LOCUS       NM_029548               2135 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus rabphilin 3A-like (without C2 domains) (Rph3al),
            transcript variant 1, mRNA.
ACCESSION   NM_029548 XM_354629
VERSION     NM_029548.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Matsunaga,K., Taoka,M., Isobe,T. and Izumi,T.
  TITLE     Rab2a and Rab27a cooperatively regulate the transition from granule
            maturation to exocytosis through the dual effector Noc2
  JOURNAL   J Cell Sci 130 (3), 541-550 (2017)
   PUBMED   27927751
  REMARK    GeneRIF: These results suggest that the dual effector, Noc2,
            regulates the transition from Rab2a-mediated granule biogenesis to
            Rab27a-mediated granule exocytosis.
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Ogata,S., Miki,T., Seino,S., Tamai,S., Kasai,H. and Nemoto,T.
  TITLE     A novel function of Noc2 in agonist-induced intracellular Ca2+
            increase during zymogen-granule exocytosis in pancreatic acinar
            cells
  JOURNAL   PLoS One 7 (5), e37048 (2012)
   PUBMED   22615885
  REMARK    GeneRIF: In pancreatic acinar cells, Noc2 is not indispensable for
            the membrane fusion of ZG per se, but instead performs a novel
            function favoring agonist-induced physiological [Ca(2+)](i)
            increases.
REFERENCE   3  (bases 1 to 2135)
  AUTHORS   Teramae,H., Fujimoto,W., Seino,S. and Iwanaga,T.
  TITLE     Cellular expression of Noc2, a Rab effector protein, in endocrine
            and exocrine tissues in the mouse
  JOURNAL   Histochem Cell Biol 127 (1), 1-11 (2007)
   PUBMED   16835753
  REMARK    GeneRIF: investigated localization of Noc2 immunohistochemically in
            various endocrine and exocrine tissues in normal mice, including
            pancreatic islets, the adrenal gland, pituitary gland, salivary
            gland, and thyroid gland
REFERENCE   4  (bases 1 to 2135)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   5  (bases 1 to 2135)
  AUTHORS   Matsumoto,M., Miki,T., Shibasaki,T., Kawaguchi,M., Shinozaki,H.,
            Nio,J., Saraya,A., Koseki,H., Miyazaki,M., Iwanaga,T. and Seino,S.
  TITLE     Noc2 is essential in normal regulation of exocytosis in endocrine
            and exocrine cells
  JOURNAL   Proc Natl Acad Sci U S A 101 (22), 8313-8318 (2004)
   PUBMED   15159548
  REMARK    GeneRIF: Results show that Noc2, a critical effector of Rab3, is
            essential in normal regulation of exocytosis in both endocrine and
            exocrine cells.
REFERENCE   6  (bases 1 to 2135)
  AUTHORS   Fukuda,M., Kanno,E. and Yamamoto,A.
  TITLE     Rabphilin and Noc2 are recruited to dense-core vesicles through
            specific interaction with Rab27A in PC12 cells
  JOURNAL   J Biol Chem 279 (13), 13065-13075 (2004)
   PUBMED   14722103
REFERENCE   7  (bases 1 to 2135)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   8  (bases 1 to 2135)
  AUTHORS   Leenders,A.G., Lopes da Silva,F.H., Ghijsen,W.E. and Verhage,M.
  TITLE     Rab3a is involved in transport of synaptic vesicles to the active
            zone in mouse brain nerve terminals
  JOURNAL   Mol Biol Cell 12 (10), 3095-3102 (2001)
   PUBMED   11598194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV660756.1, DV651301.1, AA616014.1, AI594476.1, BU610075.1,
            BQ176035.1 and BX631599.1.
            
            On Mar 27, 2014 this sequence version replaced NM_029548.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB158403.1, BC127960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-636               DV660756.1         93-728
            637-791             DV651301.1         484-638
            792-869             DV651301.1         640-717
            870-1024            AA616014.1         73-227
            1025-1181           AI594476.1         228-384
            1182-1771           BU610075.1         29-618
            1772-2121           BQ176035.1         18-367              c
            2122-2135           BX631599.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..2135
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.92 cM"
     gene            1..2135
                     /gene="Rph3al"
                     /gene_synonym="Gm1753; Noc2"
                     /note="rabphilin 3A-like (without C2 domains)"
                     /db_xref="GeneID:380714"
                     /db_xref="MGI:MGI:1923492"
     exon            1..110
                     /gene="Rph3al"
                     /gene_synonym="Gm1753; Noc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..942
                     /gene="Rph3al"
                     /gene_synonym="Gm1753; Noc2"
                     /note="isoform 1 is encoded by transcript variant 1; rab
                     effector Noc2; no C2 domains protein; rabphilin-3A-like
                     protein"
                     /codon_start=1
                     /product="rab effector Noc2 isoform 1"
                     /protein_id="NP_083824.1"
                     /db_xref="CCDS:CCDS25058.1"
                     /db_xref="GeneID:380714"
                     /db_xref="MGI:MGI:1923492"
                     /translation="MADTIFSSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRS
                     QCLSPGELEIILQVIQRAERLDILEQQRIGRLVERLETMQRNVMGNGLSQCLLCGEVL
                     GFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLP
                     KYILPLKTPGRADDPHFRPLPVEPTETQPPSAETSRVYTWARGRVVSSDSDSDSDLSS
                     SSLEDRPLPSGVKGTKGDKPRGDSGASMESPRLGPARPPSHLSGSQSSLGSEAGTGAT
                     EPQGGTPAQPEPRVPGKRHTWATPRY"
     exon            111..254
                     /gene="Rph3al"
                     /gene_synonym="Gm1753; Noc2"
                     /inference="alignment:Splign:2.1.0"
     exon            255..384
                     /gene="Rph3al"
                     /gene_synonym="Gm1753; Noc2"
                     /inference="alignment:Splign:2.1.0"
     exon            385..471
                     /gene="Rph3al"
                     /gene_synonym="Gm1753; Noc2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..646
                     /gene="Rph3al"
                     /gene_synonym="Gm1753; Noc2"
                     /inference="alignment:Splign:2.1.0"
     exon            647..760
                     /gene="Rph3al"
                     /gene_synonym="Gm1753; Noc2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..907
                     /gene="Rph3al"
                     /gene_synonym="Gm1753; Noc2"
                     /inference="alignment:Splign:2.1.0"
     exon            908..2130
                     /gene="Rph3al"
                     /gene_synonym="Gm1753; Noc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1538..1543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rph3al"
                     /gene_synonym="Gm1753; Noc2"
                     /note="hexamer: ATTAAA"
     polyA_site      1568
                     /gene="Rph3al"
                     /gene_synonym="Gm1753; Noc2"
                     /note="major polyA site"
     regulatory      2095..2100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rph3al"
                     /gene_synonym="Gm1753; Noc2"
                     /note="hexamer: AATAAA"
     polyA_site      2121
                     /gene="Rph3al"
                     /gene_synonym="Gm1753; Noc2"
                     /note="major polyA site"
ORIGIN      
        1 atgtgactcc tgccctgggc tgtgctcccc gtcatggctg acaccatctt cagcagtgga
       61 aatgatcagt gggtttgccc caacgatcgg cagcttgctc tgagagccaa gctgcagacg
      121 ggctggtctg tgcacacgta ccagacggag aagcagagga ggagccagtg cctgagcccc
      181 ggagagctgg agatcatcct tcaggtcatc cagagagcag agaggctaga catcctggag
      241 cagcagagaa ttgggcggct ggtggagcgg ctggagacaa tgcagaggaa cgtgatgggc
      301 aacggtctct cccagtgtct gctctgcggg gaggtgctgg gattcctggg cagctcctcc
      361 gtattctgca aagactgcag gaagaaagtc tgcaccaagt gtgggatcga ggcttccccc
      421 ggccagaagc ggcccctgtg gctgtgtaag atctgcagtg agcagagaga ggtctggaag
      481 aggtcagggg cctggttcta caaagggctc cccaagtaca tcttgcccct gaaaacccct
      541 ggccgggctg atgatcccca cttccgacct ctgcctgtgg agcccacaga aacacagcct
      601 ccgagtgctg aaaccagccg tgtctacaca tgggcccgag ggagagtggt ttccagtgac
      661 agtgacagtg actcagatct cagctcctcc agcctggagg acagaccctt gccctctggg
      721 gtcaagggca caaaaggtga caagcctaga ggggactcag gtgccagcat ggagtcaccc
      781 aggctggggc ctgcccgtcc acccagccat ctctcgggca gtcagagcag cctaggcagt
      841 gaggctggga caggtgctac agagccacag ggaggcaccc cagcccagcc tgagcccagg
      901 gtacccggca aaagacacac atgggcaact ccccgctact gaagtggcca gctgacatct
      961 ccaggctgag gcaaactctt ccagaggaag attcagagag ggacaacggg gccagcctcg
     1021 cagagcgccc ctctgaaggt tcttgaggct tcccaagctc cttgatacct tgacgtgcta
     1081 ctcaacaagc cagtgtttgg ggactgagca tgcttgcccc caccctgtca tgccttatcg
     1141 actatctcac tcagcacccc acctttattt attgttcttc tcccatccca gtcacatctc
     1201 tatttgcttg ggtcttgggt tgggctgaga aggccttcct atatgcactg aagtttgggt
     1261 gggaccacac agggctttct tggtactaat gatgagaaac ctaaccctca gtgtgaccct
     1321 gtagagctga gcaacccacc cccgccccca cccccagtgt tagcctggag cacccacccc
     1381 tttccctctt ccttcaactg ttggaggcca gaacagggtc ctatttgccc cgaggcttgt
     1441 ccaggagctg agttaaatcc agctttgagg tttccctgaa gccccctatt ggcctctggg
     1501 tttttgttcc accctgaaac acagcttcct ctaagacatt aaagcgcttt ttgttcttca
     1561 gtggaaaaca aggctcccac cctgcctcat gcttgctggc cctgcctggg agtttcaaat
     1621 tctgaaaaaa atactcaaaa tacagaaaaa tacagatgcc tctgggaaac ccctccctgg
     1681 ggtggggagg tgtccaatgc ccttccttcc ctgaggccag ttccatccct cctgaccagt
     1741 cccttcgtcc ttggagggct ttctctccaa gcccaccacc gttaaccttt tgcctgttgc
     1801 tgctggcaga agacaaactt accatgtccc tgtgacacgt aacccatcag cactaacatt
     1861 ataaacacga gaattttcac acggagtctc tctctcttcc aaagaccaca atccccacgc
     1921 tccgacctgt gttgggaaag cggtggatgg attgaaatag gtagcgccaa ttcactgaaa
     1981 cctttctaaa gcctgagcaa gagaaaccag ccagatcagt gtctcagtgc acctcccaac
     2041 cctaacacta aatcaagtcc atctatacag aaaaactaat caaaatgggt cctaaataaa
     2101 cctacttctg gctacatgtg atagactggg aaaaa
//
