LOCUS       NM_009075               1789 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ribose 5-phosphate isomerase A (Rpia), mRNA.
ACCESSION   NM_009075
VERSION     NM_009075.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1789)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1789)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1789)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   4  (bases 1 to 1789)
  AUTHORS   Bowman,C.E., Zhao,L., Hartung,T. and Wolfgang,M.J.
  TITLE     Requirement for the Mitochondrial Pyruvate Carrier in Mammalian
            Development Revealed by a Hypomorphic Allelic Series
  JOURNAL   Mol Cell Biol 36 (15), 2089-2104 (2016)
   PUBMED   27215380
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1789)
  AUTHORS   Ciou,S.C., Chou,Y.T., Liu,Y.L., Nieh,Y.C., Lu,J.W., Huang,S.F.,
            Chou,Y.T., Cheng,L.H., Lo,J.F., Chen,M.J., Yang,M.C., Yuh,C.H. and
            Wang,H.D.
  TITLE     Ribose-5-phosphate isomerase A regulates hepatocarcinogenesis via
            PP2A and ERK signaling
  JOURNAL   Int J Cancer 137 (1), 104-115 (2015)
   PUBMED   25429733
  REMARK    GeneRIF: Study provides new insight into the molecular mechanisms
            by which RPIA overexpression can induce oncogenesis in
            hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 1789)
  AUTHORS   Cossette,S.M., Gastonguay,A.J., Bao,X., Lerch-Gaggl,A., Zhong,L.,
            Harmann,L.M., Koceja,C., Miao,R.Q., Vakeel,P., Chun,C., Li,K.,
            Foeckler,J., Bordas,M., Weiler,H., Strande,J., Palecek,S.P. and
            Ramchandran,R.
  TITLE     Sucrose non-fermenting related kinase enzyme is essential for
            cardiac metabolism
  JOURNAL   Biol Open 4 (1), 48-61 (2014)
   PUBMED   25505152
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1789)
  AUTHORS   Poltorak,A., Merlin,T., Nielsen,P.J., Sandra,O., Smirnova,I.,
            Schupp,I., Boehm,T., Galanos,C. and Freudenberg,M.A.
  TITLE     A point mutation in the IL-12R beta 2 gene underlies the IL-12
            unresponsiveness of Lps-defective C57BL/10ScCr mice
  JOURNAL   J Immunol 167 (4), 2106-2111 (2001)
   PUBMED   11489994
REFERENCE   8  (bases 1 to 1789)
  AUTHORS   Apel,T.W., Scherer,A., Adachi,T., Auch,D., Ayane,M. and Reth,M.
  TITLE     The ribose 5-phosphate isomerase-encoding gene is located
            immediately downstream from that encoding murine immunoglobulin
            kappa
  JOURNAL   Gene 156 (2), 191-197 (1995)
   PUBMED   7758956
REFERENCE   9  (bases 1 to 1789)
  AUTHORS   Gumaa,K.A. and McLean,P.
  TITLE     The pentose phosphate pathway of glucose metabolism. Enzyme
            profiles and transient and steady-state content of intermediates of
            alternative pathways of glucose metabolism in Krebs ascites cells
  JOURNAL   Biochem J 115 (5), 1009-1029 (1969)
   PUBMED   5360673
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156398.13, AK137235.1 and CO043650.1.
            
            On May 4, 2006 this sequence version replaced NM_009075.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053526.1, AK137235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               AC156398.13        91799-92088         c
            291-1220            AK137235.1         126-1055
            1221-1789           CO043650.1         1-569               c
FEATURES             Location/Qualifiers
     source          1..1789
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.06 cM"
     gene            1..1789
                     /gene="Rpia"
                     /gene_synonym="RPI"
                     /note="ribose 5-phosphate isomerase A"
                     /db_xref="GeneID:19895"
                     /db_xref="MGI:MGI:103254"
     exon            1..290
                     /gene="Rpia"
                     /gene_synonym="RPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..938
                     /gene="Rpia"
                     /gene_synonym="RPI"
                     /EC_number="5.3.1.6"
                     /note="phosphoriboisomerase"
                     /codon_start=1
                     /product="ribose-5-phosphate isomerase"
                     /protein_id="NP_033101.2"
                     /db_xref="CCDS:CCDS39504.1"
                     /db_xref="GeneID:19895"
                     /db_xref="MGI:MGI:103254"
                     /translation="MQRPGPFSTLYGRVLAPLPGRAGGAASGGGGNNWGLSGSHVQLP
                     GRAHSETRGDKGGSSAGGPAPSTMSKAEEAKKLASHTAVENHVKNNQVLGIGSGSTIV
                     HAVQRIAERVKQENLDLICIPTSFQARQLILQYGLTLSDLDQHPEIDLAIDGADEVDA
                     ELNLIKGGGGCLTQEKIVAGYASRFIVIADFRKDSKNLGDRWHKGIPIEVIPMAYVPV
                     SRAVAQKFGGEVELRMAVNKAGPVVTDNGNFILDWKFDRVHKWSEVNTAIKMTPGVVD
                     TGLFINMAERVYFGMQDGSVNVREKPF"
     exon            291..351
                     /gene="Rpia"
                     /gene_synonym="RPI"
                     /inference="alignment:Splign:2.1.0"
     exon            352..407
                     /gene="Rpia"
                     /gene_synonym="RPI"
                     /inference="alignment:Splign:2.1.0"
     exon            408..467
                     /gene="Rpia"
                     /gene_synonym="RPI"
                     /inference="alignment:Splign:2.1.0"
     exon            468..532
                     /gene="Rpia"
                     /gene_synonym="RPI"
                     /inference="alignment:Splign:2.1.0"
     exon            533..601
                     /gene="Rpia"
                     /gene_synonym="RPI"
                     /inference="alignment:Splign:2.1.0"
     exon            602..743
                     /gene="Rpia"
                     /gene_synonym="RPI"
                     /inference="alignment:Splign:2.1.0"
     exon            744..843
                     /gene="Rpia"
                     /gene_synonym="RPI"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1772
                     /gene="Rpia"
                     /gene_synonym="RPI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1748..1753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpia"
                     /gene_synonym="RPI"
                     /note="hexamer: AATAAA"
     polyA_site      1770
                     /gene="Rpia"
                     /gene_synonym="RPI"
                     /note="major polyA site"
ORIGIN      
        1 cggagaggct ggagcgaggc ggcgggatgc agcgccccgg gcccttcagc accctctacg
       61 ggcgggtcct ggccccactg cccgggcggg ccgggggcgc ggcctcgggc gggggcggga
      121 acaactgggg cctctcgggt tcccacgtgc agttgccggg gcgtgcacat tcggagaccc
      181 gcggcgacaa gggaggctcg agcgcgggcg gcccggcccc ctccacgatg tccaaggccg
      241 aggaggctaa gaagctggcg agccacacgg cggtggagaa ccacgtgaag aataaccaag
      301 tgctgggaat tggaagtggt tctacaattg tccacgctgt gcagcgaata gctgaaagag
      361 tgaagcaaga gaatctggac ctcatctgca tccccacatc tttccaggcc aggcagctta
      421 tcttgcagta tggcttaacc ctcagtgacc tggatcaaca cccagagatt gaccttgcca
      481 tcgatggtgc tgacgaagtg gatgctgagc tcaatctcat caagggtgga ggaggctgcc
      541 tgacccagga gaagatcgtg gctggttatg caagtcgttt cattgtgatt gctgatttca
      601 ggaaagattc aaagaacctc ggggatcggt ggcacaaggg gattcccatt gaagtcatcc
      661 caatggccta cgtcccagtg agccgggctg tggcccagaa gtttgggggt gaggtggaac
      721 ttcgaatggc tgtcaacaag gcagggccag tggtgacgga taacgggaat tttatcctgg
      781 actggaagtt tgaccgggtg cataaatgga gtgaagtgaa cacagctatc aaaatgactc
      841 caggcgtggt ggacacaggc cttttcatca acatggcaga gagagtctac tttgggatgc
      901 aggatggctc agtgaacgtg cgggagaagc ccttctagcc ctgagaggag cagggtcctc
      961 accttgagtc tccagcccag gcacagtgga cacgcctcac caggagcctt tgccttaatg
     1021 taccttcatg tagctgtcca cagtgccaga gtggacggct ggcatgggtg ggtgggtggg
     1081 ggtagtcaaa tccagtctta tgaagtattg ctatgtgtct ttttaaaaag aaatttaaat
     1141 atatatatat ttttactatt aaaatattca gtttttttat aaaatagaac ttgattttat
     1201 gttttatatg aaaccttacc aaaaacaaaa aaaacgtata aataaaaata agagatcagg
     1261 actgtctctg aaagctttga ctggacctgc tggttaacct tctgaagttt tgggtttgct
     1321 gagaaagaac gtttttctaa gctggtgcag gtctcctgat gccttatggg aaaccttgtt
     1381 tactgtttac tttcttgtga cactcttgtg ttttcattgt taccactccc aaatcttagt
     1441 tacattttaa gatcaggtgt agggaattgt gaatggagca gcggggctgt agtgacgtgg
     1501 gtacaaactc caggtgagcg agaatgcacc ttctcttgga tcctggcttg gctttgctcc
     1561 tgctgctgtt ggaagccccc ggtggaagcg gaagcgcctg ctggcagtgc acagcactgt
     1621 ctgagatgtg aagcacttac tttttgttgt ttgaatgttt tctttatgtg aatatcgttt
     1681 tgttcctccg atgacccttg tatgatttgg tatcagaagc tgtcactttg tgctgttcga
     1741 aggttgaaat aaacgttact gtgccatttg gaaaaaaaaa aaaaaaaaa
//
