LOCUS       NM_144911               2322 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RNA polymerase II associated protein 2 (Rpap2),
            transcript variant 1, mRNA.
ACCESSION   NM_144911 XM_986011 XM_986041 XM_986067 XM_986099 XM_986136
VERSION     NM_144911.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2322)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2322)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117574.7, AK145830.1, AK034418.1 and AV221546.1.
            
            On Jan 24, 2014 this sequence version replaced NM_144911.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (A).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021895.1, AK145830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC117574.7         169623-169650       c
            29-1421             AK145830.1         4-1396
            1422-1422           AC117574.7         146719-146719       c
            1423-2070           AK145830.1         1398-2045
            2071-2307           AK034418.1         2087-2323
            2308-2322           AV221546.1         269-283
FEATURES             Location/Qualifiers
     source          1..2322
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 52.23 cM"
     gene            1..2322
                     /gene="Rpap2"
                     /note="RNA polymerase II associated protein 2"
                     /db_xref="GeneID:231571"
                     /db_xref="MGI:MGI:2141142"
     exon            1..165
                     /gene="Rpap2"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1937
                     /gene="Rpap2"
                     /EC_number="3.1.3.16"
                     /note="isoform A is encoded by transcript variant 1;
                     putative RNA polymerase II subunit B1 CTD phosphatase
                     Rpap2"
                     /codon_start=1
                     /product="putative RNA polymerase II subunit B1 CTD
                     phosphatase Rpap2 isoform A"
                     /protein_id="NP_659160.2"
                     /db_xref="CCDS:CCDS19506.1"
                     /db_xref="GeneID:231571"
                     /db_xref="MGI:MGI:2141142"
                     /translation="MADSAVPCSLGPSTRASSTHRDATGTKQTRALKRGDASKRQAEL
                     EAAIQRKVEFERKAVRIVEQLLEENITEEFLKECGMFITPAHYSDVVDERSIIKLCGY
                     PLCQKKLGVIPKQKYRISTKTNKVYDITERKSFCSNFCYRASKFFETQIPKTPVWVRE
                     EERPPDFQLLKKGQSGSSGEVVQFFRDAVTAADVDGSGALEAQCDPASSSSWSERASD
                     EEEQGFVSSLLPGNRPKAVDTRPQPHTKSSIMRKKAAQNVDSKEGEQTVSEVTEQLDN
                     CRLDSQEKVATCKRPLKKESTQISSPGPLCDRFNTSAISEHKHGVSQVTLVGISKKSA
                     EHFRSKFAKSNPGSGSASGLVHVRPEVAKANLLRVLSDTLTEWKTEETLKFLYGQNHD
                     SVCLKPSSASEPDEELDEDDISCDPGSCGPALSQAQNTLDATLPFRGSDTAIKPLPSY
                     ESLKKETEMLNLRVREFYRGRCVLNEDTTKSQDSKESVLQRDPSFPLIDSSSQNQIRR
                     RIVLEKLSKVLPGLLGPLQITMGDIYTELKNLIQTFRLSNRNIIHKPVEWTLIAVVLL
                     LLLTPILGIQKHSPKNVVFTQFIATLLTELHLKFEDLEKLTMIFRTSC"
     exon            166..211
                     /gene="Rpap2"
                     /inference="alignment:Splign:2.1.0"
     exon            212..326
                     /gene="Rpap2"
                     /inference="alignment:Splign:2.1.0"
     exon            327..425
                     /gene="Rpap2"
                     /inference="alignment:Splign:2.1.0"
     exon            426..491
                     /gene="Rpap2"
                     /inference="alignment:Splign:2.1.0"
     exon            492..580
                     /gene="Rpap2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..616
                     /gene="Rpap2"
                     /inference="alignment:Splign:2.1.0"
     exon            617..1550
                     /gene="Rpap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1645
                     /gene="Rpap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1726
                     /gene="Rpap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1795
                     /gene="Rpap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1949
                     /gene="Rpap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2322
                     /gene="Rpap2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2284..2289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpap2"
                     /note="hexamer: AATAAA"
     polyA_site      2305
                     /gene="Rpap2"
                     /note="major polyA site"
ORIGIN      
        1 gccctccctg ggcccgcccc cagcccggtt ccgggcgaag cgtgaggagg tagatgtgct
       61 gtcccgaccc cctcttctga ccgcatttcc ccatggctga ctctgccgta ccttgctctc
      121 taggcccaag tacccgggct tccagcaccc accgagatgc taccggtact aaacagaccc
      181 gagccctgaa acgaggagat gcatctaaaa ggcaagcaga actggaagct gctatacaaa
      241 ggaaggtgga gtttgaaagg aaagctgtgc gcatcgtaga gcagctctta gaggagaaca
      301 tcacagaaga attcctgaag gagtgtggca tgttcatcac accagctcac tacagcgacg
      361 ttgtggatga gcggtccatc atcaaactct gtggctatcc tttgtgtcag aagaagctag
      421 gggttatccc gaaacagaaa tatcgaattt ctactaaaac caataaagtc tatgatatta
      481 ctgaaaggaa gtctttctgc agcaattttt gttacagagc atctaaattt tttgaaacac
      541 agattcccaa aactccagta tgggttcgag aggaagagag gcctcctgac tttcagctgc
      601 tgaagaaagg acaaagcggc agttctggag aagtagtaca gttcttccga gatgccgtga
      661 cagcagcaga tgttgacggt tccggcgcct tggaggcgca gtgtgaccct gcttcttcca
      721 gctcttggag tgagcgagcc agtgatgagg aggagcaagg ctttgtttct tctcttctac
      781 caggaaacag accaaaggca gtggatacaa gaccgcagcc gcacacaaaa agcagcatca
      841 tgagaaagaa ggctgctcag aacgtggact ccaaggaggg agagcagacc gtgtcagagg
      901 ttaccgagca gctggataat tgcagattag atagtcagga gaaagtggcc acttgtaaac
      961 gtcctttaaa gaaagaaagt actcagattt cttcacctgg ccctttgtgt gacagattta
     1021 acacttcagc catttctgaa cataaacacg gtgtatcaca agttacgctt gtaggcataa
     1081 gcaagaagag tgctgagcat ttcaggagca aatttgccaa gtcaaatcca ggttctgggt
     1141 cagcctctgg tttggtacac gtgcgtcctg aggttgcgaa ggcaaattta ctccgagttc
     1201 tgtcggacac tctgactgaa tggaagacag aagaaacact gaagttttta tatggccaga
     1261 accacgattc tgtgtgtctg aaaccctctt cagcctctga gcctgatgaa gaacttgatg
     1321 aagatgacat aagttgtgac ccaggtagtt gtggtcctgc cctgagtcaa gctcagaaca
     1381 ccctagatgc aacactgccc tttagaggct cagacacagc cattaagcca ctgccaagtt
     1441 atgagagctt gaaaaaggaa acggagatgc tgaacctgag ggtcagggag ttctacagag
     1501 ggcgctgtgt tttaaatgaa gacactacca agtctcagga ctctaaagag agtgtgcttc
     1561 agcgtgaccc cagcttcccg ctgatagatt caagttccca gaaccagatt agaagacgga
     1621 ttgttcttga aaaactgagc aaagtattgc ctggactttt gggtcctctt cagattacaa
     1681 tgggagatat ttacactgaa cttaaaaacc tcattcagac tttcagatta tcaaatagaa
     1741 acattataca caaacctgtg gagtggactt taattgctgt ggtcttgctg ttactattga
     1801 caccgattct tggcattcag aagcattctc cgaaaaatgt ggtttttaca cagtttatag
     1861 ccaccctgct gacagaattg catttaaaat tcgaagatct tgaaaaatta accatgatat
     1921 ttagaaccag ctgctagcta acaagaatga tgtaactgag gaagacagaa gaggaatgct
     1981 cctcaccagg cctggtgttt tcgccagtga gagtccatgg gtgactgatg actaagtgtg
     2041 taacttcctc agacacagac aagccattac cccagcaaga aggaagctct tacatccaga
     2101 acctcagaac acaggatttg aggggaaaat gaagtcttaa actgaaattt gaatggatat
     2161 tggggaaaat gtaattacct ttattctttt tgattggtta ccaccaacac aaccaaaact
     2221 taagaaaatg gtaattgtgg cctattgtaa actctgtcat acaaataaca gcaaagttag
     2281 gtcaataaat gtgatcgtca gtgaagccac tttttcagaa gc
//
