LOCUS       NM_013846               3985 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus receptor tyrosine kinase-like orphan receptor 2
            (Ror2), mRNA.
ACCESSION   NM_013846
VERSION     NM_013846.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3985)
  AUTHORS   Kamizaki,K., Katsukawa,M., Yamamoto,A., Fukada,S.I., Uezumi,A.,
            Endo,M. and Minami,Y.
  TITLE     Ror2 signaling regulated by differential Wnt proteins determines
            pathological fate of muscle mesenchymal progenitors
  JOURNAL   Cell Death Dis 15 (10), 784 (2024)
   PUBMED   39468010
  REMARK    GeneRIF: Ror2 signaling regulated by differential Wnt proteins
            determines pathological fate of muscle mesenchymal progenitors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3985)
  AUTHORS   Dias,A.P., Rehmani,T., Applin,B.D., Salih,M. and Tuana,B.
  TITLE     SLMAP3 is crucial for organogenesis through mechanisms involving
            primary cilia formation
  JOURNAL   Open Biol 14 (10), rsob240206 (2024)
   PUBMED   39417621
REFERENCE   3  (bases 1 to 3985)
  AUTHORS   Polsani,N., Yung,T., Thomas,E., Phung-Rojas,M., Gupta,I.,
            Denker,J., Lau,K., Feng,X., Ibarra,B., Hopyan,S. and Atit,R.P.
  TITLE     Mesenchymal Wnts are required for morphogenetic movements of
            calvarial osteoblasts during apical expansion
  JOURNAL   Development 151 (12) (2024)
   PUBMED   38814743
REFERENCE   4  (bases 1 to 3985)
  AUTHORS   Griffiths,S.C., Tan,J., Wagner,A., Blazer,L.L., Adams,J.J.,
            Srinivasan,S., Moghisaei,S., Sidhu,S.S., Siebold,C. and Ho,H.H.
  TITLE     Structure and function of the ROR2 cysteine-rich domain in
            vertebrate noncanonical WNT5A signaling
  JOURNAL   Elife 13, e71980 (2024)
   PUBMED   38780011
  REMARK    GeneRIF: Structure and function of the ROR2 cysteine-rich domain in
            vertebrate noncanonical WNT5A signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3985)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 3985)
  AUTHORS   Matsuda,T., Nomi,M., Ikeya,M., Kani,S., Oishi,I., Terashima,T.,
            Takada,S. and Minami,Y.
  TITLE     Expression of the receptor tyrosine kinase genes, Ror1 and Ror2,
            during mouse development
  JOURNAL   Mech Dev 105 (1-2), 153-156 (2001)
   PUBMED   11429290
REFERENCE   7  (bases 1 to 3985)
  AUTHORS   Oldridge,M., Fortuna,A.M., Maringa,M., Propping,P., Mansour,S.,
            Pollitt,C., DeChiara,T.M., Kimble,R.B., Valenzuela,D.M.,
            Yancopoulos,G.D. and Wilkie,A.O.
  TITLE     Dominant mutations in ROR2, encoding an orphan receptor tyrosine
            kinase, cause brachydactyly type B
  JOURNAL   Nat Genet 24 (3), 275-278 (2000)
   PUBMED   10700182
REFERENCE   8  (bases 1 to 3985)
  AUTHORS   DeChiara,T.M., Kimble,R.B., Poueymirou,W.T., Rojas,J.,
            Masiakowski,P., Valenzuela,D.M. and Yancopoulos,G.D.
  TITLE     Ror2, encoding a receptor-like tyrosine kinase, is required for
            cartilage and growth plate development
  JOURNAL   Nat Genet 24 (3), 271-274 (2000)
   PUBMED   10700181
REFERENCE   9  (bases 1 to 3985)
  AUTHORS   Takeuchi,S., Takeda,K., Oishi,I., Nomi,M., Ikeya,M., Itoh,K.,
            Tamura,S., Ueda,T., Hatta,T., Otani,H., Terashima,T., Takada,S.,
            Yamamura,H., Akira,S. and Minami,Y.
  TITLE     Mouse Ror2 receptor tyrosine kinase is required for the heart
            development and limb formation
  JOURNAL   Genes Cells 5 (1), 71-78 (2000)
   PUBMED   10651906
REFERENCE   10 (bases 1 to 3985)
  AUTHORS   Oishi,I., Takeuchi,S., Hashimoto,R., Nagabukuro,A., Ueda,T.,
            Liu,Z.J., Hatta,T., Akira,S., Matsuda,Y., Yamamura,H., Otani,H. and
            Minami,Y.
  TITLE     Spatio-temporally regulated expression of receptor tyrosine
            kinases, mRor1, mRor2, during mouse development: implications in
            development and function of the nervous system
  JOURNAL   Genes Cells 4 (1), 41-56 (1999)
   PUBMED   10231392
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK157705.1 and BC070436.1.
            
            On Jan 15, 2019 this sequence version replaced NM_013846.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070436.1, AK157705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AK157705.1         2-16
            16-3985             BC070436.1         1-3970
FEATURES             Location/Qualifiers
     source          1..3985
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 27.68 cM"
     gene            1..3985
                     /gene="Ror2"
                     /gene_synonym="Ntrkr2"
                     /note="receptor tyrosine kinase-like orphan receptor 2"
                     /db_xref="GeneID:26564"
                     /db_xref="MGI:MGI:1347521"
     exon            1..344
                     /gene="Ror2"
                     /gene_synonym="Ntrkr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..3082
                     /gene="Ror2"
                     /gene_synonym="Ntrkr2"
                     /EC_number="2.7.10.1"
                     /note="tyrosine-protein kinase transmembrane receptor
                     ROR2; neurotrophic tyrosine kinase, receptor-related 2"
                     /codon_start=1
                     /product="tyrosine-protein kinase transmembrane receptor
                     ROR2 precursor"
                     /protein_id="NP_038874.3"
                     /db_xref="CCDS:CCDS26520.1"
                     /db_xref="GeneID:26564"
                     /db_xref="MGI:MGI:1347521"
                     /translation="MARGWVRPSRVPLCARAVWTAAALLLWTPWTAGEVEDSEAIDTL
                     GQPDGPDSPLPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPV
                     VQEPRRVIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGPTHSP
                     NHNFQDDDQEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTQ
                     LSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLENDLCRQEYTIARSNPL
                     ILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGADYRGMASTTKSG
                     HQCQPWALQHPHSHRLSSTEFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRVELCDVP
                     PCSPRDGSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQ
                     DMEMPLISQHKQAKLKEISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKT
                     LKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLV
                     MRSPHSDVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVY
                     DKLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKFSIDSDIWSYGVVL
                     WEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFK
                     DIHSRLRSWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYMAPKQKAQPFPQ
                     PQFIPMKGQIRPLVPPAQLYIPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMV
                     PKPSSHHSGSGSTSTGYVTTAPSNTSVADRAALLSEGTEDAQNIAEDVAQSPVQEAEE
                     EEEGSVPETELLGDNDTLQVTEAAHVQLEA"
     exon            345..422
                     /gene="Ror2"
                     /gene_synonym="Ntrkr2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..710
                     /gene="Ror2"
                     /gene_synonym="Ntrkr2"
                     /inference="alignment:Splign:2.1.0"
     exon            711..741
                     /gene="Ror2"
                     /gene_synonym="Ntrkr2"
                     /inference="alignment:Splign:2.1.0"
     exon            742..869
                     /gene="Ror2"
                     /gene_synonym="Ntrkr2"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1184
                     /gene="Ror2"
                     /gene_synonym="Ntrkr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1430
                     /gene="Ror2"
                     /gene_synonym="Ntrkr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1633
                     /gene="Ror2"
                     /gene_synonym="Ntrkr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..3985
                     /gene="Ror2"
                     /gene_synonym="Ntrkr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3965..3970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ror2"
                     /gene_synonym="Ntrkr2"
                     /note="hexamer: AATAAT"
     polyA_site      3985
                     /gene="Ror2"
                     /gene_synonym="Ntrkr2"
                     /note="major polyA site"
ORIGIN      
        1 gttccgcccc ccctgtgctc ttcccggcgg ccggcgggac gcccgtgccc gagccccaga
       61 gtctctgcag tgaatcggtg catcggggca gggaaaaagg gacaccagag tggccctcga
      121 aggggaccag cctgcgaagc gcgaggaagg aagaagcgga cgcgtggcgg ggaggggttg
      181 aggcgccccg gcccgaagcc caaaggccga gcgcgcggta ggcgaccggg cacccacggc
      241 ccgcagcatg gctcggggct gggtgcggcc gagccgtgtg cctctgtgcg cccgggccgt
      301 ctggacggct gcggcgctcc tgctctggac accctggacg gcaggtgaag tggaagattc
      361 ggaggcaatc gacaccttgg gacaacctga tggaccggac agcccacttc ccactctgaa
      421 aggctacttt ctgaattttc tggagccagt caacaatatc accattgttc agggccagac
      481 ggcaatcctg cactgcaagg tggcgggaaa cccacctccc aatgtgcggt ggctgaagaa
      541 tgatgccccg gttgtgcaag agccacgaag ggtcatcatc cggaagacag aatacggctc
      601 ccggctgcgg atccaagacc tggacacaac agacacaggc tactaccagt gtgtggctac
      661 caacgggctg aagaccatca ctgccactgg ggttctatat gtgcggctcg gtccgacgca
      721 cagcccgaac cacaattttc aggatgacga tcaggaagat ggcttctgcc agccgtaccg
      781 agggatcgct tgtgcgcgct tcattgggaa ccggactatt tatgtggact ccctccagat
      841 gcagggggag attgaaaacc gaatcacagc tgccttcacc atgatcggca cctccacgca
      901 actgtcagac cagtgttcac agtttgccat cccatccttc tgccacttcg tcttccctct
      961 gtgcgacgca cgctcccggg cgcccaagcc tcgggaactg tgccgggatg aatgtgaggt
     1021 gctggagaac gacctgtgcc gccaggagta caccatcgcc cgctccaacc cgctcatcct
     1081 catgcggctc cagctgccca agtgcgaagc gctgcccatg cccgagagcc cggatgctgc
     1141 gaactgcatg cgcatcggga tcccggcgga gaggctgggt cgctaccacc agtgctacaa
     1201 cggctctggc gccgattaca gggggatggc cagtaccacc aagtcaggcc accagtgtca
     1261 gccttgggct ctgcagcacc cccacagcca tcgcctatcc agcacggaat tccctgagct
     1321 gggaggaggc catgcctact gccggaaccc cgggggccag atggaaggcc cgtggtgctt
     1381 tacgcagaat aaaaacgtac gcgtggaact gtgtgacgta cccccgtgta gtccccgaga
     1441 tggcagcaag atggggattc tgtacatcct ggtccccagc attgccatcc ccctggtcat
     1501 cgcttgcctg ttcttcctcg tctgcatgtg ccgcaacaaa cagaaggctt cggcctccac
     1561 cccacagcgc cggcagctga tggcctcgcc cagccaggac atggagatgc cactcatcag
     1621 ccagcacaaa caggccaaac tcaaagagat cagcttgtcc acagtgaggt tcatggagga
     1681 gctcggggag gaccggtttg gcaaggtcta caaaggccac ctgttcgggc ctgccccagg
     1741 agaacccacc caggccgtgg ccatcaagac gctgaaagac aaggctgagg ggcccctgcg
     1801 ggaggagttc cggcaagagg cgatgctccg ggcccgactg cagcacccca acatcgtctg
     1861 cctcctaggc gtcgtgacca aggaccaacc cttgagcatg atcttcagct actgttccca
     1921 tggcgacctc catgagttcc tggtcatgcg ctcgccgcac tccgatgtgg gcagcaccga
     1981 tgacgaccgc accgtgaagt cagccctgga gcccccggac ttcgtgcacg tggtggcgca
     2041 gatcgctgcg gggatggagt tcctgtccag ccaccacgtg gtccataagg acctggccac
     2101 acgcaatgtg ctggtgtacg acaagctgaa cgtgaggatc tcagacttgg gcctcttccg
     2161 tgaggtatac tccgcagatt actacaaact catgggcaat tcactgctgc ccatccgctg
     2221 gatgtccccc gaggccgtca tgtatggaaa gttctccatc gactctgaca tctggtccta
     2281 cggtgtggtc ctctgggagg tctttagcta cggcctgcag ccctactgtg ggtactccaa
     2341 ccaggacgtg gtggagatga tccggagccg gcaggtgctg ccctgtccgg atgactgccc
     2401 cgcctgggtc tatgccctca tgattgaatg ctggaatgag ttcccaagcc ggaggccccg
     2461 ctttaaggac atccacagcc ggctccggtc ctggggcaac ctatccaact ataatagttc
     2521 cgcgcagacc tcaggagcca gcaacaccac acagaccagc tccctgagca ccagccctgt
     2581 aagcaatgtg agcaatgccc gctatatggc ccccaagcag aaggcccagc ccttcccaca
     2641 gcctcagttc atccccatga agggtcagat cagacccttg gtgcccccgg cacagctgta
     2701 catcccggtg aacggctatc agccggtacc ggcatacggg gcctacctgc ccaacttcta
     2761 cccagtccag atccccatgc agatggcccc acagcaggtg ccccctcaga tggtccccaa
     2821 gccgagctca caccacagtg gcagcggctc caccagcact ggctacgtca ccacggcgcc
     2881 ctccaataca tctgtggcgg acagggcggc cctactctct gagggcaccg aggatgcaca
     2941 gaacatcgcg gaagacgtgg cccagagccc tgtgcaggaa gcagaggagg aggaggaggg
     3001 gtctgtccct gagactgaac tcctgggaga caatgacacg ctccaggtga ccgaggcggc
     3061 tcatgtccag cttgaagcct gaggaatata aggggcctgg agcaccagcc ctgctgtgac
     3121 cagatgggga cctcaaaatg gctctgtgaa gtcccaaaga ggggcccatc accagagccc
     3181 agggactggc aggctggttt gagcctaccc acctgagact gtgagagatt ttttactatc
     3241 tcctgcaccc tgtgcccata aaactgccgc tgcagcgccg acttggctgg aggccatttc
     3301 agacagggac cctgggcagg gtccctgcag cgtgaccacc tcagaaacag gacagggaga
     3361 ccccgcctct gtctgcttta tcctgatggt agatgggtag tgagctaagg atattgggca
     3421 cagaaacagg ctacatcttc accgccctgc tttatgggcg gagggttcag agactggggg
     3481 cggaggcatg gccgcgacag gcagcagaga ggcaccttgg agcttagatg ctccgtgagc
     3541 cccctgctgg cggaggatgg agagagtttt tctttctctc tgtggccccc tgcgaacgtg
     3601 ttctttttta acagccaaag gccagcagga gctcgatgct gccatctgct ggagtccaaa
     3661 ggacagagtt gcttctgaac acttgggagt gccttgtatt aaagagagaa aaaaaagtgc
     3721 ctttacaaaa accagcacga ttttgtattt ttgtgaaggg ttttaattat actgcgtgtg
     3781 tattttgcct acttttctgg aattcaaagg aaaaaatgtt tcctgggttt agaatgttca
     3841 aaaggaagca acgttgtaca gaaagcagta ttgttaattt tttaaaaaaa gaatcctgtg
     3901 cagaccctaa atgtaattta tatggttttc cgtgtgccgt tttcatggaa gtgttttgat
     3961 cctgaataat gacttagtaa tttaa
//
