LOCUS       NM_027186               1214 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RPA interacting protein (Rpain), transcript variant 1,
            mRNA.
ACCESSION   NM_027186 XM_126152
VERSION     NM_027186.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1214)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1214)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1214)
  AUTHORS   Kim,K., Lee,E.J., Lee,S.H., Seo,T., Jang,I.S., Park,J. and Lee,J.H.
  TITLE     Species-specific variation of RPA-interacting protein (RIP) splice
            isoforms
  JOURNAL   BMB Rep 42 (1), 22-27 (2009)
   PUBMED   19192389
  REMARK    GeneRIF: The alternative splicing of RIPalpha in the Drosophila,
            Xenopus, and mouse system, was examined.
REFERENCE   4  (bases 1 to 1214)
  AUTHORS   Park,J., Seo,T., Kim,H. and Choe,J.
  TITLE     Sumoylation of the novel protein hRIP{beta} is involved in
            replication protein A deposition in PML nuclear bodies
  JOURNAL   Mol Cell Biol 25 (18), 8202-8214 (2005)
   PUBMED   16135809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596136.5, CB588111.1, AK010289.1, BC047996.1 and BY576068.1.
            
            On May 8, 2018 this sequence version replaced NM_027186.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047996.1, AK010289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL596136.5         129416-129416
            2-276               CB588111.1         1-275
            277-1015            AK010289.1         5-743
            1016-1085           BC047996.1         1002-1071
            1086-1214           BY576068.1         295-423
FEATURES             Location/Qualifiers
     source          1..1214
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.21 cM"
     gene            1..1214
                     /gene="Rpain"
                     /gene_synonym="2400006N03Rik; Rip"
                     /note="RPA interacting protein"
                     /db_xref="GeneID:69723"
                     /db_xref="MGI:MGI:1916973"
     exon            1..389
                     /gene="Rpain"
                     /gene_synonym="2400006N03Rik; Rip"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..968
                     /gene="Rpain"
                     /gene_synonym="2400006N03Rik; Rip"
                     /note="isoform 1 is encoded by transcript variant 1; RPA
                     interacting protein epsilon; RPA interacting protein delta
                     2"
                     /codon_start=1
                     /product="RPA-interacting protein isoform 1"
                     /protein_id="NP_081462.1"
                     /db_xref="CCDS:CCDS24969.1"
                     /db_xref="GeneID:69723"
                     /db_xref="MGI:MGI:1916973"
                     /translation="MAESSGSPHRLLYKQVGSPHWKETFRQGCLERMRNSRHRLLNKY
                     RQAAGSTPGTASDRLLVQEVMEEEWASLQSVENCPEALLQLELPLDLAVLQDIEQELC
                     NEEKSIISEYEEDLEFDESCLRRMLAEWEANSLICPVCIKYNLRIMNSVVTCPCGLHI
                     PVHSTDLTEQKLRACLEENVNEHSVHCPHTPVFSVTGGTEEKPSLLMNCLTCDTWAVI
                     L"
     exon            390..560
                     /gene="Rpain"
                     /gene_synonym="2400006N03Rik; Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            561..621
                     /gene="Rpain"
                     /gene_synonym="2400006N03Rik; Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            622..733
                     /gene="Rpain"
                     /gene_synonym="2400006N03Rik; Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            734..797
                     /gene="Rpain"
                     /gene_synonym="2400006N03Rik; Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            798..938
                     /gene="Rpain"
                     /gene_synonym="2400006N03Rik; Rip"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1214
                     /gene="Rpain"
                     /gene_synonym="2400006N03Rik; Rip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1064..1069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpain"
                     /gene_synonym="2400006N03Rik; Rip"
                     /note="hexamer: ATTAAA"
     polyA_site      1084
                     /gene="Rpain"
                     /gene_synonym="2400006N03Rik; Rip"
                     /note="major polyA site"
     polyA_site      1114
                     /gene="Rpain"
                     /gene_synonym="2400006N03Rik; Rip"
     regulatory      1187..1192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rpain"
                     /gene_synonym="2400006N03Rik; Rip"
                     /note="hexamer: AATAAA"
     polyA_site      1210
                     /gene="Rpain"
                     /gene_synonym="2400006N03Rik; Rip"
ORIGIN      
        1 gtagcgttaa ggatgagaga tgtgtgtctg attgtctact ggacaacttc ctctgggtaa
       61 acccagaact ttctctcaag attcacctcc ctcagcccgg gtggtgttta cttctcaact
      121 gtcactgctt catctatcct cggattcccc taaatctgtc actgtgaggg gatagaaact
      181 agatacaatt ccaagaaagc ccggcggcct gaagtacaga cagactgcgc cgagactaca
      241 acttccagaa tcctttgcgc gcggctaagg ggcggtgatt tgggcgctgt ttcccgctaa
      301 gggaggagat ggcagagtcc tcggggtctc cgcaccgctt gttgtacaag caggtgggct
      361 cgccccactg gaaagaaact ttcaggcagg gatgtctgga gagaatgaga aacagcaggc
      421 acaggctcct gaacaaatat cgccaggctg caggtagcac gccggggaca gcctcagaca
      481 gacttcttgt gcaagaagta atggaggaag agtgggcttc tttgcagtct gtggagaatt
      541 gtccggaggc cttgcttcag ttggaattgc cactggacct agctgtgctg caggacatcg
      601 agcaggagct gtgtaatgaa gaaaagtcca tcataagcga gtatgaagag gacttagagt
      661 ttgatgaaag ttgtctcagg agaatgttgg ctgagtggga agcaaactcc ctcatctgtc
      721 ctgtgtgtat aaagtacaac ctgagaataa tgaacagtgt ggtcacgtgt ccatgtggcc
      781 tgcacatccc tgttcactca acagacctga cagagcagaa gcttcgagcc tgtttggaag
      841 aaaatgtgaa tgagcacagt gtacactgtc cccacacccc tgtgttctca gtcaccggtg
      901 gaacagaaga gaagcccagt cttctgatga actgcctgac ttgtgacacc tgggctgtga
      961 tcctctagcc atcccgacct cacacttcac tactgagctg agaacaactc atttcctgag
     1021 agggccctgt atgcacaagc cttttgtata taacggattt tatattaaaa cttcagacat
     1081 ctctgctctt ggtgttctga tgtgggcgaa agaacctcaa ctttcctgga gatttattgg
     1141 agtcagattt attgtccatc atcatgttat acaaaaatct acaaataata aatttgtaca
     1201 gagaaaaaaa gccc
//
