LOCUS       NM_011283               6854 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus retinitis pigmentosa 1 (human) (Rp1), transcript
            variant 1, mRNA.
ACCESSION   NM_011283
VERSION     NM_011283.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6854)
  AUTHORS   Langouet,M., Jolicoeur,C., Javed,A., Mattar,P., Gearhart,M.D.,
            Daiger,S.P., Bertelsen,M., Tranebjaerg,L., Rendtorff,N.D.,
            Gronskov,K., Jespersgaard,C., Chen,R., Sun,Z., Li,H., Alirezaie,N.,
            Majewski,J., Bardwell,V.J., Sui,R., Koenekoop,R.K. and Cayouette,M.
  TITLE     Mutations in BCOR, a co-repressor of CRX/OTX2, are associated with
            early-onset retinal degeneration
  JOURNAL   Sci Adv 8 (36), eabh2868 (2022)
   PUBMED   36070393
REFERENCE   2  (bases 1 to 6854)
  AUTHORS   Pan,M., Yin,Y., Wang,X., Wang,Q., Zhang,L., Hu,H. and Wang,C.
  TITLE     Mice deficient in UXT exhibit retinitis pigmentosa-like features
            via aberrant autophagy activation
  JOURNAL   Autophagy 17 (8), 1873-1888 (2021)
   PUBMED   32744119
REFERENCE   3  (bases 1 to 6854)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6854)
  AUTHORS   Collin,G.B., Won,J., Krebs,M.P., Hicks,W.J., Charette,J.R.,
            Naggert,J.K. and Nishina,P.M.
  TITLE     Disruption in murine Eml1 perturbs retinal lamination during early
            development
  JOURNAL   Sci Rep 10 (1), 5647 (2020)
   PUBMED   32221352
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6854)
  AUTHORS   Dharmat,R., Eblimit,A., Robichaux,M.A., Zhang,Z., Nguyen,T.T.,
            Jung,S.Y., He,F., Jain,A., Li,Y., Qin,J., Overbeek,P., Roepman,R.,
            Mardon,G., Wensel,T.G. and Chen,R.
  TITLE     SPATA7 maintains a novel photoreceptor-specific zone in the distal
            connecting cilium
  JOURNAL   J Cell Biol 217 (8), 2851-2865 (2018)
   PUBMED   29899041
REFERENCE   6  (bases 1 to 6854)
  AUTHORS   Ostrowski,L.E., Blackburn,K., Radde,K.M., Moyer,M.B.,
            Schlatzer,D.M., Moseley,A. and Boucher,R.C.
  TITLE     A proteomic analysis of human cilia: identification of novel
            components
  JOURNAL   Mol Cell Proteomics 1 (6), 451-465 (2002)
   PUBMED   12169685
REFERENCE   7  (bases 1 to 6854)
  AUTHORS   Gao,J., Cheon,K., Nusinowitz,S., Liu,Q., Bei,D., Atkins,K.,
            Azimi,A., Daiger,S.P., Farber,D.B., Heckenlively,J.R., Pierce,E.A.,
            Sullivan,L.S. and Zuo,J.
  TITLE     Progressive photoreceptor degeneration, outer segment dysplasia,
            and rhodopsin mislocalization in mice with targeted disruption of
            the retinitis pigmentosa-1 (Rp1) gene
  JOURNAL   Proc Natl Acad Sci U S A 99 (8), 5698-5703 (2002)
   PUBMED   11960024
REFERENCE   8  (bases 1 to 6854)
  AUTHORS   Liu,Q., Zhou,J., Daiger,S.P., Farber,D.B., Heckenlively,J.R.,
            Smith,J.E., Sullivan,L.S., Zuo,J., Milam,A.H. and Pierce,E.A.
  TITLE     Identification and subcellular localization of the RP1 protein in
            human and mouse photoreceptors
  JOURNAL   Invest Ophthalmol Vis Sci 43 (1), 22-32 (2002)
   PUBMED   11773008
REFERENCE   9  (bases 1 to 6854)
  AUTHORS   Guillonneau,X., Piriev,N.I., Danciger,M., Kozak,C.A.,
            Cideciyan,A.V., Jacobson,S.G. and Farber,D.B.
  TITLE     A nonsense mutation in a novel gene is associated with retinitis
            pigmentosa in a family linked to the RP1 locus
  JOURNAL   Hum Mol Genet 8 (8), 1541-1546 (1999)
   PUBMED   10401003
REFERENCE   10 (bases 1 to 6854)
  AUTHORS   Pierce,E.A., Quinn,T., Meehan,T., McGee,T.L., Berson,E.L. and
            Dryja,T.P.
  TITLE     Mutations in a gene encoding a new oxygen-regulated photoreceptor
            protein cause dominant retinitis pigmentosa
  JOURNAL   Nat Genet 22 (3), 248-254 (1999)
   PUBMED   10391211
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113280.12.
            
            On Jan 6, 2023 this sequence version replaced NM_011283.2.
            
            Summary: This gene encodes a member of the doublecortin family. The
            protein encoded by this gene contains two doublecortin domains,
            which bind microtubules and regulate microtubule polymerization.
            The encoded protein is a photoreceptor microtubule-associated
            protein and is required for correct stacking of outer segment disc.
            This protein and the RP1L1 protein, another retinal-specific
            protein, play essential and synergistic roles in affecting
            photosensitivity and outer segment morphogenesis of rod
            photoreceptors. Because of its response to in vivo retinal oxygen
            levels, this protein was initially named ORP1 (oxygen-regulated
            protein-1). This protein was subsequently designated RP1 (retinitis
            pigmentosa 1) when it was found that mutations in this gene cause
            autosomal dominant retinitis pigmentosa. Mutations in this gene
            also cause autosomal recessive retinitis pigmentosa. [provided by
            RefSeq, Jun 2019].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC120927.1, SRR17784644.557385.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC113280.12        50274-50377
            105-740             AC113280.12        57740-58375
            741-912             AC113280.12        58496-58667
            913-6854            AC113280.12        60486-66427
FEATURES             Location/Qualifiers
     source          1..6854
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 1.65 cM"
     gene            1..6854
                     /gene="Rp1"
                     /gene_synonym="Dcdc3; Gm38717; mG145; Orp1; Rp1h"
                     /note="retinitis pigmentosa 1 (human)"
                     /db_xref="GeneID:19888"
                     /db_xref="MGI:MGI:1341105"
     exon            1..104
                     /gene="Rp1"
                     /gene_synonym="Dcdc3; Gm38717; mG145; Orp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            105..740
                     /gene="Rp1"
                     /gene_synonym="Dcdc3; Gm38717; mG145; Orp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..6404
                     /gene="Rp1"
                     /gene_synonym="Dcdc3; Gm38717; mG145; Orp1; Rp1h"
                     /note="isoform 1 is encoded by transcript variant 1;
                     retinitis pigmentosa RP1 protein homolog; oxygen-regulated
                     protein 1; retinitis pigmentosa 1 homolog; lipoxygenase
                     homology domain-containing protein 1"
                     /codon_start=1
                     /product="oxygen-regulated protein 1 isoform 1"
                     /protein_id="NP_035413.1"
                     /db_xref="CCDS:CCDS14804.1"
                     /db_xref="GeneID:19888"
                     /db_xref="MGI:MGI:1341105"
                     /translation="MSDTPSTSFSMIHLTSEGQVPSPRHSNITHPVVAKRISFYKSGD
                     PQFGGVRVVVNPRSFKTFDALLDSLSRKVPLPFGVRNISTPRGRHSITRLEELEDGKS
                     YVCSHNKKVLPVDLDKARRRPRPWLSSRSISTHVQLCPATANMSTMAPGMLRAPRRLV
                     VFRNGDPKNKHVVLLSRRITQSFEAFLQYLTQVMQCPVAKLYATDGRKVPSLQAVILS
                     SGAVVAAGREPFKPGNYDIQKYLLPAKLPGISHRVHQKGKAKIEKRKMSTHMPSDLRP
                     QTDSLISEKTYDCFSDFSVAPENYLALETHESQSLSTYPSEDDVEKSIVFNQDGTMTV
                     VMKVRFKIKEEETVKWTTTVNRAGLSNNDEKNKKSSYPGKTDYGPSSLKLEACSLPED
                     IVDTTQQGSLTEEENTQMTEQQALSCSSASWENASMETDIQESQKQVKHFYRPPTPGP
                     RRMRQKKSVIGTVTVVSETEVQEKQFSYSEERKGGEKSEYHMFTHSCSKMSSVSNKLV
                     QIGSDNEMESALERTRESGSLKSQAINAGAIEITSQKVLKMCHNNALPSTAPENSVVE
                     EGTDNSAVSGTATIKHFRTCGNANDSFSSITADSTPTSVNNYSNDRNISELPSVGSPV
                     LTMRLVNEFAHCGLTEKPENRKKVLSSSASKKKKKKSQQRMITSNDKKKVIETKGPPN
                     IAGKIPRAGTTAQERLLQESDCPDKGGRVCEQGLNISPMAIESNNFFPKSNPTFSKNF
                     YKNKLNTFQNPKTQKLLAKRKSRPRKIVSTERLRKQEIGQEDKILLHSDSKLCESHLE
                     KQSLFHVFNILEEDQKVLHRPPFQVEKVARNLKGMAKKSLVPKVNDLHIMLRNQKKQM
                     GVKLKSGAEVSEQHVTTRADPLASLKKPDFPEGIPHHSGKSYVKRWLQNINSYPDFEH
                     RKSGPLCQNRSDVVNYNRNGFLGNNLHTTSSKGNGFLMESNKSKTKNDNWSGNTNQET
                     GKSLVAKDNGEELNKHHCESQNGSLYDSYLVSLHDNCTLSQTTINEPSTKSHLSIEKS
                     RPEVKLVYQEMNFATKRQSIEVAIQVDTMGENVLKDYLPALLLRHLEAFVPNNQKHQN
                     GISQIPGSLAEVVFPSVIDNSSTNLLLAWLLVLNLKRTMNSFCQSDAHKMTNRPSETA
                     ALLEVLKHVAITEEADDLKAAVANLMESTKTCSGSSGREQDMLPVNCTASSLHSVDEC
                     NENGSAQKTLLDEGYSVMGDCTSEMVSKSCNSSCEMHMVSKTNPPKQVDDQSDGLLTS
                     NSCTVSQRSTGACFLTDGVYSHEACAQKEGVYEGACLSDETHIPIRDCHTIHSVHSKE
                     NKCTDDLESTEELKTVDKVPKGLSILADSMYKNDSNVSTFQNVNKLSSQRTLLSKTYL
                     DSDKDYSPLEEFQNCPRKKIVNKKKSISSDKEESRTSEEPRSITNSMTSSERNAISEL
                     ESFEELESQDTSIFNMNVRAEKKSTKETMQKQSEARMSSELINVSGRKIIEQERRNTA
                     ILETTARGQVTPPSLAFCYDSNKNTEKEISEGETKMRVKKMVDSMENESYSESSLNFK
                     KHHRSPGTLDWSDYGSDSESGYPCKASSNSHNDDSGQEKEPTRGIVKRAIEKLYGKAE
                     IIKPPFFHGSIHKSQVCPYNSVEVQCAKKTNFYESECQSLVSSEQVSRSSLIFQEFPQ
                     VDANGMGDSFGDSSIENVTKSSAHDRVFTEKENGKLIDNGKWLLRENHLWRVSSDNPG
                     MYGNADTTSVDTLIDKNSIEVPYSHFGELAPGPTMAELSSSEIEEMTQPLEVKCNYFN
                     FPHGSDSEPFGEDFPDAQNKTCPKEKIPNHHTEEKGNYPSERLCTSVTQAFVSAGNKV
                     HPVCSDAIKTQPLPGSNITHGALQEGDSLDKLYALCGQHCPILTVIIQPVNEESRGFA
                     YRKDSDIENSLDFQLWMKIYPFMPQSKKHVFRSDGRNVSVGEEFAGNVIGDLCDQLYF
                     KSMIDLVDQRANSLGKEINLKKFQLYLKKSFSDPLSTSLLVVENRNSVSLSPSSWTDN
                     FKSIDENNNFLNRLPNSSKNPNQVVRENTNFQFHLELFGQVYLLDICQVEKPLNIKTR
                     SKLEMYYILEGEVLFIWEEEK"
     exon            741..912
                     /gene="Rp1"
                     /gene_synonym="Dcdc3; Gm38717; mG145; Orp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            913..6854
                     /gene="Rp1"
                     /gene_synonym="Dcdc3; Gm38717; mG145; Orp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6832..6837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rp1"
                     /gene_synonym="Dcdc3; Gm38717; mG145; Orp1; Rp1h"
                     /note="hexamer: AATAAA"
     polyA_site      6854
                     /gene="Rp1"
                     /gene_synonym="Dcdc3; Gm38717; mG145; Orp1; Rp1h"
                     /note="major polyA site"
ORIGIN      
        1 agacatttgt ttacgtgaaa caagcaggtt gcatatccag tgacgtttat acagaccaca
       61 caaactattt actcttttct tcgtaaggaa aggttcaact tctggtctca cccaaaatga
      121 gtgacacacc ttctactagt ttctccatga ttcatctgac ttctgaaggt caagttcctt
      181 cccctcgcca ttcaaatatc actcatcctg tagtggctaa acgcatcagt ttctataaga
      241 gtggagaccc acagtttggc ggcgttcggg tggtggtcaa ccctcgttcc tttaagactt
      301 ttgacgctct gctggacagt ttatccagga aggtacccct gccctttggg gtaaggaaca
      361 tcagcacgcc ccgtggacga cacagcatca ccaggctgga ggagctagag gacggcaagt
      421 cttatgtgtg ctcccacaat aagaaggtgc tgccagttga cctggacaag gcccgcaggc
      481 gccctcggcc ctggctgagt agtcgctcca taagcacgca tgtgcagctc tgtcctgcaa
      541 ctgccaatat gtccaccatg gcacctggca tgctccgtgc cccaaggagg ctcgtggtct
      601 tccggaatgg tgacccgaag aataagcatg tggtccttct tagccggagg atcactcaga
      661 gcttcgaagc ctttctgcag tacctgacac aggttatgca gtgtcctgtg gccaagctgt
      721 atgccacaga tggaagaaaa gttcctagtc tccaggcagt gatactcagc tctggagctg
      781 tggtggcagc tggaagggag ccatttaaac caggaaatta cgacatacaa aagtacttgc
      841 ttcctgccaa gttaccagga atctctcatc gtgtgcacca gaagggaaaa gccaagatag
      901 aaaaaagaaa gatgagcaca catatgcctt cagacctaag accccagact gattccctga
      961 tctcggagaa aacatatgat tgcttttcag atttttctgt agcccctgag aattacttgg
     1021 ccttagaaac acatgagtct cagtctctat caacttatcc ttctgaagat gatgttgaga
     1081 aatcgattgt ttttaatcaa gatggtacga tgacggtcgt gatgaaagtt cgattcaaga
     1141 taaaagaaga agaaactgtt aagtggacaa caactgtcaa tagagctggt ctttctaata
     1201 atgatgaaaa gaataagaaa agtagttatc ctggaaaaac agattatgga ccatctagtt
     1261 taaagcttga agcatgttcg ttgcctgaag acatcgtaga taccactcag cagggcagtt
     1321 tgacagagga agaaaatact caaatgacag agcagcaggc tctgtcatgt agctctgcta
     1381 gttgggagaa tgcctctatg gagacagaca ttcaggaaag ccagaaacaa gtgaaacact
     1441 tttatagacc cccaactcct ggaccaagga gaatgagaca aaagaaatct gtgataggga
     1501 ctgtcacagt agtatctgaa acagaggttc aagaaaagca gttttcctat agtgaagaaa
     1561 gaaagggtgg agaaaaatct gagtatcata tgtttacaca ttcttgcagt aaaatgtcat
     1621 cagtatctaa taaacttgtt cagatcggta gcgataatga gatggagtca gcattagaaa
     1681 gaacaaggga aagtggatca ctcaagtcac aggccataaa tgctggtgct attgaaatta
     1741 caagtcagaa ggtcttaaag atgtgccaca acaatgcttt accgtcaact gcaccagaga
     1801 actcagtcgt ggaagaaggc acagacaaca gtgcagtatc aggcacagcc actatcaagc
     1861 acttcagaac ttgtggtaat gccaatgaca gcttcagttc tatcacagca gattcaactc
     1921 ctacctcagt taacaattat tcaaatgaca gaaatatttc tgagcttcct tctgtaggat
     1981 ctcctgtact caccatgaga cttgttaatg aatttgctca ttgtggttta acagaaaaac
     2041 cagaaaacag aaagaaggtt ttatcttctt ctgctagcaa gaagaagaaa aagaaatctc
     2101 agcagcgaat gataacttcc aatgataaga aaaaagtgat tgaaaccaaa ggacccccaa
     2161 atatagctgg gaagataccc agagctggaa caactgcaca ggaaagacta ttgcaagaat
     2221 cagactgtcc tgataaagga ggaagagttt gtgagcaggg ccttaatata agtcctatgg
     2281 caattgaatc aaataatttt tttcccaaaa gtaatcccac attttctaag aatttctata
     2341 aaaataaatt aaatactttt caaaatccta agactcaaaa acttttggcc aaaagaaaat
     2401 caaggccacg aaagattgta agcacagaaa gactcagaaa acaagagatt ggtcaagaag
     2461 ataaaatact tctccatagt gactcgaaac tctgtgaaag tcatttggaa aaacaaagtt
     2521 tatttcatgt gtttaatatc cttgaagaag atcagaaagt tttgcacaga ccaccgttcc
     2581 aagtggagaa agtagctaga aatttgaaag gaatggcaaa aaagagttta gtcccaaaag
     2641 tcaatgattt acacataatg ttaagaaacc agaaaaaaca aatgggagtt aaattaaagt
     2701 caggtgctga ggtaagtgaa cagcatgtta caaccagggc agatccatta gcttctctga
     2761 aaaaacctga ttttcctgag ggcattcccc atcattcagg taaaagctat gtaaagcgat
     2821 ggttgcagaa cataaactca tatccagatt ttgagcatag aaagtccggt ccactatgcc
     2881 aaaatagaag tgatgtggta aattataacc gcaatggctt tctaggaaat aatctccata
     2941 caacttcttc aaaaggaaat ggttttttaa tggaaagtaa taagagcaaa actaaaaacg
     3001 acaattggtc aggcaataca aatcaagaga caggtaaatc tcttgttgct aaagataatg
     3061 gtgaagagct caataaacat cactgtgaga gccagaatgg gtctctgtat gattcttact
     3121 tggtttcttt gcatgacaat tgtactttgt cacagaccac tattaatgag cctagtacta
     3181 aaagtcattt atctattgaa aagtcaagac cagaagtaaa gcttgtttac caagaaatga
     3241 actttgctac aaaaaggcaa agtattgaag ttgccattca ggtagatact atgggagaaa
     3301 atgttctaaa agactactta ccagccttgt tgctacggca cctggaagct tttgttccta
     3361 ataatcagaa acatcagaat ggaatttctc aaataccagg ttcattagca gaggttgtct
     3421 tcccttctgt aatagataat tcatccacaa atctccttct ggcttggctt ttggtactaa
     3481 acctaaagag aactatgaat agcttctgtc aaagtgatgc tcataagatg accaacagac
     3541 cttcggaaac tgctgcattg ttggaagttc tgaagcatgt tgccatcaca gaggaagctg
     3601 atgacttgaa ggctgctgtt gccaacttga tggaatcaac caaaacttgc agtgggtcca
     3661 gtgggagaga acaagatatg ctaccagtaa attgtacagc atccagcctt catagtgtgg
     3721 acgagtgtaa tgaaaatggg agtgctcaga agaccctctt ggatgaaggc tattctgtca
     3781 tgggggattg tacctcagaa atggttagca agtcatgtaa ctcctcatgt gagatgcaca
     3841 tggtgagcaa aactaatcct ccaaaacagg tagatgacca gagtgatggc cttcttacta
     3901 gcaatagctg cactgtgagt cagcgctcca caggggcctg tttccttaca gatggggtgt
     3961 attcccatga ggcttgtgct cagaaggagg gcgtctatga gggagcttgc ctaagtgatg
     4021 agactcacat tcctatcaga gactgccata caattcactc tgtgcattca aaagaaaaca
     4081 aatgcactga tgatctggaa tcaactgaag aactcaaaac tgttgacaaa gttccaaaag
     4141 gtctaagcat tctggcagat tctatgtata aaaatgactc taatgtatct acatttcaaa
     4201 atgtcaataa gttaagttcc caacgcactc tcctaagtaa aacttatcta gactctgata
     4261 aggactatag tcctctagaa gaatttcaaa attgcccacg taagaaaatt gtgaataaaa
     4321 agaaatctat ttcttctgat aaggaagaat caaggacttc tgaggaacca aggtcaataa
     4381 ccaatagcat gacatcaagt gaaagaaatg ccatttcaga attagaatct tttgaagaat
     4441 tagaaagcca agacacaagt atcttcaata tgaatgtaag ggctgaaaaa aaatctacca
     4501 aggaaacgat gcaaaaacaa tcagaggcta ggatgagttc agaattgata aacgtatcag
     4561 ggaggaaaat tatagaacag gaaagaagaa atactgccat tctggagaca accgctaggg
     4621 ggcaggtgac accaccatct ttagcttttt gctacgattc taacaaaaac accgaaaaag
     4681 agatcagtga aggagaaact aagatgagag ttaagaagat ggtagacagc atggaaaatg
     4741 aaagttactc ggagtcctca cttaatttta aaaaacatca cagaagtcca ggaaccttag
     4801 actggtcaga ctatggatca gatagtgaga gtggatatcc ttgtaaagca tcgagcaata
     4861 gtcacaatga tgactctggc caagagaaag agcccacaag aggaattgtt aaaagagcaa
     4921 tagaaaagct ttatggcaaa gcagagatta tcaaaccacc atttttccat gggtctatac
     4981 acaaatctca agtttgtcct tataattctg tggaagttca gtgtgctaag aaaaccaatt
     5041 tttatgagtc tgaatgccag tcattggtct cttctgaaca ggtatccaga agttcactca
     5101 tatttcagga attccctcag gttgatgcta atggcatggg agacagtttt ggggacagca
     5161 gcatagaaaa tgttacaaaa tcaagtgcgc atgacagggt ctttacagaa aaagagaatg
     5221 gaaaactgat tgacaatggc aaatggctcc tgagagaaaa tcatttgtgg cgggtgtcat
     5281 cggacaatcc tggcatgtac ggcaatgcag acaccacatc agtggatact ctaatagata
     5341 agaacagcat tgaggtgcca tattcacatt tcggagagct ggctcctggt ccaacaatgg
     5401 ctgaactgtc ctcttcagaa atagaggaaa tgactcaacc ccttgaagtg aaatgcaatt
     5461 attttaactt ccctcatggt agtgactctg agccttttgg tgaagatttt ccagatgcac
     5521 agaataaaac ttgtcccaaa gagaaaatac ccaaccatca cacagaggag aagggtaatt
     5581 atccatcgga aagactgtgt acatctgtta ctcaagcctt tgtttctgct ggtaataaag
     5641 tccacccggt ctgcagtgac gctattaaaa ctcagccatt acctgggagt aacatcactc
     5701 acggcgcact tcaggaaggt gactctttgg ataaactcta tgctctttgt ggtcaacatt
     5761 gtccgatact aactgttatt attcaacctg taaatgagga aagccgagga tttgcttatc
     5821 gcaaagattc tgatattgaa aattctttgg attttcagtt atggatgaaa atatacccat
     5881 ttatgccaca gtcaaagaaa cacgtgttta gaagtgatgg caggaatgtg agtgtgggtg
     5941 aagaatttgc tggtaatgtc attggtgatc tctgtgatca actttatttc aaaagcatga
     6001 ttgacttagt ggatcaaaga gctaactctt tagggaagga aattaatttg aagaaattcc
     6061 aactatattt aaagaaaagc ttttccgatc ctttgtccac gtcattgcta gtggtggaga
     6121 ataggaattc tgtttcacta agccctagca gttggacaga taacttcaaa agtattgatg
     6181 agaataacaa cttccttaac agattaccga actcaagtaa aaatcccaac caagtagtaa
     6241 gagagaacac taattttcag ttccacttag aactgtttgg tcaagtttac ttgttagata
     6301 tttgccaagt tgagaaaccc ttaaatatca aaaccagaag taaattagaa atgtattaca
     6361 ttttagaggg tgaagttctt ttcatctggg aagaagaaaa atgaattaaa tataatagat
     6421 actgaaggcc ctaatgagtg ggatgattta taatttcagt attcacacaa tcaccagctg
     6481 tcaatatgtt tttcccataa aaagatgcag tacatgggat agaatttagc atacattctc
     6541 taagaatttc ttactctttc aaaatgagaa tactctggaa aacgtatttt tggaaaaaat
     6601 ggatttggtt ttcttcattg ctttgctcct cattttctca gtaaagtttt atgtagtttc
     6661 attgtaaaca gataattttg catagctatg actttgttat caggatatca gaaatatggt
     6721 caggacaaga aatatatcct taaaatattg tctagtacat atatatgttg aatatattaa
     6781 tgggtaaatg taactttaaa ctacttcatt tattaatgta agtgctgatt taataaaaag
     6841 tattattaaa cctt
//
