LOCUS       NM_001291134            4520 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus regulation of nuclear pre-mRNA domain containing 1B
            (Rprd1b), transcript variant 1, mRNA.
ACCESSION   NM_001291134 XM_006500160
VERSION     NM_001291134.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4520)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4520)
  AUTHORS   Yang,L., Yang,H., Chu,Y., Song,Y., Ding,L., Zhu,B., Zhai,W.,
            Wang,X., Kuang,Y., Ren,F., Jia,B., Wu,W., Ye,X., Wang,Y. and
            Chang,Z.
  TITLE     CREPT is required for murine stem cell maintenance during
            intestinal regeneration
  JOURNAL   Nat Commun 12 (1), 270 (2021)
   PUBMED   33431892
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4520)
  AUTHORS   Ali,I., Ruiz,D.G., Ni,Z., Johnson,J.R., Zhang,H., Li,P.C.,
            Khalid,M.M., Conrad,R.J., Guo,X., Min,J., Greenblatt,J.,
            Jacobson,M., Krogan,N.J. and Ott,M.
  TITLE     Crosstalk between RNA Pol II C-Terminal Domain Acetylation and
            Phosphorylation via RPRD Proteins
  JOURNAL   Mol Cell 74 (6), 1164-1174 (2019)
   PUBMED   31054975
  REMARK    GeneRIF: Crosstalk between RNA Pol II C-terminal domain acetylation
            and phosphorylation via RPRD1B protein and its isoforms has been
            reported.
REFERENCE   4  (bases 1 to 4520)
  AUTHORS   Liang,Z., Feng,Q., Xu,L., Li,S. and Zhou,L.
  TITLE     CREPT regulated by miR-138 promotes breast cancer progression
  JOURNAL   Biochem Biophys Res Commun 493 (1), 263-269 (2017)
   PUBMED   28893536
  REMARK    GeneRIF: Mechanistically, CREPT regulated beta-catenin/TCF4/cyclin
            D1 pathway in BC. In conclusion, the data suggested that
            miR-138/CREPT involved BC progression, providing potential
            therapeutic targets for BC.
REFERENCE   5  (bases 1 to 4520)
  AUTHORS   Ichise,H., Hori,A., Shiozawa,S., Kondo,S., Kanegae,Y., Saito,I.,
            Ichise,T. and Yoshida,N.
  TITLE     Establishment of a tamoxifen-inducible Cre-driver mouse strain for
            widespread and temporal genetic modification in adult mice
  JOURNAL   Exp Anim 65 (3), 231-244 (2016)
   PUBMED   26923756
REFERENCE   6  (bases 1 to 4520)
  AUTHORS   Patidar,P.L., Motea,E.A., Fattah,F.J., Zhou,Y., Morales,J.C.,
            Xie,Y., Garner,H.R. and Boothman,D.A.
  TITLE     The Kub5-Hera/RPRD1B interactome: a novel role in preserving
            genetic stability by regulating DNA mismatch repair
  JOURNAL   Nucleic Acids Res 44 (4), 1718-1731 (2016)
   PUBMED   26819409
REFERENCE   7  (bases 1 to 4520)
  AUTHORS   Zhang,Y., Liu,C., Duan,X., Ren,F., Li,S., Jin,Z., Wang,Y., Feng,Y.,
            Liu,Z. and Chang,Z.
  TITLE     CREPT/RPRD1B, a recently identified novel protein highly expressed
            in tumors, enhances the beta-catenin.TCF4 transcriptional activity
            in response to Wnt signaling
  JOURNAL   J Biol Chem 289 (33), 22589-22599 (2014)
   PUBMED   24982424
  REMARK    GeneRIF: study suggests that CREPT acts as an activator to promote
            transcriptional activity of the beta-catenin.TCF4 complex in
            response to Wnt signaling.
REFERENCE   8  (bases 1 to 4520)
  AUTHORS   Lu,D., Wu,Y., Wang,Y., Ren,F., Wang,D., Su,F., Zhang,Y., Yang,X.,
            Jin,G., Hao,X., He,D., Zhai,Y., Irwin,D.M., Hu,J., Sung,J.J.,
            Yu,J., Jia,B. and Chang,Z.
  TITLE     CREPT accelerates tumorigenesis by regulating the transcription of
            cell-cycle-related genes
  JOURNAL   Cancer Cell 21 (1), 92-104 (2012)
   PUBMED   22264791
REFERENCE   9  (bases 1 to 4520)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   10 (bases 1 to 4520)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011979.1, AK035806.1, AK147930.1, AK045404.1, AK013301.1 and
            AI843346.1.
            
            On Mar 26, 2014 this sequence version replaced XM_006500160.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ372939.1, SRR1660817.19428.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AK011979.1         3-13
            12-926              AK035806.1         2-916
            927-1346            AK147930.1         886-1305
            1347-2670           AK045404.1         1020-2343
            2671-2726           AK147930.1         2630-2685
            2727-3617           AK013301.1         30-920
            3618-4499           AK147930.1         3577-4458
            4500-4520           AI843346.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..4520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.72 cM"
     gene            1..4520
                     /gene="Rprd1b"
                     /gene_synonym="2610304G08Rik; 2810446G03Rik; Crept"
                     /note="regulation of nuclear pre-mRNA domain containing
                     1B"
                     /db_xref="GeneID:70470"
                     /db_xref="MGI:MGI:1917720"
     exon            1..549
                     /gene="Rprd1b"
                     /gene_synonym="2610304G08Rik; 2810446G03Rik; Crept"
                     /inference="alignment:Splign:2.1.0"
     CDS             399..1379
                     /gene="Rprd1b"
                     /gene_synonym="2610304G08Rik; 2810446G03Rik; Crept"
                     /note="isoform a is encoded by transcript variant 1;
                     regulation of nuclear pre-mRNA domain-containing protein
                     1B; cell cycle-related and expression-elevated protein in
                     tumor"
                     /codon_start=1
                     /product="regulation of nuclear pre-mRNA domain-containing
                     protein 1B isoform a"
                     /protein_id="NP_001278063.1"
                     /db_xref="CCDS:CCDS71177.1"
                     /db_xref="GeneID:70470"
                     /db_xref="MGI:MGI:1917720"
                     /translation="MSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVW
                     HRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKK
                     PLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKAAEEKKSLKRTFQQIQEEEDDD
                     YPGSYSPQDPSAGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKIT
                     DKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKEVLSEKEKKL
                     EEYKQKLARVTQVRKELKSHIQSLPDLSLLPNVTGGLAPLPSAGDLFSTD"
     exon            550..679
                     /gene="Rprd1b"
                     /gene_synonym="2610304G08Rik; 2810446G03Rik; Crept"
                     /inference="alignment:Splign:2.1.0"
     exon            680..813
                     /gene="Rprd1b"
                     /gene_synonym="2610304G08Rik; 2810446G03Rik; Crept"
                     /inference="alignment:Splign:2.1.0"
     exon            814..926
                     /gene="Rprd1b"
                     /gene_synonym="2610304G08Rik; 2810446G03Rik; Crept"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1053
                     /gene="Rprd1b"
                     /gene_synonym="2610304G08Rik; 2810446G03Rik; Crept"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1229
                     /gene="Rprd1b"
                     /gene_synonym="2610304G08Rik; 2810446G03Rik; Crept"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..4507
                     /gene="Rprd1b"
                     /gene_synonym="2610304G08Rik; 2810446G03Rik; Crept"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3595..3600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rprd1b"
                     /gene_synonym="2610304G08Rik; 2810446G03Rik; Crept"
                     /note="hexamer: AATAAA"
     polyA_site      3620
                     /gene="Rprd1b"
                     /gene_synonym="2610304G08Rik; 2810446G03Rik; Crept"
                     /note="major polyA site"
     regulatory      4467..4472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rprd1b"
                     /gene_synonym="2610304G08Rik; 2810446G03Rik; Crept"
                     /note="hexamer: AATAAA"
     polyA_site      4502
                     /gene="Rprd1b"
                     /gene_synonym="2610304G08Rik; 2810446G03Rik; Crept"
ORIGIN      
        1 ctcactgcgc cggcgcgcgg gcgcgagcgg ttaaagcgca ttttcggtgt tcgaggacct
       61 ggatttgttc cctcggcctg gccggctaga agtcagggac caaggatact gccgcctcct
      121 aaggatcgtt ttcctccggc tccgaagcct ctcggcgccc ggctgtggcc cttgcccttt
      181 gacccccgtg gcggcggggt gagaggtcgg gtggccatct tgtggcggcg gcgcgggcgg
      241 ctgttactgc ggagacctgt cccctccccc cacctggtac cccgagctgt ctgtcagtcg
      301 gcggagagcc ctgcagcctg tcagcggagg cctgggccga gtgcggtcgc tttccccgtc
      361 tcatcgggcg gcccgggctg ctccccacca ccgccaccat gtcctccttc tcagaatcgg
      421 cgctggaaaa gaagctctca gagctgagca actctcagca gagcgtgcag accctctccc
      481 tgtggctcat ccaccaccgc aagcacgcag gacccatcgt ctccgtgtgg caccgcgagc
      541 tccgcaaagc caaatcaaat agaaagctta cttttctata cttagcaaat gatgtcatcc
      601 aaaacagtaa aaggaaagga cctgagttca caagagaatt tgagtctgtg cttgtggatg
      661 ctttttctca tgttgccaga gaggcagatg aaggctgtaa aaaaccttta gaaagattgc
      721 tgaacatctg gcaagaacga agtgtgtacg gcggcgagtt catacagcag ctgaagctgt
      781 ctatggagga ctccaagagc cctcccccca aagcagcaga agagaagaag tctctaaaac
      841 gaacttttca gcagatacaa gaggaggaag atgatgacta ccctggaagc tactctcccc
      901 aagacccttc tgcaggccct ctcttgactg aggagttaat caaagctttg caggatctgg
      961 aaaatgctgc gtcaggggat gctactgtcc gacagaagat cgcttccctg cctcaggaag
     1021 tgcaagacgt gtcgctgcta gagaaaatta cagacaaaga ggcagctgaa cgtctttcaa
     1081 aaacagtaga tgaagcatgt ctgttactag cggaatataa cgggcgcctg gcagcggaac
     1141 tggaagaccg gcgccagctg gctcggatgc tggtggaata cacccagaac cagaaagagg
     1201 ttttgtcaga aaaagagaaa aaactagaag agtataaaca gaagcttgct cgagtaaccc
     1261 aggtccgcaa ggaactcaag tcccacattc agagcttgcc agacctttcg ctgttgccta
     1321 atgtcacagg gggcctggca cctctgccct ctgctggtga cctcttttca actgactagg
     1381 acaggtatca tgccccaggt tcccatgtgt gccagagaaa agaagcaagt cactgctgga
     1441 gacagtcccc tgccccagct ccatctcttc agccagcatc tgcctcagta atgaagcggg
     1501 gaactctgac ttcttactct cctccggctc ccctctgagc atggttcaga gccatgcaga
     1561 tggactcagt tttgattcat atttgctaag aacacagact ctccctccca ctcatgtctc
     1621 ttgccactgc tgcttttcca tctttcgctc tcttacaccc ataagccatg aaaatcatgt
     1681 gtacttctgg aagctttcaa gagaagcttg cctcagtgac agcacatgcc atggaagtct
     1741 gagctggcct tgaccaggtt cagaacaggc tcccaatgag gactcaggct gcagggattg
     1801 ggctttcctg gccaccattg ctcacaaggt cggcagcata gctttgccac aaagagtttg
     1861 ccaaattgcc gacatttcct gatctaaaca cttctgttag agaagtgttg tcatggttag
     1921 gtgtgtttat ttttcgagca ttctagagaa tccaacagta agattcgaag ctgatctgag
     1981 acataaaagt tatagcgcag gtacagagtg gcagggctca caagtcgttt gccaggcttc
     2041 tcaccacagc cttccctgcc acattgctcc agggtcccca gtttcagagc accttcctaa
     2101 agcaggaccc tctgtcccct ggggctggga agggagctgt tgggatagca tgcccaggct
     2161 gataactgct ccacagctgg agtctgggct ctcgtgcatg ttgctctcac cctgaagctt
     2221 acaataacgc caccatgtgg acgcatccac agcatggtga ctggacttga acatctctac
     2281 agataggaca ctgagcgtgc caggcagttc ctgccactat atgcatcctt gctcccatgc
     2341 agagagagga gtactcaaac aactcacctc cagcagagga agggagtgga gggagactaa
     2401 tttggggttg aattccatta tcatgccagc tgacattatg actgaatgat gtagttgcga
     2461 tttttacgtc tagtaaagag tgggcctggc cctggaaatg actgtaatct ggcaggctta
     2521 tatttgacat tggaaagggc agaaaccatt ttgtcctact agtgtgatag gaattgtcgc
     2581 ccagagctga agtccaaaag ccataaaaag gaattcagtg aaggggcctg agaagcttcg
     2641 ttgctttaag ttgctgtttt caggatcacc aaaaaaaaaa aagcacacat cgtttttaca
     2701 cgttaaagca aatctgtgtg tcaccaaata ggcaggcttt ggttgaagaa gccgccccac
     2761 ctgctatgag atgggactca gttccactct gtccagcctg gtcttcgtgg aagctgttat
     2821 tcacagagtg caggctgctg tttgcttgtt cactctgcct tttctgtcag catccttttc
     2881 tccagaggtt acaggacagc actgactcag gtgaaacccc tgtctctgct gcggaacacc
     2941 tccctacaca ccacgccact ttactgtcac atgcacacac cactctgaac accctccaga
     3001 cactgctttc ccacaaaaca gaccaaaaga ctgtagcagc tctgctctga tgacaactta
     3061 gtggggtcag ctcaatggtg tttattcttt ggagtctctg accagcagtc agtgcgtaac
     3121 tcttacagca ggatcaagac gtgaccagta gcgattatgt aaatgaatgt gttggcctca
     3181 ttacaccact tccagcagat ttcctgtgag gaagttagtt tcgttttaat gaaatgcttc
     3241 agtttttaat cttccttgtt gtgtgcctcc accatgcccc cagtctccca actgtgtgcg
     3301 aacttccctt gtttaactta agtgaaactt ttgtccctga gagttgatct ggcgggtggg
     3361 gtgggtgact tctggttttg tgtttcttta gggcatccgt aggcctcaag gatctttcct
     3421 ttagggtcat attcctcaga aagtcttcag tctttctttg tttttgtttt gtttttctta
     3481 aaggatattt ttaaagctta aatttgtata ttaatttagg actttattta gaagtatagg
     3541 ctgtcattgg tggcagcagt atattctgaa atgtctcata gatatatatt tttgaataaa
     3601 gatggtgttg ttgaacaaca ttctgtgatg tttcttctcc ctgcctcgtg cagtgattag
     3661 tgatcatcaa tggagggcgc tctgtctgca cagaatcttc ccctgggggc tggtagtggt
     3721 acatacgcaa gacaactggt tgaacttact ctccaagtct ctcttggagt ttgattggcc
     3781 agttagcagt ctatactgta gcagagagcg ccaactgggt ttcatccttg tataggctga
     3841 agactggttg gggggtgggg aggacttgtg atgtcccccc acacacagag gatgtcttga
     3901 gaggcctttg gttgcagtct tttcagtcac accagcaggc cttgtgggaa ttgtttgatt
     3961 tgcagtatgg tgaagctgct cttggaaaaa cggaaaataa ccaaacatca tcttttttaa
     4021 gtgttttcat ggacttctct tctgctgagg ttgacatcca atggaagacc ctgatgactg
     4081 agtactctgg agacagggtg ctctgaagca gctgctgtgg tccggaatgg ttgagatctc
     4141 ccactaagtt atggtggggt tacctgtttc tcatgatgca aaggacttcc tttttagtaa
     4201 tggtggtcca tcaagaccac ctgcagctga agtccaagtt cactatcagg aaagtgtgtg
     4261 agttttgcct gcttgtatgt atgtgcacca tgtacatgcc aggtgcctgt agaggccaga
     4321 aggtggcatt ggattccttg gaactggaat tacaaatggt tgtgtgctgg ggatcaaacc
     4381 tgggtcttct gcaagagcca caaacactct ttactgttga gccatctctc cagcccttct
     4441 cccaaccccc cacagtgttc tggtttaata aaggttgagt gtaaagtacg aatctaagta
     4501 aacaagaaaa aaaaaaaaaa
//
