DNA damage and hypoxia suggest IGFBP-3 plays
            a role in the physiologic protection against aberrant cell growth.
REFERENCE   9  (bases 1 to 1460)
  AUTHORS   Kerns,R.T., Ravindranathan,A., Hassan,S., Cage,M.P., York,T.,
            Sikela,J.M., Williams,R.W. and Miles,M.F.
  TITLE     Ethanol-responsive brain region expression networks: implications
            for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J
            mice
  JOURNAL   J Neurosci 25 (9), 2255-2266 (2005)
   PUBMED   15745951
REFERENCE   10 (bases 1 to 1460)
  AUTHORS   Ohki,R., Nemoto,J., Murasawa,H., Oda,E., Inazawa,J., Tanaka,N. and
            Taniguchi,T.
  TITLE     Reprimo, a new candidate mediator of the p53-mediated cell cycle
            arrest at the G2 phase
  JOURNAL   J Biol Chem 275 (30), 22627-22630 (2000)
   PUBMED   10930422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK010465.1 and AB043586.1.
            
            On Apr 25, 2009 this sequence version replaced NM_023396.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK010465.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1095              AK010465.1         2-1096
            1096-1316           AB043586.1         1085-1305
            1317-1460           AK010465.1         1316-1459
FEATURES             Location/Qualifiers
     source          1..1460
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 30.69 cM"
     gene            1..1460
                     /gene="Rprm"
                     /gene_synonym="2410012A13Rik; Reprimo"
                     /note="reprimo, TP53 dependent G2 arrest mediator
                     candidate"
                     /db_xref="GeneID:67874"
                     /db_xref="MGI:MGI:1915124"
     exon            1..1460
                     /gene="Rprm"
                     /gene_synonym="2410012A13Rik; Reprimo"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..578
                     /gene="Rprm"
                     /gene_synonym="2410012A13Rik; Reprimo"
                     /note="reprimo, TP53 dependant G2 arrest mediator
                     candidate"
                     /codon_start=1
                     /product="protein reprimo"
                     /protein_id="NP_075885.1"
                     /db_xref="CCDS:CCDS16040.1"
                     /db_xref="GeneID:67874"
                     /db_xref="MGI:MGI:1915124"
                     /translation="MNSVLGNQTDVAGLFLVNSSEALERAVRCCTQASVVTDDGFAEG
                     GPDERSLYIMRVVQIAVMCVLSLTVVFGIFFLGCNLLIKSEGMINFLVKDRRPSKEVE
                     AVVVGPY"
     regulatory      1127..1132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rprm"
                     /gene_synonym="2410012A13Rik; Reprimo"
                     /note="hexamer: AATACA"
     polyA_site      1146
                     /gene="Rprm"
                     /gene_synonym="2410012A13Rik; Reprimo"
                     /note="major polyA site"
     regulatory      1427..1432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rprm"
                     /gene_synonym="2410012A13Rik; Reprimo"
                     /note="hexamer: AATAAA"
     polyA_site      1452
                     /gene="Rprm"
                     /gene_synonym="2410012A13Rik; Reprimo"
                     /note="major polyA site"
ORIGIN      
        1 agtcgtgcga gcgccgggaa cgagcactgc ctgggcagaa cacagcgcac aggagccagc
       61 ttgcggcgcg ccctgaagag gttcttgaga cacttacgga cctgggactt tgaaagggag
      121 actgaggagc cctgcgcgca caagtgatca agccagcgct ccgccgggca cctgttcgtc
      181 ccgcgctaca gccactctgg tccccacccc tccgatcctc gccttcccgg ctcccgcttg
      241 ctctcgtgat gaattcagtg ctgggcaacc agaccgacgt ggctggcctg ttcctggtca
      301 acagtagcga ggcgctggag cgcgcggtgc gctgctgcac ccaggcgtcg gtggtgaccg
      361 acgatggctt cgccgaggga ggccccgacg agcgcagcct gtacatcatg cgtgtggtgc
      421 agatcgcagt catgtgtgtg ctctcgctca ctgtggtttt tggcatcttc ttccttggct
      481 gcaacctgct catcaagtcc gaaggcatga tcaacttcct agtgaaggac cggaggccgt
      541 ctaaagaggt ggaggcagtg gtcgtgggac cctactgagt ggccctcggg tccccctcgg
      601 cgggtgcctc ccttctggca cctccagtac tccgccagcc gcgatgcacc cctcaccatc
      661 acggaccgag caacgcaaac ctgtcggagt cagttttttt ctcttgactt ctgcctttgg
      721 ggaaaaagtg accgatttct gatagctctt cgaaaggccc caagcaagac tgtacaggag
      781 gagcgcccag acttcgggat acagcagcag gtggcaaaag cagggcgcag aactttggga
      841 gtggctgctg gcgtgggata ctgggagatg aaccaggcgg cgaaggcccc tttccacctg
      901 caggtgggct cagcactggg gacagcttga gaggccgagc aaggcggggt gtggatgggt
      961 gtgtattcag aggcccagtg accggaaaaa gtgactgttt attcgccacg ctgcagacct
     1021 aattgggaag gaacatagat gcgtgtgggt tttgcgacct actaagagag tgaaactttg
     1081 atcgatagta acctgtggtt ttaggggatt tgtgttagtt tgcttgaata caaatatttg
     1141 ataagtcttt tgtgtcctag tggcctgttt gcctgcctgc gggttagagt tttttgtcat
     1201 tctgggagaa cgggtggggg gaggggagtc tgagactgtg aatggggtaa gtgctttctt
     1261 ttagtgcatt tccagctggg tctttatggg aggctagcgc tccagctacg cccgggacaa
     1321 agatccagag tagaattctt agctcctgtc tgcacggttt acgccacaaa agtgctcttg
     1381 atatccgtga caccgtttga ctctttttct tatttaacat ttccttaata aatgcaacat
     1441 ttaagtgttt tgtttctggc
//
