LOCUS       NM_029987               1862 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus retinal pigment epithelium 65 (Rpe65), mRNA.
ACCESSION   NM_029987
VERSION     NM_029987.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1862)
  AUTHORS   Leinonen,H., Zhang,J., Occelli,L.M., Seemab,U., Choi,E.H., L P
            Marinho,L.F., Querubin,J., Kolesnikov,A.V., Galinska,A.,
            Kordecka,K., Hoang,T., Lewandowski,D., Lee,T.T., Einstein,E.E.,
            Einstein,D.E., Dong,Z., Kiser,P.D., Blackshaw,S., Kefalov,V.J.,
            Tabaka,M., Foik,A., Petersen-Jones,S.M. and Palczewski,K.
  TITLE     A combination treatment based on drug repurposing demonstrates
            mutation-agnostic efficacy in pre-clinical retinopathy models
  JOURNAL   Nat Commun 15 (1), 5943 (2024)
   PUBMED   39009597
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1862)
  AUTHORS   Li,S. and Jin,M.
  TITLE     Ablation of Fatty Acid Transport Protein-4 Enhances Cone Survival,
            M-cone Vision, and Synthesis of Cone-Tropic 9-cis-Retinal in rd12
            Mouse Model of Leber Congenital Amaurosis
  JOURNAL   J Neurosci 44 (27), e1994232024 (2024)
   PUBMED   38811164
  REMARK    GeneRIF: Ablation of Fatty Acid Transport Protein-4 Enhances Cone
            Survival, M-cone Vision, and Synthesis of Cone-Tropic 9-cis-Retinal
            in rd12 Mouse Model of Leber Congenital Amaurosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1862)
  AUTHORS   Du,S.W., Komirisetty,R., Lewandowski,D., Choi,E.H., Panas,D.,
            Suh,S., Tabaka,M., Radu,R.A. and Palczewski,K.
  TITLE     Conditional deletion of miR-204 and miR-211 in murine retinal
            pigment epithelium results in retinal degeneration
  JOURNAL   J Biol Chem 300 (6), 107344 (2024)
   PUBMED   38705389
REFERENCE   4  (bases 1 to 1862)
  AUTHORS   Bassetto,M., Kolesnikov,A.V., Lewandowski,D., Kiser,J.Z.,
            Halabi,M., Einstein,D.E., Choi,E.H., Palczewski,K., Kefalov,V.J.
            and Kiser,P.D.
  TITLE     Dominant role for pigment epithelial CRALBP in supplying visual
            chromophore to photoreceptors
  JOURNAL   Cell Rep 43 (5), 114143 (2024)
   PUBMED   38676924
REFERENCE   5  (bases 1 to 1862)
  AUTHORS   Zhao,J., Kim,H.J., Montenegro,D., Dunaief,J.L. and Sparrow,J.R.
  TITLE     Iron overload and chelation modulates bisretinoid levels in the
            retina
  JOURNAL   Front Ophthalmol (Lausanne) 3, 1305864 (2023)
   PUBMED   38983013
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1862)
  AUTHORS   Redmond,T.M., Yu,S., Lee,E., Bok,D., Hamasaki,D., Chen,N.,
            Goletz,P., Ma,J.X., Crouch,R.K. and Pfeifer,K.
  TITLE     Rpe65 is necessary for production of 11-cis-vitamin A in the
            retinal visual cycle
  JOURNAL   Nat Genet 20 (4), 344-351 (1998)
   PUBMED   9843205
  REMARK    GeneRIF: Knockout of the Rpe65 gene gave severely night-blind
            animals with lack of 11-cis retinoids in retina and excess of
            all-trans retinyl esters in the retinal pigment
            epithelium,consistent with blockade of the all-trans to 11-cis
            isomerization of retinoids.
REFERENCE   7  (bases 1 to 1862)
  AUTHORS   Johansson,S., Gustafson,A.L., Donovan,M., Romert,A., Eriksson,U.
            and Dencker,L.
  TITLE     Retinoid binding proteins in mouse yolk sac and chorio-allantoic
            placentas
  JOURNAL   Anat Embryol (Berl) 195 (6), 483-490 (1997)
   PUBMED   9193722
REFERENCE   8  (bases 1 to 1862)
  AUTHORS   Quilliam,L.A., Lambert,Q.T., Mickelson-Young,L.A., Westwick,J.K.,
            Sparks,A.B., Kay,B.K., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.
            and Der,C.J.
  TITLE     Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein
            and potential effector of Rho protein signaling
  JOURNAL   J Biol Chem 271 (46), 28772-28776 (1996)
   PUBMED   8910519
REFERENCE   9  (bases 1 to 1862)
  AUTHORS   Wei,L.N., Lee,C.H., Chinpaisal,C., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Hsu,Y.C.
  TITLE     Studies of cloning, chromosomal mapping, and embryonic expression
            of the mouse Rab geranylgeranyl transferase beta subunit
  JOURNAL   Cell Growth Differ 6 (5), 607-614 (1995)
   PUBMED   7544156
REFERENCE   10 (bases 1 to 1862)
  AUTHORS   Hamel,C.P., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Redmond,T.M.
  TITLE     The gene for the retinal pigment epithelium-specific protein RPE65
            is localized to human 1p31 and mouse 3
  JOURNAL   Genomics 20 (3), 509-512 (1994)
   PUBMED   8034329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ133618.1 and BC090656.1.
            
            On May 22, 2007 this sequence version replaced NM_029987.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               CJ133618.1         2-504
            504-1862            BC090656.1         480-1838
FEATURES             Location/Qualifiers
     source          1..1862
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 82.52 cM"
     gene            1..1862
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /note="retinal pigment epithelium 65"
                     /db_xref="GeneID:19892"
                     /db_xref="MGI:MGI:98001"
     exon            1..63
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1654
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /EC_number="3.1.1.64"
                     /EC_number="5.3.3.22"
                     /note="retinol isomerase; all-trans-retinyl-palmitate
                     hydrolase; retinal pigment epithelium-specific 65 kDa
                     protein; retinal pigment epithelium, 65 kDa; modifier of
                     retinal degeneration 1; meso-zeaxanthin isomerase; lutein
                     isomerase"
                     /codon_start=1
                     /product="retinoid isomerohydrolase"
                     /protein_id="NP_084263.2"
                     /db_xref="CCDS:CCDS38683.1"
                     /db_xref="GeneID:19892"
                     /db_xref="MGI:MGI:98001"
                     /translation="MSIQIEHPAGGYKKLFETVEELSSPLTAHVTGRIPLWLTGSLLR
                     CGPGLFEVGSEPFYHLFDGQALLHKFDFKEGHVTYHRRFIRTDAYVRAMTEKRIVITE
                     FGTCAFPDPCKNIFSRFFSYFKGVEVTDNALVNIYPVGEDYYACTETNFITKINPETL
                     ETIKQVDLCNYISVNGATAHPHIESDGTVYNIGNCFGKNFTVAYNIIKIPPLKADKED
                     PINKSEVVVQFPCSDRFKPSYVHSFGLTPNYIVFVETPVKINLFKFLSSWSLWGANYM
                     DCFESNESMGVWLHVADKKRRKYFNNKYRTSPFNLFHHINTYEDNGFLIVDLCCWKGF
                     EFVYNYLYLANLRENWEEVKRNAMKAPQPEVRRYVLPLTIDKVDTGRNLVTLPHTTAT
                     ATLRSDETIWLEPEVLFSGPRQAFEFPQINYQKFGGKPYTYAYGLGLNHFVPDKLCKM
                     NVKTKEIWMWQEPDSYPSEPIFVSQPDALEEDDGVVLSVVVSPGAGQKPAYLLVLNAK
                     DLSEIARAEVETNIPVTFHGLFKRS"
     exon            64..146
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
     exon            147..297
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
     exon            298..405
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
     exon            406..547
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
     exon            548..695
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
     exon            696..777
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
     exon            778..910
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1050
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1180
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1295
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1390
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1502
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1665
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1843
                     /gene="Rpe65"
                     /gene_synonym="65kDa; A930029L06Rik; LCA2; Mord1; rd12;
                     RP20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctcatcct acagctggta ccagaactct ctctaatctt cactggaaga aaatgtctat
       61 ccaaattgaa caccctgctg gtggctacaa gaaactattt gaaactgtgg aggaactgtc
      121 ctcaccacta acagctcatg tcacaggcag gattcccctc tggctcactg gcagtctcct
      181 ccgatgtggg ccagggctct ttgaagttgg atctgagcct ttctatcacc tgtttgatgg
      241 acaagccctt ttgcacaagt ttgacttcaa ggagggccat gtcacatacc acagaagatt
      301 catccgcact gatgcttatg ttcgagcaat gactgagaag aggattgtca taacagaatt
      361 tggcacctgt gctttcccag acccctgcaa gaatatattt tccaggtttt tttcttactt
      421 taaaggagta gaggttactg acaatgccct tgtaaatatc tacccagtgg gagaagatta
      481 ctatgcatgc acagagacca actttatcac aaagattaac ccagagacct tggagacaat
      541 taagcaggtt gatctttgca actatatttc tgtcaatggt gccactgctc atccacatat
      601 tgaaagtgat ggaacagttt acaacattgg gaattgcttt ggaaaaaatt ttacagttgc
      661 ctacaacatt attaagatcc ctccactgaa agcagacaag gaagatccaa taaacaagtc
      721 agaagttgtt gtgcagttcc cctgcagtga tcgtttcaag ccatcttatg tacacagttt
      781 tggtctgact cccaactata tcgtttttgt ggagactcca gtcaaaatta accttttcaa
      841 gtttctttct tcgtggagtc tttggggagc caactacatg gactgtttcg agtccaatga
      901 aagcatgggg gtttggcttc atgttgctga taaaaaaaga agaaaatact tcaataacaa
      961 atacaggact tcccctttca atctcttcca tcatatcaat acttatgaag acaatggatt
     1021 tctgattgtg gatctctgtt gctggaaagg gtttgaattt gtttataatt acttatattt
     1081 agccaattta cgtgagaatt gggaagaagt taaaagaaat gctatgaagg ctcctcagcc
     1141 tgaagtcagg agatatgtac ttcctttgac aattgacaag gtcgacacag gcagaaattt
     1201 agtcacactg ccccatacaa ctgccacagc cactctgcgc agtgatgaga ccatatggct
     1261 ggaacctgag gttctctttt cagggcctcg tcaagccttt gaatttcctc aaatcaatta
     1321 ccagaaattt ggagggaaac cttatactta tgcatacgga cttgggttga atcactttgt
     1381 tcctgacaag ctctgtaaga tgaacgtcaa aactaaagaa atctggatgt ggcaagagcc
     1441 agattcttac ccatctgaac ccatctttgt ttctcaacca gatgctctgg aagaagatga
     1501 tggtgtggtt ctgagtgtgg tggtgagccc tggggcaggg caaaagcctg catatctcct
     1561 ggttctgaat gccaaagact tgagtgaaat tgccagggct gaagtggaga ctaatatccc
     1621 tgtgaccttc catggactgt tcaaaagatc ctgaacatat tccagagatg gctcagcagt
     1681 acaacactga ctgcccttct acagatcgtg tgttcaattc ccaaagatca cctggtgact
     1741 cacttccatc tgagacggaa tccaatgccc tcttatgctg tttctgaaga cagcaaaagt
     1801 gtactcatat atacatatga taaataaatc tttaaaaaaa acaaaaaaaa aaaaaaaaaa
     1861 aa
//
