LOCUS       NM_001408989            2042 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus ribosomal protein L21 (Rpl21), transcript variant 3,
            mRNA.
ACCESSION   NM_001408989
VERSION     NM_001408989.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2042)
  AUTHORS   Zhu,J., Long,T., Gao,L., Zhong,Y., Wang,P., Wang,X., Li,Z. and
            Hu,Z.
  TITLE     RPL21 interacts with LAMP3 to promote colorectal cancer invasion
            and metastasis by regulating focal adhesion formation
  JOURNAL   Cell Mol Biol Lett 28 (1), 31 (2023)
   PUBMED   37062845
  REMARK    GeneRIF: RPL21 interacts with LAMP3 to promote colorectal cancer
            invasion and metastasis by regulating focal adhesion formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2042)
  AUTHORS   Li,H., Huo,Y., He,X., Yao,L., Zhang,H., Cui,Y., Xiao,H., Xie,W.,
            Zhang,D., Wang,Y., Zhang,S., Tu,H., Cheng,Y., Guo,Y., Cao,X.,
            Zhu,Y., Jiang,T., Guo,X., Qin,Y. and Sha,J.
  TITLE     A male germ-cell-specific ribosome controls male fertility
  JOURNAL   Nature 612 (7941), 725-731 (2022)
   PUBMED   36517592
REFERENCE   3  (bases 1 to 2042)
  AUTHORS   Zhao,Q., Yan,S., Lu,J., Parker,D.J., Wu,H., Sun,Q., Crossman,D.K.,
            Liu,S., Wang,Q., Sesaki,H., Mitra,K., Liu,K. and Jiao,K.
  TITLE     Drp1 regulates transcription of ribosomal protein genes in
            embryonic hearts
  JOURNAL   J Cell Sci 135 (4) (2022)
   PUBMED   35099001
REFERENCE   4  (bases 1 to 2042)
  AUTHORS   Stafford,D.A., Dichmann,D.S., Chang,J.K. and Harland,R.M.
  TITLE     Deletion of the sclerotome-enriched lncRNA PEAT augments ribosomal
            protein expression
  JOURNAL   Proc Natl Acad Sci U S A 114 (1), 101-106 (2017)
   PUBMED   27986952
REFERENCE   5  (bases 1 to 2042)
  AUTHORS   Salinas,E., Byrum,S.D., Moreland,L.E., Mackintosh,S.G.,
            Tackett,A.J. and Forrest,J.C.
  TITLE     Identification of Viral and Host Proteins That Interact with Murine
            Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic
            Replication: a Role for Hsc70 in Viral Replication
  JOURNAL   J Virol 90 (3), 1397-1413 (2015)
   PUBMED   26581985
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2042)
  AUTHORS   Xie,M., Kobayashi,I., Kiyoshima,T., Nagata,K., Ookuma,Y.,
            Fujiwara,H. and Sakai,H.
  TITLE     In situ expression of ribosomal protein L21 in developing tooth
            germ of the mouse lower first molar
  JOURNAL   J Mol Histol 40 (5-6), 361-367 (2009)
   PUBMED   20043235
  REMARK    GeneRIF: Rpl21 participates in the synthesis of various
            polypeptides which might be related to the initiation and the
            development of tooth germ, and also in the synthesis of enamel
            components in the presecretory stage of the ameloblast.
REFERENCE   7  (bases 1 to 2042)
  AUTHORS   Cai,J., Ash,D., Kotch,L.E., Jabs,E.W., Attie-Bitach,T., Auge,J.,
            Mattei,G., Etchevers,H., Vekemans,M., Korshunova,Y., Tidwell,R.,
            Messina,D.N., Winston,J.B. and Lovett,M.
  TITLE     Gene expression in pharyngeal arch 1 during human embryonic
            development
  JOURNAL   Hum Mol Genet 14 (7), 903-912 (2005)
   PUBMED   15703188
REFERENCE   8  (bases 1 to 2042)
  AUTHORS   Loebel,D.A., O'Rourke,M.P., Steiner,K.A., Banyer,J. and Tam,P.P.
  TITLE     Isolation of differentially expressed genes from wild-type and
            Twist mutant mouse limb buds
  JOURNAL   Genesis 33 (3), 103-113 (2002)
   PUBMED   12124942
REFERENCE   9  (bases 1 to 2042)
  AUTHORS   Bodnar,J.S., Chatterjee,A., Castellani,L.W., Ross,D.A., Ohmen,J.,
            Cavalcoli,J., Wu,C., Dains,K.M., Catanese,J., Chu,M., Sheth,S.S.,
            Charugundla,K., Demant,P., West,D.B., de Jong,P. and Lusis,A.J.
  TITLE     Positional cloning of the combined hyperlipidemia gene Hyplip1
  JOURNAL   Nat Genet 30 (1), 110-116 (2002)
   PUBMED   11753387
REFERENCE   10 (bases 1 to 2042)
  AUTHORS   Yamaza,H., Matsuo,K., Kiyoshima,T., Shigemura,N., Kobayashi,I.,
            Wada,H., Akamime,A. and Sakai,H.
  TITLE     Detection of differentially expressed genes in the early
            developmental stage of the mouse mandible
  JOURNAL   Int J Dev Biol 45 (4), 675-680 (2001)
   PUBMED   11461004
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124828.14.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU515267.1, SRR7345562.2263929.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               AC124828.14        62346-62813
            469-547             AC124828.14        63257-63335
            548-609             AC124828.14        63521-63582
            610-722             AC124828.14        64065-64177
            723-873             AC124828.14        64637-64787
            874-2042            AC124828.14        64937-66105
FEATURES             Location/Qualifiers
     source          1..2042
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 86.5 cM"
     gene            1..2042
                     /gene="Rpl21"
                     /gene_synonym="8430440E03Rik; L21"
                     /note="ribosomal protein L21"
                     /db_xref="GeneID:19933"
                     /db_xref="MGI:MGI:1278340"
     exon            1..468
                     /gene="Rpl21"
                     /gene_synonym="8430440E03Rik; L21"
                     /inference="alignment:Splign:2.1.0"
     exon            469..547
                     /gene="Rpl21"
                     /gene_synonym="8430440E03Rik; L21"
                     /inference="alignment:Splign:2.1.0"
     CDS             481..963
                     /gene="Rpl21"
                     /gene_synonym="8430440E03Rik; L21"
                     /EC_number="3.6.5.3"
                     /note="60S ribosomal protein L21"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL21"
                     /protein_id="NP_001395918.1"
                     /db_xref="GeneID:19933"
                     /db_xref="MGI:MGI:1278340"
                     /translation="MTNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKG
                     MGTVQKGMPHKCYHGKTGRVYNVTQHAVGIIVNKQVKGKILAKRINVRIEHIKHSKSR
                     DSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELLEPIPYEFMA
                     "
     exon            548..609
                     /gene="Rpl21"
                     /gene_synonym="8430440E03Rik; L21"
                     /inference="alignment:Splign:2.1.0"
     exon            610..722
                     /gene="Rpl21"
                     /gene_synonym="8430440E03Rik; L21"
                     /inference="alignment:Splign:2.1.0"
     exon            723..873
                     /gene="Rpl21"
                     /gene_synonym="8430440E03Rik; L21"
                     /inference="alignment:Splign:2.1.0"
     exon            874..2042
                     /gene="Rpl21"
                     /gene_synonym="8430440E03Rik; L21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      976..981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpl21"
                     /gene_synonym="8430440E03Rik; L21"
                     /note="hexamer: AATAAA"
     polyA_site      1015
                     /gene="Rpl21"
                     /gene_synonym="8430440E03Rik; L21"
                     /note="major polyA site"
     regulatory      2019..2024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpl21"
                     /gene_synonym="8430440E03Rik; L21"
                     /note="hexamer: ATTAAA"
     polyA_site      2042
                     /gene="Rpl21"
                     /gene_synonym="8430440E03Rik; L21"
ORIGIN      
        1 aggtcactgc cctgggcggt gtatgctagg gagcttctat ccgggggagc cgggcctggc
       61 gcagtcttgg ttgccgggcg tccgcccaac cccagacttg agcatgtgct gtcgggctgg
      121 gacttaggat tctgcttggg tcttaacgat gccggggtgc cgaagcctgg aattggctcg
      181 ggcgaggagg gtgcccgccg ggtcagcctg gtaatgatgt aatggggacc cttcctctgg
      241 atacatgaaa cacttaggaa ttttggccct agaagacgag cgtggggaag gaaggtaaca
      301 ttaaggctgc ttaagactac aagggcaagg ggttatgtct agtacaccat gctttggagc
      361 ttcccttgtg gttaggaatg gcgggtattt ctgccctgga tgactggagt aatccaaacc
      421 ttgttggttt gtgggaatac acgatctggt tctaaatatg tgtagtagta actcgccaaa
      481 atgacgaaca caaagggaaa gaggagaggc acccggtaca tgttctctag gccttttagg
      541 aaacatggcg ttgttccttt ggccacatac atgcgaatct acaagaaggg tgatattgta
      601 gacatcaagg gaatgggcac tgttcaaaaa ggaatgcccc ataagtgcta ccacggcaaa
      661 accggaagag tctacaatgt cacccagcat gccgtgggca tcattgtcaa caagcaggtt
      721 aagggcaaaa ttctggccaa gaggatcaat gtgcggattg agcacatcaa gcactcaaag
      781 agcagagaca gcttcctgaa gcgggtgaag gagaatgacc agaagaaaaa ggaagccaaa
      841 gagaagggca cctgggtgca gctgaagcgc cagcctgcgc cacccagaga agcacacttt
      901 gtgaggacta atggaaaaga gcctgagctg ttggagccca ttccatacga attcatggcc
      961 taatgtacac aaagaaataa aataccagca ccaggactgt gaagtgtttt ccttagactg
     1021 tagtgtgggg tttgctcatt ggctttcttg ttcagatttt actaattgtt ctaaatgata
     1081 cagcttagtg tgcagaaaat atcctcttga ttggaaaata gccaaatatt tacaaaacag
     1141 gtatactagt ttgaagaggc tctatatggg gggagggggt gctggaaaac attagtgggt
     1201 gaccagtaat ggtggtacag ctctaactcc tagcaccagg agtccgaggc agggggatct
     1261 tcaggctgca tgatgtgcat agtagcatgc tggtattagg gagtgggtat ctgtggttcc
     1321 cactttgaaa ataaccaaaa ttctccaaag tgggcagacc taagccagga gagggctggc
     1381 cacagacatt tggtactgct tgctgagaaa gcactgattg ttttcctaac ctaaagatta
     1441 tatatggccc accataccat ctttgaaaca atgtgtactg gcctttggtt cacctttctt
     1501 gtctttgaag ttgtacttgg tgggtgcatt taaccttgcc acagagtggg gaggatagag
     1561 tctaatggac cttaagtggt ctctggtggc catgtcggca gtgcttaggt tgtagcccag
     1621 ggttggagtc ggcagtgaca agcaaataac tatattcttg cttgctgtgg cagctataca
     1681 gaaatttacg gtataggtaa gagggttctc tagaagtact acctgtctta gtgaaagaga
     1741 ttgcttggtt aacatcctgt tatgtagtgg ggctactttt aaactgtgtg aagtccccat
     1801 tagccacctc cataggcaat ggagctaaca ttcttgctac agtggccgca gctcattaac
     1861 acctaatgat gtgtttaaca tgtgtccaca tggtgtgaat gtgggtacgc atgtgcccag
     1921 tattcagttc acagaattgt catcatcttc catcatgtct tcagtgaggg actctgcaga
     1981 tgcccacccc agtccttggt tgtggtgatt ctgttagcat taaatgcact ggagagcttc
     2041 aa
//
