LOCUS       NM_013762               1296 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus ribosomal protein L3 (Rpl3), transcript variant 1,
            mRNA.
ACCESSION   NM_013762 XM_903640
VERSION     NM_013762.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1296)
  AUTHORS   Milenkovic,I., Santos Vieira,H.G., Lucas,M.C., Ruiz-Orera,J.,
            Patone,G., Kesteven,S., Wu,J., Feneley,M., Espadas,G., Sabido,E.,
            Hubner,N., van Heesch,S., Volkers,M. and Novoa,E.M.
  TITLE     Dynamic interplay between RPL3- and RPL3L-containing ribosomes
            modulates mitochondrial activity in the mammalian heart
  JOURNAL   Nucleic Acids Res 51 (11), 5301-5324 (2023)
   PUBMED   36882085
  REMARK    GeneRIF: Dynamic interplay between RPL3- and RPL3L-containing
            ribosomes modulates mitochondrial activity in the mammalian heart.
REFERENCE   2  (bases 1 to 1296)
  AUTHORS   Shiraishi,C., Matsumoto,A., Ichihara,K., Yamamoto,T., Yokoyama,T.,
            Mizoo,T., Hatano,A., Matsumoto,M., Tanaka,Y., Matsuura-Suzuki,E.,
            Iwasaki,S., Matsushima,S., Tsutsui,H. and Nakayama,K.I.
  TITLE     RPL3L-containing ribosomes determine translation elongation
            dynamics required for cardiac function
  JOURNAL   Nat Commun 14 (1), 2131 (2023)
   PUBMED   37080962
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1296)
  AUTHORS   Li,H., Huo,Y., He,X., Yao,L., Zhang,H., Cui,Y., Xiao,H., Xie,W.,
            Zhang,D., Wang,Y., Zhang,S., Tu,H., Cheng,Y., Guo,Y., Cao,X.,
            Zhu,Y., Jiang,T., Guo,X., Qin,Y. and Sha,J.
  TITLE     A male germ-cell-specific ribosome controls male fertility
  JOURNAL   Nature 612 (7941), 725-731 (2022)
   PUBMED   36517592
REFERENCE   4  (bases 1 to 1296)
  AUTHORS   Lavado,A., Park,J.Y., Pare,J., Finkelstein,D., Pan,H., Xu,B.,
            Fan,Y., Kumar,R.P., Neale,G., Kwak,Y.D., McKinnon,P.J.,
            Johnson,R.L. and Cao,X.
  TITLE     The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and
            Controls Neural Progenitor Number
  JOURNAL   Dev Cell 47 (5), 576-591 (2018)
   PUBMED   30523785
REFERENCE   5  (bases 1 to 1296)
  AUTHORS   Percharde,M., Wong,P. and Ramalho-Santos,M.
  TITLE     Global Hypertranscription in the Mouse Embryonic Germline
  JOURNAL   Cell Rep 19 (10), 1987-1996 (2017)
   PUBMED   28591571
REFERENCE   6  (bases 1 to 1296)
  AUTHORS   Allan,M.F., Potts,J.K. and Pomp,D.
  TITLE     Comparative mapping of RPL3, a gene overexpressed in multiple
            obesity models
  JOURNAL   Anim Biotechnol 12 (2), 167-171 (2001)
   PUBMED   11808632
REFERENCE   7  (bases 1 to 1296)
  AUTHORS   Huttenhofer,A., Kiefmann,M., Meier-Ewert,S., O'Brien,J.,
            Lehrach,H., Bachellerie,J.P. and Brosius,J.
  TITLE     RNomics: an experimental approach that identifies 201 candidates
            for novel, small, non-messenger RNAs in mouse
  JOURNAL   EMBO J 20 (11), 2943-2953 (2001)
   PUBMED   11387227
REFERENCE   8  (bases 1 to 1296)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
REFERENCE   9  (bases 1 to 1296)
  AUTHORS   Petersen,R., Sobel,S., Wang,C.T., Jaenisch,R. and Barklis,E.
  TITLE     Cellular transcripts encoded at a locus which permits retrovirus
            expression in mouse embryonic cells
  JOURNAL   Gene 101 (2), 177-183 (1991)
   PUBMED   1711497
REFERENCE   10 (bases 1 to 1296)
  AUTHORS   Peckham,I., Sobel,S., Comer,J., Jaenisch,R. and Barklis,E.
  TITLE     Retrovirus activation in embryonal carcinoma cells by cellular
            promoters
  JOURNAL   Genes Dev 3 (12B), 2062-2071 (1989)
   PUBMED   2628163
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161199.4.
            
            On Sep 8, 2022 this sequence version replaced NM_013762.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149494.1, AK144816.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC161199.4         113184-113212       c
            30-222              AC161199.4         112250-112442       c
            223-391             AC161199.4         111475-111643       c
            392-527             AC161199.4         110756-110891       c
            528-714             AC161199.4         110226-110412       c
            715-875             AC161199.4         109550-109710       c
            876-977             AC161199.4         108567-108668       c
            978-1073            AC161199.4         108191-108286       c
            1074-1193           AC161199.4         107847-107966       c
            1194-1296           AC161199.4         107652-107754       c
FEATURES             Location/Qualifiers
     source          1..1296
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     gene            1..1296
                     /gene="Rpl3"
                     /gene_synonym="F2; J1"
                     /note="ribosomal protein L3"
                     /db_xref="GeneID:27367"
                     /db_xref="MGI:MGI:1351605"
     exon            1..29
                     /gene="Rpl3"
                     /gene_synonym="F2; J1"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1238
                     /gene="Rpl3"
                     /gene_synonym="F2; J1"
                     /EC_number="3.6.5.3"
                     /note="60S ribosomal protein L3; ribosomal protein L3
                     homolog"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL3"
                     /protein_id="NP_038790.2"
                     /db_xref="CCDS:CCDS37144.1"
                     /db_xref="GeneID:27367"
                     /db_xref="MGI:MGI:1351605"
                     /translation="MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDASKPVHLT
                     AFLGYKAGMTHIVREVDRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTF
                     KTVFAEHISDECKRRFYKNWHKSKKKAFTKYCKKWQDDTGKKQLEKDFNSMKKYCQVI
                     RIIAHTQMRLLPLRQKKAHLMEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMID
                     VIGVTKGKGYKGVTSRWHTKKLPRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHH
                     RTEINKKIYKIGQGYLIKDGKLIKNNASTDYDLSDKSINPLGGFVHYGEVTNDFIMLK
                     GCVVGTKKRVLTLRKSLLVQTKRRALEKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPL
                     KKDRIAKEEGA"
     exon            30..222
                     /gene="Rpl3"
                     /gene_synonym="F2; J1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..391
                     /gene="Rpl3"
                     /gene_synonym="F2; J1"
                     /inference="alignment:Splign:2.1.0"
     exon            392..527
                     /gene="Rpl3"
                     /gene_synonym="F2; J1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..714
                     /gene="Rpl3"
                     /gene_synonym="F2; J1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..875
                     /gene="Rpl3"
                     /gene_synonym="F2; J1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..977
                     /gene="Rpl3"
                     /gene_synonym="F2; J1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1073
                     /gene="Rpl3"
                     /gene_synonym="F2; J1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1193
                     /gene="Rpl3"
                     /gene_synonym="F2; J1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1296
                     /gene="Rpl3"
                     /gene_synonym="F2; J1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1276..1281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpl3"
                     /gene_synonym="F2; J1"
                     /note="hexamer: AATAAA"
     polyA_site      1296
                     /gene="Rpl3"
                     /gene_synonym="F2; J1"
                     /note="major polyA site"
ORIGIN      
        1 ctctatctgc ggcgtgtggc ggcgagatgt ctcacaggaa attctcagct cccaggcatg
       61 ggtccttggg cttcctgcct cgcaagcgca gcagccggca tcgtgggaaa gtgaagagct
      121 tccctaagga tgacgcttcc aagcccgttc acctcacagc ctttctgggt tacaaggctg
      181 gcatgaccca catcgtccgg gaagttgaca ggccaggatc taaggtgaac aagaaagaag
      241 tcgtggaggc tgtgaccatt gtggaaactc ccccaatggt ggttgtgggc attgtgggat
      301 atgttgagac cccacgaggc ctccggacct tcaagactgt atttgctgag cacatcagcg
      361 atgagtgtaa aaggcgcttc tataagaact ggcacaagtc taagaagaag gctttcacca
      421 agtactgtaa gaaatggcag gatgacacag gcaagaagca gctggagaag gacttcaaca
      481 gcatgaagaa gtactgccag gtcatccgca tcattgccca cactcagatg cgtctgcttc
      541 ctctacgcca gaagaaggca cacttgatgg agatccaggt gaatggaggc actgtggctg
      601 agaagctcga ctgggcccga gagcggctgg agcagcaggt tcctgtgaac caggtgtttg
      661 ggcaggatga gatgattgat gtcattggcg tgacaaaagg caaagggtac aaaggggtaa
      721 ccagtcgttg gcatacaaag aaactgcccc gaaagaccca tcgaggtttg cgcaaagttg
      781 cctgtattgg agcctggcac cctgcccgtg ttgccttctc tgtggctcga gctgggcaga
      841 aaggctacca tcaccgaaca gagattaaca agaagattta caagattggt caaggctacc
      901 tcatcaagga tggcaaactg atcaagaaca atgcatctac tgactatgac ttgtctgaca
      961 agagcatcaa cccactgggt ggctttgtgc attatggtga ggtgaccaat gacttcatca
     1021 tgctcaaagg ctgtgtggtg gggaccaaga agcgagtact tactcttcgt aagtccttgc
     1081 tggttcagac caaacgtcgg gccctggaga agattgacct gaagttcatt gacaccacct
     1141 ccaaatttgg ccatggtcgc ttccagacca tggaggagaa gaaagcattt atgggaccac
     1201 tcaagaaaga tcgcattgcc aaggaggaag gagcttgatt ccaggaccac tttgtgcaga
     1261 tggtggggtc tcaccaataa aatatttcta ctcaca
//
