LOCUS       NM_023879               5238 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus retinitis pigmentosa GTPase regulator interacting
            protein 1 (Rpgrip1), transcript variant 1, mRNA.
ACCESSION   NM_023879
VERSION     NM_023879.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5238)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5238)
  AUTHORS   Dharmat,R., Eblimit,A., Robichaux,M.A., Zhang,Z., Nguyen,T.T.,
            Jung,S.Y., He,F., Jain,A., Li,Y., Qin,J., Overbeek,P., Roepman,R.,
            Mardon,G., Wensel,T.G. and Chen,R.
  TITLE     SPATA7 maintains a novel photoreceptor-specific zone in the distal
            connecting cilium
  JOURNAL   J Cell Biol 217 (8), 2851-2865 (2018)
   PUBMED   29899041
REFERENCE   3  (bases 1 to 5238)
  AUTHORS   Wiegering,A., Dildrop,R., Kalfhues,L., Spychala,A., Kuschel,S.,
            Lier,J.M., Zobel,T., Dahmen,S., Leu,T., Struchtrup,A., Legendre,F.,
            Vesque,C., Schneider-Maunoury,S., Saunier,S., Ruther,U. and
            Gerhardt,C.
  TITLE     Cell type-specific regulation of ciliary transition zone assembly
            in vertebrates
  JOURNAL   EMBO J 37 (10) (2018)
   PUBMED   29650680
  REMARK    GeneRIF: Loss of Rpgrip1 expression is associated with Ciliopathy.
REFERENCE   4  (bases 1 to 5238)
  AUTHORS   Krebs,M.P., Collin,G.B., Hicks,W.L., Yu,M., Charette,J.R.,
            Shi,L.Y., Wang,J., Naggert,J.K., Peachey,N.S. and Nishina,P.M.
  TITLE     Mouse models of human ocular disease for translational research
  JOURNAL   PLoS One 12 (8), e0183837 (2017)
   PUBMED   28859131
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5238)
  AUTHORS   Potter,P.K., Bowl,M.R., Jeyarajan,P., Wisby,L., Blease,A.,
            Goldsworthy,M.E., Simon,M.M., Greenaway,S., Michel,V., Barnard,A.,
            Aguilar,C., Agnew,T., Banks,G., Blake,A., Chessum,L., Dorning,J.,
            Falcone,S., Goosey,L., Harris,S., Haynes,A., Heise,I., Hillier,R.,
            Hough,T., Hoslin,A., Hutchison,M., King,R., Kumar,S., Lad,H.V.,
            Law,G., MacLaren,R.E., Morse,S., Nicol,T., Parker,A., Pickford,K.,
            Sethi,S., Starbuck,B., Stelma,F., Cheeseman,M., Cross,S.H.,
            Foster,R.G., Jackson,I.J., Peirson,S.N., Thakker,R.V., Vincent,T.,
            Scudamore,C., Wells,S., El-Amraoui,A., Petit,C.,
            Acevedo-Arozena,A., Nolan,P.M., Cox,R., Mallon,A.M. and Brown,S.D.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5238)
  AUTHORS   Shu,X., Fry,A.M., Tulloch,B., Manson,F.D., Crabb,J.W., Khanna,H.,
            Faragher,A.J., Lennon,A., He,S., Trojan,P., Giessl,A., Wolfrum,U.,
            Vervoort,R., Swaroop,A. and Wright,A.F.
  TITLE     RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and
            basal bodies and interacts with nucleophosmin
  JOURNAL   Hum Mol Genet 14 (9), 1183-1197 (2005)
   PUBMED   15772089
REFERENCE   7  (bases 1 to 5238)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 5238)
  AUTHORS   Zhao,Y., Hong,D.H., Pawlyk,B., Yue,G., Adamian,M., Grynberg,M.,
            Godzik,A. and Li,T.
  TITLE     The retinitis pigmentosa GTPase regulator (RPGR)- interacting
            protein: subserving RPGR function and participating in disk
            morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 100 (7), 3965-3970 (2003)
   PUBMED   12651948
REFERENCE   9  (bases 1 to 5238)
  AUTHORS   Mavlyutov,T.A., Zhao,H. and Ferreira,P.A.
  TITLE     Species-specific subcellular localization of RPGR and RPGRIP
            isoforms: implications for the phenotypic variability of congenital
            retinopathies among species
  JOURNAL   Hum Mol Genet 11 (16), 1899-1907 (2002)
   PUBMED   12140192
REFERENCE   10 (bases 1 to 5238)
  AUTHORS   Hong,D.H., Yue,G., Adamian,M. and Li,T.
  TITLE     Retinitis pigmentosa GTPase regulator (RPGRr)-interacting protein
            is stably associated with the photoreceptor ciliary axoneme and
            anchors RPGR to the connecting cilium
  JOURNAL   J Biol Chem 276 (15), 12091-12099 (2001)
   PUBMED   11104772
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC081545.1, AY008297.1 and BC086692.1.
            
            On Dec 9, 2009 this sequence version replaced NM_023879.2.
            
            Transcript Variant: This variant represents the longer transcript
            and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY008297.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-909               BC081545.1         1-909
            910-4800            AY008297.1         892-4782
            4801-4831           BC086692.1         4151-4181
            4832-5238           BC086692.1         4184-4590
FEATURES             Location/Qualifiers
     source          1..5238
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.81 cM"
     gene            1..5238
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /note="retinitis pigmentosa GTPase regulator interacting
                     protein 1"
                     /db_xref="GeneID:77945"
                     /db_xref="MGI:MGI:1932134"
     exon            1..80
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            81..169
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..4092
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /note="isoform 1 is encoded by transcript variant 1;
                     X-linked retinitis pigmentosa GTPase regulator-interacting
                     protein 1; RPGR-interacting protein 1"
                     /codon_start=1
                     /product="X-linked retinitis pigmentosa GTPase
                     regulator-interacting protein 1 isoform 1"
                     /protein_id="NP_076368.1"
                     /db_xref="CCDS:CCDS36918.1"
                     /db_xref="GeneID:77945"
                     /db_xref="MGI:MGI:1932134"
                     /translation="MQHLLEYMPEDLPVRDTDSSPLLKGTSGKNVRAQPHLGRMNQKE
                     LNCRRLHLHEEPTLVKEPSPKQRDKNRRRRTNVQRSTTTQPDLRTLAVLQEPERRRRP
                     WVSASPSPSAPPRAPVPGRKAHVQRLCPSTAVGSAQPRVHAGRRLPHIAGPNDRRSHT
                     APPAFKDYVADKNTRIEITREPSQLTHTMTTDSTHVEEIPRSPEKTSKVEKPEQRSSE
                     ECTQKAAELRASIKENVELIRLKKLLQERNTSLAATEAQLTRVQEAYEDLLQKNQGIL
                     DTAHNAFLSQVNELKAELSEESKKAVSLRTQLGDVSILQITLKEFQVRVEDLEKERKL
                     LSDSYDRLLENMLDSSHQPLDSSHQPHWSTELTGKQLPPQVCPLLDQMGTALEETKVF
                     RQATNKAAQDGKLKFQDTDILYQHEQEEESLQSTATVASSPEELCELAAQPTLLPQTD
                     QRESSEPKAQDENDLSQVLSELQVSHAETTLELEKTRDMLLLQRKINMCYQEELEATL
                     TKADRENRDHEEKLERLNHLLDFKNSRIKQLEGILRSHGLPTSEQLKDVAYGTLPPSL
                     CLEPLAAHRGDDEVDMSLLHPSENLFELHVHQAFLTPAALTQAGDTQPTTFCTYSFYD
                     FETHCTPLSTGPQPLYDFTSQYVVQADYLLLHYLQGTSVRLDLHQAMASEYHVLATGW
                     ISLDKVLGTVERVHGLATLAGAGGEDLGVLEYWMRLCLPLKPSLQACNKRKKAQAYLS
                     VSVLGARKVQSNESRSETWAPQNELRVEITRCCGLRSRRLGRQPSPYVMYRFFTFPDH
                     DTIIIPASSNPYFKDQALFPVLVTSDLDQYLRREALSVYVFDDEDPEPGSYLGRAQVP
                     LLPLAQNKSIKGDFNLTDSGEKSNGSIKVQLDWKSHYLAPEGFQMSEAEKPEGEEKEE
                     EGGEEEVKEEEVEEEEEEEEEEEEVKEEKEEEEEEEREEEEEKEEEKEEEEEEDEKEE
                     EEEEEEEEEEEEEDENKDVLEASFTEEWVPFFSQDQIASTEIPIEAGQYPEKRKPPVI
                     AEKKEREHQVASYSRRKHSKKPGVQDKNRMEYLSCNILNGNTQQMHYTEWKFSGLKKA
                     EDGGLKAQDKREEPPSPRSALRQEHPSHPRNAFSLADQESCEQASEVSETQTTDSDDI
                     IVTPQAQTVPKADSEKMCIEIVSLAFCPEADVMSDETIQQVYVEYKFCDLPLSETETP
                     MSLRKPRAGEEIHFHFSKVIDLDPVEHQSRRQFLFAMLHAQDSDEGRFKFTVVSDPLD
                     EEKKECQDIGYAYLELWQIFQSGKDILEQELEIVSPRNQAIQIGRLKVSLQAAAALHG
                     IYKEMTEDLFS"
     exon            170..311
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            312..550
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            551..650
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            651..779
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            780..885
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            886..909
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1056
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1130
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1291
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1455
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1599
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1750
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..2203
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2355
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2698
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..3114
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3318
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..3454
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3570
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            3571..3763
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            3764..3848
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..3979
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..5213
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4147..4152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /note="hexamer: TATAAA"
     regulatory      4167..4172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /note="hexamer: CATAAA"
     polyA_site      4172
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /note="major polyA site"
     polyA_site      4189
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
     regulatory      5185..5190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
                     /note="hexamer: AATAAA"
     polyA_site      5213
                     /gene="Rpgrip1"
                     /gene_synonym="0610005A07Rik; 4930401L23Rik;
                     4930505G06Rik; A930002K18Rik; nmf247"
ORIGIN      
        1 gaggattgga agcagtatta gagacagcag ggaatccagg ggaaagaact gcacagaact
       61 ctctggaagg agccaggact cctgatcatt gaggtgatgc agcatctact agaatatatg
      121 ccagaggatc tgccagttag agacacagat tcgagtcctc tgttgaaagg gacgtcgggt
      181 aagaatgtaa gggcccagcc gcacttgggc aggatgaacc agaaggagct gaactgcaga
      241 cgccttcacc tccatgaaga gcccacgttg gtgaaggaac cttctccaaa gcaacgagat
      301 aaaaacagaa ggcgaaggac gaacgtgcag cgatccacaa ctacccaacc ggacctacgg
      361 acacttgctg tgctccagga gccagagagg cgcaggcggc cgtgggtctc agcgtccccg
      421 agcccctcgg cgcccccgcg cgcaccagtt cccgggagga aagcgcatgt gcagcgcctg
      481 tgtccctcga ccgcggtagg cagtgcacag cctcgagtcc acgcgggacg cagactgccc
      541 cacatagctg ggccaaatga caggcgcagc catacagccc ctcccgcatt taaagactat
      601 gtggcggaca agaacaccag aatcgaaata accagggagc ccagccaact tactcacacc
      661 atgacgactg attctacaca tgtggaagag atccccagat ctcctgagaa aacatccaaa
      721 gttgaaaagc ctgaacagag aagctcagag gagtgcactc agaaggctgc agagcttcga
      781 gcttccatta aggagaacgt ggagctgatt cgccttaaga agctcttaca ggagaggaat
      841 acctcgctgg cagccacaga agcccaactg acacgagttc aagaggcata tgaagacttg
      901 cttcaaaaga atcagggaat attggataca gcccataatg ccttcctcag ccaagtgaat
      961 gagctcaagg cagagctgag tgaagagagc aagaaggctg tgagcttgag gactcagctg
     1021 ggagatgtgt ctatcttgca gataactctg aaggagtttc aggtcagagt tgaagatttg
     1081 gaaaaggaac ggaaactgct gagtgacagt tatgacagac tcttagagaa catgctggat
     1141 agtagtcatc agcctctgga tagcagtcat cagcctcact ggagcacgga gctcacaggg
     1201 aagcagctcc caccgcaagt ctgtccactg ctggaccaaa tgggcactgc gctggaggag
     1261 accaaagtct ttcgtcaagc aaccaacaaa gcagctcaag atggaaagct gaagtttcaa
     1321 gacaccgaca tcctttacca gcatgaacag gaagaagaga gccttcagtc aactgccact
     1381 gtagcctcat ctccagaaga gctgtgtgaa ctggctgctc agcccactct actcccacag
     1441 acagatcaga gagagtccag tgaaccaaaa gctcaagacg agaatgactt atcccaggtg
     1501 ctaagcgagc tgcaagtgtc acatgcagag accacactgg aactggaaaa aaccagagat
     1561 atgcttcttc tgcagcgcaa aatcaacatg tgttatcagg aggagctgga ggcaacactg
     1621 acaaaagctg acagggaaaa cagggaccac gaagagaaac tggagcggct gaatcacctc
     1681 ctggacttca agaacagccg catcaaacag ctggaaggta ttttaagaag ccacggcctt
     1741 ccaacatctg agcagctcaa agatgtcgcg tatggcactc tgccaccgtc gctgtgtctg
     1801 gagcccctgg cagcccacag aggtgacgat gaagtggaca tgtctctgct gcatccaagc
     1861 gagaatcttt ttgagctgca cgtccaccag gccttcctga cccctgctgc cctcacacag
     1921 gctggcgaca cccaacctac cactttctgc acttattcct tctatgattt tgaaactcac
     1981 tgcaccccac tctctactgg gccccagcct ctctatgact tcacctccca gtatgtagtg
     2041 caggcagact acctcctcct gcactacctt caaggaactt cagtacggct tgatctccat
     2101 caggccatgg ctagtgaata ccatgtcctt gctactggat ggatctcact tgacaaggtg
     2161 ctagggactg tggagagagt ccacggcttg gccacactcg ctggagctgg tggagaagac
     2221 ttgggggtgt tagagtactg gatgaggctg tgcctgcccc taaaacccag cctccaggca
     2281 tgcaataagc gaaagaaagc ccaggcctac ctgtcagtca gtgtgcttgg agctcggaag
     2341 gtccagagca atgagtccag atccgaaacc tgggcgcctc agaatgagct tcgggttgag
     2401 atcaccaggt gctgcggcct ccggagtcga cggctgggaa ggcagcccag tccgtatgtc
     2461 atgtaccgct tcttcacctt tcctgaccat gacaccatca tcattccagc cagcagcaat
     2521 ccatacttta aagaccaggc tctgtttccc gtgcttgtga cctctgacct ggaccagtat
     2581 ctgaggcggg aagctctgtc tgtctatgtt tttgatgatg aagacccaga gcctggctcc
     2641 tatcttggcc gagcccaggt gcccttgctg cctcttgcac aaaacaaatc tatcaaaggt
     2701 gatttcaatc tcacagactc tggggagaag tccaatggat ccatcaaagt gcaactagac
     2761 tggaagtctc actacctagc cccagagggc ttccagatgt cagaagctga gaagccggag
     2821 ggtgaagaga aggaggagga agggggagag gaggaggtaa aggaggaaga ggtggaggag
     2881 gaagaggaag aagaagaaga ggaagaagag gtcaaggaag agaaggagga agaggaggag
     2941 gaggaaaggg aggaggaaga ggagaaggag gaggagaagg aggaagagga ggaggaggac
     3001 gagaaggaag aggaggaaga ggaagaggaa gaagaggagg aagaggagga ggatgagaac
     3061 aaagatgtcc tggaggcctc attcacggaa gaatgggtcc cctttttttc ccaggaccag
     3121 atagcatcta cagagattcc catagaggct ggccagtacc cagagaagag aaaacctcct
     3181 gtaatagcag aaaagaagga aagagagcat caggtcgcaa gctactcacg aagaaaacac
     3241 agcaaaaaac caggtgtcca agacaagaac agaatggaat atctgagctg taacatcttg
     3301 aatggaaaca cacagcagat gcattacacg gagtggaagt tctcagggct caagaaggcc
     3361 gaggatggtg gcttaaaagc tcaggacaag agagaggaac cgccatcacc ccgttcagca
     3421 ctgagacagg agcatccctc acatcctaga aatgccttct ccctagcaga ccaggaatcc
     3481 tgtgaacaag cttctgaagt cagtgaaaca cagactaccg acagcgatga catcatagtg
     3541 acaccccagg ctcagacggt tcctaaagcc gattcagaga agatgtgcat tgaaatcgtc
     3601 tcactggcct tctgccctga ggctgacgtc atgtctgatg agactatcca gcaggtatat
     3661 gtggagtaca aattctgtga tctgcctcta tcggagacag agactccgat gtccctgagg
     3721 aaaccaaggg caggcgaaga aatccacttc cactttagca aggtgataga tctggaccct
     3781 gtggagcacc aaagccgaag gcagtttttg tttgccatgc tacatgctca agattctgat
     3841 gagggacgtt tcaagtttac agtggtaagt gatcctctgg atgaagaaaa aaaagaatgt
     3901 caagatatag gctatgcata ccttgaactg tggcagatat ttcaatctgg aaaagatatc
     3961 ctagagcaag aactagagat tgtgagccct agaaaccagg ccatccaaat tggaaggctg
     4021 aaggtttccc tccaagcagc tgctgccctc catggcattt ataaggagat gactgaagat
     4081 ctgttttcat gaaagtacaa gttctactcc actcaacgat ttgagggcat cacagtcaaa
     4141 gtgtcttata aaataacatg acatgccata aacctggtct cctgtgctat cttgctatct
     4201 gtttttcaaa ctaatgacgt ggcttacaac catcagtgaa cttgacttga cttcagaaac
     4261 tgcaaagaaa tggtcataag agacaagttt acaaaaaaaa caaaacaaaa caaaaaaaaa
     4321 tcccagttta tttatctttt agttcttcca aaattcaaaa tatcaagtcc tactgctaag
     4381 gggagaaaac aaacaaacaa acataaaatc tgagaagccc cttctcataa agtcacagaa
     4441 cagaggcggc gaagtgggac aggtggatgc agagaacctg caggggagga tggcaagata
     4501 gagcccccca gtatttcaaa gctgatcatc ggaagcaacc aacacaggac actgcagaga
     4561 aagtaaaggg aagagcagca gtgcccagcc ttgtgggtgt ggccttcttc ccgcttctct
     4621 tcttgtcaag atattctagg ccaagacacg acttactctt tgagatccat gttgactcct
     4681 ttaagcctcc ctctagattt cacctgtagt atacgaagca tgaccattct tccttagatg
     4741 tatcagaaga gacaatggta atttgtgttt gagcactgca ccacatatgg acttgtaagg
     4801 aggaaaaaaa aaaaaaaaaa aaaaaaaaaa acagccacga gtgccagtgt ttgtcttctg
     4861 atgcagcaaa aacaacccca gaatgtgcat gaggcaagaa accagaacca ctgaagacca
     4921 gacaccagcc cagctcagcc aagtcacagt catcagcaga gcccaaggac gttcttgaga
     4981 actgcagatc tggaactgat aaagggacgg acggaggact gactctgggc cagaactatg
     5041 cttcgtctaa gtacagtgac tcaagcctgt agccttagca cttgggaggc agagcgagag
     5101 gatcatacat ttgaggctag cctggcttac agtgacttca aggtaagcca tggctgcata
     5161 gcaagactgt ctcaaaacag gaaaaataaa aaagtaaaga aaaaagaatc ctaaaaaaaa
     5221 aaaaaaaaaa aaaaaaaa
//
