LOCUS       NM_001164216             469 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus reactive oxygen species modulator 1 (Romo1),
            transcript variant 3, mRNA.
ACCESSION   NM_001164216
VERSION     NM_001164216.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Chung,Y.M., Kim,J.S. and Yoo,Y.D.
  TITLE     A novel protein, Romo1, induces ROS production in the mitochondria
  JOURNAL   Biochem Biophys Res Commun 347 (3), 649-655 (2006)
   PUBMED   16842742
REFERENCE   3  (bases 1 to 469)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA058111.1, AK008300.1 and BE996606.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY645081.1, BU851721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 16842742; reported by
                                                  MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AA058111.1         1-76
            77-451              AK008300.1         12-386
            452-469             BE996606.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.36 cM"
     gene            1..469
                     /gene="Romo1"
                     /gene_synonym="2010100O12Rik"
                     /note="reactive oxygen species modulator 1"
                     /db_xref="GeneID:67067"
                     /db_xref="MGI:MGI:1914317"
     exon            1..128
                     /gene="Romo1"
                     /gene_synonym="2010100O12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..368
                     /gene="Romo1"
                     /gene_synonym="2010100O12Rik"
                     /note="ROS modulator 1; protein MGR2 homolog"
                     /codon_start=1
                     /product="reactive oxygen species modulator 1"
                     /protein_id="NP_001157688.1"
                     /db_xref="CCDS:CCDS38296.1"
                     /db_xref="GeneID:67067"
                     /db_xref="MGI:MGI:1914317"
                     /translation="MPVAVGPYGQSQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLR
                     IGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC"
     exon            129..259
                     /gene="Romo1"
                     /gene_synonym="2010100O12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            260..452
                     /gene="Romo1"
                     /gene_synonym="2010100O12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      429..434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Romo1"
                     /gene_synonym="2010100O12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      452
                     /gene="Romo1"
                     /gene_synonym="2010100O12Rik"
                     /note="major polyA site"
ORIGIN      
        1 caagtcctca gcccatgctc ccggaagtaa ctgcgctgtg ctccggaagc gatcccacgg
       61 accgcgagcg ccctccgcct agcattcgga gtgagacgtc gagctgagcg atcgcagcgg
      121 agaacgagat gccggtggcc gtgggtccct acgggcagtc ccagcccagc tgcttcgacc
      181 gcgtgaagat gggcttcgtc atgggttgcg cagtgggtat ggcggccggg gcgctgttcg
      241 gcaccttctc ctgtctcagg atcggaatgc ggggtcggga gctaatgggc ggcattggga
      301 aaaccatgat gcagagtggc ggcacgtttg gcactttcat ggccattgga atgggcatac
      361 gatgctaatt agggctagga tgccctgcaa tacctaaact tccccatcca tttcgaccct
      421 tgtacaataa taaagttgtt ttcttctcgt taaaaaaaaa aaaaaaaaa
//
