LOCUS       NM_001277113            2153 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus ribosomal protein L22 (Rpl22), transcript variant 2,
            mRNA.
ACCESSION   NM_001277113
VERSION     NM_001277113.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2153)
  AUTHORS   Ding,X., Wu,Y., Vainshtein,A., Rodriguez,V., Ricco,E., Okoh,J.T.,
            Liu,Y., Kraushaar,D.C., Peles,E. and Rasband,M.N.
  TITLE     Age-dependent regulation of axoglial interactions and behavior by
            oligodendrocyte AnkyrinG
  JOURNAL   Nat Commun 15 (1), 10865 (2024)
   PUBMED   39738113
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2153)
  AUTHORS   Loganathan,S., Menegaz,D., Delling,J.P., Eder,M. and Deussing,J.M.
  TITLE     Cacna1c deficiency in forebrain glutamatergic neurons alters
            behavior and hippocampal plasticity in female mice
  JOURNAL   Transl Psychiatry 14 (1), 421 (2024)
   PUBMED   39370418
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2153)
  AUTHORS   Mihlan,M., Wissmann,S., Gavrilov,A., Kaltenbach,L., Britz,M.,
            Franke,K., Hummel,B., Imle,A., Suzuki,R., Stecher,M., Glaser,K.M.,
            Lorentz,A., Carmeliet,P., Yokomizo,T., Hilgendorf,I., Sawarkar,R.,
            Diz-Munoz,A., Buescher,J.M., Mittler,G., Maurer,M., Krause,K.,
            Babina,M., Erpenbeck,L., Frank,M., Rambold,A.S. and Lammermann,T.
  TITLE     Neutrophil trapping and nexocytosis, mast cell-mediated processes
            for inflammatory signal relay
  JOURNAL   Cell 187 (19), 5316-5335 (2024)
   PUBMED   39096902
REFERENCE   4  (bases 1 to 2153)
  AUTHORS   Profaci,C.P., Harvey,S.S., Bajc,K., Zhang,T.Z., Jeffrey,D.A.,
            Zhang,A.Z., Nemec,K.M., Davtyan,H., O'Brien,C.A., McKinsey,G.L.,
            Longworth,A., McMullen,T.P., Capocchi,J.K., Gonzalez,J.G.,
            Lawson,D.A., Arnold,T.D., Davalos,D., Blurton-Jones,M.,
            Dabertrand,F., Bennett,F.C. and Daneman,R.
  TITLE     Microglia are not necessary for maintenance of blood-brain barrier
            properties in health, but PLX5622 alters brain endothelial
            cholesterol metabolism
  JOURNAL   Neuron 112 (17), 2910-2921 (2024)
   PUBMED   39142282
REFERENCE   5  (bases 1 to 2153)
  AUTHORS   Kaiser,T., Dattero,J., Li,L., Chen,M., Jiang,M., Harrahill,A.,
            Butovsky,O. and Feng,G.
  TITLE     Transgenic Targeting of Fcrls Creates a Highly Efficient
            Constitutively Active Microglia Cre Line with Differentiated
            Specificity
  JOURNAL   eNeuro 11 (7) (2024)
   PUBMED   38926085
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2153)
  AUTHORS   Anderson,S.J., Lauritsen,J.P., Hartman,M.G., Foushee,A.M.,
            Lefebvre,J.M., Shinton,S.A., Gerhardt,B., Hardy,R.R., Oravecz,T.
            and Wiest,D.L.
  TITLE     Ablation of ribosomal protein L22 selectively impairs alphabeta T
            cell development by activation of a p53-dependent checkpoint
  JOURNAL   Immunity 26 (6), 759-772 (2007)
   PUBMED   17555992
  REMARK    GeneRIF: Rpl22 deficiency activated a p53-dependent checkpoint that
            produced a remarkably selective block in alphabeta T cell
            development.
REFERENCE   7  (bases 1 to 2153)
  AUTHORS   Millien,G., Spira,A., Hinds,A., Wang,J., Williams,M.C. and
            Ramirez,M.I.
  TITLE     Alterations in gene expression in T1 alpha null lung: a model of
            deficient alveolar sac development
  JOURNAL   BMC Dev Biol 6, 35 (2006)
   PUBMED   16869965
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2153)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2153)
  AUTHORS   Wang,J., Yang,X., Zhou,P. and Han,H.
  TITLE     Cloning of mouse genomic ribosomal protein L6 gene and analysis of
            its promoter
  JOURNAL   Biochim Biophys Acta 1576 (1-2), 219-224 (2002)
   PUBMED   12031506
REFERENCE   10 (bases 1 to 2153)
  AUTHORS   Fujita,Y., Okamoto,T., Noshiro,M., McKeehan,W.L., Crabb,J.W.,
            Whitney,R.G., Kato,Y., Sato,J.D. and Takada,K.
  TITLE     A novel heparin-binding protein, HBp15, is identified as mammalian
            ribosomal protein L22
  JOURNAL   Biochem Biophys Res Commun 199 (2), 706-713 (1994)
   PUBMED   8135813
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL611985.22.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV456871.1, ERR3835353.206468.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AL611985.22        65229-65348
            121-225             AL611985.22        68274-68378
            226-350             AL611985.22        70797-70921
            351-2153            AL611985.22        73073-74875
FEATURES             Location/Qualifiers
     source          1..2153
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 83.03 cM"
     gene            1..2153
                     /gene="Rpl22"
                     /gene_synonym="2700038K18Rik"
                     /note="ribosomal protein L22"
                     /db_xref="GeneID:19934"
                     /db_xref="MGI:MGI:99262"
     exon            1..120
                     /gene="Rpl22"
                     /gene_synonym="2700038K18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..495
                     /gene="Rpl22"
                     /gene_synonym="2700038K18Rik"
                     /EC_number="2.1.1.100"
                     /note="isoform b is encoded by transcript variant 2; 60S
                     ribosomal protein L22; heparin-binding protein HBp15;
                     large ribosomal subunit protein eL22"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL22 isoform b"
                     /protein_id="NP_001264042.1"
                     /db_xref="GeneID:19934"
                     /db_xref="MGI:MGI:99262"
                     /translation="MPTLNTKEEEAKPLLRELNCPWCRSRKKKLVAKGGKKKKQVLKF
                     TLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFS
                     KRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED"
     exon            121..225
                     /gene="Rpl22"
                     /gene_synonym="2700038K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            226..350
                     /gene="Rpl22"
                     /gene_synonym="2700038K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            351..2153
                     /gene="Rpl22"
                     /gene_synonym="2700038K18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      532..537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpl22"
                     /gene_synonym="2700038K18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      551
                     /gene="Rpl22"
                     /gene_synonym="2700038K18Rik"
                     /note="major polyA site"
     regulatory      2119..2124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpl22"
                     /gene_synonym="2700038K18Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2139
                     /gene="Rpl22"
                     /gene_synonym="2700038K18Rik"
ORIGIN      
        1 gttccagctc ccactgacag aataaagcaa gagtggggaa tgccaacact caacaccaag
       61 gaggaagaag caaagccact tcttagagaa cttaactgtc cgtggtgccg gagcagaaag
      121 aaaaagcttg tggcgaaggg gggcaaaaaa aagaagcagg ttttgaagtt caccctggac
      181 tgcactcacc ctgtagaaga tggaatcatg gatgctgcca attttgagca gttcctccag
      241 gagagaatca aggtgaatgg gaaagctggc aacctcggcg gaggagtcgt gaccatcgaa
      301 cgcagcaaga gcaagatcac tgtcacttca gaggtgcctt tctccaaaag gtatttgaaa
      361 tatctcacca aaaaatattt gaagaagaac aacctccgag actggctgcg tgttgtcgcc
      421 aacagcaaag agagttacga gctgcgttac ttccagatta accaggatga agaggaggag
      481 gaagacgagg attaggacac attggtctgc aatgttttgt attaattcat aaataaaatt
      541 taggaacaaa accggtggtt tatccttgca tctctgcagt gtggattgga caggaagttg
      601 gaaatgacag ggactttaac tgggctgctg ctcctttgta tatagacact tttttcctgc
      661 tcagaaactt gagttctcca gtagcaatgg ccaaacagaa gaaccaggct agggggctgc
      721 atctgacaga gcaagtagac gagaggctgg gtggtgggct ccggccagcc cgagtcttag
      781 agctggtggt tggttatatc tggtgcctgt ctcgaggagg gcttgagaca cagtgtggtg
      841 ctcctcagaa gcagacaggt gatttctttg tgtgattttt cttttcccct gggacaatga
      901 cagtcagtaa gacaggtttc agggactttt gtgtccaggt ctgagcacta gtcgctcaca
      961 gttgtgtgta ctaaccttct tccttcctat tgaaatggca ggggtctttg agtctcactg
     1021 ctgcatgttc tgccttcata gggatctgta agtatgctgg gcatctgggc ttttaggggg
     1081 ctctctatag ggtgtctgag atagaggtca acaagggctt atagacaact caaacaaagc
     1141 ccatggcttg agcaagtctg caacaagctg tttgtctagc ctccagcaga gggcgaggga
     1201 gacagcttcc agatgttccc agtaggtgga gcccctccaa gcccagggct caggaggctt
     1261 acagggtggg aactccaata ctggtggagg gaggagggcg tttgatggga agatagggaa
     1321 gttgctgctt cctaaactgt cacaactggg cttggatagg agtcatagtc tgggaccaca
     1381 gccctgtggt agaatgctag cctggtgtgc tccaggttta atctccatca ctgcagaaat
     1441 gagtccaagc tgtgtgtacc tccagggcac tgggcatggg gttcccttgc cattgtgtgt
     1501 gcccggagaa ctggcaggcg ggaaatgtct ttatcaaggg ttaccttgga agaggtccca
     1561 acactgtagg gtgctcctgt tgtcaaaacc tatgcagagg catctgcttg ctctctaata
     1621 acagtatgca atgctaaagg gctcgcttac agccggtggc cacactggag gcctgcacat
     1681 caggtggcca caagttctgc tgctgcgcct ccgaggaaac acttggtcct ccgatcgatt
     1741 ttaacctgtt gaggctttgc aatccccctg tggcaaaggc tccagtgttt tctatttcta
     1801 tgcaaatttc ttgaagcaga actgttactg tctttctcct ctgccctggg aggaggcgct
     1861 agcgtttcct tccaacttca ggtgcagccc ccctcgtggt tagcggtctt aagttcgtga
     1921 cttgggtttg cagatctttt ttgttacatc gccggaccat gtggtggtct ttagctgtaa
     1981 acaacattaa ccctgggttg attagcatat gcttctaaaa gatggtccca gattctgcga
     2041 cttgtaataa aatggaaact tgctggtttt tatgcctttc taactcttgt atttgaatga
     2101 atgttgatca ctttttgtat taaagtggct gacacatggc tactgtcact gtg
//
