LOCUS       NM_024212               1392 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus ribosomal protein L4 (Rpl4), mRNA.
ACCESSION   NM_024212
VERSION     NM_024212.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1392)
  AUTHORS   Li,H., Huo,Y., He,X., Yao,L., Zhang,H., Cui,Y., Xiao,H., Xie,W.,
            Zhang,D., Wang,Y., Zhang,S., Tu,H., Cheng,Y., Guo,Y., Cao,X.,
            Zhu,Y., Jiang,T., Guo,X., Qin,Y. and Sha,J.
  TITLE     A male germ-cell-specific ribosome controls male fertility
  JOURNAL   Nature 612 (7941), 725-731 (2022)
   PUBMED   36517592
REFERENCE   2  (bases 1 to 1392)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   3  (bases 1 to 1392)
  AUTHORS   Green,L., Houck-Loomis,B., Yueh,A. and Goff,S.P.
  TITLE     Large ribosomal protein 4 increases efficiency of viral recoding
            sequences
  JOURNAL   J Virol 86 (17), 8949-8958 (2012)
   PUBMED   22718819
  REMARK    GeneRIF: Mouse and human RPL4 enhance MoMLV gag-pol readthrough.
REFERENCE   4  (bases 1 to 1392)
  AUTHORS   Kondrashov,N., Pusic,A., Stumpf,C.R., Shimizu,K., Hsieh,A.C.,
            Ishijima,J., Shiroishi,T. and Barna,M.
  TITLE     Ribosome-mediated specificity in Hox mRNA translation and
            vertebrate tissue patterning
  JOURNAL   Cell 145 (3), 383-397 (2011)
   PUBMED   21529712
REFERENCE   5  (bases 1 to 1392)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   6  (bases 1 to 1392)
  AUTHORS   Maggi,L.B. Jr., Kuchenruether,M., Dadey,D.Y., Schwope,R.M.,
            Grisendi,S., Townsend,R.R., Pandolfi,P.P. and Weber,J.D.
  TITLE     Nucleophosmin serves as a rate-limiting nuclear export chaperone
            for the Mammalian ribosome
  JOURNAL   Mol Cell Biol 28 (23), 7050-7065 (2008)
   PUBMED   18809582
REFERENCE   7  (bases 1 to 1392)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   8  (bases 1 to 1392)
  AUTHORS   Dresios,J., Aschrafi,A., Owens,G.C., Vanderklish,P.W., Edelman,G.M.
            and Mauro,V.P.
  TITLE     Cold stress-induced protein Rbm3 binds 60S ribosomal subunits,
            alters microRNA levels, and enhances global protein synthesis
  JOURNAL   Proc Natl Acad Sci U S A 102 (6), 1865-1870 (2005)
   PUBMED   15684048
REFERENCE   9  (bases 1 to 1392)
  AUTHORS   Dudek,J., Volkmer,J., Bies,C., Guth,S., Muller,A., Lerner,M.,
            Feick,P., Schafer,K.H., Morgenstern,E., Hennessy,F., Blatch,G.L.,
            Janoscheck,K., Heim,N., Scholtes,P., Frien,M., Nastainczyk,W. and
            Zimmermann,R.
  TITLE     A novel type of co-chaperone mediates transmembrane recruitment of
            DnaK-like chaperones to ribosomes
  JOURNAL   EMBO J 21 (12), 2958-2967 (2002)
   PUBMED   12065409
  REMARK    Erratum:[EMBO J 2002 Jul 15;21(14):3917]
REFERENCE   10 (bases 1 to 1392)
  AUTHORS   Jakel,S., Mingot,J.M., Schwarzmaier,P., Hartmann,E. and Gorlich,D.
  TITLE     Importins fulfil a dual function as nuclear import receptors and
            cytoplasmic chaperones for exposed basic domains
  JOURNAL   EMBO J 21 (3), 377-386 (2002)
   PUBMED   11823430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160118.2.
            
            On Mar 24, 2023 this sequence version replaced NM_024212.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003459.1, AK165962.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC160118.2         75249-75308
            61-232              AC160118.2         76699-76870
            233-339             AC160118.2         77069-77175
            340-478             AC160118.2         77459-77597
            479-603             AC160118.2         77967-78091
            604-733             AC160118.2         78816-78945
            734-890             AC160118.2         79196-79352
            891-974             AC160118.2         79596-79679
            975-1095            AC160118.2         79772-79892
            1096-1392           AC160118.2         80098-80394
FEATURES             Location/Qualifiers
     source          1..1392
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 34.54 cM"
     gene            1..1392
                     /gene="Rpl4"
                     /gene_synonym="2010004J23Rik"
                     /note="ribosomal protein L4"
                     /db_xref="GeneID:67891"
                     /db_xref="MGI:MGI:1915141"
     exon            1..60
                     /gene="Rpl4"
                     /gene_synonym="2010004J23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1317
                     /gene="Rpl4"
                     /gene_synonym="2010004J23Rik"
                     /note="60S ribosomal protein L4"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL4"
                     /protein_id="NP_077174.1"
                     /db_xref="CCDS:CCDS40667.1"
                     /db_xref="GeneID:67891"
                     /db_xref="MGI:MGI:1915141"
                     /translation="MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNL
                     RKNNRQPYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMF
                     APTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEG
                     YKKTKEAVQLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGII
                     KAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSN
                     YNLPMHKMMNTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKT
                     MRRNTILRQARNHKLRVKKLEAAATALATKSEKVVPEKGTADKKPAVGKKGKKVDAKK
                     QKPAGKKVVAKKPAEKKPTTEEKKPAA"
     exon            61..232
                     /gene="Rpl4"
                     /gene_synonym="2010004J23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            233..339
                     /gene="Rpl4"
                     /gene_synonym="2010004J23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            340..478
                     /gene="Rpl4"
                     /gene_synonym="2010004J23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            479..603
                     /gene="Rpl4"
                     /gene_synonym="2010004J23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            604..733
                     /gene="Rpl4"
                     /gene_synonym="2010004J23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            734..890
                     /gene="Rpl4"
                     /gene_synonym="2010004J23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            891..974
                     /gene="Rpl4"
                     /gene_synonym="2010004J23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1095
                     /gene="Rpl4"
                     /gene_synonym="2010004J23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1392
                     /gene="Rpl4"
                     /gene_synonym="2010004J23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1368..1373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpl4"
                     /gene_synonym="2010004J23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1392
                     /gene="Rpl4"
                     /gene_synonym="2010004J23Rik"
                     /note="major polyA site"
ORIGIN      
        1 ccttttcctg tgggagcagc cgggtagaga ggagcgtggc cttctcctct ccccgtcatg
       61 gcttgtgccc gtcccctcat atcggtgtac tccgaaaagg gagagtcatc tggcaagaat
      121 gtcactttgc cagctgtgtt caaagctccc attcgaccag atattgtgaa cttcgttcac
      181 accaacttga ggaaaaacaa cagacagccc tatgccgtca gtgaattggc aggtcatcag
      241 accagtgctg agtcttgggg tactggcaga gctgtggctc gaattccaag agttcgaggt
      301 ggtgggaccc accgatctgg ccagggtgcc tttggaaata tgtgtcgtgg gggacgcatg
      361 tttgcaccaa ccaaaacctg gcgtcgttgg caccgcagag tgaatacaac ccaaaaacga
      421 tatgccatct gttctgccct ggctgcctcg gccttaccag ctttggtgat gtctaaaggt
      481 catcgtattg aggaggttcc tgagctgccg ctggtggttg aagataaggt tgaaggttac
      541 aagaagacca aggaggctgt tcagctgctc aagaaactca aagcttggaa tgacatcaaa
      601 aaggtctatg cctctcagag aatgagagct ggcaagggca aaatgagaaa ccgacggcgg
      661 atccagcgca gggggccctg catcatctat aatgaagata atggtatcat caaggccttc
      721 cgcaacatcc ctggtattac tctgcttaat gtaagcaagc tgaacatttt gaaactggct
      781 cctggtgggc atgtgggccg tttctgcatc tggacggaga gtgctttccg gaagttggat
      841 gagctgtatg gcacttggcg gaaggctgct tccctcaaga gtaactataa cctgcccatg
      901 cacaagatga tgaacaccga ccttagcaga atcttgaaaa gcccagaaat ccaaagagcc
      961 ctccgagcac cacgcaagaa gattcatcgc agagtcttga agaagaatcc actgaagaac
     1021 ctgagaatca tgttgaagct gaacccttac gccaagacta tgcgcaggaa taccattctt
     1081 cgccaggcca gaaatcacaa acttcgtgtg aaaaagctgg aagcagcagc tactgcactg
     1141 gcaaccaaat ccgagaaggt tgttccagag aaggggactg cagacaagaa gccagcggta
     1201 ggcaagaaag gaaagaaggt ggatgccaag aagcagaagc ctgcagggaa aaaggtggtt
     1261 gccaagaaac cagcagagaa gaagcctact acagaagaaa agaagccagc tgcataaact
     1321 attaaaaatt gttaaattcc agagagcaag tagagaccgc atatttcaat aaatcaaaca
     1381 tgtggtgaca aa
//
