LOCUS       NM_013646              10878 bp    mRNA    linear   ROD 01-JAN-2024
DEFINITION  Mus musculus RAR-related orphan receptor alpha (Rora), transcript
            variant 1, mRNA.
ACCESSION   NM_013646 XM_489717
VERSION     NM_013646.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10878)
  AUTHORS   He L, Lu F, Zhang F, Fan S and Xu J.
  TITLE     Mechanism of lncRNA HOTAIR in attenuating cardiomyocyte pyroptosis
            in mice with heart failure via the miR-17-5p/RORA axis
  JOURNAL   Exp Cell Res 433 (2), 113806 (2023)
   PUBMED   37844792
  REMARK    GeneRIF: Mechanism of lncRNA HOTAIR in attenuating cardiomyocyte
            pyroptosis in mice with heart failure via the miR-17-5p/RORA axis.
REFERENCE   2  (bases 1 to 10878)
  AUTHORS   Yu W, Du J, Peng L and Zhang T.
  TITLE     RORalpha overexpression reduced interleukin-33 expression and
            prevented mast cell degranulation and inflammation by inducing
            autophagy in allergic rhinitis
  JOURNAL   Immun Inflamm Dis 11 (10), e1017 (2023)
   PUBMED   37904695
  REMARK    GeneRIF: RORalpha overexpression reduced interleukin-33 expression
            and prevented mast cell degranulation and inflammation by inducing
            autophagy in allergic rhinitis.
REFERENCE   3  (bases 1 to 10878)
  AUTHORS   Zhang S, Shen J, Zhu Y, Zheng Y, San W, Cao D, Chen Y and Meng G.
  TITLE     Hydrogen sulfide promoted retinoic acid-related orphan receptor
            alpha transcription to alleviate diabetic cardiomyopathy
  JOURNAL   Biochem Pharmacol 215, 115748 (2023)
   PUBMED   37591449
REFERENCE   4  (bases 1 to 10878)
  AUTHORS   Roberts J, Chevalier A, Hawerkamp HC, Yeow A, Matarazzo L, Schwartz
            C, Hams E and Fallon PG.
  TITLE     Retinoic Acid-Related Orphan Receptor alpha Is Required for
            Generation of Th2 Cells in Type 2 Pulmonary Inflammation
  JOURNAL   J Immunol 211 (4), 626-632 (2023)
   PUBMED   37387671
REFERENCE   5  (bases 1 to 10878)
  AUTHORS   Hua X, Blosch CD, Dorsey H, Ficaro MK, Wallace NL, Hsung RP and Dai
            J.
  TITLE     Epidermal Loss of RORalpha Enhances Skin Inflammation in a
            MC903-Induced Mouse Model of Atopic Dermatitis
  JOURNAL   Int J Mol Sci 24 (12), 10241 (2023)
   PUBMED   37373387
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10878)
  AUTHORS   Herrup,K. and Mullen,R.J.
  TITLE     Staggerer chimeras: intrinsic nature of Purkinje cell defects and
            implications for normal cerebellar development
  JOURNAL   Brain Res 178 (2-3), 443-457 (1979)
   PUBMED   509213
REFERENCE   7  (bases 1 to 10878)
  AUTHORS   Herrup,K. and Mullen,R.J.
  TITLE     Regional variation and absence of large neurons in the cerebellum
            of the staggerer mouse
  JOURNAL   Brain Res 172 (1), 1-12 (1979)
   PUBMED   466453
REFERENCE   8  (bases 1 to 10878)
  AUTHORS   Trenkner,E.
  TITLE     Postnatal cerebellar cells of staggerer mutant mice express
            immature components on their surface
  JOURNAL   Nature 277 (5697), 566-567 (1979)
   PUBMED   368650
REFERENCE   9  (bases 1 to 10878)
  AUTHORS   Hatten,M.E. and Messer,A.
  TITLE     Postnatal cerebellar cells from staggerer mutant mice express
            embryonic cell surface characteristic
  JOURNAL   Nature 276 (5687), 504-506 (1978)
   PUBMED   723931
REFERENCE   10 (bases 1 to 10878)
  AUTHORS   Landis,D.M. and Sidman,R.L.
  TITLE     Electron microscopic analysis of postnatal histogenesis in the
            cerebellar cortex of staggerer mutant mice
  JOURNAL   J Comp Neurol 179 (4), 831-863 (1978)
   PUBMED   641237
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK086033.1, U53228.1 and CT009708.6.
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_013646.3.
            
            On Feb 8, 2014 this sequence version replaced NM_013646.1.
            
            Summary: The protein encoded by this gene is a member of the NR1
            subfamily of nuclear hormone receptors. It can bind as a monomer or
            as a homodimer to hormone response elements upstream of several
            genes to enhance the expression of those genes. The encoded protein
            has been shown to interact with NM23-2, a nucleoside diphosphate
            kinase involved in organogenesis and differentiation, as well as
            with NM23-1, the product of a tumor metastasis suppressor candidate
            gene. Also, it has been shown to aid in the transcriptional
            regulation of some genes involved in circadian rhythm. Three
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U53228.1, SRR1660811.11443.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AK086033.1         2-17
            17-1663             U53228.1           1-1647
            1664-10878          CT009708.6         194870-204084       c
FEATURES             Location/Qualifiers
     source          1..10878
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 37.45 cM"
     gene            1..10878
                     /gene="Rora"
                     /gene_synonym="9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2;
                     ROR3; sg; staggerer; tmgc26"
                     /note="RAR-related orphan receptor alpha"
                     /db_xref="GeneID:19883"
                     /db_xref="MGI:MGI:104661"
     exon            1..187
                     /gene="Rora"
                     /gene_synonym="9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2;
                     ROR3; sg; staggerer; tmgc26"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1593
                     /gene="Rora"
                     /gene_synonym="9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2;
                     ROR3; sg; staggerer; tmgc26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear receptor ROR-alpha; nuclear receptor RZR-alpha;
                     retinoid-related orphan receptor-alpha; nuclear receptor
                     subfamily 1 group F member 1; RAR-related orphan receptor
                     A"
                     /codon_start=1
                     /product="nuclear receptor ROR-alpha isoform 1"
                     /protein_id="NP_038674.1"
                     /db_xref="CCDS:CCDS23314.1"
                     /db_xref="GeneID:19883"
                     /db_xref="MGI:MGI:104661"
                     /translation="MESAPAAPDPAASEPGSSGSEAAAGSRETPLTQDTGRKSEAPGA
                     GRRQSYASSSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
                     SNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEV
                     QKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSTYMDGHTPEGSKADSAV
                     SSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHL
                     AQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYV
                     VEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFK
                     SLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQ
                     LALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYK
                     ELFTSEFEPAMQIDG"
     exon            188..217
                     /gene="Rora"
                     /gene_synonym="9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2;
                     ROR3; sg; staggerer; tmgc26"
                     /inference="alignment:Splign:2.1.0"
     exon            218..303
                     /gene="Rora"
                     /gene_synonym="9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2;
                     ROR3; sg; staggerer; tmgc26"
                     /inference="alignment:Splign:2.1.0"
     exon            304..445
                     /gene="Rora"
                     /gene_synonym="9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2;
                     ROR3; sg; staggerer; tmgc26"
                     /inference="alignment:Splign:2.1.0"
     exon            446..841
                     /gene="Rora"
                     /gene_synonym="9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2;
                     ROR3; sg; staggerer; tmgc26"
                     /inference="alignment:Splign:2.1.0"
     exon            842..963
                     /gene="Rora"
                     /gene_synonym="9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2;
                     ROR3; sg; staggerer; tmgc26"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1096
                     /gene="Rora"
                     /gene_synonym="9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2;
                     ROR3; sg; staggerer; tmgc26"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1204
                     /gene="Rora"
                     /gene_synonym="9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2;
                     ROR3; sg; staggerer; tmgc26"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1315
                     /gene="Rora"
                     /gene_synonym="9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2;
                     ROR3; sg; staggerer; tmgc26"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1428
                     /gene="Rora"
                     /gene_synonym="9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2;
                     ROR3; sg; staggerer; tmgc26"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..10878
                     /gene="Rora"
                     /gene_synonym="9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2;
                     ROR3; sg; staggerer; tmgc26"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctacattg ggaaaaaaaa catggagtca gctccggcag cccccgaccc cgccgccagc
       61 gaaccgggca gcagcggctc ggaggcggcc gcgggctcca gggagacccc gctgacccag
      121 gacacgggcc gcaagagcga ggcaccgggc gcggggcgca ggcagagcta tgcgagctcc
      181 agccgaggta tctcagtcac gaagaagaca cacacatctc aaattgaaat tattccatgc
      241 aagatctgtg gagacaaatc gtcaggaatc cattatggtg tcattacgtg tgaaggctgc
      301 aagggctttt tcaggagaag tcagcagagc aatgccacct actcctgtcc tcgtcagaag
      361 aactgtttga ttgatcggac cagcagaaac cgctgccagc attgtcggct gcagaaatgc
      421 ctggccgtgg ggatgtctcg agatgctgtc aagtttggtc ggatgtccaa gaagcagaga
      481 gacagcttgt acgccgaggt gcagaagcac cggatgcagc agcagcagcg agaccaccag
      541 cagcagcctg gggaggcgga gccgctgacg cccacctaca acatctcagc caatgggctg
      601 acggaactgc atgatgacct cagcacctat atggatgggc acacccccga gggcagcaag
      661 gccgactcag ccgtcagcag cttctacctg gacatccagc cctccccaga ccagtcggga
      721 ttggacatca atgggatcaa acccgaaccc atatgtgact acacaccagc atctggcttc
      781 ttcccctact gttccttcac caacggagag acttccccaa ccgtgtccat ggcagaacta
      841 gaacaccttg cccagaacat atccaaatcc cacctggaaa cctgccagta cttgcgggaa
      901 gagctccagc agataacgtg gcagaccttc ctgcaggagg agattgaaaa ctaccagaac
      961 aagcagagag aggtgatgtg gcagctgtgt gccatcaaga ttacagaagc tatccagtat
     1021 gtggtggagt ttgccaaacg cattgatgga tttatggagc tgtgtcaaaa tgatcaaatt
     1081 gtgcttctaa aagcaggctc gctagaggtg gtgtttatta ggatgtgccg tgcctttgac
     1141 tctcagaaca acaccgtgta ctttgacggg aagtatgcga gccccgatgt cttcaagtcc
     1201 ctaggttgtg aagacttcat cagctttgtg tttgaatttg ggaagagttt gtgttctatg
     1261 cacctgaccg aagacgaaat cgcgttattt tctgcattcg tactgatgtc agcggatcgc
     1321 tcgtggcttc aggaaaaggt aaaaatagaa aagctgcaac agaaaattca gctggccctt
     1381 cagcacgtcc tacagaagaa ccaccgagaa gatggaattc taaccaagct aatatgcaag
     1441 gtgtctacgt taagagccct atgtggacga catacggaaa agctaatggc atttaaagca
     1501 atatacccag acattgtgcg actccatttt cctccattat acaaggaatt gttcacttca
     1561 gaatttgagc cagccatgca aatcgatggg taaatgtcgc gcccgagcac ttctagaaca
     1621 tctggagtac aaacatgaaa gtaagagaga aaatttttaa aaaggaaatg aaacaataac
     1681 aacgaagaca aatttaactg agacactttc tatggccctg cacagccctg gagcgccaac
     1741 aacactgcac agacatcttg tggtgaacgg ggttcaggca caaaggggaa acaatccaac
     1801 ccaatcaaag ctgaacttgt tttgctcatg catatgattt ccactatgcc tacagatatg
     1861 gacccttttt ctgtctcaac ttctagagcg gttgacctcg gcatatgaca ggagggtact
     1921 acagtcagag gagtcccctt ctcgtagctc actgcccaca gactcttacg ggtaacagca
     1981 gagtccagcg ttaatcggtg accccggtgt gtatggcggg agttgcggcg ttactttgca
     2041 cagcttgctt ttctgtgtca tgaaggaaga ttttggtttc tctcaccgat tattgccggt
     2101 cagcaggatg gcgtgaaaag gggatccata gcgctcgcaa caatagcatt ataatatatt
     2161 acacagggta aatgggcatg aagactatat atagctaaag agatattgtt tatatattgt
     2221 tttaattaat ataaaatgta gtgactggcg tagcttttcc tgttgaattg ataaggcact
     2281 ttccgttttt gcaccttttt gtttccttta aattaaatgc tagcgtgttc actgtcgccg
     2341 tgtcgcatgt acaccagaaa cacaagttta gctgagaagg cttggaaggt acgttgggag
     2401 gtatttatgc tgctgtttac aaaaacaaaa aaagaaaaaa aaagaaaaaa caacaaaaaa
     2461 aaaacccaat tacttttaaa agactggctg gtcatatcca gaaatcaaca tgttgaattt
     2521 tttttcccac ctgtaaattt ggaattagga atgaactgct ctttaaatca tactttgttt
     2581 tgcatgcaat tgagaatggg tgtgtttatg cttcatccag aattgaagga gtgtctggtg
     2641 ctgtgggctt aaaccatgtg tgcattttat tttttttaag tttttaaaat gctacctttg
     2701 ggaggcggag gaggagaggc tcattaaaca caagtcagta gtcacagaga catcgtatca
     2761 tctcgcaatt ctgatgcttt cagaacaaat tagcagctgg gatagttact ggattctagc
     2821 tcttatttag aaggactcaa agattctatg tggagcgaac atattcccca caggaagcat
     2881 ttattgacgg ccttgtgttc ttggcatcgg gagccctaag aagtcacctc agagtaaact
     2941 gaccctagac tagctgtccc agattcctga ctgttgttct gtgtatgggg tagatggtgg
     3001 atgaagaggg agggagacag tgttgaactt ggttcctgtg tttaagatac gccttcagag
     3061 tgaaggtggc gccagctgca gacatttgtg taggtatcct cactagaaaa ctgtggactg
     3121 tgatttattt tattaaatat atagaagata gtttggcttt tgtgttcagg taagaagtat
     3181 tgaggttttg attcattttt gcagttttta aaaaataatc cccagtggaa ggaggaagga
     3241 gctttgtgtt cataggtgtg catattttaa gatcatgtgc cctgggatta aagagatgat
     3301 gcttcagtgg gcaagagtat ggattgctct atcagaggac caaagcctgg aacccagcca
     3361 gcagagcagg caatttcaaa agcttgtccc tccagcccca agatatcagt gtccctttct
     3421 ggcctctgtg ggcacacaca cacacacaca cacacacaca cacgagtgag agacaagcat
     3481 aaaaacaaat ccttaaaaac aagttctctt tttttaagag gcatttagga gatgactttg
     3541 gtcacaagat actggtctgg catcaaagac cttatctgta gacaaaaagg gagcatcttc
     3601 tatggtgtac agggcacgtt tatgaagccc tatgtaccca gctgcctcct ctgccaacag
     3661 ggtccttctg gactctcttg ccagcatttc tgctcctgct gatgtccatc taagaggttc
     3721 ccagggccag cttcccagag cacatcacag tttttaactt tactgacttt ctgccttatt
     3781 tactgaggga cttggaaagt aggaaggaat tatttgtata gaaatgtgtg gggggaagcc
     3841 taaataacat ctaatttttt tttcaaaaac atagtaaggg tttaaccata aacaggggag
     3901 tgatatttaa atttcttaca agcctagaaa attttatgtg tttatatgga gaggttagtg
     3961 gtcagcatat agtatttata tttgggcaag aaggggtaaa tcaaaatttt atttaaacat
     4021 agttccttta aagattaata gtatttatat tctaaagaga gtacagtttt ttatttattt
     4081 gccttttttt tttttttcct gttgcttctc ctatgtgagg gaatggtgtg aggttttggt
     4141 ttggtttctg tttttccttc gtttagttct tcagattcac taaattcggg gatagattta
     4201 gtaaatatat taacttcatt ttaaccaaag ctttctgcat atgaccagcc tcaggtgcta
     4261 gtgcactaaa gagcaactaa acccaattcc agtgtccacg tgtgactaag gagagctggc
     4321 tgagcgtctc taagggtgag agagatagtg tgtgtgtgtg atactgaact gcagagaaat
     4381 tcattttccc aggaaggatt ctgtgtgtac cttatgtaaa ccacgaacac aaggtactcc
     4441 gatctcatac tatgccacgg gggcattgct tttaccacac accaggagag tgcggtgaga
     4501 cttccaggta ttcctgaaag aaaagcagaa agctggcttt cagagcaaag tcctccggca
     4561 ttgtagcaat ggcgctatag agccagatgt gctctgagaa actgaaagga cagctggcta
     4621 ggacttgtac ctaagttgag agtcacggtg agtcctgcac aggatgtaaa actttggcat
     4681 ttttcttttc ttcctgattg tgagaaccac ttgtgtagca cagactcatg aggcttaata
     4741 gttcctgttg ttaaagttgc ctgaacttaa aggctctcca gtctctggag actgaatctc
     4801 atcatcgtca gctcagttgc aagagggcca tcaggtagct ttttttctac agaaagtaaa
     4861 tgaggctttc gtacaaagtc tgaatgtggt tactgtgata atgcaaacga ttcaggaaca
     4921 tcattttttg gatagaccac aaaatgtgct aaggctatga gtttggggtt ttttgtttgt
     4981 tttgttttgt ttaaagcact cagtattcta atttgtgtta aatccatgga cttttttttt
     5041 cccccaaagt ctttaacatc ctgattcacc cttcctaact taaggaaaac atgacataag
     5101 acactgcttc taagtttggt tgtcctttag ccagtggata ccagatctct gtgagtggat
     5161 gggggtgggc tgagagtcag gggaggaagg agcgtgtttg cctgggtgtg tggcttttgt
     5221 gtgtatgaag tgtacacaag tgtatgtgtg ttagaccgct tctaggctac taagtgtcaa
     5281 tggaaaagaa aatgtattca aaatacataa atcaaaacta gaagatggaa aaaaagattt
     5341 attctataca aagccttgtc tggaccactc tagagagact tctatttttt taaaccctct
     5401 ataaatattt gatggcacta gaaatattcc tgcaataaaa tgtgatttgt gtaaagaaaa
     5461 aaaaaagatt ttgtaatgtg aaacaaagaa agaaagtaat gtaattttct aaaaaaaaaa
     5521 atacaaacaa acaaactttg tattattttc ttgatggaat ttgcctatct gtctttggaa
     5581 aactttttat ttcattgaat gtgccatagt agatgtacat gctttttgtt ttagactaag
     5641 ggatggctgt ttgtgttccg acattccaaa atgcaaagca acttagcaga agccttgatg
     5701 aggaggtttc ggtaggatgc aagcgtctct ccttgttgct ttttttgcac aagtcttttt
     5761 aattcttacc tagtgcaata tctgtacata gagcacttgc gggtgtactt tgatccctca
     5821 gggaaaaaca catatttgta cagttgttgg gtttgttttg gttttcttgt ttgttgtttg
     5881 atttattttc ctttttcgtt ctttggctat ggaatgtcga tcgaatcact tgttattgtt
     5941 gagaggcagc cagataatca gcctaaagcc actgtttcaa acaccgattg tttgagtcat
     6001 gtctttccag tactattatt ttaaaatgat attaataata ataataataa taaaaagcta
     6061 ttttctgaca gttctttgtg ctgactggta gaaaaaatgg taaaaaaata ataatagtaa
     6121 taagcacctt atggttgact tactgtgaac gacaatccat cttggtgtca aggacagagc
     6181 cctgttatct ggagttgggg ctgagagtca gaaacactgt gctcagggaa cttctaaaac
     6241 tcttaaaaca gggtggccag tggactggga caaattgtgg ttttactatt aaaaacaatg
     6301 atggtaacag tatccctcca aaggcacaag cgaactgtag agaagtgtct gtctgtctgt
     6361 ctgtgtgaat tcttcaccgt ctcatcttgt tgagttcgaa attcttgtgt ttcaaaacac
     6421 attaactcct gaggcagtgt gaatggaaga tgaatccgga agtgacatcc cagtagggga
     6481 acacagtgca gcccatctgc tggcttccta agaaattaag atgctcctgt gaaacacacc
     6541 tttcaacaat ttcagattct ctgtagtagg aatttagatg ttttttaaac cagcaggaag
     6601 acctatcagt gaaatggccc ccaacaaagt ccttctgaac tagaaaacaa aggggttttt
     6661 cactgtattc tcctccaggg gcaaaccaca atcctgttat gcaaaacaat tcctattccc
     6721 catccctagc ttttttgatt tgggggaggg ggagtgtttg tttgttttcc tggaagagtt
     6781 gcccttgaaa gactaattgg tccctgcatg acagaccatc gctttagttt aagggatcca
     6841 tgctctgagc tgcagttcag ttcacaaggt cccacgcacc actttccata aggccagaga
     6901 agcttagagt agctcatggt tctgagtctc ccgccccata aaacacactt ggcagaatta
     6961 cagagcttct tattacagta ggagagcaca aagtatgaga agtctgtcca ttaggtgaca
     7021 gttgatactt cacacgtatt tggagtgtag gtgacagaaa tctccccccc ccccctttac
     7081 ctctccatac atacatacac atgcacatgt gacagacatt cttacatacc atcacagggc
     7141 cactgcttac tcaaagttgt gatgcagaac cccacaacag cagcctttta ctgcggatca
     7201 gatatgtgcc caaaaaatgc agttgcaaca gtcaaatact ggtcgactgt tgctctctgt
     7261 catgctggtc ttcattcgat tccttaaaca ctaatgcatg aaatgcttcc accagctttg
     7321 atgatagcga cctccccact gctgttaaac taatgagaag gccagctgtc aatgtcttca
     7381 aaagcgatcg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgcgcg cgtgtgtgcg
     7441 tgtgtgtgtg tgtgtgcgcg cgcgtgctcg tgcgcgcaca tctatgcatg cttgtatgtg
     7501 atcagtttgt cagactctca aaatattttt tttaaaacaa acaggaaaac tggcttcata
     7561 tcaggaagcc atcatgaatg ggggcagagc atgctcggcc ataccccaga acttagagca
     7621 ataaacacta ttcagtccct tatttacttg taaatgggtg acagaatatt tgatccaaat
     7681 agaaaccacc tttcccaggg tctagtgtgg agagtggaga tgaatgtttg gaagagatcc
     7741 atgttctctg tttacatcct gtgtgttctg ttgcattagc tgtcctgtgc tttttctttg
     7801 gtcttctaga agctaatgac agacagctgg ctgttagctt tatgggctgt gcatgtcatt
     7861 gttcccccag aacaacaggc ttctctccag tgttcacata tgatcccttt ctcattcatt
     7921 gtgacttgtg tgtaggagta actactccta agaagatgat aatcactgaa cacattgcat
     7981 atgtaaatgt agatacttct tgagcaatat agtgactatg acttcacata cacacacaca
     8041 cacaccatct gtatgtactg tacacatctt cctgaatccc caattctctg cttaatcata
     8101 atggtttgaa atctcatcta caacagtggt ggatgtttta gacagtagga cattagctgg
     8161 ctgcttcttt aaatgtacct gtattgtctg cgtgctcctt ttgcggagac aagtttttgt
     8221 attggatgtt tgggccaatg ggaggcttca agctacaaca tattttccca gtttaaatat
     8281 attgaactta tgacaaaccc cagacaaggc ttttaatctg taaagaactg cagtgttggg
     8341 tggtttattt acaaaccgtt ttcaatgttg tccattttta tggcaccttt aacaatatac
     8401 ttgtttccaa agtacaaaaa aaaaataggt taaataatct agccataact gaatgtcaag
     8461 caataaaaca aatgactttt gtgcatagac tttaaaaact acaaatttta gacatctgca
     8521 tgtaaatgca atctcttgtt tactgctttc ttcaactcaa gcaacaggtt ccttacttac
     8581 tattaactta agaacttgta acggcctgta cacattttct ctcctactct tctttcaaat
     8641 ttaccttcac cctgcttttg agtcataata tttaatgttg ttctgcacac ctctatacag
     8701 ttaactttct ggcttttgtt ctgtatagat aagatgttat attataaaca gcctactcag
     8761 tgcaaatatt tatctgttta tcaaatccac aatatgctgt gtaatactgg ttttactata
     8821 taatctattt tagacatagc tgtttagaac tagagtgtgc tatttttgtg tttttctgat
     8881 gtgtggtgct agataagtta cttttgtgaa caacaacaaa aaaaatatcc cttttattcc
     8941 tagacaaaac cacctttggg tcttgttaat ttcactgagt ataactatat atttgtatat
     9001 atatacatat atatatatct atatatatat ctacctgtac ccaactggca actgtatcag
     9061 agtgctagat ttgggacatg cttttctctt taaatacata atatcattat ataaattatt
     9121 ctagagtgta tttaattagg ataaaattac ttccttagta tggatatttg acatctgttg
     9181 ggtaagtttg ttcataaata tagacatgaa aacctgttac catttattta agtgtgttgc
     9241 tcagctctac atcacatctc ctgagctgaa aaataatttg acaggccttg atcccaaagc
     9301 aacaattttg tttagtggaa aaatcctttc ttcccttctt ggagaactct gtaattggca
     9361 cctgactgga ctgtacattt aattcctagt atagataata tgtagactag tcatggcgga
     9421 ttgataggac cctaggccat tcacctcatc tgagtcatga gatgtacaag catatacatt
     9481 gggctatact ataaaatcaa caagggatga tgttctaata tgacaaccag ttctgtgaac
     9541 tgagtgaacg acctttgttt taaaaattgt ttaataatga gctaagtaaa cactatgaca
     9601 tctttcccca agattgattg gcattgttaa agtatcaaat atctaactaa ggatgtaatt
     9661 agccttctta aatattgatt agaattgttc tgtaatatta ctgaatttgt aagatcttta
     9721 gcaaagattt ttgagcaatt tataaacata gagcaaatgt ttctgtttat tgcacatttt
     9781 gtaactgaag gtgataactt ctcaagtcac aattagtgga tcccatgcat cacgatgcgt
     9841 acctacccac catgctggac attttccatt tttattgcta tgcccttgat tatcaatgca
     9901 atcaggtggt taatgaaagc tgacgacaac aattgacttt ttaaagtgaa tttgttacaa
     9961 tttagagcga aatctctttt aatgcaatca cgccattcct taactgtcta gcatgaagag
    10021 agattggaac attttgtttg tttgacggat gaatggattt gattgattga tttttgcaca
    10081 gtttagtatc ccaagcttcc ctagggcagt gatttgtctc tctttgcact tgcacatggc
    10141 cagcaaatgt caacaacact tgacaaccca actaaaacac tccccaaccc agggtgtttt
    10201 ggcaaactga taaagcctgt aaagtcttac agttaacaat tccaaccaag tctaagagtc
    10261 acattgtcct tctggaggac acgaaatgct gagtctactt gtgtgtgggt ctccaggatc
    10321 acacaaatgt cacacaactc tacaagtgac aagactggcc tgctgtgagt agtcgtgaaa
    10381 gtttggaagc agcgatgccg aacctataaa taagatgctg tctcttttgt gtacaggatg
    10441 taaagcttct ttttctgtca cactagaaat gcaaaccatt tatgggattc ctaaaaacca
    10501 tagtatggac ctaaaacttt gctaatgatc tttactagag tctcacccca cttttcgctg
    10561 acattgggtt ttcttttcag tcctctctac acagtcgtag attgcatatt cccagctgtt
    10621 tattttattg agtcctgaat ttaaagaaaa aaaatatttt gattcatttt gtaaatacaa
    10681 gctgtaaaaa aaaaagagag atttaatgtt gtcttttaaa tactccgatt ttcattctaa
    10741 tatggatgtt gttatattgt acttagaaac tgtaccttta acattacagt acctttatta
    10801 aaagtgcatt gaacacatca attttagatg tgctttgtgt gctattatcc tataataaaa
    10861 cttcagcttc taatggaa
//
