LOCUS       NM_016980               2036 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus ribosomal protein L5 (Rpl5), mRNA.
ACCESSION   NM_016980 XM_003085452
VERSION     NM_016980.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2036)
  AUTHORS   Jiang,X., Cheng,Y., Zhu,Y., Xu,C., Li,Q., Xing,X., Li,W., Zou,J.,
            Meng,L., Azhar,M., Cao,Y., Tong,X., Qin,W., Zhu,X. and Bao,J.
  TITLE     Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression
            and maturation in mice
  JOURNAL   Nat Commun 14 (1), 3729 (2023)
   PUBMED   37349316
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2036)
  AUTHORS   Franklin,D.A., Liu,S., Jin,A., Cui,P., Guo,Z., Arend,K.C.,
            Moorman,N.J., He,S., Wang,G.G., Wan,Y.Y. and Zhang,Y.
  TITLE     Ribosomal protein RPL11 haploinsufficiency causes anemia in mice
            via activation of the RP-MDM2-p53 pathway
  JOURNAL   J Biol Chem 299 (1), 102739 (2023)
   PUBMED   36435197
REFERENCE   3  (bases 1 to 2036)
  AUTHORS   Li,H., Huo,Y., He,X., Yao,L., Zhang,H., Cui,Y., Xiao,H., Xie,W.,
            Zhang,D., Wang,Y., Zhang,S., Tu,H., Cheng,Y., Guo,Y., Cao,X.,
            Zhu,Y., Jiang,T., Guo,X., Qin,Y. and Sha,J.
  TITLE     A male germ-cell-specific ribosome controls male fertility
  JOURNAL   Nature 612 (7941), 725-731 (2022)
   PUBMED   36517592
REFERENCE   4  (bases 1 to 2036)
  AUTHORS   Yu,L., Lemay,P., Ludlow,A., Guyot,M.C., Jones,M., Mohamed,F.F.,
            Saroya,G.A., Panaretos,C., Schneider,E., Wang,Y., Myers,G.,
            Khoriaty,R., Li,Q., Franceschi,R., Engel,J.D., Kaartinen,V.,
            Rothstein,T.L., Justice,M.J., Kibar,Z. and Singh,S.A.
  TITLE     A new murine Rpl5 (uL18) mutation provides a unique model of
            variably penetrant Diamond-Blackfan anemia
  JOURNAL   Blood Adv 5 (20), 4167-4178 (2021)
   PUBMED   34464976
  REMARK    GeneRIF: A new murine Rpl5 (uL18) mutation provides a unique model
            of variably penetrant Diamond-Blackfan anemia.
REFERENCE   5  (bases 1 to 2036)
  AUTHORS   Kazerounian,S., Yuan,D., Alexander,M.S., Beggs,A.H. and Gazda,H.T.
  TITLE     Rpl5-Inducible Mouse Model for Studying Diamond-Blackfan Anemia
  JOURNAL   Discoveries (Craiova) 7 (3), e96 (2019)
   PUBMED   32309614
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2036)
  AUTHORS   Chelsea,D.M., Roberts,T. and Cowell,J.K.
  TITLE     A new region of synteny between human chromosome 1p22 and mouse
            chromosome 5
  JOURNAL   Int J Mol Med 5 (5), 553-556 (2000)
   PUBMED   10762661
REFERENCE   7  (bases 1 to 2036)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   8  (bases 1 to 2036)
  AUTHORS   Rudert,F., Bronner,S., Garnier,J.M. and Dolle,P.
  TITLE     Transcripts from opposite strands of gamma satellite DNA are
            differentially expressed during mouse development
  JOURNAL   Mamm Genome 6 (2), 76-83 (1995)
   PUBMED   7767009
REFERENCE   9  (bases 1 to 2036)
  AUTHORS   Qu,L.H., Nicoloso,M., Michot,B., Azum,M.C., Caizergues-Ferrer,M.,
            Renalier,M.H. and Bachellerie,J.P.
  TITLE     U21, a novel small nucleolar RNA with a 13 nt. complementarity to
            28S rRNA, is encoded in an intron of ribosomal protein L5 gene in
            chicken and mammals
  JOURNAL   Nucleic Acids Res 22 (20), 4073-4081 (1994)
   PUBMED   7937132
REFERENCE   10 (bases 1 to 2036)
  AUTHORS   Rudert,F., Garnier,J.M. and Schuhbaur,B.
  TITLE     Cloning a pseudogene and cDNA encoding a 17-kDa ribosomal protein
            from mouse: structure and regulation of expression
  JOURNAL   Gene 133 (2), 249-254 (1993)
   PUBMED   8224911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ073701.1, BC083318.1, CV561106.1 and CD774263.1.
            
            On or before Jan 13, 2011 this sequence version replaced
            XM_003085452.1, NM_016980.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.78045.1,
                                           SRR1660821.134313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                CJ073701.1         1-60
            61-1066             BC083318.1         1-1006
            1067-1478           CV561106.1         210-621
            1479-2036           CD774263.1         1-558               c
FEATURES             Location/Qualifiers
     source          1..2036
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..2036
                     /gene="Rpl5"
                     /gene_synonym="Ska23; Ska<m23Jus>; Skax23; U21RNA"
                     /note="ribosomal protein L5"
                     /db_xref="GeneID:100503670"
                     /db_xref="MGI:MGI:102854"
     exon            1..119
                     /gene="Rpl5"
                     /gene_synonym="Ska23; Ska<m23Jus>; Skax23; U21RNA"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1010
                     /gene="Rpl5"
                     /gene_synonym="Ska23; Ska<m23Jus>; Skax23; U21RNA"
                     /EC_number="3.6.5.3"
                     /note="60S ribosomal protein L5"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL18"
                     /protein_id="NP_058676.1"
                     /db_xref="CCDS:CCDS39199.1"
                     /db_xref="GeneID:100503670"
                     /db_xref="MGI:MGI:102854"
                     /translation="MGFVKVVKNKAYFKRYQVRFRRRREGKTDYYARKRLVIQDKNKY
                     NTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTG
                     LLLARRLLNRFGMDKIYEGQVEVNGGEYNVESIDGQPGAFTCYLDAGLARTTTGNKVF
                     GALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDA
                     YKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQK
                     KDRVAQKKASFLRAQERAAES"
     exon            120..189
                     /gene="Rpl5"
                     /gene_synonym="Ska23; Ska<m23Jus>; Skax23; U21RNA"
                     /inference="alignment:Splign:2.1.0"
     exon            190..305
                     /gene="Rpl5"
                     /gene_synonym="Ska23; Ska<m23Jus>; Skax23; U21RNA"
                     /inference="alignment:Splign:2.1.0"
     exon            306..440
                     /gene="Rpl5"
                     /gene_synonym="Ska23; Ska<m23Jus>; Skax23; U21RNA"
                     /inference="alignment:Splign:2.1.0"
     exon            441..643
                     /gene="Rpl5"
                     /gene_synonym="Ska23; Ska<m23Jus>; Skax23; U21RNA"
                     /inference="alignment:Splign:2.1.0"
     exon            644..821
                     /gene="Rpl5"
                     /gene_synonym="Ska23; Ska<m23Jus>; Skax23; U21RNA"
                     /inference="alignment:Splign:2.1.0"
     exon            822..910
                     /gene="Rpl5"
                     /gene_synonym="Ska23; Ska<m23Jus>; Skax23; U21RNA"
                     /inference="alignment:Splign:2.1.0"
     exon            911..2019
                     /gene="Rpl5"
                     /gene_synonym="Ska23; Ska<m23Jus>; Skax23; U21RNA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1044..1049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpl5"
                     /gene_synonym="Ska23; Ska<m23Jus>; Skax23; U21RNA"
                     /note="hexamer: AATAAA"
     polyA_site      1067
                     /gene="Rpl5"
                     /gene_synonym="Ska23; Ska<m23Jus>; Skax23; U21RNA"
                     /note="major polyA site"
     regulatory      1997..2002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpl5"
                     /gene_synonym="Ska23; Ska<m23Jus>; Skax23; U21RNA"
                     /note="hexamer: AATAAA"
     polyA_site      2019
                     /gene="Rpl5"
                     /gene_synonym="Ska23; Ska<m23Jus>; Skax23; U21RNA"
ORIGIN      
        1 gtgctggtgg tgctacatac tgcgcatgcg tacgtgactc cggtcttttt cccccttagc
       61 gcggccgact ctgcaggtct gcgtggagcc gcggttgcgg gtctctattc cgcaggatgg
      121 ggtttgtgaa agttgtcaag aataaggcct actttaaaag ataccaagtg agatttcgaa
      181 ggcggcgaga gggtaaaact gactactatg ctcgaaaacg attggtgatc caggacaaga
      241 ataagtacaa cacacccaaa tataggatga tagttcgtgt aactaacaga gatatcatct
      301 gccagattgc atatgcccgt atagaagggg atatgatcgt ctgtgcagca tatgcacatg
      361 aacttccaaa atatggtgtg aaagttggcc tgacaaatta tgctgcagcc tattgcactg
      421 gcctgctgct ggcccgcagg cttctgaata ggtttggcat ggacaagatc tatgaaggcc
      481 aagtggaggt gaatggaggt gaatacaatg tggaaagcat tgacggtcag cctggtgcct
      541 tcacttgcta tctggatgca ggtcttgccc gaactacaac tggcaataaa gtttttgggg
      601 ccctgaaggg agctgtggat ggaggcttgt ctatccctca tagtaccaaa cgattccctg
      661 gttatgactc tgaaagcaag gagttcaatg cagaggtaca tcggaagcac atcatgggtc
      721 agaatgtggc agactacatg cgctacctaa tggaggaaga tgaagatgcg tataagaaac
      781 agttctctca gtacatcaag aacaacgtaa ctccagacat gatggaggag atgtataaga
      841 aagctcatgc tgctatccga gagaatccag tctatgagaa gaagcccaag agagaagtga
      901 agaagaagag gtggaatcgt cccaaaatgt ctcttgccca gaagaaagat cgggttgctc
      961 aaaagaaggc aagcttcctc agagctcagg aaagggctgc tgaaagctaa agcagttttc
     1021 tatgaagatt ttttcataaa gacaataaac atattgatca agcagctttt tctgtgttaa
     1081 gctgttatta atgagactat aggaaatagt gtgaaattac aaaagcaaag aagtagatag
     1141 ttatttaatt aattaaatta attttacctt ttgtgttgca ccataaccta ccactggtgg
     1201 gattaagggc aagtattacc atgcctagct gagagtcttt ctccaggaaa aaccagctta
     1261 catgggttcc tgcaaatctc atgagtgttt cttgggtttc tagtcttcct gggaggtgtc
     1321 cttatctttc agattttcag atctggtaat tagcatgatc atcaggacat ttattacaaa
     1381 caaattgatt agtgggaaga aagtatctca aggtcaatct tggaagtgaa caactggtgc
     1441 taatccatgg ctttaaagat ttgagaacaa cggtgaaatt tggtttgagg agaagggggt
     1501 gtctaggacg tttcattttt atggtacatg ccagacatga atgtacatag gaaaataact
     1561 tgaaagggtc aaatattaaa ccttgaatat caggttcact tgggaaagca ttaggtgctt
     1621 atgcctctta gtaaatagcc cttcatccca gaaggagcaa gaattgtctt cctgacttaa
     1681 tccagtctta gctgaggtgc tgtgcatctt tatcatcttt gccttgcctc acagtgtcag
     1741 gctctgtggt actggggcta cacaggtcag gtaaacagtt aactgcttac ctacatcccc
     1801 agcaaagata atgtgacgat actaagatga acctatcaga gcttaaagat aatgagtttc
     1861 agtcacagtg ataactgcat gctaacttca gcatgtagaa tatatgccga agctaaaagc
     1921 cattccacag ttgactccat ctgaagttaa agtgtgtaag tacacagtaa atcatgctat
     1981 attaactgaa ctttttaata aatgagtcat ttgaatttaa aaaaaaaaaa aaaaaa
//
