LOCUS       NM_001177950            3680 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus retinitis pigmentosa GTPase regulator (Rpgr),
            transcript variant 1, mRNA.
ACCESSION   NM_001177950
VERSION     NM_001177950.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3680)
  AUTHORS   Thorson,M.T., Wei,S.E., Johnson,C., Gabriel,C.J., Arshavsky,V.Y.
            and Pearring,J.N.
  TITLE     Nrl:CreERT2 mouse model to induce mosaic gene expression in rod
            photoreceptors
  JOURNAL   Front Mol Neurosci 16, 1161127 (2023)
   PUBMED   37181654
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3680)
  AUTHORS   Muller,B., Serafin,F., Laucke,L.L., Rheinhard,W., Wimmer,T. and
            Stieger,K.
  TITLE     Characterization of Double-Strand Break Repair Protein Ku80
            Location Within the Murine Retina
  JOURNAL   Invest Ophthalmol Vis Sci 63 (6), 22 (2022)
   PUBMED   35737378
REFERENCE   3  (bases 1 to 3680)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3680)
  AUTHORS   Falasconi,A., Biagioni,M., Novelli,E., Piano,I., Gargini,C. and
            Strettoi,E.
  TITLE     Retinal Phenotype in the rd9 Mutant Mouse, a Model of X-Linked RP
  JOURNAL   Front Neurosci 13, 991 (2019)
   PUBMED   31607844
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3680)
  AUTHORS   Orlans,H.O., Merrill,J., Barnard,A.R., Charbel Issa,P.,
            Peirson,S.N. and MacLaren,R.E.
  TITLE     Filtration of Short-Wavelength Light Provides Therapeutic Benefit
            in Retinitis Pigmentosa Caused by a Common Rhodopsin Mutation
  JOURNAL   Invest Ophthalmol Vis Sci 60 (7), 2733-2742 (2019)
   PUBMED   31247114
REFERENCE   6  (bases 1 to 3680)
  AUTHORS   Hong,D.H., Pawlyk,B.S., Shang,J., Sandberg,M.A., Berson,E.L. and
            Li,T.
  TITLE     A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse
            model for X-linked retinitis pigmentosa (RP3)
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3649-3654 (2000)
   PUBMED   10725384
REFERENCE   7  (bases 1 to 3680)
  AUTHORS   Zeiss,C.J., Ray,K., Acland,G.M. and Aguirre,G.D.
  TITLE     Mapping of X-linked progressive retinal atrophy (XLPRA), the canine
            homolog of retinitis pigmentosa 3 (RP3)
  JOURNAL   Hum Mol Genet 9 (4), 531-537 (2000)
   PUBMED   10699176
REFERENCE   8  (bases 1 to 3680)
  AUTHORS   Kirschner,R., Rosenberg,T., Schultz-Heienbrok,R., Lenzner,S.,
            Feil,S., Roepman,R., Cremers,F.P., Ropers,H.H. and Berger,W.
  TITLE     RPGR transcription studies in mouse and human tissues reveal a
            retina-specific isoform that is disrupted in a patient with
            X-linked retinitis pigmentosa
  JOURNAL   Hum Mol Genet 8 (8), 1571-1578 (1999)
   PUBMED   10401007
REFERENCE   9  (bases 1 to 3680)
  AUTHORS   Linari,M., Ueffing,M., Manson,F., Wright,A., Meitinger,T. and
            Becker,J.
  TITLE     The retinitis pigmentosa GTPase regulator, RPGR, interacts with the
            delta subunit of rod cyclic GMP phosphodiesterase
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1315-1320 (1999)
   PUBMED   9990021
REFERENCE   10 (bases 1 to 3680)
  AUTHORS   Yan,D., Swain,P.K., Breuer,D., Tucker,R.M., Wu,W., Fujita,R.,
            Rehemtulla,A., Burke,D. and Swaroop,A.
  TITLE     Biochemical characterization and subcellular localization of the
            mouse retinitis pigmentosa GTPase regulator (mRpgr)
  JOURNAL   J Biol Chem 273 (31), 19656-19663 (1998)
   PUBMED   9677393
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671042.10.
            
            [WARNING] On Feb 20, 2024 this sequence was replaced by
            NM_001177950.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ238396.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AL671042.10        79054-79297         c
            245-370             AL671042.10        76031-76156         c
            371-463             AL671042.10        75227-75319         c
            464-526             AL671042.10        74300-74362         c
            527-685             AL671042.10        73101-73259         c
            686-835             AL671042.10        71175-71324         c
            836-994             AL671042.10        68625-68783         c
            995-1150            AL671042.10        64512-64667         c
            1151-1275           AL671042.10        61413-61537         c
            1276-1458           AL671042.10        58474-58656         c
            1459-1624           AL671042.10        57320-57485         c
            1625-1722           AL671042.10        44457-44554         c
            1723-1788           AL671042.10        40773-40838         c
            1789-2667           AL671042.10        38505-39383         c
            2668-2868           AL671042.10        28578-28778         c
            2869-2926           AL671042.10        27224-27281         c
            2927-3015           AL671042.10        25104-25192         c
            3016-3680           AL671042.10        20718-21382         c
FEATURES             Location/Qualifiers
     source          1..3680
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 4.62 cM"
     gene            1..3680
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /note="retinitis pigmentosa GTPase regulator"
                     /db_xref="GeneID:19893"
                     /db_xref="MGI:MGI:1344037"
     exon            1..244
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            245..370
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            371..463
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            464..526
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            527..685
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            686..835
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            836..994
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1150
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1275
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1458
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1624
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1722
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1788
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..2667
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2868
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..2926
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3015
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3680
                     /gene="Rpgr"
                     /gene_synonym="Rd9; Rp3h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcctccttc caaaagcctt tcgcccctcc ccgccccgca aggctccgcc tccgttgccc
       61 ctagcgtctg tttgttgact tccgggagca cagtagtggt ctatgccaag agggtcgcga
      121 tgggggtccc agggggtagg gcagcacctt aggctcaatc gagtcgcccc tgctatcttt
      181 ccgaagcagg cacagattcc gttcgcaggc ttcggcatgg cggaatctga gtcactggtg
      241 cccgatacag gtgctgtgtt tacgtttgga aaaactaaat ttgccgaaaa tattcctagc
      301 aaattctggt ttaaaaatga catacccata tgtctttcat gtggagatga acatactgct
      361 attgttacag gaaataataa attgtacatg ttcggcagta acaactgggg tcagttagga
      421 ttaggatcaa aagctgctat catcaagcca acatgtatca aagctcttaa gcctgagaag
      481 gtgaaacttg ctgcctgtgg aaggaaccac accttagttt caacagatac tggtggcgta
      541 tatgcagctg gtggaaataa tgaaggtcaa ctggggcttg gtgacactga cgatagagac
      601 acctttcatc aaattgtctt ctttacacct gctgatacca ttaaacagct ctctgctggc
      661 gccaatacat ccgctgctct tactgaggat ggaaaacttt ttatgtgggg tgacaattct
      721 gaagggcaga ttggtctaga agataaaagt aatgtatgta tccctcatga agtgactgtt
      781 ggaaagccaa tttcctggat ctcttgtgga tattaccatt cagcttttgt aacaatggat
      841 ggggagctct acacatttgg agaacccgag aatgggaagt tgggccttcc caatgagctg
      901 ctgatgaatc acagatcacc ccagcgtgtg ctgggcattc ctgagagggt cattcaagtg
      961 gcctgtggtg gagggcacac tgtggttctc acagagaaag ttgtgtatgc ctttgggctg
     1021 gggcagtttg gacaactggg ccttggcact tttctctttg aaacatcaga acccaaaatt
     1081 attgagcgta ttaaggatca gaaaatatgt catatttcct gtggagaaaa ccatacagct
     1141 ttgatgacag aactaggcct cctgtatact tttggagacg gccgacatgg aaagttagga
     1201 cttgggatgg agaatttcac caatcagttc tttcctacct tgtgctctaa ctttttgaga
     1261 tttgcagttc aattgattgc ctgtggtgga tgtcatatgc tagtttttgc cactccacga
     1321 cttggtacaa tagatgaacc taaatttgaa gacgtatatg agccttatat aagtacaggt
     1381 tctttttcca tcaatgacct ctccccaaga agttcactga atagatcttt atcagcacgt
     1441 ctgcggcgaa gagagcggga gagaccccca tgctcagctt caatggtggg aacactgcct
     1501 ccattagagg ggacttctgc ctccacttca gcttattttt accccagttc accccccttc
     1561 catttgtctg tgaataacta cccagagaaa agcccctctg aatcaatgga gccactggac
     1621 tcagattatt ttgaagataa aatgaacaaa gacacagaga cagaaaattc ttcagcagtg
     1681 gattcagaaa actttggtga aactaatgat atcttaaata tgacacatat gatgactacg
     1741 agttccaatg agaagttatt agatttttca ccaattcaaa aacaacagaa tcaagacaca
     1801 tttgagaaag tgatggaaag tacaccgtgc actgaaaatg aggatagtta tgaatatgaa
     1861 gaaatgtcaa aaataaaaga agtgacagtg tacaaacaat atttagcaaa agggatctac
     1921 atgatacgac cagccgagat tctggaagca ttttcagatg aggaagtggg taatggccta
     1981 gaccaggtgg aggagccgcg ggtcttcact gatggaaagg gcttacaaag caagcaagta
     2041 ggaaaggaaa gtgatgaaga aatagtctct gagaagaaaa ctgaggtgat ggaagtggca
     2101 gatgtgaaaa agattagaga aagtgaagag aactcaaaat cagattcact ttttgatgac
     2161 ttaccagata aaaccatgaa ttctgagagt gaagacaata aagatattgc tgaggaaagg
     2221 agaagcagtg agcagaatat gacctttgac agtgaaacag aattggtaga agaaccagac
     2281 agttacatgg aatgtgagag gcacagtgag caagacagtg ctgaggagtt ggagcagccc
     2341 aagctagtag aatatagtag cgaagagaaa gatgagaaag atgagaaaga tgacgatgaa
     2401 gtggagactg agaacttatg gtacgacagg aactgtactg agcaagaaac tgagaatgta
     2461 ttcagagcaa ccagattttt cccaaagttc gatcttaagc atgatcattt gtcagggata
     2521 ccagaggagc aggaaggacc agaggattca gaaggaaatg tagtagtgga gcaagtagta
     2581 caggcacaaa aggaaaattt ggaatttgaa ggagacagaa aggaggcaaa agcagaagcc
     2641 ccatcagatg tcattacaga aaaagaggct cctcaacttt cagaaactgt gaaaccagaa
     2701 gaaggggaaa tggatgagga aattagtatc ctgaatgtag aagacactgt agaagaagaa
     2761 aggaaggaag gagagaagga gattgtagaa gaaggaagta tacctgaaac agaaggctca
     2821 gaaactattg atattactga tgagaagcta gatgaagtcc ttaaagagga agacagtgcc
     2881 agccttctgc aacgggccct tcgtgagtac aatgaaaatc caaaaggaca catgtatgat
     2941 cgtgtaaaga gcagctcttc agaaattctg ggaggtaatg atccaacaag taaagacata
     3001 aaaaaagcta aaaaaatttc cttctttaat cggatgtcat tgacaggtca gaaactgatg
     3061 cagaatacta atgatccact cccagagata aagccaatag gagatcagat agccttacaa
     3121 agtgataaga aagatgccaa ccagaaccac atgggtcaaa atcttcagga ttcgacaaca
     3181 ccaaatatgg agggaaagtc caaatcctgt acaattctat aaatgcatgt ttatgtttca
     3241 atggtcaccg agcacatttg ttcttcatac ttgaaaaatg gtgtgacttc tgaagaaaat
     3301 cccctgacaa cactgtttaa aaaggtataa attagtatgt ttggcttggt ttgaacaata
     3361 tgaacagttt taatatttat ttatgttaat attcttaaca gtttccaaag tatgtgtacc
     3421 tccaactctc tttgaagtgt tctggcctta caactgctca gtgttgcata aaacaatcta
     3481 tttttatatt tgaaagacga atgaagctat ttcatagttt tgccaacaca gttattgtac
     3541 tttgtaattt cctaagacaa tgttcacaat attacgacac tggaacagtt ttgagtatat
     3601 ttacaacatt taaaaacagg gaccattgta atgaacttat tttaataaac tatgtctggt
     3661 tggttctgct gtcaaaatgg
//
