LOCUS       NM_023323               1480 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ribosome production factor 2 homolog (Rpf2),
            transcript variant 1, mRNA.
ACCESSION   NM_023323
VERSION     NM_023323.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1480)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   2  (bases 1 to 1480)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   3  (bases 1 to 1480)
  AUTHORS   Hackney,J.A., Charbord,P., Brunk,B.P., Stoeckert,C.J.,
            Lemischka,I.R. and Moore,K.A.
  TITLE     A molecular profile of a hematopoietic stem cell niche
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13061-13066 (2002)
   PUBMED   12226475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ828311.1, AK012641.1 and AK051135.1.
            
            On Jul 14, 2006 this sequence version replaced NM_023323.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012641.1, AK012188.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               BQ828311.1         12-137
            127-1246            AK012641.1         106-1225
            1247-1480           AK051135.1         1598-1831
FEATURES             Location/Qualifiers
     source          1..1480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 21.76 cM"
     gene            1..1480
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /note="ribosome production factor 2 homolog"
                     /db_xref="GeneID:67239"
                     /db_xref="MGI:MGI:1914489"
     exon            1..87
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..985
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /note="isoform 1 is encoded by transcript variant 1; brix
                     domain containing 1; brix domain-containing protein 1;
                     ribosome biogenesis protein RPF2 homolog"
                     /codon_start=1
                     /product="ribosome production factor 2 homolog isoform 1"
                     /protein_id="NP_075812.3"
                     /db_xref="CCDS:CCDS59543.1"
                     /db_xref="GeneID:67239"
                     /db_xref="MGI:MGI:1914489"
                     /translation="MDALDKVLKPKTKRAKRFLEKREPKLTENIKNAMLIKGGNANAT
                     VTQVLRDMYALKKPYGVLYKKKNITRPFEDQTSLEFFSKKSDCSLFMFGSHNKKRPNN
                     LVIGRMYDYHVLDMIELGIEKFVSLKDIKTSKCPEGTKPMLIFAGDDFDVTEDFRRLK
                     NLLIDFFRGPTVSNVRLAGLEYVLHFTALNGKVYFRSYKLLLKKSGCRTPRIELEEMG
                     PSLDLVMRRTHLASDDLYKLSMKVPKALKPKKRKNISQDTFGTTFGRIHMQKQDLSKL
                     QTRKMKGLKKRPAENGVDDQGKKSKRIKKN"
     exon            88..220
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            221..258
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            259..298
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..380
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..457
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..557
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..660
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..805
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1480
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1021..1026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /note="hexamer: ACTAAA"
     polyA_site      1039
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /note="major polyA site"
     regulatory      1061..1066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /note="hexamer: GATAAA"
     polyA_site      1085
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
     polyA_site      1232
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /note="major polyA site"
     polyA_site      1249
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
     regulatory      1363..1368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
                     /note="hexamer: ATTAAA"
     polyA_site      1394
                     /gene="Rpf2"
                     /gene_synonym="2810470K21Rik; Bxdc1"
ORIGIN      
        1 ggcgctcgcg gcggcttccc ggaagtaatc ggtacacgtg cattcgctaa gggatcttgc
       61 agctatggat gctttggaca aagttctaaa gcctaaaact aaaagggcta agagattcct
      121 tgagaagaga gaaccgaaac tcactgagaa cattaagaat gccatgctga ttaaaggcgg
      181 aaatgcaaat gcaaccgtga cacaagtact cagagacatg tatgcactga agaaaccata
      241 tggagttctc tataaaaaga aaaatattac aagaccattt gaggatcaga cgtcactgga
      301 gttcttttca aagaagtcag actgctcttt attcatgttt ggctcccata acaagaagag
      361 gccaaataac ctagtaatag gtcgtatgta tgactaccat gtgctggata tgattgaatt
      421 aggtattgag aaatttgtgt ctctaaaaga tattaagact agtaagtgcc ccgagggaac
      481 aaaaccgatg ttgatatttg ctggtgatga ttttgatgta acagaagact tcagaagatt
      541 aaaaaatctt cttattgatt tcttcagagg ccccacagta tcgaacgtcc ggctggctgg
      601 attagagtat gttctgcact tcactgcact gaatgggaag gtttacttcc gaagctataa
      661 gctgctgttg aagaaatctg ggtgcagaac accgcgaatc gagctagaag agatgggacc
      721 atcactggac ctggtcatga ggaggacaca cctagcatca gatgaccttt ataaactgtc
      781 catgaaagtg cccaaggctc tcaagccaaa gaagagaaag aatatctctc aggatacttt
      841 tggcacaaca tttggaagga ttcatatgca aaagcaagac ttaagcaaac tacaaacgag
      901 gaaaatgaag gggttgaaga agcgacctgc agagaatgga gtagacgacc aggggaaaaa
      961 atcaaagaga attaagaaaa attgacctga ctgactacga gcactttctt atggttgttt
     1021 actaaagaga attgctctac ttgaggctgt tcggtttcct gataaaaatt tgttgcttat
     1081 ttgaatgagg gtgtaacaaa atttcacact atagcccggg ctggtctcag ccttccacgt
     1141 gctgtgatta taggcaggta ccaccatata cagcatattg tatgtgtcta taacattatt
     1201 tattacgtaa acttttttta aaaaaattga aacttgtgtt tggatcatac tcaccccagc
     1261 tctcactgtt tttaattttt aaaattgatt tgtgtgtgca catgtatgtc acagtgtggg
     1321 tgtggccaaa agacattatg gagtcggtta taccctgtgg ggattaaatg atacctcagt
     1381 gtgtcagact cctactatgg gaagtgcctt tatccactga accatcctgt tagcctagtt
     1441 tattacctat ttttatgaac aaataacata ctacgagttt
//
