LOCUS       NM_133933               3642 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ribophorin I (Rpn1), mRNA.
ACCESSION   NM_133933 XM_981668
VERSION     NM_133933.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3642)
  AUTHORS   Kweon,H.J., Gu,S., Witham,E., Dhara,M., Yu,H., Mandon,E.D.,
            Jawhari,A. and Bredt,D.S.
  TITLE     NACHO Engages N-Glycosylation ER Chaperone Pathways for alpha7
            Nicotinic Receptor Assembly
  JOURNAL   Cell Rep 32 (6), 108025 (2020)
   PUBMED   32783947
REFERENCE   2  (bases 1 to 3642)
  AUTHORS   Ramirez,A.S., Kowal,J. and Locher,K.P.
  TITLE     Cryo-electron microscopy structures of human
            oligosaccharyltransferase complexes OST-A and OST-B
  JOURNAL   Science 366 (6471), 1372-1375 (2019)
   PUBMED   31831667
REFERENCE   3  (bases 1 to 3642)
  AUTHORS   Graham,D.B., Lefkovith,A., Deelen,P., de Klein,N., Varma,M.,
            Boroughs,A., Desch,A.N., Ng,A.C.Y., Guzman,G., Schenone,M.,
            Petersen,C.P., Bhan,A.K., Rivas,M.A., Daly,M.J., Carr,S.A.,
            Wijmenga,C. and Xavier,R.J.
  TITLE     TMEM258 Is a Component of the Oligosaccharyltransferase Complex
            Controlling ER Stress and Intestinal Inflammation
  JOURNAL   Cell Rep 17 (11), 2955-2965 (2016)
   PUBMED   27974209
REFERENCE   4  (bases 1 to 3642)
  AUTHORS   Yamamoto,S., Yamazaki,T., Komazaki,S., Yamashita,T., Osaki,M.,
            Matsubayashi,M., Kidoya,H., Takakura,N., Yamazaki,D. and
            Kakizawa,S.
  TITLE     Contribution of calumin to embryogenesis through participation in
            the endoplasmic reticulum-associated degradation activity
  JOURNAL   Dev Biol 393 (1), 33-43 (2014)
   PUBMED   25009997
REFERENCE   5  (bases 1 to 3642)
  AUTHORS   Quille,M.L., Carat,S., Quemener-Redon,S., Hirchaud,E., Baron,D.,
            Benech,C., Guihot,J., Placet,M., Mignen,O., Ferec,C., Houlgatte,R.
            and Friocourt,G.
  TITLE     High-throughput analysis of promoter occupancy reveals new targets
            for Arx, a gene mutated in mental retardation and
            interneuronopathies
  JOURNAL   PLoS One 6 (9), e25181 (2011)
   PUBMED   21966449
REFERENCE   6  (bases 1 to 3642)
  AUTHORS   Tateossian,H., Powles,N., Dickinson,R., Ficker,M. and Maconochie,M.
  TITLE     Determination of downstream targets of FGF signalling using gene
            trap and cDNA subtractive approaches
  JOURNAL   Exp Cell Res 292 (1), 101-114 (2004)
   PUBMED   14720510
REFERENCE   7  (bases 1 to 3642)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3642)
  AUTHORS   Harding,H.P., Zhang,Y. and Ron,D.
  TITLE     Protein translation and folding are coupled by an
            endoplasmic-reticulum-resident kinase
  JOURNAL   Nature 397 (6716), 271-274 (1999)
   PUBMED   9930704
  REMARK    Erratum:[Nature 1999 Mar 4;398(6722):90]
REFERENCE   9  (bases 1 to 3642)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   10 (bases 1 to 3642)
  AUTHORS   Shirozu,M., Tada,H., Tashiro,K., Nakamura,T., Lopez,N.D.,
            Nazarea,M., Hamada,T., Sato,T., Nakano,T. and Honjo,T.
  TITLE     Characterization of novel secreted and membrane proteins isolated
            by the signal sequence trap method
  JOURNAL   Genomics 37 (3), 273-280 (1996)
   PUBMED   8938438
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY308146.1, AK029923.1 and BC085483.1.
            
            On Dec 30, 2009 this sequence version replaced NM_133933.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029923.1, SRR1660815.244866.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BY308146.1         2-44
            44-778              AK029923.1         2-736
            779-787             BC085483.1         720-728
            788-3642            AK029923.1         746-3600
FEATURES             Location/Qualifiers
     source          1..3642
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.13 cM"
     gene            1..3642
                     /gene="Rpn1"
                     /gene_synonym="D6Wsu137e; Rpn-1"
                     /note="ribophorin I"
                     /db_xref="GeneID:103963"
                     /db_xref="MGI:MGI:98084"
     exon            1..322
                     /gene="Rpn1"
                     /gene_synonym="D6Wsu137e; Rpn-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1885
                     /gene="Rpn1"
                     /gene_synonym="D6Wsu137e; Rpn-1"
                     /EC_number="2.4.99.18"
                     /note="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit 1; RPN-I; ribophorin-1;
                     dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase 67 kDa subunit"
                     /codon_start=1
                     /product="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit 1 precursor"
                     /protein_id="NP_598694.3"
                     /db_xref="CCDS:CCDS20332.1"
                     /db_xref="GeneID:103963"
                     /db_xref="MGI:MGI:98084"
                     /translation="MESPVALLLLLLLCLGALAPTPGSASSEAPPLVNEDVKRTVDLS
                     SHLAKVTAEVVLVHPGGGSTSRASSFVLALEPELESRLAHLGVQIKGEDEEDNNLEVR
                     ETKIKGKSGRFFTVKLPVALDPGSKISVVVETVYTHVLHPYPTQITQSEKQFVVFEGN
                     HYFYSPYPTKTQTMRVKLASRNVESYTKLGNPSRSEDVLDYGPFKDIPAYSQDTFKVH
                     YENNSPFLTITSMTRVIEVSHWGNIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGIS
                     SIRSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFPLFGGWKTHYIVG
                     YNLPSYEYLYNLGDQYALKMRFVDHVFDEQVIDSLTVKIILPEGAKNIQVDSPYDISR
                     APDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHYTFNKVLMLQEPLLVVAAFYIL
                     FFTVIIYVRLDFSITKDPAAEARMKVACITEQVLTLVNKRLGLYRHFDETVNRYKQSR
                     DISTLNSGKKSLETEHKAVTSEIAVLQSRLKTEGSDLCDRVSEMQKLDAQVKELVLKS
                     AVEAERLVAGKLKKDTYLENEKLSSGKRQELVTKIDHILDAL"
     exon            323..387
                     /gene="Rpn1"
                     /gene_synonym="D6Wsu137e; Rpn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..694
                     /gene="Rpn1"
                     /gene_synonym="D6Wsu137e; Rpn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..904
                     /gene="Rpn1"
                     /gene_synonym="D6Wsu137e; Rpn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1097
                     /gene="Rpn1"
                     /gene_synonym="D6Wsu137e; Rpn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1197
                     /gene="Rpn1"
                     /gene_synonym="D6Wsu137e; Rpn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1336
                     /gene="Rpn1"
                     /gene_synonym="D6Wsu137e; Rpn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1456
                     /gene="Rpn1"
                     /gene_synonym="D6Wsu137e; Rpn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1702
                     /gene="Rpn1"
                     /gene_synonym="D6Wsu137e; Rpn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..3642
                     /gene="Rpn1"
                     /gene_synonym="D6Wsu137e; Rpn-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2278..2283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpn1"
                     /gene_synonym="D6Wsu137e; Rpn-1"
                     /note="hexamer: AATAAA"
     polyA_site      2302
                     /gene="Rpn1"
                     /gene_synonym="D6Wsu137e; Rpn-1"
                     /note="major polyA site"
ORIGIN      
        1 agcggttgcg ccgtggcggg ggggcggggc gcgtgtcggt ggcgctcagc tcgcggtcat
       61 ggagtcgccg gtcgccttgc tgttgctgct gctgctatgt ctcggggcct tggccccgac
      121 gcccggcagc gcctcctcgg aggctccgcc gctggtcaac gaggacgtga agcgcacggt
      181 ggacctgagc agccacctag ccaaggtgac ggctgaggtg gtcctggtac acccgggcgg
      241 cggctccaca tcacgagcca gctctttcgt tctggccctg gagccagaac tggagtcgcg
      301 gcttgcgcac ctaggcgtgc agataaaggg agaagatgag gaagacaaca acctagaagt
      361 acgagaaacc aaaattaaag ggaaaagtgg gagatttttc acggtcaagc tcccagttgc
      421 tcttgatcct gggtccaaga tctcggtcgt tgtggaaact gtctacaccc atgtgcttca
      481 tccgtatccg actcagataa ctcagtcaga gaaacagttc gtcgtgtttg agggcaacca
      541 ttatttctac tctccctatc caacaaagac ccagaccatg cgagtgaaac tggcgtcccg
      601 aaatgtggaa agctatacca agctggggaa cccctcgaga tctgaggacg tccttgatta
      661 tgggcctttt aaagacatcc ctgcctacag tcaggacact ttcaaagtac attacgagaa
      721 caatagccct ttcctgacca tcaccagtat gacccgggtc atcgaggtat ctcactgggg
      781 caatattgct gtggaagaga acgtggactt gaagcacacg ggcgcagtgc tgaaggggcc
      841 tttctcccgc tacgattacc agaggcagcc tgacagtggg atctcctcca ttcgttcttt
      901 taagaccatc cttcctgctg ccgcccagga tgtctattac cgggatgaga ttggtaatgt
      961 ttccaccagc cacctcctta tcttggatga ctctgtggaa atggaaatcc ggcctcgatt
     1021 tcctctcttt ggagggtgga agacacacta catcgttggt tacaacctcc caagctatga
     1081 atacctctat aatctgggtg accagtatgc actgaagatg cggtttgtag accacgtgtt
     1141 tgatgagcaa gtgatagatt ctctgacagt gaagatcatc ttgcccgagg gagccaagaa
     1201 catccaggtg gacagtccct acgatatcag ccgggcccca gacgagctgc attataccta
     1261 cctagacacg ttcggccgcc cggtgattgt ggcttacaag aagaatctcg tcgagcaaca
     1321 cattcaggac attgtggtgc actacacgtt caacaaggtt ctcatgctgc aggagccgct
     1381 gctggtcgtg gccgccttct acatcctgtt cttcaccgtc atcatctacg tccgtctgga
     1441 cttttccatc accaaggatc cagctgcaga agccaggatg aaagtggcct gtatcacaga
     1501 gcaggtctta accctggtca acaagaggct gggcctctac cgtcactttg atgagactgt
     1561 caatagatac aagcagtccc gggatatctc taccctcaac agtggcaaga agagcctaga
     1621 gacagagcac aaggctgtga ccagcgagat tgctgtactg cagtctcggc tgaagacgga
     1681 gggctcagac ctgtgtgaca gggtgagtga gatgcagaag ctggacgccc aggtcaagga
     1741 gctggtcctg aagtcggcgg tagaagcaga gaggctggtg gctggcaagc tcaagaagga
     1801 tacgtacctg gaaaacgaga agctcagctc aggaaaacgc caggagctgg tcaccaagat
     1861 cgaccacatc ctggatgctc tgtagctcct ggctccagag caggcccagg tgcctagact
     1921 tccagtggca ttggataggt agaaagagga ggttgtggtt agcccaaggc ctcaagacac
     1981 cactgaggcc tgtccgtggc agtggcctat ccgtggcact gcgggaagct tgtcccttat
     2041 ttctgaatgg ttcccttttt tttaaaaaag caaaaaccta gacaaaaaat tctgtttaaa
     2101 agacaaactt ggctgtgttt tgagcacagg cgtttcagca gttgatgggt ggtttctgtt
     2161 ttgacagctg gggatttttc tgtcttcaag tcctgtttta tggtcttctg atttctaatg
     2221 tttgggtctt ttgtgagcgt atgcatggtt ttttaaaagt gtgtatgacc aaatgaaaat
     2281 aaaggaggga ctgtgaacat ttgcttttgc tgtactgaaa aatctctcat gtaattctga
     2341 agtttgggga tattgctttt atcaagatgg gttttcttgt tgtgtgtgca aggcaagtgt
     2401 cagaacactg atacaagtct cgagaggccc agtaaggtcc ggaggccaca caacaggggt
     2461 ggagtgagcc tttgtattcc ttaaatctgt gccacacgtg ctgagcatta gaaactgtga
     2521 tgggcgagca gtcatggttc ataatctcca attggccaca ctgtgaggaa gtcatggact
     2581 ggagaacact gggctaagtc tgggtgggtg tgtgtttgag gggaggggag tccagagctg
     2641 agccttaaga accgtgcagg ccagtgttcc aggcagtggg cagtgtgtgt gaagggccct
     2701 ggtgcttgag gacccacaga gggcctgtac tagagtggat attacaggtt atgacagggc
     2761 tgcagaggtg caagtccaga acaagatagc ttcataggtc tctaaggctc tggcttactt
     2821 tatatcaggg cagactgagc actgggccag ggctgttttg gttgaaaaca cagccagagt
     2881 ttggtatgag aaagccagga gcatattgta atccaggtca aagatgatac ccagatgtgg
     2941 gggttggtgt tgggtggttg agaacgtgct aggaagcatc tgcctgtttg ctccttcaag
     3001 taacatacag aggtcaggaa gctgtcacct gactgagtca ggctctcgtg cacctcctgc
     3061 acatcttagg tgactgttgt aacgtgacct gggccagcag acagatagaa gctcaccttc
     3121 tggctaacac taatagatgg ctacgggctg cctgtctggc ttatgtacat cttaggttgg
     3181 tggcgctgtc tgatgtgttt gtaccatcca ctgagaacag agaactatgg gccagttttg
     3241 agaaacgggt ggactggttt ctgataccaa tcatgagacg cctgagagct ccaaatagga
     3301 tgtccacaga cagcccagaa cctgacaagg agatatgtgg ttggggatgt catgtggttt
     3361 atccagcaca aagttggtta gggaaatggg atggagattg tggtgggtag gtgtgcccat
     3421 gaagaatgta gaattagaag acacctaggg cattcgtggc aggatatggt ctgctactta
     3481 gaaggctgag gatcactgaa caaagaaatt tgagatcaga gcaatgtgga gagactctct
     3541 ctttaagaaa gcatttattg aatggaaatc aatacttttt aatatctgca agccaacgct
     3601 gagctcactt tattcaagaa tgaataaacg agatgaatat ac
//
