LOCUS       NM_009076                643 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus ribosomal protein L12 (Rpl12), mRNA.
ACCESSION   NM_009076
VERSION     NM_009076.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 643)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 643)
  AUTHORS   Li,H., Huo,Y., He,X., Yao,L., Zhang,H., Cui,Y., Xiao,H., Xie,W.,
            Zhang,D., Wang,Y., Zhang,S., Tu,H., Cheng,Y., Guo,Y., Cao,X.,
            Zhu,Y., Jiang,T., Guo,X., Qin,Y. and Sha,J.
  TITLE     A male germ-cell-specific ribosome controls male fertility
  JOURNAL   Nature 612 (7941), 725-731 (2022)
   PUBMED   36517592
REFERENCE   3  (bases 1 to 643)
  AUTHORS   Gregorio,I., Mereu,M., Contarini,G., Bello,L., Semplicini,C.,
            Burgio,F., Russo,L., Sut,S., Dall'Acqua,S., Braghetta,P.,
            Semenza,C., Pegoraro,E., Papaleo,F., Bonaldo,P. and Cescon,M.
  TITLE     Collagen VI deficiency causes behavioral abnormalities and cortical
            dopaminergic dysfunction
  JOURNAL   Dis Model Mech 15 (9) (2022)
   PUBMED   35946603
REFERENCE   4  (bases 1 to 643)
  AUTHORS   Basta,J.M., Singh,A.P., Robbins,L., Stout,L., Pherson,M. and
            Rauchman,M.
  TITLE     The core SWI/SNF catalytic subunit Brg1 regulates nephron
            progenitor cell proliferation and differentiation
  JOURNAL   Dev Biol 464 (2), 176-187 (2020)
   PUBMED   32504627
REFERENCE   5  (bases 1 to 643)
  AUTHORS   Oliver,K.E., Rauscher,R., Mijnders,M., Wang,W., Wolpert,M.J.,
            Maya,J., Sabusap,C.M., Kesterson,R.A., Kirk,K.L., Rab,A.,
            Braakman,I., Hong,J.S., Hartman,J.L. 4th, Ignatova,Z. and
            Sorscher,E.J.
  TITLE     Slowing ribosome velocity restores folding and function of mutant
            CFTR
  JOURNAL   J Clin Invest 129 (12), 5236-5253 (2019)
   PUBMED   31657788
  REMARK    GeneRIF: suppression of RPL12 rescues F508del CFTR protein
            synthesis and activity
REFERENCE   6  (bases 1 to 643)
  AUTHORS   Kondrashov,N., Pusic,A., Stumpf,C.R., Shimizu,K., Hsieh,A.C.,
            Ishijima,J., Shiroishi,T. and Barna,M.
  TITLE     Ribosome-mediated specificity in Hox mRNA translation and
            vertebrate tissue patterning
  JOURNAL   Cell 145 (3), 383-397 (2011)
   PUBMED   21529712
REFERENCE   7  (bases 1 to 643)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 643)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   9  (bases 1 to 643)
  AUTHORS   Plafker,S.M. and Macara,I.G.
  TITLE     Ribosomal protein L12 uses a distinct nuclear import pathway
            mediated by importin 11
  JOURNAL   Mol Cell Biol 22 (4), 1266-1275 (2002)
   PUBMED   11809816
REFERENCE   10 (bases 1 to 643)
  AUTHORS   Hou,E.W. and Li,S.S.
  TITLE     Sequence analysis of mouse cDNAs encoding ribosomal proteins L12
            and L18
  JOURNAL   Gene 130 (2), 287-290 (1993)
   PUBMED   8359697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY295120.1, AK151592.1 and AA267752.1.
            
            On Nov 15, 2007 this sequence version replaced NM_009076.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB840362.1, BU525700.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BY295120.1         2-3
            3-635               AK151592.1         2-634
            636-643             AA267752.1         218-225
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..643
                     /gene="Rpl12"
                     /gene_synonym="E430018F03"
                     /note="ribosomal protein L12"
                     /db_xref="GeneID:269261"
                     /db_xref="MGI:MGI:98002"
     exon            1..128
                     /gene="Rpl12"
                     /gene_synonym="E430018F03"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..589
                     /gene="Rpl12"
                     /gene_synonym="E430018F03"
                     /note="60S ribosomal protein L12"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL11"
                     /protein_id="NP_033102.2"
                     /db_xref="CCDS:CCDS15936.1"
                     /db_xref="GeneID:269261"
                     /db_xref="MGI:MGI:98002"
                     /translation="MPPKFDPNEVKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGD
                     DIAKATGDWKGLRITVKLTIQNRQAQIEVVPSASALIIKALKEPPRDRKKQKNIKHSG
                     NITFDEIVNIARQMRHRSLARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAV
                     ECPAS"
     exon            129..202
                     /gene="Rpl12"
                     /gene_synonym="E430018F03"
                     /inference="alignment:Splign:2.1.0"
     exon            203..301
                     /gene="Rpl12"
                     /gene_synonym="E430018F03"
                     /inference="alignment:Splign:2.1.0"
     exon            302..383
                     /gene="Rpl12"
                     /gene_synonym="E430018F03"
                     /inference="alignment:Splign:2.1.0"
     exon            384..470
                     /gene="Rpl12"
                     /gene_synonym="E430018F03"
                     /inference="alignment:Splign:2.1.0"
     exon            471..583
                     /gene="Rpl12"
                     /gene_synonym="E430018F03"
                     /inference="alignment:Splign:2.1.0"
     exon            584..638
                     /gene="Rpl12"
                     /gene_synonym="E430018F03"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      596
                     /gene="Rpl12"
                     /gene_synonym="E430018F03"
     regulatory      611..616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpl12"
                     /gene_synonym="E430018F03"
                     /note="hexamer: AATAAA"
     polyA_site      638
                     /gene="Rpl12"
                     /gene_synonym="E430018F03"
                     /note="major polyA site"
ORIGIN      
        1 gtcttttcgg ctttcggctc ggaggaggca acggtgcaac tttcttcggt cgtcccgaat
       61 ccgggttcat ccgacaccag ccgcctccac catgccgccc aagttcgacc ccaacgaggt
      121 caaagtcgtg tacctgaggt gcaccggagg cgaggtcggc gccacatccg ccttggcccc
      181 gaagatcggt cctctgggtc tgtctccgaa gaaagttggc gatgacattg ccaaggctac
      241 cggtgactgg aagggtctca gaattacagt gaaactgacc atccagaaca gacaggccca
      301 gatcgaggtg gtgccttctg cctcagccct gatcatcaaa gccctcaagg agccaccgag
      361 agacaggaag aagcagaaga acattaaaca cagtgggaac attacttttg atgagattgt
      421 caacattgcc cggcagatga gacaccggtc tttggctaga gaactttctg gaactatcaa
      481 ggagatcctg ggtactgcac agtctgtggg ctgcaatgtg gatggccgcc accctcatga
      541 catcatagat gacatcaaca gtggtgcagt ggagtgccca gctagttaag aagcaacaag
      601 aaaatattcc aataaaagac tatctgataa ccagtgaaaa aaa
//
