LOCUS       NM_019642               2716 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus ribophorin II (Rpn2), transcript variant 2, mRNA.
ACCESSION   NM_019642 XM_977943
VERSION     NM_019642.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2716)
  AUTHORS   Liu,Y., Li,J., Ding,C., Tong,H., Yan,Y., Li,S., Li,S. and Cao,Y.
  TITLE     Leu promotes C2C12 cell differentiation by regulating the
            GSK3beta/beta-catenin signaling pathway through facilitating the
            interaction between SESN2 and RPN2
  JOURNAL   J Sci Food Agric 104 (11), 6696-6705 (2024)
   PUBMED   38551359
  REMARK    GeneRIF: Leu promotes C2C12 cell differentiation by regulating the
            GSK3beta/beta-catenin signaling pathway through facilitating the
            interaction between SESN2 and RPN2.
REFERENCE   2  (bases 1 to 2716)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2716)
  AUTHORS   Kweon,H.J., Gu,S., Witham,E., Dhara,M., Yu,H., Mandon,E.D.,
            Jawhari,A. and Bredt,D.S.
  TITLE     NACHO Engages N-Glycosylation ER Chaperone Pathways for alpha7
            Nicotinic Receptor Assembly
  JOURNAL   Cell Rep 32 (6), 108025 (2020)
   PUBMED   32783947
REFERENCE   4  (bases 1 to 2716)
  AUTHORS   Ramirez,A.S., Kowal,J. and Locher,K.P.
  TITLE     Cryo-electron microscopy structures of human
            oligosaccharyltransferase complexes OST-A and OST-B
  JOURNAL   Science 366 (6471), 1372-1375 (2019)
   PUBMED   31831667
REFERENCE   5  (bases 1 to 2716)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2716)
  AUTHORS   Honma,K., Iwao-Koizumi,K., Takeshita,F., Yamamoto,Y., Yoshida,T.,
            Nishio,K., Nagahara,S., Kato,K. and Ochiya,T.
  TITLE     RPN2 gene confers docetaxel resistance in breast cancer
  JOURNAL   Nat Med 14 (9), 939-948 (2008)
   PUBMED   18724378
  REMARK    Erratum:[Nat Med. 2008 Oct;14(10):1128]
REFERENCE   7  (bases 1 to 2716)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 2716)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2716)
  AUTHORS   Loffler,C., Rao,V.V. and Hansmann,I.
  TITLE     Mapping of the ribophorin II (RPN II) gene to human chromosome
            20q12-q13.1 by in-situ hybridization
  JOURNAL   Hum Genet 87 (2), 221-222 (1991)
   PUBMED   2066112
REFERENCE   10 (bases 1 to 2716)
  AUTHORS   Pirozzi,G., Zhou,Z.M., D'Eustachio,P., Sabatini,D.D. and
            Kreibich,G.
  TITLE     Rat ribophorin II: molecular cloning and chromosomal localization
            of a highly conserved transmembrane glycoprotein of the rough
            endoplasmic reticulum
  JOURNAL   Biochem Biophys Res Commun 176 (3), 1482-1486 (1991)
   PUBMED   1710116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004968.1.
            
            On Apr 5, 2007 this sequence version replaced NM_019642.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame 3'
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004968.1, AK018761.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2716              AK004968.1         2-2717
FEATURES             Location/Qualifiers
     source          1..2716
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.2 cM"
     gene            1..2716
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /note="ribophorin II"
                     /db_xref="GeneID:20014"
                     /db_xref="MGI:MGI:98085"
     exon            1..238
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..2121
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /EC_number="2.4.99.18"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit 2; RPN-II; ribophorin-2;
                     dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase 63 kDa subunit"
                     /codon_start=1
                     /product="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit 2 isoform 2 precursor"
                     /protein_id="NP_062616.2"
                     /db_xref="CCDS:CCDS16975.1"
                     /db_xref="GeneID:20014"
                     /db_xref="MGI:MGI:98085"
                     /translation="MAPPGSSAVFLLALTITASVQALTPTHYLTKQDVERLKASLDRP
                     FTDLESAFYSIVGLSSLGVQVPDVKKACTFIKSNLDPSNVDSLFYAAQSSQVLSGCEI
                     SVSNETKELLLAAVSEDSPIAQIYHAVAALSGFGLPLASNEALGALTARLGKEETVLA
                     TVQALQTASHLSQQADLRNIVEEIEDLVARLDELGGVYLQFEEGLELTALFVAATYKL
                     MDHVGTEPSMKEDQVIQLMNTIFSKKNFESLSEAFSVASAAAALSQNRYHVPVVVVPE
                     GSTSDTQEQAILRLQVSNVLSQPLAQAAVKLEHAKSAATRATVLQKTPFSLVGNVFEL
                     NFKNVKLSSGYYDFSVRVEGDSRYIANTVELRVKISTEVGITNVDLSTVDKDQSIAPK
                     TTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFV
                     AEPDNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEE
                     EAPSTVLSQSLFTPKQEIQHLFREPEKRPPTVVSNTFTALILSPLLLLFALWIRIGAN
                     VSNFTFAPSTVIFHLGHAAMLGLMYIYWTQLNMFQTLKYLAVLGTVTFLAGNRMLAQH
                     AVKRTAH"
     exon            239..432
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            433..528
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            529..704
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            705..780
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            781..915
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1092
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1211
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1317
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1409
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1524
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1719
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1806
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1902
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1978
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2108
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2716
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2432..2437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /note="hexamer: AATAAA"
     polyA_site      2455
                     /gene="Rpn2"
                     /gene_synonym="1300012C06Rik; Rpn-2"
                     /note="major polyA site"
ORIGIN      
        1 aggacccgtg agtgaggttc gcacgccgcg actcaactgc cccacactgc ggctgccggg
       61 cacggccctg ccaagcggga ccgccgcgac tgacctttgc cgggagccca ttctggcaag
      121 tggcgtgtgc cgcgggtccc tggcgtcccc tccggcgcgc tcttggagcc acttcccgga
      181 gcggaagtct gcctgctcgg gctccggtgg gacctgctcg gaggaatggc gccgccgggt
      241 tcaagcgctg tcttcctgtt ggccctgaca atcactgcca gcgtccaggc tctgaccccc
      301 acccactacc tcaccaagca ggatgtggaa aggctgaagg cctcactgga ccgccccttc
      361 acagatttgg agtctgcctt ctactccatc gtgggactca gcagccttgg ggtacaggtg
      421 ccagatgtca agaaagcgtg taccttcatc aagtccaacc ttgatcccag caacgtggat
      481 tctctcttct atgcagccca gtccagccag gtcctctcag gctgtgagat atctgtttca
      541 aatgagacca aagagctcct gctggcagca gtgagtgaag actcccccat tgcccagatc
      601 taccatgcag ttgcagcact cagcgggttt gggcttccct tggcatccaa tgaagccctc
      661 ggtgccctta ccgctcgcct cggcaaggaa gagactgtgc tagcaacggt ccaggctctg
      721 cagacagcgt cccacctctc ccagcaggct gacctgagga acattgtaga ggagattgag
      781 gaccttgttg ctcggctgga tgaactaggg ggtgtgtatc tgcagtttga ggaaggactg
      841 gagctcacgg cgctgtttgt tgctgccacc tacaagctca tggaccacgt ggggaccgaa
      901 ccgtccatga aggaggatca ggttatccag ctcatgaaca caatcttcag caagaagaac
      961 tttgagtccc tctcagaagc cttcagtgtg gcctctgctg ctgctgcatt gtcccagaat
     1021 cgctaccacg taccagtggt ggttgtgccc gagggctcta cttctgacac tcaagaacag
     1081 gctatcctga ggttgcaggt cagcaatgtt ttgtctcagc ctctggctca agctgcagtg
     1141 aagctggagc atgctaagtc ggcggctacc agggctaccg tcctgcagaa gacgcccttt
     1201 tcgcttgtgg ggaatgtttt tgagctaaac ttcaagaatg ttaaactttc cagtggctac
     1261 tatgacttct ctgtccgagt tgaaggtgac agccgttaca ttgcaaacac tgtagagctt
     1321 cgagtcaaga tctccactga agttggcatc acaaatgttg atctttccac tgtggataag
     1381 gatcagagca ttgcacccaa aactacccgg gtgacctacc cagccaaagc caagggtaca
     1441 ttcatcgcag acagccatca gaactttgcc ctgtttttcc agctggtaga tgtgaacacc
     1501 ggtgcggagc tcacccctca ccagacgttt gttcgacttc ataaccagaa gactggccag
     1561 gaagtggtgt ttgttgctga gccagataac aagaatgtat ataagtttga actggacacc
     1621 tctgaaagga agattgaatt tgactctgcc tctggcacct acacactcta cttaatcatc
     1681 ggggatgcca cattgaagaa cccaatcctc tggaacgtgg ctgacgtggt tatcaagttc
     1741 cctgaggagg aagccccctc gactgtgctg tcccagagcc tgtttacccc aaaacaggaa
     1801 attcagcacc tgttccgaga gcctgagaag aggcccccca cagtggtgtc caatacattc
     1861 acggccctca tcctctcgcc cttgctcctg ctctttgcac tgtggatccg gattggagcc
     1921 aatgtctcca acttcacatt tgctcctagc acagttatct tccacctggg acatgctgcg
     1981 atgctgggcc tcatgtatat ctactggact cagctcaaca tgttccagac cctcaagtac
     2041 ctggctgtcc tgggcactgt gacgtttctg gctggcaacc gaatgctggc ccagcatgca
     2101 gttaagagaa cagcacatta gttccagaag aagtctgaag accctgaagg ctgaaatgaa
     2161 catttaacaa ggagtgggga cagttcatgg tgtgaaagga agaactgggg acacaacagg
     2221 agggaggaga tgcctgttcg ttaaaaagag aaaagctgag ctgtgcttac atgtttactt
     2281 gtttctcact ttttgcttca cagagcagac atgtttgggc ccagattgtc tgtccctttg
     2341 tcttgatgcc tggcaagatg ctgtgaatat cccaggctac ccagatgttg tatttgaaaa
     2401 gttgaaatct gtaattcatc atcagctttg gaataaagag aatggtggac tcccagtgtt
     2461 gatggagcct tgcatgtgtg atatgaagac tcagcagtct tcagttgggc catctcaccc
     2521 ctttcttaaa agtactaaaa gtggctagaa aaagcctgtg tcctttcggc tccagtagca
     2581 aacactttgt aggagccctg cttgtctttg aagattcttc tcttcaaaag acctgctcta
     2641 ggcttttgcc ttgaacattt gggcttggtg tgtagagaag ggttaaaatt ttgtcaataa
     2701 aaagctgact gcctcg
//
