LOCUS       NM_011282               7401 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus Ros1 proto-oncogene (Ros1), mRNA.
ACCESSION   NM_011282
VERSION     NM_011282.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7401)
  AUTHORS   Kiyozumi,D. and Ikawa,M.
  TITLE     Adhesion G protein-coupled receptor G2 is dispensable for lumicrine
            signaling regulating epididymal initial segment differentiation and
            gene expressiondagger
  JOURNAL   Biol Reprod 109 (4), 474-481 (2023)
   PUBMED   37531264
REFERENCE   2  (bases 1 to 7401)
  AUTHORS   Kiyozumi,D., Shimada,K., Chalick,M., Emori,C., Kodani,M., Oura,S.,
            Noda,T., Endo,T., Matzuk,M.M., Wreschner,D.H. and Ikawa,M.
  TITLE     A small secreted protein NICOL regulates lumicrine-mediated sperm
            maturation and male fertility
  JOURNAL   Nat Commun 14 (1), 2354 (2023)
   PUBMED   37095084
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7401)
  AUTHORS   Jun,H.J., Ali,Z.A. and Charest,A.
  TITLE     Male sterility in ROS1 receptor tyrosine kinase conditionally
            deleted in epididymal epithelial
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1870 (3), 119413 (2023)
   PUBMED   36535370
REFERENCE   4  (bases 1 to 7401)
  AUTHORS   Su,J., Miao,X., Archambault,D., Mager,J. and Cui,W.
  TITLE     ZC3H4-a novel Cys-Cys-Cys-His-type zinc finger protein-is essential
            for early embryogenesis in micedagger
  JOURNAL   Biol Reprod 104 (2), 325-335 (2021)
   PUBMED   33246328
REFERENCE   5  (bases 1 to 7401)
  AUTHORS   Kiyozumi,D., Noda,T., Yamaguchi,R., Tobita,T., Matsumura,T.,
            Shimada,K., Kodani,M., Kohda,T., Fujihara,Y., Ozawa,M., Yu,Z.,
            Miklossy,G., Bohren,K.M., Horie,M., Okabe,M., Matzuk,M.M. and
            Ikawa,M.
  TITLE     NELL2-mediated lumicrine signaling through OVCH2 is required for
            male fertility
  JOURNAL   Science 368 (6495), 1132-1135 (2020)
   PUBMED   32499443
REFERENCE   6  (bases 1 to 7401)
  AUTHORS   Narayana,L. and Nagarajan,L.
  TITLE     A mouse c-ros genomic clone: identification of a highly conserved
            22-amino acid segment in the juxta-membrane domain
  JOURNAL   Gene 118 (2), 297-298 (1992)
   PUBMED   1324876
REFERENCE   7  (bases 1 to 7401)
  AUTHORS   Tessarollo,L., Nagarajan,L. and Parada,L.F.
  TITLE     c-ros: the vertebrate homolog of the sevenless tyrosine kinase
            receptor is tightly regulated during organogenesis in mouse
            embryonic development
  JOURNAL   Development 115 (1), 11-20 (1992)
   PUBMED   1638975
REFERENCE   8  (bases 1 to 7401)
  AUTHORS   Haefliger,J.A., Bruzzone,R., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Paul,D.L.
  TITLE     Four novel members of the connexin family of gap junction proteins.
            Molecular cloning, expression, and chromosome mapping
  JOURNAL   J Biol Chem 267 (3), 2057-2064 (1992)
   PUBMED   1370487
REFERENCE   9  (bases 1 to 7401)
  AUTHORS   Siracusa,L.D., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification and applications of repetitive probes for gene
            mapping in the mouse
  JOURNAL   Genetics 127 (1), 169-179 (1991)
   PUBMED   1673105
REFERENCE   10 (bases 1 to 7401)
  AUTHORS   Justice,M.J., Siracusa,L.D., Gilbert,D.J., Heisterkamp,N.,
            Groffen,J., Chada,K., Silan,C.M., Copeland,N.G. and Jenkins,N.A.
  TITLE     A genetic linkage map of mouse chromosome 10: localization of
            eighteen molecular markers using a single interspecific backcross
  JOURNAL   Genetics 125 (4), 855-866 (1990)
   PUBMED   1975791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155831.7 and AC153950.8.
            
            On Sep 14, 2006 this sequence version replaced NM_011282.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U15443.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-414               AC155831.7         66584-66997
            415-459             AC155831.7         80005-80049
            460-519             AC155831.7         81607-81666
            520-546             AC155831.7         82855-82881
            547-607             AC155831.7         88927-88987
            608-756             AC155831.7         91715-91863
            757-895             AC155831.7         93087-93225
            896-1097            AC155831.7         95581-95782
            1098-1174           AC155831.7         96412-96488
            1175-1297           AC155831.7         97821-97943
            1298-1482           AC155831.7         98938-99122
            1483-1580           AC155831.7         99922-100019
            1581-2077           AC155831.7         106550-107046
            2078-2290           AC155831.7         115868-116080
            2291-2401           AC155831.7         116953-117063
            2402-2580           AC155831.7         118403-118581
            2581-2772           AC155831.7         119497-119688
            2773-2873           AC155831.7         130842-130942
            2874-3088           AC155831.7         132051-132265
            3089-3249           AC155831.7         132729-132889
            3250-3394           AC155831.7         133267-133411
            3395-3657           AC155831.7         135847-136109
            3658-3721           AC155831.7         137707-137770
            3722-3924           AC155831.7         138409-138611
            3925-4130           AC155831.7         140827-141032
            4131-4414           AC155831.7         143425-143708
            4415-4591           AC155831.7         145766-145942
            4592-4791           AC155831.7         159920-160119
            4792-4936           AC155831.7         161687-161831
            4937-5169           AC155831.7         162926-163158
            5170-5346           AC155831.7         165630-165806
            5347-5515           AC155831.7         170714-170882
            5516-5633           AC155831.7         173830-173947
            5634-5824           AC155831.7         176474-176664
            5825-5908           AC153950.8         1623-1706
            5909-6044           AC153950.8         5681-5816
            6045-6207           AC153950.8         7690-7852
            6208-6272           AC153950.8         10533-10597
            6273-6402           AC153950.8         11482-11611
            6403-6500           AC153950.8         16563-16660
            6501-6701           AC153950.8         17252-17452
            6702-6836           AC153950.8         18857-18991
            6837-7000           AC153950.8         32628-32791
            7001-7401           AC153950.8         37339-37739
FEATURES             Location/Qualifiers
     source          1..7401
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 26.18 cM"
     gene            1..7401
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="Ros1 proto-oncogene"
                     /db_xref="GeneID:19886"
                     /db_xref="MGI:MGI:97999"
     exon            1..414
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..7311
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /EC_number="2.7.10.1"
                     /note="proto-oncogene tyrosine-protein kinase ROS;
                     c-ros-1; proto-oncogene c-Ros-1; c-Ros receptor tyrosine
                     kinase; receptor tyrosine kinase c-ros oncogene 1"
                     /codon_start=1
                     /product="proto-oncogene tyrosine-protein kinase ROS
                     precursor"
                     /protein_id="NP_035412.2"
                     /db_xref="CCDS:CCDS23838.1"
                     /db_xref="GeneID:19886"
                     /db_xref="MGI:MGI:97999"
                     /translation="MKNICWLTLKLVKFVVLGCIIWISVAQSTVLSSCLTSCVTNLGR
                     QLDSGTRYNLSEACIHGCQFWNSVDQETCALKCNDTYATICERESCEVGCSNAEGSYE
                     EEVLESTELPTAPFASSIGSHGVTLRWNPANISGVKYIIQWKYAQLPGSWTFTETVSK
                     LSYTVEPLHPFTEYIFRVVWIFTAQLHLYSPPSPSYRTHPYGVPETAPLILNMESWSP
                     DTVEVSWAPPHFPGGPILGYNLRLISKNQKLDSGTQRTSFQFYSTLPNTTYRFSIAAV
                     NEVGEGPEAESTVTTPSPSVQEEEQWLFLSRKTSLRKRSLKYLVDEAHCLWSDAIHHN
                     ITGISVYAQQQVVYFSEGTVIWMKGAANMSDVSDLRIFYQGSGLVSSISIDWLYQRMY
                     FIMDKLVYVCELKNCSNLEEITPFSLIAPQKVVVDSYNGYLFYLLRDGIYRVNLPLPS
                     GRDTKAVRIVESGTLKDFAVKPQSKRIIYFNDTMQLFMSTFLDGSAFHRVLPWVPLVT
                     VKSFACENNDFLITDGKAIFQQDSLSFNEFIVGCDLSHIEEFGFGNLVIFGSSVQSYP
                     LPGHPQEVSVLFGSREALIQWTPPALAIGASPSAWQNWTYEVKVYSQDILEITQVFSN
                     ISGTMLNVPELQSSTKYTVSVRASSPKGPGPWSAPSVGTTLVPATEPPFIMAVKEDGL
                     WSKPLCSFGPGEFLSSDVGNVSDMDWYNNSLYYSDTKGNVYVRPLNGMDISENYHIPS
                     IVGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMAVDSVGGYLY
                     WTTLYSVESTRLNGESSLVLQAQPWLSGKKVIALTLDLSDGLLYWLVQDNQCIHLYTA
                     VLRGWSGGDATITEFAAWSTSEISQNALMYYSGRLFWINGFRIITAQEIGQRTSVSVS
                     EPAKFNQFTIIQTSLKPLPGNFSSTPKVIPDPVQESSFRIEGHTSSFQILWNEPPAVD
                     WGIVFYSVEFSTHSKFLIIEQQSLPIFTVEGLEPYTLFNLSVTPYTYWGKGQKTSLSF
                     RAPESVPSAPENPRIFILSSGRYTKKNEVVVEFRWNKPKHENGVLTKFEIFYHISKQS
                     GTNRSTEDWMSASVIPPVMSFQLEAVSPEYTVAFQVRVFTSKGPGPFSDIVMSKTSEI
                     KPCPYLISLLGNKIVFLDMDQNQVLWTFSLEGDVSTVGYTTDDEMGYFAQGDTLFLLN
                     LRNHSSSKLFQDALVSDIRVIAVDWIARHLYFALKASQNGTQIFNVDLEHKVKSPREV
                     KTCKAHTTIISFSIYPLLSRLYWTEVSDLGHQMFYCNISNHTSQHVLQPKASNQHGRS
                     QCSCNVTESELSGAMTVDTSDPDRPWIYFTKRQEIWAMDLEGCQCWKVIMVPTIPGKR
                     IISLTVDGEFIYWIMKTKDDAQIYQAKKGSGAILSQVKASRSKHILAYSSALQPFPDK
                     AYLSLASDMVEATILYATNTSLTLKLPPVKTNLTWHGITHPTSTYLIYYMEANRANSS
                     DRRHKMLESQENVARIEGLQPFSMYMIQIAVKNYYSEPLEHLPLGKEIQGQTKSGVPG
                     AVCHINATVLSDTSLHVFWTESHKPNGPKESVRYQLVMSYLAPIPETPLRQGEFPSAK
                     LSLLITKLSGGQLYVMKVLACHPEEMWCTESHPVSVNMFDTPEKPSALVPENTSLQLD
                     WKARSNVNLTGFWFELQKWKYNEFYHVKASCSQGPVYVCNITDLQPYTSYNIRVVVVY
                     TTGENSSSIPESFKTKAGVPSKPGIPKLLEGSKNSIQWEKAEDNGSRLMYYTLEVRKG
                     ISNDSQNQSSRWKVVFNGSCSSICTWRSKNLKGTFQFRAVAANEIGLGEYSEISEDIT
                     LVEDGVWITETSFILTIIVGIFLVATVPLTFVWHRSLKSHKASKEGLSVLNDNDKELA
                     ELRGLAAGVGLANACYAVHTVPTQEEIENLPAFPREKLSLRLLLGSGAFGEVYEGTAI
                     DILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLGEPQY
                     IILELMEGGDLLSYLRKARGTTFHGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLA
                     ARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGEGLLPVRWMAPENLMDGIFT
                     SQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMSQC
                     WAQEPDQRPTFHNIQNQLQLFRNVFLNNVSHCGEAAPTGGVINKGFEGEDDEMVTLNS
                     DDTMPVALMETKNQEGLNYMVLATKCSQGEGSYEGPLGPKELGSCDLKKDKKQPQADK
                     DFCQEPQVAYGSPGLSEGLNYACLAHSEHGDVSE"
     exon            415..459
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..519
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..546
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..607
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..756
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..895
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1097
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1174
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1297
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1482
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1580
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..2077
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2290
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2401
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2580
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2772
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2873
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3088
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3249
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3394
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..3657
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3658..3721
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3924
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..4130
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4131..4414
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4415..4591
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4592..4791
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4792..4936
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4937..5169
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5170..5346
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5347..5515
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5516..5633
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5634..5824
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5825..5908
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5909..6044
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6045..6207
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6208..6272
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6273..6402
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6403..6500
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6501..6701
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6702..6836
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6837..7000
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7001..7401
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7373..7378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="hexamer: AATAAA"
     polyA_site      7395
                     /gene="Ros1"
                     /gene_synonym="c-ros; Ros-1"
                     /note="major polyA site"
ORIGIN      
        1 cctggatcta acttttagcc agggaatgtc ttttgttatg ggagcaaaag gaagctaaac
       61 tataaaatag ccttgctgcg atgttctggg ctatctaaga tccaaaggtc taaactaatc
      121 caaaggcctc aatattcttt ttaaagagag aatgatattc taacattgcg aaagaaaaca
      181 gaaaacctac ttgtcacact tgcaactgaa gtatgaagcc taaagagttc ttaaagcaag
      241 gtggagctat gaggacccca gctgtgtagg aagccagccc tcctgaggat gaagaacatc
      301 tgctggctca ccctgaaact tgtgaagttt gtggtccttg ggtgcatcat atggatttct
      361 gtggcacaga gtacagttct gagcagctgc ctaacgtcct gtgtaactaa cctgggcagg
      421 cagcttgaca gtggcacacg gtacaatctg agtgaggcgt gcatccatgg atgtcagttt
      481 tggaactctg tagatcagga aacgtgtgct ttaaagtgta atgacaccta cgccaccatt
      541 tgtgagaggg agtcctgtga ggtcggctgc agcaatgcgg agggtagcta cgaagaggaa
      601 gtgctggaaa gcacagaact tcctacagca ccctttgcat cttccattgg aagtcatggt
      661 gtgacattac gctggaaccc tgccaacatc tctggagtca aatacataat tcaatggaaa
      721 tatgcccaac ttccaggaag ctggactttc acggagaccg tgtccaagct ctcatacacg
      781 gtggaacccc tgcatccatt cacagaatat atttttcgag tggtttggat cttcacagcc
      841 caactgcatc tttattcccc accaagtccc agttacagga ctcatcctta tggagttcca
      901 gaaactgcac ctctcatcct gaacatggaa agctggagcc ctgatactgt ggaggtcagc
      961 tgggctccac ctcatttccc aggtggacct attttgggtt ataatttaag gctcatcagt
     1021 aaaaatcaaa aattagattc agggacacag agaaccagtt tccagtttta ttctactcta
     1081 ccaaacacca cctacaggtt ttctatcgca gcagtcaatg aagttggtga ggggccagaa
     1141 gcagaatcta cagttaccac tccatcccca tcagttcaag aagaagaaca atggctcttt
     1201 ttatccagaa aaacttctct aagaaagagg tctttgaagt acttagtaga tgaagcacat
     1261 tgcctttggt cagatgctat acaccataat attacaggaa tatcagtcta tgctcagcag
     1321 caagtggttt atttttcaga aggaactgtc atctggatga agggggctgc caacatgtct
     1381 gatgtgtctg acctgagaat tttttaccaa ggctcaggtc tagtgtcttc tatctccata
     1441 gactggctgt accaaaggat gtatttcatc atggataaac tggtatatgt ctgtgaatta
     1501 aagaattgct caaatttaga ggaaatcact cccttctctc ttattgcacc tcagaaagtt
     1561 gtggttgact cctacaatgg gtacctcttt tatctcctga gagacggcat ctacagagtc
     1621 aatctccctt tgccatctgg cagggacacc aaagctgtgc gtattgtgga gagtggcaca
     1681 ttaaaggact ttgcagtaaa gccccaatcc aagcgaatca tttacttcaa tgacaccatg
     1741 caactcttca tgtcaacgtt tctggatggc tctgccttcc accgggtcct gccttgggtc
     1801 ccccttgtga ctgtgaagag ctttgcttgt gaaaacaatg acttcctcat cacagatggc
     1861 aaggccattt ttcagcagga ctccctgtct ttcaatgaat tcatcgtggg atgtgacctg
     1921 agtcacatag aagagtttgg gtttggtaac ttggtcatct ttggctcctc tgtccagtca
     1981 taccctctgc caggacatcc acaggaggtc tcagtgctgt ttggttctcg agaggccctt
     2041 attcagtgga cgcctcctgc tctcgccata ggagccagtc cttccgcctg gcagaactgg
     2101 acttatgaag tcaaagttta ttcccaggac atccttgaaa tcactcaagt tttctcgaac
     2161 ataagcggga ccatgcttaa tgtacccgaa ctgcagagtt ctacaaagta cactgtctct
     2221 gtgagagcaa gttctcctaa aggcccaggc ccctggtcag caccatcagt gggtaccacc
     2281 ttggtaccag ctactgaacc accattcatc atggctgtga aagaagatgg gctctggagc
     2341 aaaccactct gtagttttgg tccaggagaa ttcctgtcct ctgatgtagg aaacgtgtca
     2401 gatatggatt ggtacaacaa cagcctctac tacagtgaca caaaaggcaa cgtttatgtg
     2461 cggcctctga atgggatgga tatctcagag aattatcaca tacccagcat tgtaggagct
     2521 ggggctttgg cctttgaatg gctgggtcac tttctctact gggctgggaa gacatatgtg
     2581 atccaaaggc agtctgtgtt gacgggacac acggacattg tgactcatgt gaagctgttg
     2641 gtgaatgaca tggctgtgga ttcagttggt ggctatctct attggacaac actctactca
     2701 gttgaaagca ccagactcaa tggagaaagt tctcttgtac tacaggctca gccctggctc
     2761 tctggaaaaa aggttattgc tctaacacta gacctcagtg atgggctcct gtattggctg
     2821 gtgcaggaca atcagtgtat tcatctgtac acagctgttc ttcgaggatg gagtggtggg
     2881 gatgctacca tcacagagtt tgcagcctgg agtacttctg aaatctccca gaatgcactg
     2941 atgtactaca gtggtagact cttctggatc aatggattta ggatcattac agcacaggaa
     3001 ataggtcaga gaaccagtgt gtctgtttcg gagccagcga aattcaatca gttcacaatt
     3061 atacagacat ctctcaagcc tctgccagga aacttttcct ctactcccaa ggttatccca
     3121 gatcctgttc aggagtcttc atttcgaatt gaaggacaca cttcaagttt ccaaatcctg
     3181 tggaatgagc cccctgcggt ggactggggc atcgttttct acagtgtgga atttagcact
     3241 cattccaagt tcctgattat tgaacaacag tctttaccta tttttactgt ggaaggactg
     3301 gagccctata ccttatttaa tctttctgtc actccttata cctactgggg aaagggccaa
     3361 aaaacatctc tatcatttcg tgcacctgaa tcagttccat cagcaccaga aaaccccaga
     3421 atatttatat tgtcaagcgg aagatacacc aagaagaatg aagttgtggt agagttcagg
     3481 tggaataaac ctaagcatga aaatggagtg ctaaccaaat ttgaaatctt ctatcacata
     3541 tctaaacaaa gtggcacaaa tagatcaact gaagactgga tgtctgccag tgttataccc
     3601 ccagtgatgt cttttcaact tgaggctgtg agtcctgagt atactgttgc cttccaggtt
     3661 agagtcttca catccaaagg gccagggcca ttttctgata tagtgatgtc taaaacatca
     3721 gaaatcaagc catgtccgta tctcatatct cttctcggca ataagatcgt gtttctagac
     3781 atggatcaaa atcaagtttt gtggacattt tccctggagg gagacgtcag cacagtgggg
     3841 tacacaacag acgatgaaat ggggtatttc gctcaaggag acacgctctt ccttctgaat
     3901 ttgcgtaatc attccagttc caagcttttc caggatgcac tggtttctga cattagagtt
     3961 attgctgttg attggattgc aaggcacctc tactttgctc tgaaagcatc acaaaacgga
     4021 acacagatat tcaatgttga ccttgaacac aaggtgaaat cccccaggga ggtgaagact
     4081 tgcaaagcac atacaacaat aatttctttc tctatatatc ccctcttgag tcgcttgtat
     4141 tggacagaag tttcagatct gggccatcag atgttctact gcaatattag caatcacacc
     4201 tcgcaacatg ttctacaacc caaggcttca aaccaacatg gaaggagtca atgttcttgt
     4261 aatgtgacag aatctgagtt aagtggggca atgactgtgg atacctctga cccagacaga
     4321 ccatggatat actttaccaa aaggcaagag atctgggcca tggatctgga aggatgtcag
     4381 tgttggaaag tcatcatggt acctactatc cctggaaaaa gaatcattag cttaacagtg
     4441 gatggggagt ttatatattg gatcatgaaa acaaaggatg atgcccaaat ttatcaagca
     4501 aagaagggaa gcggggccat cctttcccaa gtgaaggcct ccaggagtaa gcatatcttg
     4561 gcttacagtt ctgctctgca gccttttcca gataaagcat atctgtctct agcttcagat
     4621 atggtagaag caactatatt atatgccacc aacaccagcc tcacactcaa attacctcca
     4681 gtcaagacaa acctcacgtg gcatggtatt acccacccca cgtcaacata cctgatttac
     4741 tatatggaag ctaatagggc aaacagctct gacaggagac acaaaatgct ggaatcacag
     4801 gagaatgtag cccggattga aggtctgcag ccattttcaa tgtacatgat tcagatagct
     4861 gtgaagaact attattcaga gcctttagaa catttacctc ttggaaaaga gattcaagga
     4921 caaactaaaa gtggagtgcc tggggcagtt tgtcatatca acgcaactgt gttgtcggac
     4981 accagtctcc atgtattctg gacagaatcc cataagccaa acggaccaaa agagtcagtc
     5041 cgctatcagc tggttatgtc atacctggct cccattcctg agactcctct aagacagggt
     5101 gaatttccaa gtgccaagct ttctctgctc atcactaaac tatctggtgg acagctctat
     5161 gtgatgaagg ttctggcgtg ccaccctgag gaaatgtggt gtactgagag tcatcctgtc
     5221 agtgtcaaca tgtttgacac accagagaaa ccctctgcct tggttccaga gaacactagt
     5281 ctgcagttag attggaaggc tcgatcaaac gttaacctca ccggattttg gtttgaactc
     5341 cagaagtgga aatataatga gttttaccat gtcaaagctt catgcagcca aggtccagtt
     5401 tatgtctgta acatcacaga tctacaacct tacacctcct ataacattcg agtggtggtg
     5461 gtctatacga caggagaaaa tagctcctcc attccagaga gtttcaagac aaaagccgga
     5521 gtcccaagca aaccaggtat tcctaaatta ctagaaggga gtaaaaattc catccagtgg
     5581 gaaaaagctg aagataatgg gagcagattg atgtactaca cccttgaggt cagaaaaggc
     5641 atttcaaatg actcacagaa ccagagttca aggtggaagg tggtgtttaa tgggtcctgc
     5701 agtagcattt gcacatggag atcaaaaaac ctaaaaggaa catttcagtt cagagcagtt
     5761 gctgcaaatg aaattggact tggagaatat agtgaaatca gtgaagacat tacattagtg
     5821 gaagatggtg tttggataac agaaacaagt tttatactta ctatcatagt tgggatattt
     5881 ctggttgcta cagtcccact gacctttgtc tggcatagaa gcttgaaaag tcacaaagct
     5941 tccaaggaag gcctctcggt tctcaacgac aacgacaaag agttggctga gcttcgaggt
     6001 ctggcggctg gagtgggact ggccaatgcc tgctacgcag tacatactgt tccaacccaa
     6061 gaagagattg aaaatcttcc tgccttccct cgggagaagc tgagcctgcg tcttttgttg
     6121 ggaagtggag cttttggaga agtgtatgaa ggcacagcta tagacatcct aggcgtggga
     6181 agtggagaaa tcaaagtggc agtgaagacc ttgaagaaag gttcaacaga ccaggagaag
     6241 attgagttcc tgaaggaggc gcacctgatg agcaagttta atcaccccaa cattctgaag
     6301 cagctgggag tctgtctgtt aggcgaaccc cagtacatta ttctggaact gatggaaggg
     6361 ggagaccttc taagctatct gcgcaaagct cgggggacaa cgtttcatgg tccttcactc
     6421 accttgcttg accttgtaga gctgtgtgta gatatttcaa aaggctgcgt ctacttggag
     6481 cagatgcact tcattcacag ggatctggca gctcggaatt gccttgtatc agtgaaagac
     6541 tacaccagtc ctcgggtagt caagattggt gactttggat tggcaagaga aatctataaa
     6601 aatgattatt atagaaagag aggggaaggc ctgcttcctg ttcggtggat ggctcctgaa
     6661 aacttgatgg acggaatctt cacttctcag tctgatgtat ggtcctttgg aattttggtg
     6721 tgggagattt taactctcgg tcatcaacct tatccagcgc attccaacct tgatgtttta
     6781 aactatgtgc aagcaggagg gagactggag ccaccaagaa attgtcctga tgatctgtgg
     6841 aatttaatgt cccaatgctg ggctcaagaa cctgaccaaa gacccacttt ccataacatt
     6901 caaaaccagc ttcagttatt cagaaatgtt ttcttaaaca atgtttctca ttgtggagaa
     6961 gcagctccca ccggtggagt catcaacaaa ggctttgaag gtgaagatga tgaaatggtc
     7021 actttgaact cagatgacac gatgccagtt gccttgatgg aaaccaagaa ccaagaagga
     7081 ttaaattata tggtgcttgc cacaaaatgt agccaaggtg aaggaagtta tgagggtcct
     7141 ctaggcccta aggaacttgg gtcatgtgat ctgaagaaag acaagaagca accacaggca
     7201 gacaaagatt tctgccagga accacaggtg gcttatggct ctcctggcct gtctgaaggc
     7261 ctgaattatg cctgtcttgc tcacagtgaa catggagatg tgtctgaata atagtgtctc
     7321 gtaggaaata cagcactgag atcaacatcg tgttaagtta cttgcagaaa agaataaagt
     7381 tgtggtggca gttgactctg a
//
