LOCUS       NM_144861               4297 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus regulation of nuclear pre-mRNA domain containing 1A
            (Rprd1a), transcript variant 1, mRNA.
ACCESSION   NM_144861
VERSION     NM_144861.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4297)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4297)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   3  (bases 1 to 4297)
  AUTHORS   De Jager,P.L., Zuo,J. and Heintz,N.
  TITLE     An approximately 1.2-Mb bacterial artificial chromosome contig
            refines the genetic and physical maps of the lurcher locus on mouse
            chromosome 6
  JOURNAL   Genome Res 7 (7), 736-746 (1997)
   PUBMED   9253602
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK220475.1.
            
            On Jun 21, 2005 this sequence version replaced NM_144861.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220475.1, SRR1660815.284126.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4297              AK220475.1         1-4297
FEATURES             Location/Qualifiers
     source          1..4297
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.18 cM"
     gene            1..4297
                     /gene="Rprd1a"
                     /gene_synonym="mKIAA4077"
                     /note="regulation of nuclear pre-mRNA domain containing
                     1A"
                     /db_xref="GeneID:225283"
                     /db_xref="MGI:MGI:2385066"
     exon            1..289
                     /gene="Rprd1a"
                     /gene_synonym="mKIAA4077"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1077
                     /gene="Rprd1a"
                     /gene_synonym="mKIAA4077"
                     /note="p15INK4B-related protein; cyclin-dependent kinase
                     inhibitor 2B-related protein"
                     /codon_start=1
                     /product="regulation of nuclear pre-mRNA domain-containing
                     protein 1A"
                     /protein_id="NP_659110.1"
                     /db_xref="CCDS:CCDS29102.1"
                     /db_xref="GeneID:225283"
                     /db_xref="MGI:MGI:2385066"
                     /translation="MSAFSEAALEKKLSELSNSQQSVQTLSLWLIHHRKHSRPIVTVW
                     ERELRKAKPNRKLTFLYLANDVIQNSKRKGPEFTKDFAPVIVEAFKHVSSETDESCKK
                     HLGRVLSIWEERSVYENDVLEQLKHALYGDKKARKRTYEQIKVDENENCSSLGSPSEP
                     PQTLDLVRALQDLENAASGDAAVHQRIASLPVEVQEVSLLEKITDKESGERLSKMVED
                     ACMLLADYNGRLAAEIDDRKQLTRMLADFLRCQKEALAEKEHKLEEYKRKLARVSLVR
                     KELRARIQSLPDLSRLPNVTGSHMHLPFAGDIYSED"
     exon            290..419
                     /gene="Rprd1a"
                     /gene_synonym="mKIAA4077"
                     /inference="alignment:Splign:2.1.0"
     exon            420..526
                     /gene="Rprd1a"
                     /gene_synonym="mKIAA4077"
                     /inference="alignment:Splign:2.1.0"
     exon            527..624
                     /gene="Rprd1a"
                     /gene_synonym="mKIAA4077"
                     /inference="alignment:Splign:2.1.0"
     exon            625..751
                     /gene="Rprd1a"
                     /gene_synonym="mKIAA4077"
                     /inference="alignment:Splign:2.1.0"
     exon            752..927
                     /gene="Rprd1a"
                     /gene_synonym="mKIAA4077"
                     /inference="alignment:Splign:2.1.0"
     exon            928..4297
                     /gene="Rprd1a"
                     /gene_synonym="mKIAA4077"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1268
                     /gene="Rprd1a"
                     /gene_synonym="mKIAA4077"
     regulatory      1288..1293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rprd1a"
                     /gene_synonym="mKIAA4077"
                     /note="hexamer: AATGAA"
     polyA_site      1316
                     /gene="Rprd1a"
                     /gene_synonym="mKIAA4077"
                     /note="major polyA site"
ORIGIN      
        1 ccggcctcgg actcgggggt ggtggtggtg agggcgtggg gaagggtggg gtgtgggggc
       61 gaggcggcga cgagggcggc gacactctcc tcccctcggc tccacggcgt aggacggcgc
      121 gaacgtggtt ccggagggat gtccgccttc tctgaggcgg cgctggagaa gaagctgtcc
      181 gagttgagca actcgcagca gagcgtgcag accctgtccc tgtggctcat ccaccatcgc
      241 aaacactcgc ggcccatcgt cacggtgtgg gaacgggagc tacgcaaagc caaacccaac
      301 aggaagctta cttttctcta cttggccaat gatgtcattc aaaacagcaa aaggaagggg
      361 ccagagttca caaaagattt tgcaccagta atagtggagg cattcaagca tgtttcaagt
      421 gaaactgatg aaagctgtaa gaagcacctt ggaagagtgt tatctatttg ggaagaacga
      481 tctgtttatg aaaatgatgt attagagcaa ctcaagcacg cgctgtatgg agataagaag
      541 gcaaggaaga ggacttatga gcaaataaag gtggatgaga atgaaaattg ttcctctcta
      601 gggtccccaa gtgagccacc acagactctc gaccttgtta gagcattaca agatttagaa
      661 aatgcagcct caggtgacgc agcagtccat caaaggatag cgtctttgcc tgtcgaagtt
      721 caagaagtgt ccctgcttga gaagataaca gacaaagaat ctggagagag gctttctaaa
      781 atggtagaag atgcttgtat gctgctggca gattataatg gcagactggc ggcagaaata
      841 gatgatagaa agcaactcac ccgaatgtta gcagattttc ttcgttgtca aaaggaagcc
      901 cttgcagaga aagaacataa attggaagaa tacaagcgca agttagcccg agtttccctg
      961 gtacgcaaag aactaagagc ccggatccag agcctgccag atttatctcg tttgcccaat
     1021 gtcactggca gtcacatgca cctgcccttt gcgggggaca tctacagtga agactgatgg
     1081 ccagtctcct ccagggccag gactttggca gacatggaga caggttaggt gaatagtcct
     1141 gtagagttat ttttgtacat tgttgagaat ggtactaaca taagaaatga caaggaagta
     1201 taaaatgtta aaatgttggt ttgttttgct attttattag tgagttaaca tgacttagtt
     1261 aaaaccaagt gatgatttct gtgtattaat gaacttaatg attattttca aaaaaatctt
     1321 ttgtaagttt tttttttgat ccaaggcctt gtgagaaatt ccatgtttct atttcttcat
     1381 gtattttcaa ttacttttct ttattttttt tcagtatcta atcactgtac actatctaat
     1441 tcctaatggg aagaactgat caggagctga tgtgagactg tttatgggat cgttagagct
     1501 tgattataga agagactaaa tgtttcaact tcaccttact cttgccaccc aaatactggt
     1561 tctgtgtgtc ctcatgcctt tcgagtttaa cactagacat ggatgccgtg cagggtcaaa
     1621 taaagcctag agaaggttcc ccggtagtac tatagtagtt ccatctcaaa tgccatccca
     1681 ggatcgaagg tctgttaact agacactccc tggatcgcac tatttagact aagtgcagtt
     1741 aatgctttac gaatgttgta agttctgctg tcctaatgag cacaactcca gctctccagc
     1801 tgactgcttc tgtcgtcagt cttcttacat cagatccctt taacaaaaca ccagctgtgg
     1861 ggtgtaaagg gaacaccagg cagcgacaca gtcccagtgc ttaatccctg cccatgtcat
     1921 gtaaacgtag ctcttagcct gagcagctca acaactcagt acccatagtg ctcaattacg
     1981 cagcccgaaa cagtttattt ctgtaatgtt tttgaatgat tatattttgg aattaagcaa
     2041 tgctgtacta cagggtagat gtggtgagtt ttatatttgt ctgtttacag gtgtaaatac
     2101 acagcaaatg tacctttatc tgtacttgaa cctggtgtgt tagagcaggt gcatgctctc
     2161 cagctttctc ttaagttcca ctgtgaagct gcaggtttgt gtttcatgat ggcagaggga
     2221 gatgtttttc tcctttattg ctttgcattt ctcatgtaat cggagtccaa gtgaatagtt
     2281 tgtaggacac cttttagatt tcacaggcca gttatactca ctactctgaa tggcttcact
     2341 gtttctttct cagtattaga ggatatagtt gaaatgaatt tccatgtgaa gaaatgacag
     2401 gtaattttct ttaatagcca gtagatttgg gaacagtgct ttaaacactg gcctttctcc
     2461 aaaacagagt tacatgtatg gcatcacccc gtcccatgaa tgttctatct tccaatgaca
     2521 acttttggga attaggacac atttcctcac agaagctata gctgttctct gtgcacaccg
     2581 ctgaagctca actggaagcc caaaccactg gacctcggat atgcttgtaa tgagctgaca
     2641 agtggctctc gcacatcctg agcagcgttt gtctgtcaaa taagggtttg tgtgcagcag
     2701 ccagaccttc acactggggt ggctgccagt gctgctatcc tttccttagg ggtagtgatc
     2761 taagaaagag tcagcaaagg agatgcacat tacataccct gattatgcct gttttgaaag
     2821 tatgccaagt aagtttttgt tgttttggaa agcaaaagct ttgtgtgtta acttattttc
     2881 agtatcttaa acttatttat gatttgctga cacagtgatt tatccatcta aactagatac
     2941 ttttccattt aaaactaact tataaatggt atactcttgg gaagatataa actcttttag
     3001 aagtttcctg aaatattttc accatgaaga cagacttaga tactcttttg atgccactat
     3061 ctgatctaaa tatttatgat aaaatgtatt atttttttaa agagcgtgat gagatctgtg
     3121 ataaatgcta gtactcaaaa cccgaatccc caaaccacaa gttgttggtt agctcactaa
     3181 ttgaacagac tgtacagttt gttctagaag taagtttttc agccttacag tcgttaatgt
     3241 tcctttctga aaggaagact aaacttaatg ggcttaaacc aggtgtggtg gttcatgcct
     3301 ttaatttcag tacttgggag gcagaggcag gaggatctct gtgaaggcca gcctggtctg
     3361 tagagtgaga tcaatgccat tagttacatg agtgagactc tgcagtaaga aaaagaaaaa
     3421 aagaaatggg cctaggtgag gggtataaaa taccaagctg taaatcatgc acattttctc
     3481 tcccatgtac cggaggcaaa ttacaagtat gagagcaacc tggtctggcc ctcaagggaa
     3541 agtatgtcac attgtagcaa ggtcctgtgc tgtgaatgga caccattcct cttttttcca
     3601 caaacagtgc agagagctgt cggagtggca atttgagcag attcccggtg ctccctctgc
     3661 tcctacaata ctacagtaag taaatgagcc gtaggggagc ggggagtctg gagaggagct
     3721 gagctctgta gccggccttc cccgaggaag gccgtcctgc ctgtagctgc tgtgatagct
     3781 gctcacagcg ttctgaatca gggtttctct gtaagaaatc ccgtagcatt aacaaaaact
     3841 acgatgatcc acccttcatg attttcacag ttcagaggat gttgtctgct gtcactgctg
     3901 tgagtagctt tgtggtgtgt ggttcatgaa ctggtctgga gtctggagag gacagtgact
     3961 gggaggtagg agggccttcc tcagtcccca ctctgaagtc atgcaaaagc ccgacactag
     4021 ctattaattg tactagctat taggagttcc tcctagagat gagccctgct tctcagttgt
     4081 gctagaaaaa gcttttgacg gtgtgaattc agttcttctc tgtacagaag ggaacactgg
     4141 gttacttaat ggatttgtgt atacacagca tctgttgcca tctagtctgc cgtgtcaaga
     4201 gcacatggaa aaaggatact ccatctttta taaacccttt tctttggctg tatctgatga
     4261 cagtgtaaga tcctaataaa gttttatgtt ctttttg
//
