LOCUS       NM_011286               4163 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus rabphilin 3A (Rph3a), transcript variant 1, mRNA.
ACCESSION   NM_011286
VERSION     NM_011286.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4163)
  AUTHORS   Sekine,Y., Kannan,R., Wang,X. and Strittmatter,S.M.
  TITLE     Rabphilin3A reduces integrin-dependent growth cone signaling to
            restrict axon regeneration after trauma
  JOURNAL   Exp Neurol 353, 114070 (2022)
   PUBMED   35398339
REFERENCE   2  (bases 1 to 4163)
  AUTHORS   Bourgeois-Jaarsma,Q., Miaja Hernandez,P. and Groffen,A.J.
  TITLE     Ca2+ sensor proteins in spontaneous release and synaptic
            plasticity: Limited contribution of Doc2c, rabphilin-3a and
            synaptotagmin 7 in hippocampal glutamatergic neurons
  JOURNAL   Mol Cell Neurosci 112, 103613 (2021)
   PUBMED   33753311
  REMARK    GeneRIF: Ca(2+) sensor proteins in spontaneous release and synaptic
            plasticity: Limited contribution of Doc2c, rabphilin-3a and
            synaptotagmin 7 in hippocampal glutamatergic neurons.
REFERENCE   3  (bases 1 to 4163)
  AUTHORS   Ren,C., Yuan,Q., Jian,X., Randazzo,P.A., Tang,W. and Wu,D.
  TITLE     Small GTPase ARF6 Is a Coincidence-Detection Code for RPH3A
            Polarization in Neutrophil Polarization
  JOURNAL   J Immunol 204 (4), 1012-1021 (2020)
   PUBMED   31924649
  REMARK    GeneRIF: Small GTPase ARF6 Is a Coincidence-Detection Code for
            RPH3A Polarization in Neutrophil Polarization.
REFERENCE   4  (bases 1 to 4163)
  AUTHORS   Qin,L., Ahn,K.J., Wine Lee,L., de Charleroy,C. Jr. and
            Crenshaw,E.B. 3rd.
  TITLE     Analyses with double knockouts of the Bmpr1a and Bmpr1b genes
            demonstrate that BMP signaling is involved in the formation of
            precerebellar mossy fiber nuclei derived from the rhombic lip
  JOURNAL   PLoS One 14 (12), e0226602 (2019)
   PUBMED   31869353
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4163)
  AUTHORS   Avagliano Trezza,R., Sonzogni,M., Bossuyt,S.N.V., Zampeta,F.I.,
            Punt,A.M., van den Berg,M., Rotaru,D.C., Koene,L.M.C., Munshi,S.T.,
            Stedehouder,J., Kros,J.M., Williams,M., Heussler,H., de
            Vrij,F.M.S., Mientjes,E.J., van Woerden,G.M., Kushner,S.A.,
            Distel,B. and Elgersma,Y.
  TITLE     Loss of nuclear UBE3A causes electrophysiological and behavioral
            deficits in mice and is associated with Angelman syndrome
  JOURNAL   Nat Neurosci 22 (8), 1235-1247 (2019)
   PUBMED   31235931
REFERENCE   6  (bases 1 to 4163)
  AUTHORS   Ozaki,N., Shibasaki,T., Kashima,Y., Miki,T., Takahashi,K., Ueno,H.,
            Sunaga,Y., Yano,H., Matsuura,Y., Iwanaga,T., Takai,Y. and Seino,S.
  TITLE     cAMP-GEFII is a direct target of cAMP in regulated exocytosis
  JOURNAL   Nat Cell Biol 2 (11), 805-811 (2000)
   PUBMED   11056535
REFERENCE   7  (bases 1 to 4163)
  AUTHORS   Fenster,S.D., Chung,W.J., Zhai,R., Cases-Langhoff,C., Voss,B.,
            Garner,A.M., Kaempf,U., Kindler,S., Gundelfinger,E.D. and
            Garner,C.C.
  TITLE     Piccolo, a presynaptic zinc finger protein structurally related to
            bassoon
  JOURNAL   Neuron 25 (1), 203-214 (2000)
   PUBMED   10707984
REFERENCE   8  (bases 1 to 4163)
  AUTHORS   Schluter,O.M., Schnell,E., Verhage,M., Tzonopoulos,T., Nicoll,R.A.,
            Janz,R., Malenka,R.C., Geppert,M. and Sudhof,T.C.
  TITLE     Rabphilin knock-out mice reveal that rabphilin is not required for
            rab3 function in regulating neurotransmitter release
  JOURNAL   J Neurosci 19 (14), 5834-5846 (1999)
   PUBMED   10407024
REFERENCE   9  (bases 1 to 4163)
  AUTHORS   Ostermeier,C. and Brunger,A.T.
  TITLE     Structural basis of Rab effector specificity: crystal structure of
            the small G protein Rab3A complexed with the effector domain of
            rabphilin-3A
  JOURNAL   Cell 96 (3), 363-374 (1999)
   PUBMED   10025402
REFERENCE   10 (bases 1 to 4163)
  AUTHORS   Inagaki,N., Mizuta,M. and Seino,S.
  TITLE     Cloning of a mouse Rabphilin-3A expressed in hormone-secreting
            cells
  JOURNAL   J Biochem 116 (2), 239-242 (1994)
   PUBMED   7822236
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU067470.1 and BC042585.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_011286.4.
            
            On Oct 11, 2014 this sequence version replaced NM_011286.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042585.1, AB112924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AU067470.1         1-20
            21-4163             BC042585.1         1-4143
FEATURES             Location/Qualifiers
     source          1..4163
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 61.17 cM"
     gene            1..4163
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /note="rabphilin 3A"
                     /db_xref="GeneID:19894"
                     /db_xref="MGI:MGI:102788"
     exon            1..301
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            302..417
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            418..494
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..2481
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /note="exophilin-1; Doc2 family"
                     /codon_start=1
                     /product="rabphilin-3A"
                     /protein_id="NP_035416.1"
                     /db_xref="CCDS:CCDS39246.1"
                     /db_xref="GeneID:19894"
                     /db_xref="MGI:MGI:102788"
                     /translation="MTDTVVNRWMYPGDGPLQSNDKEQLQAGWSVHPGAQTDRQRKQE
                     ELTDEEKEIINRVIARAEKMEAMEQERIGRLVDRLETMRKNVAGDGVNRCILCGEQLG
                     MLGSACVVCEDCKKNVCTKCGVETSNNRPHPVWLCKICLEQREVWKRSGAWFFKGFPK
                     QVLPQPMPIKKTKPQQPAGEPATQEQPTPESRHPARAPARGDMEDRRPPGQKPGPDLT
                     SAPGRGSHGPPTRRASEARMSTAARDSEGWDHAHGGGTGDTSRSPAGLRRANSVQAAR
                     PAPAPVPSPAPPQPVQPGPPGGSRATPGPGRFPEQSTEAPPSDPGYPGAVAPAREERT
                     GPAGGFQAAPHTAAPYSQAAPARQPPPAEEEEEEANSYDSDEATTLGALEFSLLYDQD
                     NSNLQCTIIRAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPVWNETL
                     QYHGITEEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKANQRKNFNICLERVIP
                     MKRAGTTGSARGMALYEEEQVERIGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAA
                     MDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDI
                     SVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD"
     exon            495..506
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            507..653
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            654..783
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            784..870
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1036
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1075
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1228
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1315
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1375
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1567
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1647
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1722
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1832
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1959
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2016
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2171
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2253
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2350
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..4150
                     /gene="Rph3a"
                     /gene_synonym="2900002P20Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaatgcatc gcggtgggag gcaagctggg ctcccctgct ccgccgggaa gcggctgccc
       61 ctccctctgg atcacacagg gttcttgcag taggtgacag caggatcggg caccagggaa
      121 gcaattgatt cgtctcttac ccgcatccca gagttgccta cgctgcccag agagggagag
      181 aggaaagaga agaagggaga gaaagaaaga gacttacaaa accttccatg tggagtagtc
      241 tgggtgattc gctgcccacc gctgcagact ctagctgcac ttagttttcg cctctgacgg
      301 ggcatatctg ctgttctttc aagccaagtc gctgggactt aacacctccc ccccccccca
      361 gcagggagtt ggcaagaatt tggctcccgt attctgctgc aatcctctac tgtcccggtg
      421 tgccagcctt ccaccatgac tgacactgtg gtgaaccgat ggatgtaccc tggtgatggc
      481 cctctgcagt caaatgacaa ggaacagctg caggcaggat ggtccgtcca tcctggagca
      541 cagaccgaca ggcagaggaa gcaggaagaa ctgacagacg aggagaagga gatcatcaac
      601 agagtgattg ctcgggcaga gaagatggaa gccatggaac aggaacgcat tgggcgcctg
      661 gtggaccgtc tggagaccat gaggaagaat gtggctggag atggcgtgaa ccgctgcatt
      721 ctgtgtgggg aacagctggg tatgctgggc tcggcctgtg tcgtgtgtga agactgtaag
      781 aagaatgtct gcaccaagtg tggggttgag acctccaaca accgtccgca tccggtatgg
      841 ctctgcaaga tctgccttga gcagagagag gtctggaagc gctcaggagc atggttcttc
      901 aaaggtttcc ccaagcaggt ccttccacag cccatgccta taaagaagac caagccccag
      961 cagcctgctg gtgaaccggc cacccaggag cagcctacac ctgagtccag gcatccagcc
     1021 agggctccag ctcgaggtga catggaggac aggaggcccc cagggcagaa gccaggccct
     1081 gacctcacct ctgctcctgg gagaggaagc catgggcctc ccacgcgtag ggcctctgag
     1141 gcacggatga gtacagccgc ccgggattct gagggctggg accatgccca tggtgggggt
     1201 actggagaca ccagccgtag cccagcaggt ttgaggcgag ctaactcagt ccaggcagcc
     1261 cgccctgccc cagccccagt gccaagccca gcacctcctc agccggtgca gccagggccc
     1321 cctgggggca gcagggccac tcctgggcca ggacgctttc cggagcagag cacagaggct
     1381 cctccaagtg accctggcta tccaggggct gtcgccccag cccgagagga gaggacagga
     1441 cctgcggggg gcttccaggc agcgccgcac actgcagccc cctattccca ggcagcccct
     1501 gctcgccagc caccacctgc ggaggaggag gaggaagaag ccaatagtta tgactctgat
     1561 gaagcaacca cactgggtgc cctggaattc agccttctct atgaccaaga caacagcaac
     1621 ctgcagtgca ccatcatcag ggcgaaggga ctgaagccca tggattccaa tggcttggca
     1681 gatccctatg tgaagcttca tctgctgcct ggagccagca agtccaacaa gcttcgtaca
     1741 aagaccctgc gcaacactcg gaaccctgtg tggaatgaga cactgcagta tcatggcatt
     1801 acagaggagg acatgcagag gaagacacta aggatctccg tgtgtgacga ggacaagttt
     1861 ggccacaacg agttcattgg tgagaccagg ttctcgctca agaagctgaa ggctaaccag
     1921 aggaaaaact tcaacatctg cctggagcgg gtgatcccga tgaagagagc agggaccacc
     1981 gggtcggccc gtggcatggc tctctatgag gaggagcagg tagagcggat cggcgatata
     2041 gaggaacggg gcaagatcct ggtgtccctc atgtacagca cgcagcaggg cggcctcatt
     2101 gtgggaatca tccgctgtgt gcacctggcc gccatggatg ccaacggcta ctcagacccc
     2161 tttgtcaagc tctggctgaa accggacatg gggaagaaag ccaagcacaa gactcagatt
     2221 aaaaagaaga ccctgaatcc cgagtttaac gaggagttct tttatgatat caaacacagc
     2281 gacctggcta aaaagtccct ggatatctcg gtgtgggact acgacattgg caagtctaat
     2341 gattacatcg gaggctgcca gctggggatc tcggccaaag gcgagcgctt gaaacattgg
     2401 tatgagtgtt tgaagaacaa agacaagaag attgagcgct ggcaccaact gcagaacgag
     2461 aaccacgtgt ccagtgatta ggacctggtg ccctggtgtc ccctgtctct gccccagccg
     2521 ctctcccctt tcagagcctc ccctgccaac tatgaacctt tcatgtctcc cccacttcag
     2581 gtcctgctac agaagaagaa tctctgggct tcagggtctg gatgtgagcc ctctctggtc
     2641 cccagaggtt gggtagtggg tgtggggaga catttacaaa gagatttact ctgaccttaa
     2701 gcatcttcag gtccccttgg gcactggtga acccataggt tgtaaggacc aggaggaggg
     2761 cagaaattat acattgaggc tgcctctgtc catccaaagc actccaggaa gaaaaaaaaa
     2821 aaggagagag agagagagag agagacagag agagacagag acagagacag agagacagag
     2881 agagagagac agatagatac acacacccat cctctctagg cacaccagga actagataca
     2941 gagaatacac agagggcctg cccctccccc accctttcag gaagctgtcc attggcttcc
     3001 tagtaaaact aacttcctcc ttgctccttg ctcatcttat cagtacctcc tcacccaccc
     3061 tccctcccct cccctcttct cccacctcca cagtggggga tgcaaggcag agcctcccca
     3121 tgtgcccctt gccagcctgg ccagcaacct cccaagctgg atgaagctgg gccccacatc
     3181 tctgacatta acacatctcc cattggcatg gctggctatc tttgagcctg gggcccgcag
     3241 ctggcacagc ctgggtgcat ggcagcacta tagatatcct gagaaacagg atctctcttt
     3301 ctcatccctg gctccccaaa tgggcacagg tggcacggag ctctgtgtat gaggggactt
     3361 gctcctggac cccatgcttc tatccttcct ctactctttg caaagagcaa aggaccctct
     3421 ccccaaactt ccactcagag ccacctctgt tctgtctacc ttccactctc ttccccgtga
     3481 ttcctggtgg tgatcaaata accgtattta gagctttaat taggtcagaa ctctcttggt
     3541 ccatgacaaa tccagaggaa tgtacacctg aggctggagt caggccatct tcctcacatg
     3601 agaggcaagt ctggtttttc ccatcttgat agttttgccc catcaacatc acaaacccca
     3661 ctactcccta tagcgtcagg cagaccaaga ctaaaaccct cccattccca agtctcacag
     3721 tcttgcttgt tccttccaac atctcttgag atgcaccctg ctctcagtaa ctcgtgctgt
     3781 tcctgaggga ctcttgtgtt tccctgaaat gactctcttc tagaatcagg ctctgcctgc
     3841 cccaaggtgg ctaaccttcc cacttccatg gctcccctgg ttagtcccta taggtctgat
     3901 gctccgccca cttgcccact tccctgtcat ggtcaccttt aggagaaagc atgctggctg
     3961 agtcgcccaa gcctgatgct ggttttggct ctggactcgg aatgcagcct gctcacagcg
     4021 ccctgatgcc ctccgtgaca cacataccca cccctccaca tagaacacaa gtcccccggt
     4081 gcatgcacca tgcccactgc ctttctttgc actgatgtag ccaaaaataa agtaggaata
     4141 tccaaggaaa aaaaaaaaaa aaa
//
