LOCUS       NM_009072               8012 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus Rho-associated coiled-coil containing protein kinase 2
            (Rock2), mRNA.
ACCESSION   NM_009072
VERSION     NM_009072.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8012)
  AUTHORS   Sedmera,D., Olejnickova,V., Sankova,B., Kolesova,H., Bartos,M.,
            Kvasilova,A., Phillips,L.C., Bamforth,S.D. and Phillips,H.M.
  TITLE     Morphological, electrophysiological, and molecular alterations in
            foetal noncompacted cardiomyopathy induced by disruption of ROCK
            signalling
  JOURNAL   Front Cell Dev Biol 12, 1471751 (2024)
   PUBMED   39435333
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8012)
  AUTHORS   Funahashi,Y., Ahammad,R.U., Zhang,X., Hossen,E., Kawatani,M.,
            Nakamuta,S., Yoshimi,A., Wu,M., Wang,H., Wu,M., Li,X., Faruk,M.O.,
            Shohag,M.H., Lin,Y.H., Tsuboi,D., Nishioka,T., Kuroda,K., Amano,M.,
            Noda,Y., Yamada,K., Sakimura,K., Nagai,T., Yamashita,T., Uchino,S.
            and Kaibuchi,K.
  TITLE     Signal flow in the NMDA receptor-dependent phosphoproteome
            regulates postsynaptic plasticity for aversive learning
  JOURNAL   Sci Signal 17 (853), eado9852 (2024)
   PUBMED   39255336
REFERENCE   3  (bases 1 to 8012)
  AUTHORS   Akamine,T., Terabayashi,T., Sasaki,T., Hayashi,R., Abe,I.,
            Hirayama,F., Nureki,S.I., Ikawa,M., Miyata,H., Tokunaga,A.,
            Kobayashi,T., Hanada,K., Thumkeo,D., Narumiya,S. and Ishizaki,T.
  TITLE     Conditional deficiency of Rho-associated kinases disrupts
            endothelial cell junctions and impairs respiratory function in
            adult mice
  JOURNAL   FEBS Open Bio 14 (6), 906-921 (2024)
   PUBMED   38604990
REFERENCE   4  (bases 1 to 8012)
  AUTHORS   Tao,X., Zhang,W., Chen,C., Tao,Y., Tao,Y., Chen,Z. and Zhang,G.
  TITLE     miR-101a-3p/ROCK2 axis regulates neuronal injury in Parkinson's
            disease models
  JOURNAL   Aging (Albany NY) 16 (10), 8732-8746 (2024)
   PUBMED   38775730
  REMARK    GeneRIF: miR-101a-3p/ROCK2 axis regulates neuronal injury in
            Parkinson's disease models.
REFERENCE   5  (bases 1 to 8012)
  AUTHORS   Matoba,K., Nagai,Y., Sekiguchi,K., Ohashi,S., Mitsuyoshi,E.,
            Shimoda,M., Tachibana,T., Kawanami,D., Yokota,T., Utsunomiya,K. and
            Nishimura,R.
  TITLE     Deletion of podocyte Rho-associated, coiled-coil-containing protein
            kinase 2 protects mice from focal segmental glomerulosclerosis
  JOURNAL   Commun Biol 7 (1), 402 (2024)
   PUBMED   38565675
  REMARK    GeneRIF: Deletion of podocyte Rho-associated,
            coiled-coil-containing protein kinase 2 protects mice from focal
            segmental glomerulosclerosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8012)
  AUTHORS   Zhao,Z. and Rivkees,S.A.
  TITLE     Rho-associated kinases play an essential role in cardiac
            morphogenesis and cardiomyocyte proliferation
  JOURNAL   Dev Dyn 226 (1), 24-32 (2003)
   PUBMED   12508221
REFERENCE   7  (bases 1 to 8012)
  AUTHORS   Gaikwad,J.S., Cavender,A. and D'Souza,R.N.
  TITLE     Identification of tooth-specific downstream targets of Runx2
  JOURNAL   Gene 279 (1), 91-97 (2001)
   PUBMED   11722849
REFERENCE   8  (bases 1 to 8012)
  AUTHORS   Wei,L., Roberts,W., Wang,L., Yamada,M., Zhang,S., Zhao,Z.,
            Rivkees,S.A., Schwartz,R.J. and Imanaka-Yoshida,K.
  TITLE     Rho kinases play an obligatory role in vertebrate embryonic
            organogenesis
  JOURNAL   Development 128 (15), 2953-2962 (2001)
   PUBMED   11532918
REFERENCE   9  (bases 1 to 8012)
  AUTHORS   Di Cunto,F., Imarisio,S., Hirsch,E., Broccoli,V., Bulfone,A.,
            Migheli,A., Atzori,C., Turco,E., Triolo,R., Dotto,G.P., Silengo,L.
            and Altruda,F.
  TITLE     Defective neurogenesis in citron kinase knockout mice by altered
            cytokinesis and massive apoptosis
  JOURNAL   Neuron 28 (1), 115-127 (2000)
   PUBMED   11086988
REFERENCE   10 (bases 1 to 8012)
  AUTHORS   Nakagawa,O., Fujisawa,K., Ishizaki,T., Saito,Y., Nakao,K. and
            Narumiya,S.
  TITLE     ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil
            forming protein serine/threonine kinase in mice
  JOURNAL   FEBS Lett 392 (2), 189-193 (1996)
   PUBMED   8772201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ127012.1, AK163082.1, U58513.1, AK045517.1, CN536850.1,
            AK048955.1 and AK153280.1.
            
            On Mar 31, 2007 this sequence version replaced NM_009072.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               CJ127012.1         102-248
            148-1519            AK163082.1         2-1373
            1520-3772           U58513.1           1308-3560
            3773-5331           AK045517.1         1535-3093
            5332-5872           CN536850.1         5-545
            5873-7571           AK048955.1         345-2043
            7572-8012           AK153280.1         231-671
FEATURES             Location/Qualifiers
     source          1..8012
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.04 cM"
     gene            1..8012
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /note="Rho-associated coiled-coil containing protein
                     kinase 2"
                     /db_xref="GeneID:19878"
                     /db_xref="MGI:MGI:107926"
     exon            1..353
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..4379
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /EC_number="2.7.11.1"
                     /note="p164 ROCK-2; rho-associated, coiled-coil-containing
                     protein kinase 2; Rho-associated coiled-coil forming
                     kinage 2; rho-associated, coiled-coil-containing protein
                     kinase II"
                     /codon_start=1
                     /product="rho-associated protein kinase 2"
                     /protein_id="NP_033098.2"
                     /db_xref="CCDS:CCDS36410.1"
                     /db_xref="GeneID:19878"
                     /db_xref="MGI:MGI:107926"
                     /translation="MSRPPPTGKMPGAPETAPGDGAGAGRQRKLEALIRDPRSPINVE
                     SLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGA
                     FGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQ
                     DDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPD
                     NMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECD
                     WWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDTEISKHAKNLICAFLT
                     DREVRLGRNGVEEIKQHPFFKNDQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKG
                     DVETFPIPKAFVGNQLPFIGFTYFRENLLLSDSPPCRENDAIQTRKSEESQEIQKKLY
                     ALEEHLSSEVQAKEELEQKCKSINTRLEKTAKELEEEITLRKSVESTLRQLEREKALL
                     QHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQSSQISTEKVNQLQKQLDE
                     ANALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQ
                     SALESERRDRTHGSEIINDLQGRISGLEEDLKTGKALLAKVELEKRQLQEKLTDLEKE
                     KSNMEIDMTYQLKVIQQSLEQEEAEHKTTKARLADKNKIYESIEEAKSEAMKEMEKKL
                     LEERSLKQKVENLLLEAEKRCSILDCDLKQSQQKLNELLKQKDVLNEDVRNLTLKIEQ
                     ETQKRCLMQNDLKMQTQQVNTLKMSEKQIKQENNHLMEMKMNLEKQNTELRKERQDAD
                     GQMKELQDQLEAEQYFSTLYKTQVRELKEENEEKTKLCKELQQKKQDLQDERDSLAAQ
                     LEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDTTIASLE
                     ETNRTLTSDVANLANEKEELNNKLKDSQEQLSKLKDEEMSAAAIKAQFEKQLLNERTL
                     KTQAVNKLAEIMNRKEPVKRGSDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKEL
                     NEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGMDSSSIGSGPGDAEPDD
                     GFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDK
                     LFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEPEFPVEPVGEKSNYICHKGHE
                     FIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYD
                     ISSAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRP
                     SRQLAPNKPS"
     exon            354..435
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            436..536
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            537..674
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            675..935
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1080
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1219
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1311
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1471
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1532
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1544
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1624
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1673
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1809
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1901
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2148
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2255
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2415
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2576
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2761
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2831
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2935
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3122
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3216
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3311
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3491
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..3660
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3661..3731
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3732..3820
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3821..3899
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3900..4161
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4162..4375
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4376..8012
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5310..5315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /note="hexamer: AATAAT"
     polyA_site      5333
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /note="major polyA site"
     regulatory      7531..7536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /note="hexamer: AATAAA"
     regulatory      7540..7545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /note="hexamer: AAGAAA"
     polyA_site      7549
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
     polyA_site      7556
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /note="major polyA site"
ORIGIN      
        1 gggcggggtg gtgcggcgcg ggcgcccctt ccccgctccc gcccgccggg tcctggcgag
       61 ctcgctacgg gccgggcggc gcgcgtgcgg ctgaggggcg gggacgccgt gtgcctcgct
      121 gctcccggcc gggccgggcg gctcctcaga cagcggcgcg cggcgtgccg gggcggaggt
      181 tccgcgggcg gcgctaggcc cggcgaagcg gcatgagccg gcccccgccg acggggaaaa
      241 tgcccggcgc ccccgagacc gcgccggggg acggggcggg cgccggccgt cagaggaagc
      301 tggaggcgct catccgagac cctcgctcgc ccatcaacgt ggagagtctg ctggatggct
      361 taaattcctt ggtccttgat ttggattttc ctgctttgag gaaaaataaa aatatagata
      421 acttcttaaa tagatatgag aaaattgtga aaaaaatcag aggtttacag atgaaagcgg
      481 aagactatga tgttgtaaaa gttattggaa gaggtgcttt tggtgaagtt cagttggttc
      541 gtcataaggc atcacagaag gtttatgcaa tgaagcttct tagtaaattt gaaatgataa
      601 aaagatcaga ttctgctttt ttctgggaag aaagagatat tatggccttt gccaacagtc
      661 cctgggtagt tcagctcttc tgtgcctttc aagatgacag gtacctgtac atggtgatgg
      721 agtacatgcc aggcggagac ctcgtcaacc ttatgagtaa ttatgatgta cctgaaaagt
      781 gggccaagtt ttacactgct gaagtagtgc ttgcactgga tgcaatacac tccatgggct
      841 taatacacag agatgtgaag cctgataaca tgctattgga taaacatgga catctaaagt
      901 tagcagattt tggcacatgt atgaaaatgg atgaaacagg catggtgcat tgcgacacag
      961 cagttggaac tcccgactac atatcgcccg aggttctgaa atcacaagga ggtgatggtt
     1021 actatgggcg agaatgtgat tggtggtctg taggtgtttt cctttttgag atgttagtag
     1081 gggacactcc attttacgca gattcacttg taggaaccta cagcaaaatt atggatcata
     1141 aaaattcact gtgttttcct gaagatacag aaatttctaa acatgcgaag aatctcatat
     1201 gtgccttctt aacagacagg gaggtacgac ttggaagaaa tggggtagaa gaaatcaaac
     1261 agcatccttt ctttaagaat gatcaatgga attgggataa cataagagag acggcagctc
     1321 cagtggtacc tgagctcagc agtgacatag acagcagcaa ctttgacgac attgaggatg
     1381 acaaaggcga tgtagagacc ttcccgattc ctaaagcttt tgtgggaaat cagctgcctt
     1441 ttataggatt tacctacttt agagaaaatt tgttattaag tgactctcca ccttgtagag
     1501 aaaatgatgc aatacaaaca aggaaaagtg aagaaagtca ggagattcag aaaaaattat
     1561 atgcactaga agaacacctt agcagtgagg tgcaagccaa ggaggagctg gaacagaagt
     1621 gcaaatctat taatactcgc ctagagaaaa cagcaaagga gctagaagaa gagattacct
     1681 tacggaaaag tgtggaatca acattaagac agctggaaag agaaaaggcc cttcttcagc
     1741 acaaaaatgc agagtatcag cggaaagctg atcatgaagc cgacaagaag cggaacttgg
     1801 aaaatgatgt taacagctta aaagatcaac ttgaagatct gaagaaaagg aaccagagct
     1861 ctcagatatc cactgagaag gtcaatcagc tccagaaaca actggatgaa gctaatgctt
     1921 tgctgagaac agagtctgat actgcagcac ggttaagaaa aacccaggca gaaagttcca
     1981 aacagattca gcagctggaa tctaacaata gagatctaca agataaaaac tgcctgcttg
     2041 agactgccaa gttaaaactt gaaaaggaat ttatcaatct tcagtcagct ttagaatctg
     2101 aaagaaggga ccggacccat ggatcagaga taattaatga tttacaaggt agaatatctg
     2161 ggttggaaga agatttgaag actggcaaag ccttactagc aaaagtagag ctggagaaga
     2221 gacagctgca ggagaagctc actgacttag agaaggaaaa aagcaacatg gaaatagata
     2281 tgacatatca actgaaagtt atacagcaga gtttagaaca agaagaagct gaacacaaga
     2341 ccacaaaagc acggctagcg gataaaaata agatctatga atccattgaa gaagctaaat
     2401 cagaagccat gaaagaaatg gagaagaagc tgttggaaga gaggtcttta aagcagaaag
     2461 tggagaacct gctcctggaa gccgagaaaa gatgctctat attggactgt gacctcaaac
     2521 agtctcagca gaagctaaat gagctgctga agcagaaaga tgtgctgaac gaggatgtta
     2581 gaaatttgac attaaaaata gagcaggaaa ctcagaagcg ttgtcttatg caaaatgacc
     2641 tgaagatgca gacccaacaa gttaacaccc taaaaatgtc agaaaagcaa ataaaacaag
     2701 aaaataatca tcttatggaa atgaaaatga acttggaaaa gcaaaatact gaacttcgaa
     2761 aagagcggca ggatgcagat gggcagatga aggaactgca agaccaactt gaagcagagc
     2821 agtatttctc aaccctctat aaaacacaag ttagagaact taaagaagaa aatgaagaga
     2881 agacaaaact ttgtaaagag ttgcaacaga agaagcagga tttacaggat gaaagagact
     2941 ctttggctgc ccagctggaa attaccctta ccaaagcaga ttctgagcag ctggctcgtt
     3001 ccattgctga agaacaatac tctgatttgg aaaaagagaa gatcatgaaa gagctggaga
     3061 tcaaagagat gatggctaga cacaaacaag aacttactga aaaggatact acaattgcat
     3121 ctcttgaaga aacaaatagg acactaacta gcgatgttgc aaatcttgca aatgagaaag
     3181 aagaattaaa caacaagctg aaagatagcc aagaacaact gtccaagttg aaagatgaag
     3241 agatgagtgc agcagctatt aaagcacagt ttgagaagca gcttctgaat gagagaactc
     3301 tcaagactca agctgtgaat aagttggcgg agatcatgaa tcgaaaagaa cctgtcaagc
     3361 gtggtagtga cacagatgtg cgaagaaaag agaaggaaaa cagaaagcta catatggagc
     3421 ttaagtctga acgtgaaaaa ttgacacaac agatgatcaa atatcagaaa gaactgaatg
     3481 aaatgcaggc tcaaatagct gaagagagcc aaattcgaat agaactccag atgaccctgg
     3541 acagtaaaga cagcgacatt gaacagctgc ggtcacagct ccaggccttg catattggta
     3601 tggacagttc cagtataggc agtggaccag gcgatgctga gcctgatgat ggatttccag
     3661 aatcaagatt agaaggatgg ttgtcattgc ctgtgcgcaa caacactaaa aagtttggat
     3721 gggttaaaaa gtatgtgatt gtaagcagca agaagattct tttttatgac agcgaacaag
     3781 ataaagagca gtccaaccct tacatggtgt tagacataga caagctattt cacgtccgac
     3841 ctgttaccca gacagatgta tacagagcag atgctaaaga aattccaagg atatttcaga
     3901 ttctatatgc caatgaagga gaaagtaaga aggaaccaga gtttccagtg gaaccagtgg
     3961 gagaaaaatc taattatatt tgtcacaaag gacatgagtt tattcctact ctttatcact
     4021 tcccaaccaa ctgtgaggca tgtatgaagc cgctgtggca catgtttaag cctcctcctg
     4081 ctctagagtg ccgtaggtgc cacattaaat gtcataaaga tcacatggac aagaaggaag
     4141 agattatagc gccctgcaaa gtttattatg atatatcgtc ggcaaagaat ctgttgttat
     4201 tagcaaattc aacagaagaa cagcagaaat gggttagtcg gttggtgaaa aagataccta
     4261 aaaagcctcc agctccagac ccttttgccc gatcatcccc tagaacttca atgaaaatac
     4321 aacaaaacca gtccattcgg cggcccagtc gacagcttgc tccaaacaag ccaagctaac
     4381 tgccttctat gaaagcagtt attgaaggtg atcgtattct tcaagctaca agactgaaat
     4441 aagatttctc aaaactaaaa ggctatattt tactgagaca catacataca ccacacgtgc
     4501 gcgcgcatgc ttgccctacc ttcccccctg aaataattac aaattatgaa gaggtttttt
     4561 ctgggctact ttgaaacaag ttgaacaaaa gtggtcggtg agtaaaggtg tcctgcagtt
     4621 ctcccagact gcgtcataaa gtcacactac attgcacagg actgagaaga gtttaaagaa
     4681 atcacatttc agcttcaaca gagggtttca ccagcacatt agccagaaga atttgggagt
     4741 gaatcccact acagcgatgc tgactgcatc tttaagaagt gaccatgata ttgtgttcat
     4801 gtatgtatat acatatgagt tgagcctcat atagatatgt acacacatac acataaaaca
     4861 cattgtactg taatactgca aggttttttt taacttacca ttttattttt tatacacatt
     4921 aatcagctat cattatttca gttgcaacta tgcacttgta taaagccata atgttggagt
     4981 ttatatcctt cattcatgta cctaataagg agttgcatgt ttgtgtaaaa aaaaaaataa
     5041 ctgtaacaag aagtttgaag ttaattattc cagtttccta atgcttaagg taggcagctt
     5101 tacccatttt gaatgcctta atttaatttt ctctcccccc aaatctcagc ccttttctat
     5161 atttaactaa agaaagaaca agtgtttacc agctcttagg atgcagcttg ctttgtgggg
     5221 aaagtagtgc acaattttat gtgtagtagt tatatcagtg ttggcctatt tgatgtatat
     5281 tggtttttaa tgtacttggt catagaaaca ataatggatt ctattgaaac taatgtgtgt
     5341 gatgtacctc tgttactgtt ttcatccctt tttgcagact ttagcaggtc tgtgactata
     5401 gaatatttcc tttgctttga actttctggt taccttagat gtgtttttat ttatggtaaa
     5461 gataattttt catgttttca ttcaatattc aaaaattgtc tcaaatataa ggaaaactaa
     5521 catgtactgt gtagatatat tttaaatatt taaatgtgat cctaaaaaaa aatctgtgtg
     5581 tggcaatatt tcagctttga tatctgggaa gaggcagctt caaaagtgct taatttgatt
     5641 ttcactgtta aatgctgctg agggtagaga acaggtagga cctatcctgc catgctactg
     5701 gcccaggtaa gtgtgcttaa ccccacagca gagtgcagca gtgagcagca tcaggctctg
     5761 tacatatgca aagttcaata tgacattgaa atgtttgcct gatattttag tgaaaccagt
     5821 agacattttt gattgcttcc ttctagggtc agtgtagaga tgttgtaaaa actttgatcc
     5881 tcgctatagt tactattgtg gaaatagtgg ctgttggccc actgatatac taaatccagt
     5941 tctgtgacct tcagatggcc cagtttgcat ctttcatgct ttctgttaag attacatgtg
     6001 catgccattt ccctggaagc agctgtgctc tggttgggaa cacaacttgc ttcctccctc
     6061 ttctccctcc ctccttcctt caggtttaaa aatgaaaata tataaaattt atatagaaga
     6121 actatttcca ttcattagag ttgtttaaaa ggagactgaa ttaatatttt atataaagat
     6181 tttgttacta tgggaggttc tatcctattc tgaattggag agtatatata tatatatatt
     6241 tttaataaac tttattaagg tgaaataatg tcaagtttac acatgaataa ttgaagtatt
     6301 tgagtaaaaa aggaaaaagt tttaattttg gatgctgttc gtgtatatat gtgtaagagt
     6361 ttggagaatc atgatgtgat acaactgtat aaggcaatta atgtgaagga ttcaggggaa
     6421 taaaacatcc tgaggggtga aaaaaaaatc tctccatgga gcgtcttcac atatggctta
     6481 ctagggattt ataaggttat ttgtccaaca gtcagaattc caagtaaaag ccacacgacc
     6541 ttagagaagc attcactctt cgcactcatc tccatgtatg tgggtgcgca tgcctgccat
     6601 ttcctcccca aaccaacagt cattacaaca acaacctaat tttgtgccag tttctttttt
     6661 tcttgaggcc tccaatcctt caagataaat gtgtaccagc acaaatactg cttcctttgg
     6721 tcccccagag ctgtaaatac ttggcatttg ggatctaaaa gacagggaat gctgggtttc
     6781 cttagttgga tgctattctt atcctttgtg gaaataaaaa agacagacgt aaaagaaaaa
     6841 cttaagtacc agtattactg ttgaaaatta atgtagaatt aatttttaag cgttaatttt
     6901 cagtaacatc tcaaagcaag attaaaacaa aacaaaactg tgatcccaag ggaaggctgc
     6961 tgtttgtggc caacctttga gaggccatgg ccctagaggg ctttgctcag ttcatgtgta
     7021 gatcctagtg agacatgctc gaggctgcca aaccaactga agatggcata ctgctgctgt
     7081 cagtctgtta gggttcccag ggtgaaggaa gagaaactca gacactaact aaccttgtag
     7141 agatgcgtta ggcagcatgg tgaagccccc agtaaagcac gtagcttccg agcttctcag
     7201 gcccttgact gctactgatt cttttttttc tgactgaaga tgacttcagc tcccctggct
     7261 cgtggaggtg ccacagccaa tgttaaagca ctttgacaag cactgtgtga cagtgctgag
     7321 tgttgttccc tgggacctca cctttgttcc tttccctgtg gtgacttttg tttgcaactg
     7381 taataagtta taaactgcat gatttagaga gtcatcttgg atcagtccct tcccccaaca
     7441 aaaaaatcat cccctcttga tttatttttt attttgttgc atctttgtag taatgtaatt
     7501 gtatttttat gcctgctttt tgtttaaaaa aataaataaa agaaactaag atgtaagcat
     7561 cttttcctgt gaaatagttg tggaatgctg cagcttcttc acctgtcttc ttaaaggatg
     7621 ctaatagtag atgaggtgat gtcatcatag tgaaatcact tctgccttac atcctggaga
     7681 gtttagttct agagtccgcc tccgattcac tttgggtatg caggcttaaa catctgattc
     7741 caggtggaaa gggtagaggg cagagagtgc ctttctgtct gaaaacagta tgatggacac
     7801 ttcctagaag gtgtcttact gggaatttat ggctgctttt tgttctgggg ttgggtattc
     7861 tgtaaactgg agactgtcta cttgttggtt tgaaatacga taatagtgca tgtgagatag
     7921 ctgtagtaac tcagatattc cttccaaaag tggggaaatg gccagtgatg gggatgcatg
     7981 ctggtaaaat acattgaaga gatgaaggca ga
//
