LOCUS       NM_025683               2692 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ribulose-5-phosphate-3-epimerase (Rpe), transcript
            variant 2, mRNA.
ACCESSION   NM_025683
VERSION     NM_025683.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2692)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2692)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   3  (bases 1 to 2692)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2692)
  AUTHORS   Bowman,C.E., Zhao,L., Hartung,T. and Wolfgang,M.J.
  TITLE     Requirement for the Mitochondrial Pyruvate Carrier in Mammalian
            Development Revealed by a Hypomorphic Allelic Series
  JOURNAL   Mol Cell Biol 36 (15), 2089-2104 (2016)
   PUBMED   27215380
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2692)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   6  (bases 1 to 2692)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 2692)
  AUTHORS   Crozet,F., el Amraoui,A., Blanchard,S., Lenoir,M., Ripoll,C.,
            Vago,P., Hamel,C., Fizames,C., Levi-Acobas,F., Depetris,D.,
            Mattei,M.G., Weil,D., Pujol,R. and Petit,C.
  TITLE     Cloning of the genes encoding two murine and human cochlear
            unconventional type I myosins
  JOURNAL   Genomics 40 (2), 332-341 (1997)
   PUBMED   9119401
REFERENCE   8  (bases 1 to 2692)
  AUTHORS   Gumaa,K.A. and McLean,P.
  TITLE     The pentose phosphate pathway of glucose metabolism. Enzyme
            profiles and transient and steady-state content of intermediates of
            alternative pathways of glucose metabolism in Krebs ascites cells
  JOURNAL   Biochem J 115 (5), 1009-1029 (1969)
   PUBMED   5360673
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK619266.1 and AK017774.1.
            
            On Jul 16, 2015 this sequence version replaced NM_025683.2.
            
            Transcript Variant: This variant (2) uses an alternate splice
            junction in the 5' end and lacks an alternate 5' exon compared to
            variant 1. The resulting isoform (2) has the same N- and C-termini
            but is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017774.1, BC006953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               CK619266.1         1-506
            507-2692            AK017774.1         446-2631
FEATURES             Location/Qualifiers
     source          1..2692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 33.61 cM"
     gene            1..2692
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /note="ribulose-5-phosphate-3-epimerase"
                     /db_xref="GeneID:66646"
                     /db_xref="MGI:MGI:1913896"
     exon            1..198
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..763
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /EC_number="5.1.3.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ribulose-phosphate 3-epimerase;
                     ribulose-5-phosphate-epimerase"
                     /codon_start=1
                     /product="ribulose-phosphate 3-epimerase isoform 2"
                     /protein_id="NP_079959.2"
                     /db_xref="CCDS:CCDS15022.1"
                     /db_xref="GeneID:66646"
                     /db_xref="MGI:MGI:1913896"
                     /translation="MASGCKIGPSILNSDLANLGAECLRMLDSGADYLHLDVMDGHFV
                     PNITFGHPVVESLRKQLGQDPFFDMHMMVSRPEQWVKPMAVAGANQYTFHLEATENPG
                     ALIKDIRENGMKVGLAIKPGTTVEYLAPWANQIDMALVMTVEPGFGGQKFMEDMMPKV
                     HWLRTQFPTLDIEVDGGVGPDTVQKCAEAGANMIVSGSAIMRSDDPRAVINLLRNVCS
                     EAAQKRSLDR"
     exon            199..278
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            279..418
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            419..553
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            554..640
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            641..2692
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1286..1291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1306
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /note="major polyA site"
     regulatory      1534..1539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1560
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /note="major polyA site"
     regulatory      2374..2379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /note="hexamer: AATAAA"
     regulatory      2385..2390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2397
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
     polyA_site      2403
                     /gene="Rpe"
                     /gene_synonym="2810429B02Rik; 5730518J08Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcggcgcgcc caatcgggac ggagtcttgg ctggcccggg ctctcgtggg ctcactcgct
       61 ctagggaacc ggcaccatgg cgtcgggctg caagatcggc ccgtccatcc tcaacagcga
      121 cctggccaac ctgggggccg agtgcctgcg catgctggac tcgggggccg actacctgca
      181 cctggatgta atggacgggc attttgttcc caatatcact tttggtcacc ctgtggttga
      241 aagcctccga aagcagctag gccaggaccc tttctttgat atgcacatga tggtgtctag
      301 gccagaacag tgggtaaaac caatggctgt ggcaggtgcc aatcaatata cctttcatct
      361 tgaggcaact gagaacccag gggctttgat taaagacatc cgggagaatg ggatgaaggt
      421 tggccttgcc atcaaaccag gaactacagt tgaatatttg gccccatggg ctaatcaaat
      481 agatatggcc ttggtaatga ccgtagaacc tgggtttgga gggcagaaat tcatggaaga
      541 catgatgccc aaggttcact ggttgaggac ccagtttcca actttggata tagaggtcga
      601 tggcggagta ggtcctgaca ctgttcagaa gtgtgcggag gcaggagcta acatgattgt
      661 gtctggcagt gccattatga ggagtgatga ccccagagct gttatcaact tactaagaaa
      721 cgtttgctca gaagcggctc agaaacgttc ccttgatcga tgaagccaca aggaacccag
      781 tttctgctca tgaaaccttt ttttactgga aaaaggaata ttgactacca aatcacattg
      841 caatcgaagc agtgctgcat tccagtgatt aaaatcaatt gtgcaggatg ttcaagaggt
      901 tagaaataac tacctttata gagatgtcat ttagaaattt agcgtgatga aaatattcat
      961 gtttatactg ggagaatgat ttttgtaaag agtgaaaata tgatttctta agattacaga
     1021 cagaaatgtg tcttaatggc taaagaggaa aattagatac tatgaaaaac atttttctgt
     1081 atttttacaa agaatgttct gttgattccc tggtttattc ctaaagcaaa tgacatccac
     1141 attttctcta gttcatgtca tttgtgattt gcttatatgc ctgagaatat gaatggaatg
     1201 agactaaaat tagaagcttt ggtggggtgg catgtcatgg tctggcattg gaattatttt
     1261 tactttttaa tcttacactt ggtttattaa aaactataaa aaacaatgta tgaagcctag
     1321 ggtttctgaa atgcaagcac agacttatca aggtatttac tttgtcacag cagactactc
     1381 tgtcattcct tcctgcccct gggtctcact caaccaccct tctgagggga atgaaatagc
     1441 cagaggcaga aaggaaccat acagtttctc ttggaagtgc cactgggttg gacaccaata
     1501 gaacagagta ccctattcta gctctttaac tttaataaaa tcacccaact gttttcacta
     1561 taaacgctta tgtatatcga atgaaaccat aactattgtg catttgagaa ttaaaagcat
     1621 aacatgattt tggaaggctt atagttgtac tcctagactg tagaagatgc tcaacacaaa
     1681 atggcaagca tcatgtctgt tttatgagtt attaagcact tttctataat catattaact
     1741 gctaaattgt cctataattg ttagaacagg aatttttttc cctattttaa gactaaaaac
     1801 cgtaaagctc tccagtagcc tggcacatag aaagggtcca gtcagaagca gttttctggt
     1861 gtgtactact gctctgacta caaacagagc ccctgaagtg gattagaaaa aaaagttttt
     1921 acttttctta ttttcagtgt aactgaatcc tctggcagaa tcagagtaag ttaagaatat
     1981 tctggaagta tagattttga ctccaagaat ggatagatgg atatatatat atataatttc
     2041 taagaaggaa gaagtaggct aagatgatac agtacagact taatccataa ataagtagta
     2101 ataaaataag aacactgaca aataggcatg gaatagagag cttgcttggg ctttttcctg
     2161 ccctgtaaga taaaagttta ttaatacttg tttttatttt agcttacgaa aggtttgtgc
     2221 atttaatcaa atcacacaat acaaggcata tagaaataac tttaattaaa aaaaaactat
     2281 gtagaaggtt ataatatcag tcatgacaaa gatttgaaat tatttgttgg gacaacttgt
     2341 atttttctgg cttttgttat ctttttcttt aaaaataaat gtacagtaaa actataagca
     2401 aaagtttgta agtattgaat ttaaatggtt ccccaccccc cttctgcagg gatcagttta
     2461 atttctaatc ctcaacaaaa ccttatatat ctaatcccat agagtccaag ctcagtggcc
     2521 aggattttca gtagtatggg aactacaaat tgagtaacct ttctttgcat aacaaaaagt
     2581 ggttgataca aattgtcctt aactttcatc taggaaaaaa aaatggtatg gcttcaaaaa
     2641 gaattttcct taatgtacac tcctcagtat tctatattaa agttttggtc tt
//
