LOCUS       NM_001043354            9289 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus RAR-related orphan receptor beta (Rorb), transcript
            variant 1, mRNA.
ACCESSION   NM_001043354 XR_106008
VERSION     NM_001043354.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9289)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9289)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   3  (bases 1 to 9289)
  AUTHORS   Barao,S., Xu,Y., Llongueras,J.P., Vistein,R., Goff,L.,
            Nielsen,K.J., Bae,B.I., Smith,R.S., Walsh,C.A., Stein-O'Brien,G.
            and Muller,U.
  TITLE     Conserved transcriptional regulation by BRN1 and BRN2 in
            neocortical progenitors drives mammalian neural specification and
            neocortical expansion
  JOURNAL   Nat Commun 15 (1), 8043 (2024)
   PUBMED   39271675
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9289)
  AUTHORS   Bragg-Gonzalo,L., Aguilera,A., Gonzalez-Arias,C., De Leon
            Reyes,N.S., Sanchez-Cruz,A., Carballeira,P., Leroy,F., Perea,G. and
            Nieto,M.
  TITLE     Early cortical GABAergic interneurons determine the projection
            patterns of L4 excitatory neurons
  JOURNAL   Sci Adv 10 (19), eadj9911 (2024)
   PUBMED   38728406
REFERENCE   5  (bases 1 to 9289)
  AUTHORS   Escoubas,C.C., Dorman,L.C., Nguyen,P.T., Lagares-Linares,C.,
            Nakajo,H., Anderson,S.R., Barron,J.J., Wade,S.D., Cuevas,B.,
            Vainchtein,I.D., Silva,N.J., Guajardo,R., Xiao,Y., Lidsky,P.V.,
            Wang,E.Y., Rivera,B.M., Taloma,S.E., Kim,D.K., Kaminskaya,E.,
            Nakao-Inoue,H., Schwer,B., Arnold,T.D., Molofsky,A.B., Condello,C.,
            Andino,R., Nowakowski,T.J. and Molofsky,A.V.
  TITLE     Type-I-interferon-responsive microglia shape cortical development
            and behavior
  JOURNAL   Cell 187 (8), 1936-1954 (2024)
   PUBMED   38490196
REFERENCE   6  (bases 1 to 9289)
  AUTHORS   Greiner,E.F., Kirfel,J., Greschik,H., Huang,D., Becker,P.,
            Kapfhammer,J.P. and Schule,R.
  TITLE     Differential ligand-dependent protein-protein interactions between
            nuclear receptors and a neuronal-specific cofactor
  JOURNAL   Proc Natl Acad Sci U S A 97 (13), 7160-7165 (2000)
   PUBMED   10860982
REFERENCE   7  (bases 1 to 9289)
  AUTHORS   Simpson,E.H., Suffolk,R., Bell,J.A., Jordan,S.A., Johnson,D.K.,
            Hunsicker,P.R., Weber,J.S., Justice,M.J. and Jackson,I.J.
  TITLE     A comparative transcript map and candidates for mutant phenotypes
            in the Tyrp1 (brown) deletion complex homologous to human 9p21-23
  JOURNAL   Mamm Genome 11 (1), 58-63 (2000)
   PUBMED   10602994
REFERENCE   8  (bases 1 to 9289)
  AUTHORS   Zhou,C., Qiu,Y., Pereira,F.A., Crair,M.C., Tsai,S.Y. and Tsai,M.J.
  TITLE     The nuclear orphan receptor COUP-TFI is required for
            differentiation of subplate neurons and guidance of thalamocortical
            axons
  JOURNAL   Neuron 24 (4), 847-859 (1999)
   PUBMED   10624948
REFERENCE   9  (bases 1 to 9289)
  AUTHORS   Miyashita-Lin,E.M., Hevner,R., Wassarman,K.M., Martinez,S. and
            Rubenstein,J.L.
  TITLE     Early neocortical regionalization in the absence of thalamic
            innervation
  JOURNAL   Science 285 (5429), 906-909 (1999)
   PUBMED   10436162
REFERENCE   10 (bases 1 to 9289)
  AUTHORS   Andre,E., Conquet,F., Steinmayr,M., Stratton,S.C., Porciatti,V. and
            Becker-Andre,M.
  TITLE     Disruption of retinoid-related orphan receptor beta changes
            circadian behavior, causes retinal degeneration and leads to
            vacillans phenotype in mice
  JOURNAL   EMBO J 17 (14), 3867-3877 (1998)
   PUBMED   9670004
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ057253.1, AK134790.1, BC058269.1, AC116594.4 and AC140458.3.
            
            On or before Jul 27, 2011 this sequence version replaced
            XR_106008.1, NM_001043354.1.
            
            Summary: The protein encoded by this gene is a member of the NR1
            subfamily of nuclear hormone receptors. It is a DNA-binding protein
            that can bind as a monomer or as a homodimer to hormone response
            elements upstream of several genes to enhance the expression of
            those genes. The encoded protein has been shown to interact with
            NM23-2, a nucleoside diphosphate kinase involved in organogenesis
            and differentiation, and to help regulate the expression of some
            genes involved in circadian rhythm. Three transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) has an alternate exon in place
            of the first exon compared to variant 2. The resulting isoform (1)
            has a shorter and distinct N-terminus compared to isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134790.1, AB258405.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               CJ057253.1         3-237
            236-999             AK134790.1         2-765
            1000-2256           AK134790.1         767-2023
            2257-3330           BC058269.1         1630-2703
            3331-3887           AC116594.4         106596-107152
            3888-9289           AC140458.3         180615-186016       c
FEATURES             Location/Qualifiers
     source          1..9289
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 13.28 cM"
     gene            1..9289
                     /gene="Rorb"
                     /gene_synonym="hstp; Nr1f2; Rorbeta; RZR-beta; RZRB"
                     /note="RAR-related orphan receptor beta"
                     /db_xref="GeneID:225998"
                     /db_xref="MGI:MGI:1343464"
     exon            1..645
                     /gene="Rorb"
                     /gene_synonym="hstp; Nr1f2; Rorbeta; RZR-beta; RZRB"
                     /inference="alignment:Splign:2.1.0"
     CDS             639..2018
                     /gene="Rorb"
                     /gene_synonym="hstp; Nr1f2; Rorbeta; RZR-beta; RZRB"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear receptor ROR-beta; nuclear receptor RZR-beta;
                     retinoid-related orphan receptor-beta; nuclear receptor
                     subfamily 1 group F member 2"
                     /codon_start=1
                     /product="nuclear receptor ROR-beta isoform 1"
                     /protein_id="NP_001036819.1"
                     /db_xref="CCDS:CCDS37932.1"
                     /db_xref="GeneID:225998"
                     /db_xref="MGI:MGI:1343464"
                     /translation="MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASY
                     SCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQ
                     RLQEQRQQQSGEAEALARVYSSSISNGLSNLNTETGGTYANGHVIDLPKSEGYYSIDS
                     GQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMSEIDRIAQN
                     IIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEF
                     AKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALG
                     SDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFAL
                     QHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPDIVNTLFPPLYKELF
                     NPDCAAVCK"
     exon            646..731
                     /gene="Rorb"
                     /gene_synonym="hstp; Nr1f2; Rorbeta; RZR-beta; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            732..873
                     /gene="Rorb"
                     /gene_synonym="hstp; Nr1f2; Rorbeta; RZR-beta; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1275
                     /gene="Rorb"
                     /gene_synonym="hstp; Nr1f2; Rorbeta; RZR-beta; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1397
                     /gene="Rorb"
                     /gene_synonym="hstp; Nr1f2; Rorbeta; RZR-beta; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1530
                     /gene="Rorb"
                     /gene_synonym="hstp; Nr1f2; Rorbeta; RZR-beta; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1638
                     /gene="Rorb"
                     /gene_synonym="hstp; Nr1f2; Rorbeta; RZR-beta; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1749
                     /gene="Rorb"
                     /gene_synonym="hstp; Nr1f2; Rorbeta; RZR-beta; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1862
                     /gene="Rorb"
                     /gene_synonym="hstp; Nr1f2; Rorbeta; RZR-beta; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..9289
                     /gene="Rorb"
                     /gene_synonym="hstp; Nr1f2; Rorbeta; RZR-beta; RZRB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2239..2244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rorb"
                     /gene_synonym="hstp; Nr1f2; Rorbeta; RZR-beta; RZRB"
                     /note="hexamer: AATATA"
     polyA_site      2257
                     /gene="Rorb"
                     /gene_synonym="hstp; Nr1f2; Rorbeta; RZR-beta; RZRB"
ORIGIN      
        1 acctctctcc tctttctctc tcgctccctt cgtctctgca actgaacagt gaaaattcac
       61 attgtggatc cgctaacagg cacagatgtc atgtgaaaac gcacatgctc tgcaatccat
      121 gccgcctttc tttcttttct gtttcctttt tttccccctt gataattctc cctcttcttt
      181 gtaactaaca aaaccaccac caactcctcc tcctgccgct gccctcctcc tcctcctcag
      241 tctaagtgat cacaaaagaa atctccgagc cccgaggcgg tggcattttt tttttttaaa
      301 gcaagcacat tggagagaaa gaaaaaaaga aacaaacaaa caaacaaaag caaaacaaaa
      361 cccaggcacc agcagctagg acattttttt tccactctgc ctgaaaacaa acaaacagcc
      421 atcagaaaca gtcatcagca acagcatcaa aactgttagc ttagcggcgg cggccaccgt
      481 caccctgtgg ccacgacatc tgcctaaagg gatgcttctc tcagcggagc agctcttcgc
      541 cgaccgcctt cttccctcgt gctgagcgga atttttgggt tctctggggt tcgggctggg
      601 agcttcatga ctacgcggag caggacagcg gccacatcat gcgagcacaa attgaagtga
      661 taccatgcaa aatttgtggc gataaatcct ccgggatcca ctacggagtc atcacgtgtg
      721 aaggctgcaa gggattcttc aggaggagcc agcagaacaa tgcctcttac tcctgcccaa
      781 ggcagagaaa ctgtttaatt gacagaacca acaggaaccg ttgccaacac tgccgcctgc
      841 agaagtgtct tgccctagga atgtcaagag atgctgtaaa gttcgggagg atgtccaaga
      901 agcagcggga cagcctgtat gctgaggtgc agaagcatca gcaaaggctg caggagcagc
      961 ggcagcagca gagtggggag gcggaggccc tcgccagggt gtacagcagc agcattagca
     1021 atggcctcag caacctgaac accgagaccg gcggcacata cgccaacggg cacgtcattg
     1081 acctgcccaa gtccgaaggt tattacagca tagattccgg tcagccgtct cccgatcagt
     1141 caggactgga catgactggg atcaaacaga taaagcaaga acctatctat gacctcacat
     1201 ctgtacccaa cttgtttacc tatagctctt tcaacaacgg gcagttagct cccgggataa
     1261 caatgtctga gatcgatcga attgcacaga acatcattaa gtcccatttg gagacatgtc
     1321 agtacaccat ggaagaactc catcagctgg catggcagac ccacacctac gaggaaatca
     1381 aggcgtatca aagcaagtcc agggaggctc tgtggcagca gtgtgccatc cagatcaccc
     1441 atgctatcca gtacgtggtg gagttcgcca agcggataac aggcttcatg gagctgtgtc
     1501 agaacgatca gatcttactt ctgaagtcag gttgcttgga agtggtttta gtgagaatgt
     1561 gtcgtgcctt caacccatta aacaacactg ttctgtttga aggaaaatat ggaggaatgc
     1621 aaatgttcaa agccttaggt tcggatgacc tagtgaatga agcatttgac tttgcgaaga
     1681 atctgtgttc cttgcagctg actgaggaag agattgctct gttctcctct gctgttctga
     1741 tatccccaga ccgagcctgg ctgatcgaac caagaaaagt ccagaagctt caggaaaaga
     1801 tttattttgc actgcaacat gtgattcaga agaaccacct ggatgatgag accctggcaa
     1861 agttaatagc caagatacca actatcacgg cagtctgcaa cttgcatggg gagaagctgc
     1921 aggtatttaa gcagtctcat ccagacatag tgaatacact gtttcctcca ttgtacaagg
     1981 agctctttaa tcctgactgt gctgcggtct gcaaatgaag gggacgagaa ctctcagagt
     2041 catggaatgc atcgccgtta agacaaaagc aatgtgttca tggggactta aggaaaatgt
     2101 cactactgca acattaggaa tgtcctgcac ttaatagaaa tatttttcac cgctacagtt
     2161 tgaagaatgt aaatatgcac ctgagtgggg ctcttttgtt tgttcgtttg ttgtttgttt
     2221 gtttttgaaa tgatcataaa tatacaaata taggacactg ggtgttatct tttttaattt
     2281 tattcgggta tgttttggag acaactgttt atagaatttt attgtagata tatacacaaa
     2341 cagagccgta ctttccatga ttactcttcc cgttgattga ttgttcgact ctaatttaag
     2401 acgattccac ttactaggct ttacctattt ctatgttttt aggtagttga tgcatgtgca
     2461 aattcgtaac taactgtctt ggaaagtact gtgcatgtat gtaatgagta tataatatgt
     2521 aagagtatta tatatgacta ttacgtattc atgcactgtg gcttaaaata ccatgcccac
     2581 tagcaatgga ggttcagtca ggctttcatg tgatttgctg ttgttatatg ttacttttat
     2641 gttagacaat cagggttttc atttccagcc agagttttta tccatccata acaacatgat
     2701 aggacccatg caaaaggaaa tctacaaaag aatcggggta acacataatt gttcttttaa
     2761 aagctccatt tctatcaatt acttcaaagc cccatcaaga tggcacatac cgggaagagg
     2821 ggaagccaaa aggatttgaa gccactttcc tgttttatag accagataat gatattgtct
     2881 atttattacc atattacaaa atattgaggt tcctccacat tggatttgga atccaattct
     2941 gaatgaaact tcactttggt ggttataatt tcttcaagac aacaaaaaat tcagtctata
     3001 gattatcacc accatcaacg tttttagaaa tatttgacta gaagtataaa acaagttcct
     3061 tgtacccatt ttgtgtagat attttctaac cattttccca acaaaaaaag agaaatagag
     3121 catacaaagt taagaagtaa attcactaaa ttatactcat ggtaatttgt tagaaatgag
     3181 aaaataggcg ggagcctgtt ttttcaactt caaaatgcta tattataaaa tatagaaaaa
     3241 attcagatta gaaaacagta aatcttttgt ctatgggact aatatatccc aatgccaaaa
     3301 ttctatccta cacagttata aatgacatcc tctattcaaa ctggttattt tttagccact
     3361 aaaatgtata gaatggaacg gcaacctata caggttcttc acctactttc ctacaaaatt
     3421 aagcaccaga aaggcatgag ttagaagcta tttgttctct ctgttcctgg aaggcctagg
     3481 tctttagtat gaactagtct aagccacaca cacgcacgaa catgcacaca gatgacacag
     3541 ccacccacag acacacacac atacacacac acacacacac acacacacac acacacaccg
     3601 ctttgtagaa acttgggtct tttggtttgg gtttctgggt ttgtttgttt gttttttctt
     3661 ttcttttctt ttcttttctt ttcttttctt ttcttttttt tttttttttt tttttttttt
     3721 tttttttttt tttttttttt gagtcatttt tagtccctta tgctctctca aagttctgga
     3781 ttgagagtca tcttcaggat gcctcagaac tccagtggat gatcagagca cagtagtgtt
     3841 agtcttgcct ttcagaaaac aggggccttt ctcacctcat gattgatgaa ttccaagcca
     3901 ttgggggaaa acaaaaagac tttaaaataa tgaatctctt tttcaaccac tgttatattc
     3961 aattaattta actacattga accaaattac ctttggttct gagaagacag ctgtagactg
     4021 cttattatgc tgctacaggg actcagttct ttttggtgta aatgtcactc ctgctagctc
     4081 tttgtataaa gaattaattc caagagtcat atttccttct aatggaaaga ttactttact
     4141 gattgctagg aaaacagggt aatggaaggc actcaattaa accaagccgt ttccaaatgc
     4201 gatatatgtt ttatgattgg cttgtgatag gaaatgctta ctgtgtctac ttgatgttcc
     4261 cctttgagct ttgaactcat gtcaaacttt gttttcattg ttctgttggc ccagtgtttc
     4321 ccattgtcag cctgaagatc ccactgggct gcaaagggga atcatttgtt gtcttcagtt
     4381 taccttggag gatttacatc agctcaattg atgaagtagc taagaatttt tttcctccct
     4441 tgccccatgg gtggtgtagg aaagagattg ttccccacat ttgcctcagg agatactggt
     4501 tttgaaattg tgtcatttcc actagcccta gcctttcatt gggatggcat gaaccttttg
     4561 aagcagaggg acaggaaaca gagctaggaa ctgaaccaga accaaacagt ggtaactagg
     4621 accggctcag cccactttcc acccagagga gagagctcca gttttggctt cagttgccga
     4681 gttttccctt taaagagaag tcatgttttt aacggtaagg aagcctttaa acactgccct
     4741 ttgaacatct cagttgacta catgaaattt cagtaaaaaa caaaaacaaa accaaacaac
     4801 aacaaaaact ctctttacca cacacagtct cagcaagctg ttccttttcc tgagaatggg
     4861 ccaatgttca gaatgtgcta ggatgaggtg aacattggaa gaaggaactg ggctctgaag
     4921 tctcctttaa acctcaagga tgacaatcac tgcttgatgc agatgttgca ctgaatctgc
     4981 tcagggatgc ttcatttaaa aaaaaaaaaa gtgcgtcgag aagggggagg ggcaaaacag
     5041 gaaactgaaa acaaaatgta aatgccataa attgaacagg tcagcgagag accctccctg
     5101 acaggcttca gagaggccac agtggcttaa ggcagaaaat tgaatgaact tctttttctt
     5161 ctttgaacct gcctagaagt tctacccaag tagagacatt agttcccttc tctagaatga
     5221 gcaaggaaca agataacaag actgcccccc cccccccaca tatctcccaa ttaatccagg
     5281 cttcctgtgt aaatccttag caaaggaaat acagggtctg atctaagggt cagaggtcag
     5341 agctgatagg caattgagca aaacaaacgc tgtgcctctg tactctgtag aaagaaagac
     5401 aaatcttgaa taaaaatgaa taatttcaaa tcttggttgg cagttacaaa tggccacatt
     5461 gtctgtgaat tggtctatct ttgtggaaca tttttctggg gctctttttt tttcctgata
     5521 gtacattgag ggtcaggata gactttccaa acacactctg cattttcttt gttttatttc
     5581 tttcttcaag gctctgggct aaaagacctc caagtaaaaa agcagagaat actgtggtct
     5641 taggcgatta gattcccctg gcagcagctg gaagactctg cattgtaccc aactgagtat
     5701 taatggtagg catcaggggc catcagtgca tttatatcat ggctgcctta tcaatcaagc
     5761 aggttacatc ccagcagaca agctgagcta tttgtagaaa gccttgcaga tggatggcca
     5821 actcttactg cctcttcata gtactatgtg taagggggct caaattctaa aatccaatac
     5881 atgggtccta aggacaacca aaaattttac ttgcctctcc cccataaaca ccagaaatga
     5941 gtaatgacgg tgtaagtcca catcctgttt attccacaaa caggaaattt ttgagtgctg
     6001 gcaaatcatt tttcctggct tttgtttggt tggttttttt ttttttattt tagggggttt
     6061 ttcttgccca tattcacttt tgtttctaat aaaattacca caaagggcag taggttcagg
     6121 caagaatgtc tctactctga caaacaccat tctgtagtta gcagtagttc ctaagcacac
     6181 atctgaaggg aaacttctgc cgagtctcct tataaagagg caagaaggaa acactaccat
     6241 gtagatgaag tgctatttga tgttctatat ttgcaactgc tggtgcatgt gtagccagaa
     6301 gaaaaacctg gtgtggaaag tcatggagtc ttttcacaaa aagctggtta cctatttttc
     6361 tttttaaggg gagtatgttt tagaaccaga ggtgcctgcc tatttgaatc aacacaaaac
     6421 ccccaaaaat gtcaaggcat ggatgcaaat agtgctgtgg agctcggtta agttagccgg
     6481 gaaatgcccc acctacaata gggcaaccaa catttggcca aggcctcatg cccacagtgc
     6541 ttctgtatta tgggggcaga ctcgtttgta aacgatgaaa gttgtctgtg agtatagtac
     6601 acaccaaaca catccccggg cagaagaggg ccataggcag ccatcttgcc tcctcttgtt
     6661 ggtattaaaa accacatcta gaagtctatt gggttagagc cagtcaggcc aggtttgata
     6721 gagggtgaca ctgggatgct ggcgcacagt gggtgagaga agagatactg ctgttctccc
     6781 tctcgatcta gtttccatat tttcctatca ctactcaaag atataatgac aggtggcttg
     6841 aacaaagtag caatcgaaag ataaaggcga atccactgaa tgatggctta caaaagacac
     6901 ttgcatgtgt cccaccgagc tccactgtgg aagcgccaaa gggaactaga tgtcttgtcc
     6961 attttttttt tcctctgaaa gtcagatata taactttcat gtttttgagc ctgtatatgt
     7021 gtccttaaat gtatggcttc aaatctgtga cactttctcc ctttctctta attgtacctt
     7081 tctgagcaat ttattctgtc accaagatcg cctcgcccca cccccctctt gttctgaagt
     7141 gcaggtcaca ggtcactggt tcctacacag caggtgggac tgtctgtctg tgcacttttt
     7201 tcctaagctg ctgaaattcc tccgagatca actagtcaca gcaaccgatg cttcctgcct
     7261 gaccaaagca caacgacagt ggatcagaga aaccaggcca gtggttgttc tcatagccaa
     7321 aactaaagca caaagattac tggaattaaa caagtccatc tacccaacta tgggaaatgc
     7381 aggtgtctgc gcccctattg acagcatgag gctcgtagta tcgcttatac actcgctgtg
     7441 gctagtggtg ggcgctccca tgtcaccagc acagccgtac atagacactc atgaagaatg
     7501 tctgaaatcc acaagcccca cagcaccatt cgcttcttcc cattaacaca cacccaagaa
     7561 tgaaaatcac acacacagaa aactgagtat gtattgtaga aatgtagagg aaaaataaaa
     7621 aaaaatattt tttcaaatgt aattactttt aatatatgct tgtggaaggt ctaatacaat
     7681 gtatgctgtc tccatacttt ttgctgtaaa taactggaga cagtggatac actggttttt
     7741 ctatgtctct gtttaagcat aagactttgt aacaattttt tagaggggtt aaacaacaaa
     7801 ggtaaatatg tactcgctcc ctttctgagt gttaatgtac ctctcggttt ttaagcggga
     7861 aatggttgta atggtttaag catctggatg ggttgtcaat gttacttgta cacttacttc
     7921 tctttgtagt acaactaaga aagggacagg gctatcaatc aaccactcca aagaatttgt
     7981 attgaagatt ggcctaagac ctgcaaacac catctaaact agacagtgtg aaaataggaa
     8041 catgtagaaa gaaaactgtt gtctaaggga agtcgtcttt cctcatagcg aatggctctg
     8101 tccaagccca ttctacacgg aagagcttaa ggaaaacaaa ccctgctttc tgatgaacaa
     8161 aatatttttg tacatgttta tttcttatga ataacttgag gtcagaccac tcatttgctg
     8221 aagccataac tgacctccac caaataaatg cagtaaagaa gctggggagg ggtggggaga
     8281 aactgagagg tagaaaagtc tgagggtgaa gatagcaacc gagggaagag cagggctggt
     8341 ctggtgaaac tggcgctttt ttccctgcat cccaaatatg actttaaaag gctagtattt
     8401 tatgatgacc gatttataaa ataataataa aaaagatatt tagttaaatg agactttcca
     8461 atatttttta aatccctgac aatgcttcct tgcttttagg attgagataa aaataatttt
     8521 ccctatactt ccaatgttct gaggtttaat gcttctgccg tagctccagc ctacagtgca
     8581 aggtgcagag ccgctgagtc cagaggttga agccatggac tggctggggc gtggctgttc
     8641 ctactcccca gctgaaccag gaggagcatc atggaaggta cagcttgctc ctccttagca
     8701 tgcacaccac tgtggcggca ggccgatgtt gcattgccac aagtatgtaa aataaaagca
     8761 ttcattcaga aaagctaagt atactttttc aaaagagcaa ggcctcctgg agtcaacctc
     8821 tgatttttcg ggagctgaat tagtctatta ccatatactc ttaccagcct gtagaggcaa
     8881 aagtcaaact acaaataaac ccagtgatat tatgtagttt ttacatcttc aattttctgg
     8941 tctctctctc tctctctctc tctctctctc cttgtttaat atataagccc taatttctgt
     9001 gtatgtgagt aaaactgcag cctgagtcat ttaggaagta agcattgaat ttttttaatt
     9061 ataaatataa tagattaaag cagcactccc taacaactaa aaagagtttt ctattacttt
     9121 agaatgtaac ggggtttgtc cttattttat gtcctgtaaa ttattagttg aatactgtta
     9181 gcattcccag ataatgcaca catgatttct gaatgtttcc tgtaaatgac aatcaatgtt
     9241 tatgactttc cctccctcaa tgctgaacaa attaaaagaa gaaaaagaa
//
