LOCUS       NM_146246               6811 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus retinitis pigmentosa 1 homolog like 1 (Rp1l1), mRNA.
ACCESSION   NM_146246 XM_484387 XM_914910 XM_994064
VERSION     NM_146246.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6811)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6811)
  AUTHORS   Kowalchuk,A.M., Maurer,K.A., Shoja-Taheri,F. and Brown,N.L.
  TITLE     Requirements for Neurogenin2 during mouse postnatal retinal
            neurogenesis
  JOURNAL   Dev Biol 442 (2), 220-235 (2018)
   PUBMED   30048641
REFERENCE   3  (bases 1 to 6811)
  AUTHORS   Davidson,A.E., Sergouniotis,P.I., Mackay,D.S., Wright,G.A.,
            Waseem,N.H., Michaelides,M., Holder,G.E., Robson,A.G., Moore,A.T.,
            Plagnol,V. and Webster,A.R.
  TITLE     RP1L1 variants are associated with a spectrum of inherited retinal
            diseases including retinitis pigmentosa and occult macular
            dystrophy
  JOURNAL   Hum Mutat 34 (3), 506-514 (2013)
   PUBMED   23281133
REFERENCE   4  (bases 1 to 6811)
  AUTHORS   Dijkmans,T.F., van Hooijdonk,L.W., Fitzsimons,C.P. and
            Vreugdenhil,E.
  TITLE     The doublecortin gene family and disorders of neuronal structure
  JOURNAL   Cent Nerv Syst Agents Med Chem 10 (1), 32-46 (2010)
   PUBMED   20236041
  REMARK    Review article
REFERENCE   5  (bases 1 to 6811)
  AUTHORS   Yamashita,T., Liu,J., Gao,J., LeNoue,S., Wang,C., Kaminoh,J.,
            Bowne,S.J., Sullivan,L.S., Daiger,S.P., Zhang,K., Fitzgerald,M.E.,
            Kefalov,V.J. and Zuo,J.
  TITLE     Essential and synergistic roles of RP1 and RP1L1 in rod
            photoreceptor axoneme and retinitis pigmentosa
  JOURNAL   J Neurosci 29 (31), 9748-9760 (2009)
   PUBMED   19657028
  REMARK    GeneRIF: Rp1 and Rp1L1 play essential and synergistic roles in
            affecting photosensitivity and morphogenesis of rod photoreceptors.
            Our findings suggest that mutations in RP1L1 could underlie
            retinopathy or modify RP1 disease expression
REFERENCE   6  (bases 1 to 6811)
  AUTHORS   Reiner,O., Coquelle,F.M., Peter,B., Levy,T., Kaplan,A., Sapir,T.,
            Orr,I., Barkai,N., Eichele,G. and Bergmann,S.
  TITLE     The evolving doublecortin (DCX) superfamily
  JOURNAL   BMC Genomics 7, 188 (2006)
   PUBMED   16869982
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6811)
  AUTHORS   Coquelle,F.M., Levy,T., Bergmann,S., Wolf,S.G., Bar-El,D.,
            Sapir,T., Brody,Y., Orr,I., Barkai,N., Eichele,G. and Reiner,O.
  TITLE     Common and divergent roles for members of the mouse DCX superfamily
  JOURNAL   Cell Cycle 5 (9), 976-983 (2006)
   PUBMED   16628014
REFERENCE   8  (bases 1 to 6811)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 6811)
  AUTHORS   Bowne,S.J., Daiger,S.P., Malone,K.A., Heckenlively,J.R., Kennan,A.,
            Humphries,P., Hughbanks-Wheaton,D., Birch,D.G., Liu,Q.,
            Pierce,E.A., Zuo,J., Huang,Q., Donovan,D.D. and Sullivan,L.S.
  TITLE     Characterization of RP1L1, a highly polymorphic paralog of the
            retinitis pigmentosa 1 (RP1) gene
  JOURNAL   Mol Vis 9, 129-137 (2003)
   PUBMED   12724644
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 6811)
  AUTHORS   Conte,I., Lestingi,M., den Hollander,A., Alfano,G., Ziviello,C.,
            Pugliese,M., Circolo,D., Caccioppoli,C., Ciccodicola,A. and
            Banfi,S.
  TITLE     Identification and characterisation of the retinitis pigmentosa
            1-like1 gene (RP1L1): a novel candidate for retinal degenerations
  JOURNAL   Eur J Hum Genet 11 (2), 155-162 (2003)
   PUBMED   12634863
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY742376.1, BC129887.1 and
            BC031365.1.
            
            On or before Jun 3, 2007 this sequence version replaced
            XM_484387.3, XM_914910.2, XM_994064.1, NM_146246.2.
            
            Summary: This gene encodes a member of the doublecortin family.
            This protein is a retinal-specific protein. It contains two
            N-terminal doublecortin domains, which can assemble and stabilize
            axonemal microtubules, but lacks the C-terminal repetitive regions
            including the 16aa repeat found in human RP1L1. This protein and
            the RP1 protein, another retinal-specific protein, play essential
            and synergistic roles in affecting photosensitivity and outer
            segment morphogenesis of rod photoreceptors. [provided by RefSeq,
            Sep 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129887.1, SRR9219381.190484.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BY742376.1         1-75
            76-5971             BC129887.1         1-5896
            5972-6811           BC031365.1         2110-2949
FEATURES             Location/Qualifiers
     source          1..6811
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.34 cM"
     gene            1..6811
                     /gene="Rp1l1"
                     /gene_synonym="Dcdc4; Rp1hl1"
                     /note="retinitis pigmentosa 1 homolog like 1"
                     /db_xref="GeneID:271209"
                     /db_xref="MGI:MGI:2384303"
     exon            1..198
                     /gene="Rp1l1"
                     /gene_synonym="Dcdc4; Rp1hl1"
                     /inference="alignment:Splign:2.1.0"
     exon            199..852
                     /gene="Rp1l1"
                     /gene_synonym="Dcdc4; Rp1hl1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..994
                     /gene="Rp1l1"
                     /gene_synonym="Dcdc4; Rp1hl1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..6759
                     /gene="Rp1l1"
                     /gene_synonym="Dcdc4; Rp1hl1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6759
                     /gene="Rp1l1"
                     /gene_synonym="Dcdc4; Rp1hl1"
ORIGIN      
        1 gaggtggtga gtcctccatg tgagagggcc ggtggctggg cagagagttc tggaagccac
       61 cgaagaccgt ccagaggcat gtccagagag cccatcaaaa aaccagtggg gaggtcagca
      121 tctgcctcag cctgaccttg attagccgtt ccccgggctc agaaagccaa gccatgccca
      181 agtgctccct ggaggacgag ctgtctgggc ccccacatca tgaacagcac cccaggagac
      241 acgagggatg ctcctgcacc aagccaccct gcaccaagcc accggcagtg tctcctgccc
      301 tccgtggctc acactccctc cgttactgag gtgacaccgg ccaagaagat aaccttcctc
      361 aagcgaggtg atccccagtt tgctggggtt cgcctggctg ttcaccagcg caccttcaag
      421 accttcagct ccctaatgga tgagctgtct cagcgcatgc ctctttcctt tggggtgcgt
      481 tccgtcacca caccccgggg cttgcatggc ctcagtgccc tggagcagct gcaagatggg
      541 ggctgctacc tctgctctga taggaagccc cccaaaacct ccagagagcc aggccggctt
      601 caacggaaaa gcccctctgc tgggcaggca caggttttcc aaggtgggca tgaagctcca
      661 gaaacatcct attcctggaa aggtcccgtg gccccaagga ggctgactct ggtgaagaac
      721 ggggatccta gacgccagca gacagtggtt ctcagtcaca agaataccag gagtctggca
      781 gctttcctcg gcaaagcctc tgagcttctg cgctttcccg tcaagcaggt gtacacgacc
      841 cgggggaaga aggtggactc tctgcagaca ctccttgatg gcccctctgt gctggtatgt
      901 gctgggaacg aggccttcag atgtctggag atggaaaatg acagaggaaa caggaccaga
      961 aagttatcta gtgtgactgc gaggagtgaa cgtggttgct ggggaccaaa cgccaaacaa
     1021 agtgtcatac actcgagggg caggtctggc ggcaagctgc ggcaggtttc cttgacgtca
     1081 gagaggtctg gtctcagtga ccatccagca tccggtcatc gagcctgggc aggccctgct
     1141 ttggacaggt gccctcagga catgcctgtc ccacctggtt ccttggtggc tgctgatgat
     1201 gtggagaaga aggtctgcat gaatgaggac ggcagtctgt ctgtggagat gaaagtccgc
     1261 ttccaacttc tgggcgagga caccctgcgg tggtcccaaa gggtggggca ggccagtgtc
     1321 ttcacagcag ccagtggaaa gggtcaggac ccgagggagg ctgacaggtt ctgttgcaga
     1381 caggagggct acccttgggg catcttaaag cctggggcac agggactggg ttcctatgat
     1441 ggaggatgcc aggaagcctt tgatgtgggc caaaagtcac aacccagcta tgacatatgg
     1501 aggaaccccc tggccacccc tgagggcaca ggaccaacac ctcgaaggag atggggtctg
     1561 gctaagctct ctggatgcaa gagccactgg agacaggagg ccaatcatag gaaagggcat
     1621 gacaaggata atctcagccg agtctcaact cccaggcacc ctagaagtgt ccagccaggc
     1681 tcctgctgtc cttggactcc agacggcgat acaggcagtg acaccttgca tccagtctcc
     1741 tcagcttctt cccacaatga gactgacctg gaatctggtg aaggcctctg cctagaggac
     1801 acaggacccc atggctcgag acctgagacc caaagtacag aaagggccct gtctgataca
     1861 tcagtcagtg ccaagtctcg tgaggagtct agtgaaggtg gtggtcagct ccacagaagc
     1921 tcaagccagg caagggtcat ggcttcccgg gagcaagtca ccaagggtga caacccctgt
     1981 atttccaccc agagtcactt acctttgaat cacatgggtc ttcagacaga gaagtataga
     2041 cagggcacca ggggttggga ggtcagcgga gagcctgaac tgagactggc cctggttcca
     2101 ggccattctg gctctcagga cacacagaga gatgctctcc cagctcctgc ctgtgcccca
     2161 gcccaatgga ggcagagaaa gcagaagagg ccagctagtg ttgagtgttt gcccagtgtc
     2221 tctgtccctt accaagtggc tcagaaaggc catgccaggc aggatcacta ttacagggac
     2281 actcaatcct cactggacac agccttgcaa atgccaatgc ctcaggaaag agaacaggcc
     2341 tgcccaggaa gcccagcacc acaatctcct tcaaattcac ccagtgctgg gaatcaagcc
     2401 tctgaggacc tgagatcccc attctctagt tctcttgatc ttcaggaacc acaagccacc
     2461 agcaaagcca ccaccatcgc cgtgagtggc tcagactgtg tttgccacag cactcgctct
     2521 gtggagccag caggagacac caagtgccag gctcactcat caactcccac acctgcccac
     2581 agaggagagc ttggttgcct gtgggacaag gcagggacca cccctgagcc tttctcattc
     2641 tctgtgctac tggacagatg ccctgaggca gatgatccaa gaacctacca cgattgctgc
     2701 tgcttacagg ctgtgccatc ttctcccctt gcagccccca gtggtcagac acaaacctcc
     2761 atctctgagg cctgcttagg gggcagtagt ttctgcccaa ctccacccaa ggagcaaaca
     2821 tgctttggga gggagtctgc aagcaacggt agtaccagca gtggtcacag tcgagccgat
     2881 ggctttgccg ggcccaggag gactctgctg gtgaagtccc ccggtgtcag gggaagcctt
     2941 gaggagcggg aagcagatgg tggtgtgacg ccgagcgctc tgccttacgc ctctccagat
     3001 gctgtggttc gtgagtggct aggcaacatc ccagaaaagc cggtactcat gacgtatgag
     3061 atggcagacg agaacacaga ggtgcccagt gatggcccag aaggtcccaa ggaggactct
     3121 ttgaaagtcc tgggggaacc gtctcaggcc aaacagcagc ccccggaagg ggctaccaat
     3181 gagcacccag agccagcggg agtcctctca ggacctggct ctgtgtgctg cagactggga
     3241 ggtgatctgc atccagatgc aacatcaggt gaaaggctca aggctcctgc agaagctgga
     3301 ataggagaag gggccagagt ggaccatggt gtaagcttat gtgcactccc cactaaggtc
     3361 gcagcctcta cacagatcat gaaggccctg ctgggctcca agccaggtcg gcccagcagt
     3421 ctaccagagg tctctagcac agtagcccag aggctcagta gctctgctgg ggccttcatt
     3481 gcctgccttg ccaggctcca tttctttgat gagagtctgg ggcctctgga tggcaaagtg
     3541 aggcttgaag agtcccctaa gtaccaggag atgctgagac tcttccagac gctgtggcct
     3601 gggagtgagc tttggcaagg ccagctggac ttcagcctca ggaagctcac ttcgcaccag
     3661 gctctgctag ggactgagga cttcacaccc acctcctcct ccggcgtgga tgtgagcagt
     3721 ggttctggag gctcagggga gagcagcgtg ccctgtgtca tggataacac cctggctccc
     3781 gagaagagag atttgccctt gaaaatccct tctcaaagac ctgattccag gaaccagggg
     3841 tacccagaac tagtgggtca ttccacagtc tcatctgtct cccaggtgag ggcttgtgcc
     3901 accggtgggg aggagacagg taaaggaggc aggaagcaga catggggcaa tgccccagaa
     3961 caatcggtcc atagcacgat gctggaaggt gatgcactgt cagaagaaac agaagggaga
     4021 gtgagagaaa ggctacagga aaatagtgtc catggaaagg ggctgccaga agaaggggtt
     4081 agggtctgca gtcaggaaat gcttgcagct ggctctcagg atggagcagg ttcaccagaa
     4141 gataccagag tgccaacaga tgaagcagga gctgatgcgg cctctggagg actgtggccc
     4201 ctagatggga gagaggagcc cacagagtcc cctcagcatt tcagcgagag caactcaagg
     4261 gttcgtgagc atcaaagcgc tcacaaactg gagctagggt tggaagaggt gtccagattg
     4321 gatgcaaggg gctgcaagca agcctgcatc aaggccagct caggaaccat ggctcacaag
     4381 ggatctctgg accctgaccc aatctgggtg tccaagctgc tgaagaagat agagaaagcc
     4441 ttcatggctc acctggctga tgccacagcc gaactccgag cccgatggga tcttcatgac
     4501 aatcacctgc tggaccagat ggtgaccgag ctggagcagg atgtgggccg acggctgcag
     4561 gcaagcactg ttatggaagt caggaagatc cagagccggg cagggaggat ggttccagaa
     4621 ccaccccggg aagccctcag aggccaggct tctctacaga cagagcagcg caggcgtcgc
     4681 cttcagggct tgcgcaactt ctcagccgtc cctggccagg gtcccctctc cctcaccctg
     4741 gaggatgggc ccacactcaa aacagcctta gggaccaagt caggtgcaga gcctgcggag
     4801 gatgagttct gtccctgtga aatctgtctg aagaagaaga ggacccctag attcccaaag
     4861 gatgctgcaa cagtctctgg tgctcctgtc agaaaggcct ttgacctgca gcaaattcta
     4921 cagagcaaga aaggaggaag cagcaataga gaggccatgg aggtggcccc tcagaggaca
     4981 ggaaggatgt tgtctcagga ggacctcgga actgtccagg gagctgatga gaagcaaggg
     5041 cttggggtgg ctgagggaga ggagggggaa gggaaacaga ggctgagagc agaggaggat
     5101 cccgagattt tgaaaacaga aggatctggt tgctgtgcac cagaagagga tgaagccact
     5161 gaggaagatg gggaaatctg catcggcact gcccaagaaa gccagcagtt agaggggact
     5221 gagatgggca aggagggaac cctgccccag agctttagag atggaggcac tttagaggct
     5281 ccagcaagac agggtaccca ctctgtggag attcaggaag cttccagaga aagacagcag
     5341 gaggtagaag gaagacatca agatgtaaag gaagacagtc cttgggtgag ctcaggagag
     5401 agccagggaa gggtgggttc tgaaaacacc agcctagacc aagaggggag gctcctgaac
     5461 caccatcaaa ggccaggccc ccagagccac cacacagcat gctcctccag ggcattgtct
     5521 ctggacaaca gttcacaggt gtctcagaag ggctcagatg gagacttaac aagtggagac
     5581 ctcaagtgca ccaaagccaa gaacagcagg gtattgcatg cagagaagaa agtccccgtg
     5641 atgtatccag agagatcctc ttctgagcaa gaagtcccct ccagcccaag gcttccaaag
     5701 caagggaaag gggaagatga aggatcagct ggaagcttgg cttgtaccca ggttgggggc
     5761 aaggtagatg gctttggcca ggatgactta gatttctaga catcaaatga taggatagta
     5821 atggaggtga gaaatgcctg cataaatgta ttgcccttac acccaagaga ggttcaggcc
     5881 actgaggatg tacaaggagc atgacaaaga ccaaagaatt gctgcctgcc ctggaactgc
     5941 aggcctagca tccctgccac tcaggaggct aaggaggaag gatagaaagt tctagactcg
     6001 ccctgggcta tagagcaagt tcaaaacccc agcttggaca gcttagcgag acagtgtttc
     6061 aggcgctgag agtatagccc agtggcagaa tgcttgccgg gcttgtgtat ggttctgggg
     6121 tcaaccttgg cagtaactga aaaggaccat gttgtccctg ggatctaaaa ttcaaagccc
     6181 tgtactcact gtaaagtaat agctgcaagc ctgccatgtt atcagaggtc agccagttcc
     6241 tctgtccaca cagctcaaga ggatagaagg atctggaaag acgccttggg gcttctctgt
     6301 gtgttggctt ctttgtcagc aagtagctct ccccatcgat ctcctgttac tttccccttg
     6361 gcctctctgg gtatactcac cttttttgac tttgaggaac tttttttgct ggtttggaat
     6421 atatgtggtg actctgcaga tgtgcattac ctagaaaaag cagataaatt cagggtcatt
     6481 ggataaggtt tgttcttagt cccgatgtct tagtttctgc aacaccacca cgcaccccca
     6541 actcatacta tttgtaagga gaaaagggaa gagctgtcag gaaacgtgat ctcccgttga
     6601 ccagggacct gagacagctt tgtgaagtga tcagatgcaa tgctttccat cgttatctgg
     6661 atgtctcata gagatttttg tatatgattt acatactgct ttaacagatg atttaacata
     6721 tgatttaaca aatgtttaaa tatatatcca tttatctaaa aaaaaaaaaa aaaaaaaaaa
     6781 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
