LOCUS       NM_018739               1142 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus retinitis pigmentosa 9 (human) (Rp9), mRNA.
ACCESSION   NM_018739
VERSION     NM_018739.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1142)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1142)
  AUTHORS   Lv,J.N., Zhou,G.H., Chen,X., Chen,H., Wu,K.C., Xiang,L., Lei,X.L.,
            Zhang,X., Wu,R.H. and Jin,Z.B.
  TITLE     Targeted RP9 ablation and mutagenesis in mouse photoreceptor cells
            by CRISPR-Cas9
  JOURNAL   Sci Rep 7, 43062 (2017)
   PUBMED   28216641
  REMARK    GeneRIF: Rp9 gene knockout & point mutation knock in (Rp9, c.A386T,
            P.H129L) analogous to reported one in the retinitis pigmentosa
            patients (RP9, c.A410T, P.H137L) were studied. Proliferation and
            migration were significantly decreased in the mutated cells. Gene
            expression profiling by RNA-Seq demonstrated that retinitis
            pigmentosa associated genes, Fscn2 and Bbs2, were down-regulated in
            the mutated cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1142)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1142)
  AUTHORS   Maita,H., Kitaura,H., Ariga,H. and Iguchi-Ariga,S.M.
  TITLE     CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative
            splicing
  JOURNAL   Exp Cell Res 303 (2), 375-387 (2005)
   PUBMED   15652350
REFERENCE   5  (bases 1 to 1142)
  AUTHORS   Kuroda,T.S., Maita,H., Tabata,T., Taira,T., Kitaura,H., Ariga,H.
            and Iguchi-Ariga,S.M.
  TITLE     A novel nucleolar protein, PAPA-1, induces growth arrest as a
            result of cell cycle arrest at the G1 phase
  JOURNAL   Gene 340 (1), 83-98 (2004)
   PUBMED   15556297
REFERENCE   6  (bases 1 to 1142)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 1142)
  AUTHORS   Maita,H., Harada,Y., Nagakubo,D., Kitaura,H., Ikeda,M., Tamai,K.,
            Takahashi,K., Ariga,H. and Iguchi-Ariga,S.M.
  TITLE     PAP-1, a novel target protein of phosphorylation by pim-1 kinase
  JOURNAL   Eur J Biochem 267 (16), 5168-5178 (2000)
   PUBMED   10931201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY239981.1, AK168391.1 and AI481652.1.
            
            On Aug 14, 2009 this sequence version replaced NM_018739.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168391.1, D78255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BY239981.1         1-8
            9-1139              AK168391.1         2-1132
            1140-1142           AI481652.1         1-3                 c
FEATURES             Location/Qualifiers
     source          1..1142
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 9.16 cM"
     gene            1..1142
                     /gene="Rp9"
                     /gene_synonym="PAP-1; Rp9h"
                     /note="retinitis pigmentosa 9 (human)"
                     /db_xref="GeneID:55934"
                     /db_xref="MGI:MGI:2157166"
     exon            1..283
                     /gene="Rp9"
                     /gene_synonym="PAP-1; Rp9h"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..797
                     /gene="Rp9"
                     /gene_synonym="PAP-1; Rp9h"
                     /note="pim-1-associated protein; retinitis pigmentosa 9
                     homolog; Pim-1 associated protein"
                     /codon_start=1
                     /product="retinitis pigmentosa 9 protein homolog"
                     /protein_id="NP_061209.1"
                     /db_xref="CCDS:CCDS40564.1"
                     /db_xref="GeneID:55934"
                     /db_xref="MGI:MGI:2157166"
                     /translation="MSSGAGSRRPREPPEHELQRRREQKRRRHDAQQLQQLKHLESFY
                     EKPPPGFIKEDETKPEDCIPDVPGNEHAREFLAHAPTKGLWMPLGREVKVMQCWRCKR
                     YGHRTGDKECPFFIKGNQKLEQFRVAHEDPMYDIIRENKRHEKDVRIQQLKQLLEDST
                     SDDDGSSSSSSGDREKRKKRKKKEKHKKRKKEKKKKKKRKHKASKSSESSDSE"
     exon            284..314
                     /gene="Rp9"
                     /gene_synonym="PAP-1; Rp9h"
                     /inference="alignment:Splign:2.1.0"
     exon            315..444
                     /gene="Rp9"
                     /gene_synonym="PAP-1; Rp9h"
                     /inference="alignment:Splign:2.1.0"
     exon            445..536
                     /gene="Rp9"
                     /gene_synonym="PAP-1; Rp9h"
                     /inference="alignment:Splign:2.1.0"
     exon            537..598
                     /gene="Rp9"
                     /gene_synonym="PAP-1; Rp9h"
                     /inference="alignment:Splign:2.1.0"
     exon            599..1142
                     /gene="Rp9"
                     /gene_synonym="PAP-1; Rp9h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1115..1120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rp9"
                     /gene_synonym="PAP-1; Rp9h"
                     /note="hexamer: AATAAA"
     polyA_site      1142
                     /gene="Rp9"
                     /gene_synonym="PAP-1; Rp9h"
                     /note="major polyA site"
ORIGIN      
        1 tctcagctaa ggttcccgca ggcctcaggg ccgcgggggc ctggctgcac gttccctgtc
       61 ggcgttctgc ggcacgggcc ggtgggacgt tggtggggtt gcgctgcggg gaggaagagg
      121 cgactttcca ccttctaagc ccgcctcggg tcgcgatgtc gtccggggcc gggtctcggc
      181 ggccgcggga gccgccggag cacgagctgc agcggcggcg ggagcagaaa cggcggcggc
      241 acgacgcgca gcagctgcag cagctcaagc acctggagtc cttttatgag aaacctcctc
      301 ctgggtttat aaaggaggac gagacgaagc cagaagactg tataccagat gtgcccggca
      361 atgaacatgc cagggagttt ctggctcacg ctccgactaa aggactgtgg atgcccctgg
      421 ggagagaggt caaagttatg caatgttggc gttgcaaacg gtatggccat cgaacaggcg
      481 acaaagaatg ccctttcttt atcaaaggca accagaagtt agaacagttc cgagtcgcac
      541 atgaagatcc tatgtacgac atcattcgcg agaataaaag acatgaaaag gatgtaagga
      601 tccagcagtt aaagcagtta ctggaggact ccacctcaga tgacgacggg agcagctcca
      661 gctcctcggg ggacagagag aagcgcaaga aaaggaagaa aaaagaaaag cacaagaaac
      721 gcaagaagga gaagaaaaag aagaagaaac ggaagcacaa ggcttccaag tccagtgaga
      781 gctctgactc agagtgacag caccacccac aggccaaagg acagagccgc cgccgagagt
      841 gagagactgg acatctagca cagccctggg ccctcaccgc ctcctggtgc caagtgacca
      901 ctgcagagca ggtgggctcc tgcgacacct gtgtcctcta ccttatggtc accgtgtctg
      961 tgactgcttc agtaggccgc tgcagtggga ggtgatgaga agaccctgaa ggggcagaca
     1021 ctctagggca ctgccacggc ggcgtttgcc ctccatggtg tggtaactca ttttccatga
     1081 acttaaggct tcacccttct ttgtggtttg ggataataaa agtccatgtt ttatttttca
     1141 aa
//
