LOCUS       NM_019428               1154 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus ribonuclease P/MRP 30 subunit (Rpp30), transcript
            variant 1, mRNA.
ACCESSION   NM_019428
VERSION     NM_019428.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1154)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   2  (bases 1 to 1154)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   3  (bases 1 to 1154)
  AUTHORS   Xiao,S., Scott,F., Fierke,C.A. and Engelke,D.R.
  TITLE     Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes
  JOURNAL   Annu Rev Biochem 71, 165-189 (2002)
   PUBMED   12045094
  REMARK    Review article
REFERENCE   4  (bases 1 to 1154)
  AUTHORS   Jarrous,N., Eder,P.S., Guerrier-Takada,C., Hoog,C. and Altman,S.
  TITLE     Autoantigenic properties of some protein subunits of catalytically
            active complexes of human ribonuclease P
  JOURNAL   RNA 4 (4), 407-417 (1998)
   PUBMED   9630247
REFERENCE   5  (bases 1 to 1154)
  AUTHORS   Hoog,C.
  TITLE     Isolation of a large number of novel mammalian genes by a
            differential cDNA library screening strategy
  JOURNAL   Nucleic Acids Res 19 (22), 6123-6127 (1991)
   PUBMED   1659684
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119234.10.
            
            On Nov 28, 2022 this sequence version replaced NM_019428.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062146.1, AK004137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC119234.10        128531-128631       c
            102-157             AC119234.10        127228-127283       c
            158-214             AC119234.10        125334-125390       c
            215-289             AC119234.10        124951-125025       c
            290-361             AC119234.10        123139-123210       c
            362-451             AC119234.10        117884-117973       c
            452-568             AC119234.10        112061-112177       c
            569-598             AC119234.10        111511-111540       c
            599-636             AC119234.10        111078-111115       c
            637-716             AC119234.10        110449-110528       c
            717-1154            AC119234.10        107576-108013       c
FEATURES             Location/Qualifiers
     source          1..1154
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 30.41 cM"
     gene            1..1154
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /note="ribonuclease P/MRP 30 subunit"
                     /db_xref="GeneID:54364"
                     /db_xref="MGI:MGI:1859683"
     exon            1..101
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..826
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /EC_number="3.1.26.5"
                     /note="RNaseP protein p30; RNase P subunit 2; ribonuclease
                     P/MRP 30kDa subunit; ribonuclease P2"
                     /codon_start=1
                     /product="ribonuclease P protein subunit p30"
                     /protein_id="NP_062301.3"
                     /db_xref="CCDS:CCDS29770.1"
                     /db_xref="GeneID:54364"
                     /db_xref="MGI:MGI:1859683"
                     /translation="MAAFADLDLRAGSDLKALRGLVETAAHLGYSVVAINHIVDFKEK
                     KREIEKPIAVSELFTTLPIVQGKSRPIKILTRLTIIVTDPAHCNVLRATSSRVRLYDI
                     VAVFPKTEKLFHVACTHLDVDLVCITVTEKLPFYFKRPPVNVAIERGLGFELVYGPAI
                     RDATMRRYTISNALNLMQICKGKNVILSSAAERPLEIRGPYDVANLGLLFGLSENDGK
                     AAVSTNCRAVFLHGETRKTAFGIISTVKKPRPSEADDESLPVCKKAKCEG"
     exon            102..157
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /inference="alignment:Splign:2.1.0"
     exon            158..214
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /inference="alignment:Splign:2.1.0"
     exon            215..289
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /inference="alignment:Splign:2.1.0"
     exon            290..361
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /inference="alignment:Splign:2.1.0"
     exon            362..451
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /inference="alignment:Splign:2.1.0"
     exon            452..568
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /inference="alignment:Splign:2.1.0"
     exon            569..598
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /inference="alignment:Splign:2.1.0"
     exon            599..636
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /inference="alignment:Splign:2.1.0"
     exon            637..716
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /inference="alignment:Splign:2.1.0"
     exon            717..1154
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1128..1133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /note="hexamer: AATAAA"
     polyA_site      1154
                     /gene="Rpp30"
                     /gene_synonym="Rnasep2; TSG15"
                     /note="major polyA site"
ORIGIN      
        1 gtgctcctgg gatgtcagca tggcggcgtt cgcagatttg gatttaagag cgggctcaga
       61 cctgaaggct ctgcgcggac tcgtggagac tgctgctcac ctgggatact cagttgttgc
      121 catcaatcac attgttgact ttaaggaaaa gaaacgggaa attgaaaagc caatagcagt
      181 ttctgaactc ttcacaactt tacccatcgt acagggaaaa tcaagaccaa ttaaaatttt
      241 aactagattg acaattatag ttacagatcc agctcactgt aatgttttga gagcaacttc
      301 gtcaagggtc cggctgtatg atattgttgc agtctttcca aagacagaaa agcttttcca
      361 tgttgcttgt acacatttag atgtggattt agtctgtata actgtaacag agaaattacc
      421 attttacttc aaaagacccc ctgttaatgt ggcaattgag cgaggcctgg gctttgaact
      481 tgtctatggt cctgctatca gagatgcaac gatgagaagg tacacaatct ccaatgccct
      541 caatttgatg cagatctgca aaggaaagaa tgtaattctg tccagtgctg cagaaaggcc
      601 tttggaaata agaggaccat atgacgtggc aaacttagga ctgctgtttg ggctttctga
      661 aaatgatggc aaggctgccg tgtccacaaa ttgcagagct gtatttctcc atggagaaac
      721 tagaaaaact gcttttggaa ttatttctac agtgaagaaa ccacggccat cagaagcaga
      781 tgatgaatct cttccagtgt gcaagaaagc taaatgtgag ggctgagacg agtcctgagt
      841 ctccacgcac tgcctcctcc ccttcgtagc tcatcagtca ctgtaaaaat aaaactctgc
      901 tgagttgata ttttcattaa actagaaacc aacagtctat aaaaacaact ttatattcag
      961 accattaaaa cagcaaataa aacccagtga agcatttttt aaagactaac agcttaatta
     1021 atttagatat actttaagag aaaaactatt ttatccttca tgtgaataat gaataacagt
     1081 aggtacactg aaataagatg tctcagtatt gtaagacatt gaaaactaat aaattaacgt
     1141 ttttctactc ggta
//
