LOCUS       NM_173431               6969 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus Rpgrip1-like (Rpgrip1l), mRNA.
ACCESSION   NM_173431
VERSION     NM_173431.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6969)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6969)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6969)
  AUTHORS   Reissig,L.F., Geyer,S.H., Winkler,V., Preineder,E., Prin,F.,
            Wilson,R., Galli,A., Tudor,C., White,J.K., Mohun,T.J. and
            Weninger,W.J.
  TITLE     Detailed characterizations of cranial nerve anatomy in E14.5 mouse
            embryos/fetuses and their use as reference for diagnosing subtle,
            but potentially lethal malformations in mutants
  JOURNAL   Front Cell Dev Biol 10, 1006620 (2022)
   PUBMED   36438572
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6969)
  AUTHORS   Wiegering,A., Dildrop,R., Vesque,C., Khanna,H.,
            Schneider-Maunoury,S. and Gerhardt,C.
  TITLE     Rpgrip1l controls ciliary gating by ensuring the proper amount of
            Cep290 at the vertebrate transition zone
  JOURNAL   Mol Biol Cell 32 (8), 675-689 (2021)
   PUBMED   33625872
  REMARK    GeneRIF: Rpgrip1l controls ciliary gating by ensuring the proper
            amount of Cep290 at the vertebrate transition zone.
REFERENCE   5  (bases 1 to 6969)
  AUTHORS   Najarro,E.H., Huang,J., Jacobo,A., Quiruz,L.A., Grillet,N. and
            Cheng,A.G.
  TITLE     Dual regulation of planar polarization by secreted Wnts and Vangl2
            in the developing mouse cochlea
  JOURNAL   Development 147 (19) (2020)
   PUBMED   32907846
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6969)
  AUTHORS   Stratigopoulos,G., Padilla,S.L., LeDuc,C.A., Watson,E.,
            Hattersley,A.T., McCarthy,M.I., Zeltser,L.M., Chung,W.K. and
            Leibel,R.L.
  TITLE     Regulation of Fto/Ftm gene expression in mice and humans
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 294 (4), R1185-R1196 (2008)
   PUBMED   18256137
  REMARK    GeneRIF: Examined Fto/Ftm expression in obese mice exposed to
            overfeeding,underfeeding and cold.
            Erratum:[Am J Physiol Regul Integr Comp Physiol. 2008
            Oct;295(4):R1360-3]
REFERENCE   7  (bases 1 to 6969)
  AUTHORS   Delous,M., Baala,L., Salomon,R., Laclef,C., Vierkotten,J., Tory,K.,
            Golzio,C., Lacoste,T., Besse,L., Ozilou,C., Moutkine,I.,
            Hellman,N.E., Anselme,I., Silbermann,F., Vesque,C., Gerhardt,C.,
            Rattenberry,E., Wolf,M.T., Gubler,M.C., Martinovic,J.,
            Encha-Razavi,F., Boddaert,N., Gonzales,M., Macher,M.A., Nivet,H.,
            Champion,G., Bertheleme,J.P., Niaudet,P., McDonald,F.,
            Hildebrandt,F., Johnson,C.A., Vekemans,M., Antignac,C., Ruther,U.,
            Schneider-Maunoury,S., Attie-Bitach,T. and Saunier,S.
  TITLE     The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal
            syndrome (Joubert syndrome type B) and Meckel syndrome
  JOURNAL   Nat Genet 39 (7), 875-881 (2007)
   PUBMED   17558409
  REMARK    GeneRIF: Inactivation of mouse ortholog Rpgrip1l (Ftm)
            recapitulates the cerebral, renal and hepatic defects of
            cerebello-oculo-renal syndrome and Meckel syndrome.
REFERENCE   8  (bases 1 to 6969)
  AUTHORS   Vierkotten,J., Dildrop,R., Peters,T., Wang,B. and Ruther,U.
  TITLE     Ftm is a novel basal body protein of cilia involved in Shh
            signalling
  JOURNAL   Development 134 (14), 2569-2577 (2007)
   PUBMED   17553904
  REMARK    GeneRIF: As Ftm is not essential for cilia assembly but for full
            Shh response, Ftm can be considered as a novel component for
            cilium-related Hh signalling.
REFERENCE   9  (bases 1 to 6969)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   10 (bases 1 to 6969)
  AUTHORS   Peters,T., Ausmeier,K., Dildrop,R. and Ruther,U.
  TITLE     The mouse Fused toes (Ft) mutation is the result of a 1.6-Mb
            deletion including the entire Iroquois B gene cluster
  JOURNAL   Mamm Genome 13 (4), 186-188 (2002)
   PUBMED   11956760
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ344253.1, AK006705.1 and AC139351.4.
            
            On Apr 27, 2007 this sequence version replaced NM_173431.1.
            
            Sequence Note: Although this RefSeq record was created from
            transcript sequence data from multiple strains, its existence in a
            single strain is supported by transcript data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ344253.1, SRR17253011.5867934.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AJ344253.1         41-165
            126-165             AK006705.1         269-308
            166-1572            AJ344253.1         206-1612
            1573-1573           AC139351.4         43946-43946
            1574-2302           AJ344253.1         1614-2342
            2303-2303           AC139351.4         54734-54734
            2304-2416           AJ344253.1         2344-2456
            2417-2417           AC139351.4         57233-57233
            2418-2846           AJ344253.1         2458-2886
            2847-2847           AC139351.4         65141-65141
            2848-3081           AJ344253.1         2888-3121
            3082-3082           AC139351.4         66968-66968
            3083-3704           AJ344253.1         3123-3744
            3705-3705           AC139351.4         96895-96895
            3706-3777           AJ344253.1         3746-3817
            3778-6969           AC139351.4         98050-101241
FEATURES             Location/Qualifiers
     source          1..6969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 44.29 cM"
     gene            1..6969
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /note="Rpgrip1-like"
                     /db_xref="GeneID:244585"
                     /db_xref="MGI:MGI:1920563"
     exon            1..20
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            21..112
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..3822
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /note="fantom; RPGRIP1-like protein; RPGR-interacting
                     protein 1-like protein; nephrocystin-8"
                     /codon_start=1
                     /product="protein fantom"
                     /protein_id="NP_775607.2"
                     /db_xref="CCDS:CCDS22520.1"
                     /db_xref="GeneID:244585"
                     /db_xref="MGI:MGI:1920563"
                     /translation="MSGPSDETAGDLPVKDTGLNLFGVGGLQETSTARTVKTRQAVSR
                     VSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRL
                     GRDVEMEEMIEQLQEKVHELERQNEVLKNRLISAKQQLQVQGHRQTSYSRVQARVNTG
                     RRRASASAGSQECPGKGLRFQNVDEAETVQPTLTKYSNSLLEEARGEIRNLENVIQSQ
                     RGQIEELEHLAEILKTQLKRKENEIELSLLQLREQQATDQRSNIRDNVETIKLHKQLV
                     EKSNALSVIEGKFIQLQEKQRTLRISHDALMANGDELNKQLKEQRLKCCSLEKQLHSV
                     RFSERRVEELQDRINDLEKERELLKENYDKLYNSAFSAAHEEQWKLKEQQMKVQIAQL
                     ETALKSDLTDKTEVLDKLKTERDQNEKLVQENRDLQLQCLQQKQRLHELQSRLKFFNQ
                     ESDINADDLSEALLLIKAQKEQKNGDLSFLEKVDSKINKDLDRSMKELQATHAETVQE
                     LEKTRNMLIMQHKINKDYQMEVETVTQKMENLQQDYELKVEQYVHLLDIRAARIQKLE
                     AQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLRAS
                     GDKELVTFCTYAFYDFELQTTPIVRGLYPEYNFTSQYLVHVNDLFLQYIQKNTVTLEL
                     HQAHSTDYETIAACQLRFHEILEKSGRIFCTTSLVGTKGDIPNFGTVEYWFRLRVPMD
                     QAIRLYRERAKALGYITSNFKKPEKMQLSSQQAATTAQISPAESTDGNLNELHVTVKC
                     CTGLQSRASYLQPHAYVVYKFFDFPDHDTAIVPSSNDPQFDDHMCFPVPMNMDLDRYL
                     KSESLSFYVFDDSDTQENIYMGKVNVPLISLAHDKCISGIFELMDKEKHAAGTIQVIL
                     KWKFTYLPPSGSITTEDLGKFVCREEPEAVQRLPPKSSDVTSVVAPKPKPRQRLTFVD
                     KKVSFADTISHPSPETSPPPKDIKDSSPEVGPKPENGLSAVAYPSKESGVAKVEENVG
                     EMQQGKEDDISFLSEGQLASGSVASSEDETEITEELEPEDEDRSASDSDDCIIPSSVS
                     TNTKQPSEEIRIEIIALNLNDSQITREDTIQRLFIECRFYSLPAEETPMSLPKPQSGQ
                     WVYYNYSNVIYLDKENNPAVRDILKAILQRRELPHRSVRFTVVSDPPEDEQDLECEDI
                     GVAHVDLADLFQKGRDIIEQDIDVLDARTDGGTIGKLKVTVEALHALRSVYEQNRKDL
                     EA"
     exon            113..257
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            258..556
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            557..659
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            660..803
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            804..909
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1056
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1130
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1270
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1377
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1428
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1608
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1726
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..2179
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2331
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2710
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2901
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..2985
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3081
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3235
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3306
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..3490
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            3491..3575
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..3709
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..6969
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6580..6585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /note="hexamer: AAGAAA"
     polyA_site      6598
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /note="major polyA site"
     regulatory      6934..6939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
                     /note="hexamer: AATAAA"
     polyA_site      6963
                     /gene="Rpgrip1l"
                     /gene_synonym="1700047E16Rik; 4931437C01; Ftm; Nphp8"
ORIGIN      
        1 agctgagggc gaacgcggag atagaccatg tctggcccaa gtgacgagac agcaggagac
       61 ctgccggtga aagatacagg tctaaacctc tttggagttg gagggttaca agaaacctca
      121 actgcacgca cagtgaagac tcgccaggca gtgtcacgtg tcagtcgtga agaactggaa
      181 gacagatttt tgcgtttgca tgatgagaac attttactta aacagcatgc ccgcaagcaa
      241 gaggataaaa ttaaaagaat ggccaccaag ttaatacggc tagttaatga caagaaaaga
      301 tatgagcggg ttggtggcgg ccccaagcgg ctgggacgag atgtggaaat ggaagaaatg
      361 attgagcagc tgcaagaaaa agttcatgag cttgaaagac aaaatgaagt tctcaaaaac
      421 aggctgatat cagccaaaca gcagctccaa gtccagggac acaggcagac gtcgtacagt
      481 cgagtgcagg ctcgagttaa caccggccgc cggagagcaa gtgccagtgc aggctcgcag
      541 gaatgccctg ggaaaggtct aagatttcaa aatgtggatg aagcagaaac tgtacaaccc
      601 acgctcacaa aatacagcaa tagtttactt gaagaagcca gaggagaaat aagaaatttg
      661 gaaaatgtta ttcagtcaca gagaggccag atagaagagt tagagcactt ggcagagatc
      721 ctgaaaactc agttgaagag aaaagaaaat gaaatcgagc tatctcttct tcagcttcga
      781 gaacagcagg ctacagatca gaggtcaaat attcgggaca atgtagaaac gattaagctt
      841 cataaacaac tagtggagaa aagcaatgct ctttcagtca tagaaggaaa atttattcag
      901 cttcaagaga agcaaagaac actcaggatc agccatgatg ccttgatggc caatggagat
      961 gagctgaaca agcagcttaa ggagcagcgt ctgaagtgct gcagccttga gaagcagctg
     1021 cactcggtga ggttttcaga aaggagagta gaggagctgc aggatagaat taatgattta
     1081 gaaaaggagc gggaactatt aaaggaaaac tatgataaac tttataacag cgccttcagt
     1141 gctgcccatg aagagcagtg gaagttaaag gagcagcaga tgaaagtgca gattgctcag
     1201 ctcgaaactg ccttaaaatc tgatcttaca gacaaaaccg aagtccttga caaactaaag
     1261 actgaaagag accaaaatga gaaactggtt caagagaata gagatctaca gctgcagtgt
     1321 ctgcagcaaa agcagcggct gcatgagctt cagagccgcc tgaagttctt caaccaggag
     1381 agtgacatca atgctgatga cctcagtgaa gcactcctgc ttataaaggc tcaaaaagaa
     1441 caaaaaaatg gagatctttc atttttagaa aaagtggaca gcaaaatcaa taaagatcta
     1501 gaccgatcca tgaaagagct tcaagcaact catgcagaaa cagtacaaga acttgaaaag
     1561 acaagaaata tgttaattat gcaacataaa ataaataaag actatcagat ggaagttgaa
     1621 acagtgactc agaaaatgga aaatttgcaa caagattatg aactcaaagt ggaacaatat
     1681 gttcatcttc tcgatatcag ggctgcacgc atccaaaagc ttgaagccca gttaaaggat
     1741 attgcctatg gcactaagca gtacaaattt aaaccagaaa tcatgccaga tgactcagtt
     1801 gatgaatttg atgaaaccat ccacctagaa cgaggagaaa atctctttga aatccacatc
     1861 aacaaagtca ccttttcttc tgaagtcctt cgggcatctg gtgataaaga acttgtcact
     1921 ttctgtacct acgctttcta tgactttgaa ctgcagacta ctcccatagt gcgaggcctt
     1981 tacccggagt ataacttcac ttctcagtat ctggtccacg tcaatgactt atttttgcag
     2041 tacattcaga agaacactgt cacgctggag ctccaccaag cccacagcac agattacgaa
     2101 acaattgcag cgtgtcagtt gagattccat gagattctag aaaaaagtgg tagaattttt
     2161 tgcacaacaa gcttagttgg aactaaagga gacatcccaa attttggcac agtagaatac
     2221 tggttccgat taagagttcc catggatcaa gctattcgac tttatcgtga gcgggcaaag
     2281 gcattaggat acataacatc aaattttaag aagccagaga aaatgcaatt gtcgagtcag
     2341 caagcagcca caactgctca gatcagccca gcagagtcca cagacggcaa cttgaatgaa
     2401 cttcatgtta cagtaaaatg ctgcaccggc ctccagtccc gagcgagcta cctgcagcca
     2461 cacgcatatg tggtatacaa gttttttgat tttccagacc atgataccgc catcgttccc
     2521 agtagcaatg acccacagtt tgatgaccac atgtgtttcc cagtgccgat gaatatggat
     2581 ttggatcgct accttaagtc agagtctctg agtttctatg tttttgatga tagtgatacc
     2641 caggagaata tttacatggg aaaagtcaat gtgcctctga tttccctggc acatgacaag
     2701 tgtatctcag gaatatttga gttgatggat aaggaaaagc atgctgcagg aactatccaa
     2761 gttatattga aatggaaatt cacctacctt ccaccaagtg gatcaataac tactgaagac
     2821 cttggaaagt tcgtttgcag agaagaacca gaggctgttc agagactacc tccaaagtcc
     2881 tcagatgtta catcagttgt agcaccaaaa cctaaaccaa gacaacgttt aacatttgtg
     2941 gacaaaaagg tctcttttgc agataccata tcacacccga gtcccgagac ttctcctccc
     3001 cctaaagata taaaagacag ttctccagaa gtgggaccaa aaccagaaaa tggtctgtca
     3061 gctgttgcgt atccttccaa ggaaagcggt gtggctaagg tagaagaaaa tgtgggggaa
     3121 atgcaacaag ggaaagaaga cgacatctct ttcttatctg agggccagct tgcctcagga
     3181 agtgtggctt cctctgaaga tgaaacagaa ataactgaag aattggaacc agaagatgaa
     3241 gacagatcag cttcagacag tgatgactgt atcattccaa gttctgtctc cacaaatacc
     3301 aaacagccat cagaagaaat tcggattgag atcatagctc tgaaccttaa tgattctcaa
     3361 ataaccaggg aggatactat tcagcgactc ttcattgagt gccggttcta cagtcttccc
     3421 gctgaggaga ctcctatgtc cctgcccaaa ccccagagtg gacagtgggt ctactataac
     3481 tattccaatg tgatctacct ggataaagaa aacaacccag cggtgagaga catcttaaaa
     3541 gccatactgc aaaggcgaga actgcctcac agaagtgtgc gcttcaccgt ggtcagtgat
     3601 cctcccgagg acgagcagga cctagaatgt gaggacattg gggttgccca tgttgacctt
     3661 gctgacctgt ttcagaaagg aagagacatc atagagcaag atattgatgt tctcgatgcc
     3721 cgaacagacg gtggcaccat cggcaaactg aaggtgactg tggaagcact tcatgcccta
     3781 cggtctgtct acgagcaaaa tagaaaggac ttggaggcct gaaagaacct gttccagagg
     3841 catccgcttc taagaaaatg ctcgcatgaa agctcaagga tgagattttg agtaatcact
     3901 ctgatgtgtg taatctataa ttcatcggtt gctgggaggg agcgcctggg tttagacttg
     3961 aatgttcaag ttttgtatag gttttgtgtt tgtttatttt tctatccaat cctccccatg
     4021 actgccaccc cataggactt cagtgctcct aagtgggcta ccttatcaat aatttatagc
     4081 aacatgatag catgaagcat ctatttgcat ttgccacatt ttcttatgaa gaactaggag
     4141 tagttcccat ttttattttt cataagtaaa agcctaaaat cttaggaaac caatgaaaaa
     4201 gaaatgcttt ttatgttatc cctaattgtc ccactaaatg gaacgcctct gattagtctc
     4261 attaagactt ttatactgtg aagattttat tagaagcaat atatgaaaat tacttggatt
     4321 aatgtgttaa tctccctctt taaaatgcta atatctactt tatgcacatt aaagctcagt
     4381 atgcattttc tttgatgcat acagtttcta tcaattaaat ataaagaagg agacttggca
     4441 ccaacttatt aagttactcc cagtcctatt ttgtttcttt ataaacattg tagttgttcc
     4501 aggttatgtg gtatcagtgc atttttgatg ctgatgctgg atccagggtt gtattcatat
     4561 aaagatggat ggatggatgg atagatagat agatgcacag gaaatctata ctttaaaaat
     4621 taaagttatt gtatagaaaa aaattaaagt atggctcaaa ttctaaaatg cttagatatg
     4681 aaaggaggcc ctttatcatt tttaaactta catcaatcaa gcttattcag tgctgggatg
     4741 tatctggata tccagaccct cagaaagcag ctccaaaagt taatttctcg cttttacgca
     4801 gtctcgctga agggtttaat tgatattttt aatggagctg tgaatcagtg ctgcaaagga
     4861 attgtctctg ggggtctgag atataatgca tttcattttt taatttactt ttttatttgt
     4921 cattttcttc aaaggatttt tataggctgt gggttttcac tgtttgcaaa caggctattc
     4981 ctttttaagc atatgtaaag tattcaggga gataagtaat ttattaaaat ctacctaatt
     5041 tgccgtgcta tattaaatct ctgcttcagt gatcacagac catttcattt agagaattag
     5101 gcattccctc tttgtgtgat taaagtcctg gaaaatgagt tctttgctcc tatttgtgaa
     5161 cattcaaagc ctgctaatgg caggaagatg gaacagatta tgagacaatt cattacagtt
     5221 caacaggggg aaaagcagct ataatgcaaa aatgcaagta tgaatatcag cgtatagctg
     5281 aaccatctgt gctccaacag cttcggtgat gactcctcct tgggaggctt tgaaatgaca
     5341 tccgtacgat attaatttgt tggcgcactc tgtgggacca gtagagtatg atctgaccac
     5401 agaactctat aaattctgtc tgtaccactg ggcacccctg tcctcaggcc tgccatctcc
     5461 aagaagaatc ttgctctcat cagactgaaa aatcttcata acaactcatt cctctggaac
     5521 cttccagtga ccacaaacat ctgcagacaa aggctctcca gttctagtaa acaaccacat
     5581 gtttgttgtc actttagctg gctctgagct catcttcttg gcctcccttt ctagctttct
     5641 ttggctttgt gcagctacag tgtcattaag acccataata ttccctgcag taatttaaaa
     5701 cagccagatt ataccctagg attagccgag tgggtttgag acatttattg tggtgtgctc
     5761 ctaggaggca ggcattattg tttaaaatgt tatatccaaa actaaataat gctttctctg
     5821 gggggggaac ggggtggtgc tgacttctta gcgtccgtcg ttaagtggag acaggaagtt
     5881 acaatccaaa gaccttctac acgtgagtca gctgtgtcat atttatacct caggtaagat
     5941 tgtggattat ccaggcttct cttatatcta ctagctttaa agttctcagc ctcagactcc
     6001 tgccagcgtt cccggtactg acttcacata taacggtgac taacgggttc tgaagagaga
     6061 gatcaagtga gtgtcctcac ttgaagtgca ctggcatctt tgtctagatg tgtgttaacc
     6121 agagttcatt gaaaagttca cctccactgg tttaaagtgc tgtgctgtcc tctgtgaacc
     6181 aggcttgctc tgtagaggat ggctgggaag tgggggttcc actcacacag acacagccct
     6241 ggaggagaac ttgcagctct cagtaactgc acagtacact cagcactcta gagctgtaat
     6301 gcttttagtt tggaaatata aatagagatg tgatgtggcg tgtgggacag tgtattatac
     6361 atggtttttt tgcctactgt agtagaaatg tcaaattccc agccactgtc atgagaagca
     6421 gttgacaaaa ataagtttta tggtttacag tgtggtttac gtagagaata tttctcttca
     6481 ctctcggttt caacatgttt tctgaattat catggtttgt tgccatttaa cttaaattag
     6541 tttttttaag aataaataga gtctatgttt aatcaaataa agaaaggcca cattgaaatt
     6601 ctgctgttcc tgccattcat ttgttaccac agaacacaaa taatttctat gtgtcatgaa
     6661 gaagtgtggg ctgagacgtg gtcatgtgat ttgggagact ctgcgtgcac caatgttccc
     6721 acaacaaaac ataaattatt ttagtaatct gacatcaaga gctgtgacaa tgaaaaccag
     6781 ctcttacaca tgttctaaca agaatctgat taacattttt gtggatatgg aaaataactt
     6841 tttttagtca agctggcact gttgctgaat ttagaatgat ttccttatgt acaggattgc
     6901 aaaatgtgaa tcatgtctgt gaacaaatat gagaataaag tgtgatcttt gtgtaacata
     6961 aaacaccaa
//
