LOCUS       NM_026517                486 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus ribosomal protein L22 like 1 (Rpl22l1), transcript
            variant 1, mRNA.
ACCESSION   NM_026517
VERSION     NM_026517.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Fahl,S.P., Sertori,R., Zhang,Y., Contreras,A.V., Harris,B.,
            Wang,M., Perrigoue,J., Balachandran,S., Kennedy,B.K. and Wiest,D.L.
  TITLE     Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid
            Development without Affecting Protein Synthesis
  JOURNAL   J Immunol 208 (4), 870-880 (2022)
   PUBMED   35046107
  REMARK    GeneRIF: Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks
            Lymphoid Development without Affecting Protein Synthesis.
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Rao,S., Peri,S., Hoffmann,J., Cai,K.Q., Harris,B., Rhodes,M.,
            Connolly,D.C., Testa,J.R. and Wiest,D.L.
  TITLE     RPL22L1 induction in colorectal cancer is associated with poor
            prognosis and 5-FU resistance
  JOURNAL   PLoS One 14 (10), e0222392 (2019)
   PUBMED   31581233
  REMARK    GeneRIF: RPL22L1 might be a prognostic marker in colorectal cancer
            and predict 5-Fluorouracil responsiveness.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 486)
  AUTHORS   Zhang,Y., O'Leary,M.N., Peri,S., Wang,M., Zha,J., Melov,S.,
            Kappes,D.J., Feng,Q., Rhodes,J., Amieux,P.S., Morris,D.R.,
            Kennedy,B.K. and Wiest,D.L.
  TITLE     Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by
            Regulating Pre-mRNA Splicing
  JOURNAL   Cell Rep 18 (2), 545-556 (2017)
   PUBMED   28076796
  REMARK    GeneRIF: Rpl22, and its highly homologous paralog Rpl22-Like1
            (Rpl22l1 or Like1) play critical, extraribosomal roles in
            embryogenesis.
REFERENCE   4  (bases 1 to 486)
  AUTHORS   Wu,N., Wei,J., Wang,Y., Yan,J., Qin,Y., Tong,D., Pang,B., Sun,D.,
            Sun,H., Yu,Y., Sun,W., Meng,X., Zhang,C., Bai,J., Chen,F., Geng,J.,
            Lee,K.Y., Fu,S. and Jin,Y.
  TITLE     Ribosomal L22-like1 (RPL22L1) Promotes Ovarian Cancer Metastasis by
            Inducing Epithelial-to-Mesenchymal Transition
  JOURNAL   PLoS One 10 (11), e0143659 (2015)
   PUBMED   26618703
  REMARK    GeneRIF: RPL22L1 induces epithelial-to-mesenchymal transition and
            is critical in maintaining the aggressive phenotype of ovarian
            cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 486)
  AUTHORS   O'Leary,M.N., Schreiber,K.H., Zhang,Y., Duc,A.C., Rao,S.,
            Hale,J.S., Academia,E.C., Shah,S.R., Morton,J.F., Holstein,C.A.,
            Martin,D.B., Kaeberlein,M., Ladiges,W.C., Fink,P.J., Mackay,V.L.,
            Wiest,D.L. and Kennedy,B.K.
  TITLE     The ribosomal protein Rpl22 controls ribosome composition by
            directly repressing expression of its own paralog, Rpl22l1
  JOURNAL   PLoS Genet 9 (8), e1003708 (2013)
   PUBMED   23990801
  REMARK    GeneRIF: either ribosomal protein can support translation,
            knockdown of Rpl22l1 impairs growth of cells lacking Rpl22.
            Mechanistically, Rpl22 regulates Rpl22l1 directly by binding to an
            internal hairpin structure and repressing its expression
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122490.3.
            
            On Jun 29, 2022 this sequence version replaced NM_026517.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK795178.1, AK008915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC122490.3         71461-71493
            34-126              AC122490.3         72450-72542
            127-248             AC122490.3         72687-72808
            249-486             AC122490.3         73137-73374
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 12.27 cM"
     gene            1..486
                     /gene="Rpl22l1"
                     /gene_synonym="3110001N18Rik"
                     /note="ribosomal protein L22 like 1"
                     /db_xref="GeneID:68028"
                     /db_xref="MGI:MGI:1915278"
     exon            1..33
                     /gene="Rpl22l1"
                     /gene_synonym="3110001N18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            34..126
                     /gene="Rpl22l1"
                     /gene_synonym="3110001N18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            127..248
                     /gene="Rpl22l1"
                     /gene_synonym="3110001N18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            249..486
                     /gene="Rpl22l1"
                     /gene_synonym="3110001N18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      458..463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpl22l1"
                     /gene_synonym="3110001N18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      486
                     /gene="Rpl22l1"
                     /gene_synonym="3110001N18Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcccac ggctgcagct caacatggcg ccgcagaaag acaagaagcc taagaagtcc
       61 acctggaggt ttcatttgga ccttactcat ccagtagaag atggaatttt tgactctgga
      121 aattttgaac agtttctacg ggagaaggtt aaagtcaatg gaaaaactgg aaatcttggc
      181 aatgttgttc acattgaacg cctgaagaat aaaatcacag ttgtttctga gaaacagttc
      241 tccaaaaggt atttgaaata tcttaccaag aaatacctta agaagaataa tctccgtgat
      301 tggctacgtg tggtcgcatc tgacaaggag acttacgaac ttcgttattt ccagattagt
      361 caagatgaag atggttcaga gtctgaggac taattggcct ctgcttgtaa tacaatgaaa
      421 gtattctaaa gaaatataaa attggacttt atgagaaaat aaaagtcatt tcactctata
      481 aaaaca
//
