LOCUS       NM_009071               6187 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus Rho-associated coiled-coil containing protein kinase 1
            (Rock1), mRNA.
ACCESSION   NM_009071
VERSION     NM_009071.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6187)
  AUTHORS   Ren,C., Xi,L., Li,H., Pan,Z., Li,Y., Wang,G., Dai,J., He,D., Fan,S.
            and Wang,Q.
  TITLE     Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury
            under chronic hypoxia in Tetralogy of Fallot by maintaining
            mitochondrial quality control
  JOURNAL   Life Sci 357, 123084 (2024)
   PUBMED   39374570
  REMARK    GeneRIF: Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte
            injury under chronic hypoxia in Tetralogy of Fallot by maintaining
            mitochondrial quality control.
REFERENCE   2  (bases 1 to 6187)
  AUTHORS   Sedmera,D., Olejnickova,V., Sankova,B., Kolesova,H., Bartos,M.,
            Kvasilova,A., Phillips,L.C., Bamforth,S.D. and Phillips,H.M.
  TITLE     Morphological, electrophysiological, and molecular alterations in
            foetal noncompacted cardiomyopathy induced by disruption of ROCK
            signalling
  JOURNAL   Front Cell Dev Biol 12, 1471751 (2024)
   PUBMED   39435333
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6187)
  AUTHORS   Funahashi,Y., Ahammad,R.U., Zhang,X., Hossen,E., Kawatani,M.,
            Nakamuta,S., Yoshimi,A., Wu,M., Wang,H., Wu,M., Li,X., Faruk,M.O.,
            Shohag,M.H., Lin,Y.H., Tsuboi,D., Nishioka,T., Kuroda,K., Amano,M.,
            Noda,Y., Yamada,K., Sakimura,K., Nagai,T., Yamashita,T., Uchino,S.
            and Kaibuchi,K.
  TITLE     Signal flow in the NMDA receptor-dependent phosphoproteome
            regulates postsynaptic plasticity for aversive learning
  JOURNAL   Sci Signal 17 (853), eado9852 (2024)
   PUBMED   39255336
REFERENCE   4  (bases 1 to 6187)
  AUTHORS   Akamine,T., Terabayashi,T., Sasaki,T., Hayashi,R., Abe,I.,
            Hirayama,F., Nureki,S.I., Ikawa,M., Miyata,H., Tokunaga,A.,
            Kobayashi,T., Hanada,K., Thumkeo,D., Narumiya,S. and Ishizaki,T.
  TITLE     Conditional deficiency of Rho-associated kinases disrupts
            endothelial cell junctions and impairs respiratory function in
            adult mice
  JOURNAL   FEBS Open Bio 14 (6), 906-921 (2024)
   PUBMED   38604990
REFERENCE   5  (bases 1 to 6187)
  AUTHORS   Mardilovich,K., Naylor,G., Julian,L., Phinichkusolchit,N.,
            Keeshan,K., Blyth,K. and Olson,M.F.
  TITLE     Caspase-resistant ROCK1 expression prolongs survival of Emicro-Myc
            B cell lymphoma mice
  JOURNAL   Dis Model Mech 17 (5) (2024)
   PUBMED   38616733
  REMARK    GeneRIF: Caspase-resistant ROCK1 expression prolongs survival of
            Emicro-Myc B cell lymphoma mice.
REFERENCE   6  (bases 1 to 6187)
  AUTHORS   Wei,L., Roberts,W., Wang,L., Yamada,M., Zhang,S., Zhao,Z.,
            Rivkees,S.A., Schwartz,R.J. and Imanaka-Yoshida,K.
  TITLE     Rho kinases play an obligatory role in vertebrate embryonic
            organogenesis
  JOURNAL   Development 128 (15), 2953-2962 (2001)
   PUBMED   11532918
REFERENCE   7  (bases 1 to 6187)
  AUTHORS   Di Cunto,F., Imarisio,S., Hirsch,E., Broccoli,V., Bulfone,A.,
            Migheli,A., Atzori,C., Turco,E., Triolo,R., Dotto,G.P., Silengo,L.
            and Altruda,F.
  TITLE     Defective neurogenesis in citron kinase knockout mice by altered
            cytokinesis and massive apoptosis
  JOURNAL   Neuron 28 (1), 115-127 (2000)
   PUBMED   11086988
REFERENCE   8  (bases 1 to 6187)
  AUTHORS   Alberts,A.S., Bouquin,N., Johnston,L.H. and Treisman,R.
  TITLE     Analysis of RhoA-binding proteins reveals an interaction domain
            conserved in heterotrimeric G protein beta subunits and the yeast
            response regulator protein Skn7
  JOURNAL   J Biol Chem 273 (15), 8616-8622 (1998)
   PUBMED   9535835
REFERENCE   9  (bases 1 to 6187)
  AUTHORS   Narumiya,S., Ishizaki,T. and Watanabe,N.
  TITLE     Rho effectors and reorganization of actin cytoskeleton
  JOURNAL   FEBS Lett 410 (1), 68-72 (1997)
   PUBMED   9247125
  REMARK    Review article
REFERENCE   10 (bases 1 to 6187)
  AUTHORS   Nakagawa,O., Fujisawa,K., Ishizaki,T., Saito,Y., Nakao,K. and
            Narumiya,S.
  TITLE     ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil
            forming protein serine/threonine kinase in mice
  JOURNAL   FEBS Lett 392 (2), 189-193 (1996)
   PUBMED   8772201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149793.1, U58512.1, AA163962.1, AK077297.1 and DR754490.1.
            
            On Mar 31, 2007 this sequence version replaced NM_009071.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMN00849374,
                              SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-619               AK149793.1         255-873
            620-4536            U58512.1           145-4061
            4537-4895           AA163962.1         104-462
            4896-6081           AK077297.1         244-1429
            6082-6187           DR754490.1         326-431
FEATURES             Location/Qualifiers
     source          1..6187
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.91 cM"
     gene            1..6187
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /note="Rho-associated coiled-coil containing protein
                     kinase 1"
                     /db_xref="GeneID:19877"
                     /db_xref="MGI:MGI:107927"
     exon            1..568
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             476..4540
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /EC_number="2.7.11.1"
                     /note="p160ROCK; p160 ROCK-1; rho-associated,
                     coiled-coil-containing protein kinase 1; Rho-associated
                     coiled-coil forming kinase 1; rho-associated,
                     coiled-coil-containing protein kinase I"
                     /codon_start=1
                     /product="rho-associated protein kinase 1"
                     /protein_id="NP_033097.1"
                     /db_xref="CCDS:CCDS29053.2"
                     /db_xref="GeneID:19877"
                     /db_xref="MGI:MGI:107927"
                     /translation="MSTGDSFETRFEKIDNLLRDPKSEVNSDCLLDGLDALVYDLDFP
                     ALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVY
                     AMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGD
                     LVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFG
                     TCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDT
                     PFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKR
                     HLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIPKAFVGNQL
                     PFVGFTYYSNRRYLPSANASENRSSSNVDKSLQESLQKTIYKLEEQLHNEMQLKDEME
                     QKCRTSNLKLDKIMKELDEEGNQRRNLESAVSQIEKEKMLLQHRINEYQRKVEQENEK
                     RRNIENEVSTLKDQLEDLRKASQTSQLANEKLTQLQKQLEEANDLLRTESDTAVRLRK
                     SHTEMSKSISQLESLNRELQERNRILENSKSQADKDYYQLQAVLEAERRDRGHDSEMI
                     GDLQARITSLQEEVKHLKHNLERVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSIQQ
                     RLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVETEKQ
                     CSMLDVDLKQSQQKLEHLTENKERMEDEVKNLALQLEQESNKRLLLQNELKTQAFEAD
                     NLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLY
                     KTQVKELKEEIEEKNRENLRKIQELQSEKETLSTQLDLAETKAESEQLARGILEEQYF
                     ELTQESKKAASRNRQEITDKDHTVSRLEETNSVLTKDIEMLRKENEELNERMRTAEEE
                     YKLKKEEEINNLKAAFEKNISTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKK
                     EKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQLASKESDIE
                     QLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSVPNRGNIKRYGWKKQYVVVS
                     SKKILFYNDEQDKEQSSPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILYANEG
                     ECRKDIEVEPVQQGEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECR
                     RCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNP
                     PSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTS"
     exon            569..650
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            651..751
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            752..889
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1065
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1150
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1295
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1434
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1526
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1686
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1747
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1836
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1885
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2021
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2113
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2360
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2467
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2618
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2779
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2964
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3034
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3129
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3295
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3389
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3478
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3667
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3827
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..3898
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            3899..3987
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            3988..4066
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4328
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            4329..4536
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     exon            4537..6187
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5977..5982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /note="hexamer: AATAAA"
     polyA_site      6005
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /note="major polyA site"
     regulatory      6035..6040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /note="hexamer: AATAAT"
     polyA_site      6060
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
     regulatory      6162..6167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
                     /note="hexamer: ATTAAA"
     polyA_site      6187
                     /gene="Rock1"
                     /gene_synonym="1110055K06Rik; Rock-I"
ORIGIN      
        1 ggcggcggcg gcggcggcag ctggcgcagc tcctcaccca cccttcgctt tcgcctttcc
       61 tcttcgcctt ccctggctgc cccgagggag tctccaccct gctgcgctcc ctcttcccgc
      121 cgctgccctt ctctggactg ggccccgcca tggcgaaggc agccggggcc cgctaggctg
      181 aggtgcctcg ccggagcgac cgggctgctg gcgacggcgc tgtcggctgt cgcgaggggc
      241 tgccgggtgg gatgcgactt tgggtgtccg agcggctgcg ggtcgctgtc acaccgagcc
      301 tggggtctgg agagcagagg tcccctcagt gagggggacg agggggaacc gggcgcacct
      361 ggtgaccccg aggttccggc tcctctgccc tgcggctaca aacccaccgc ggaggaagtt
      421 ggttgaactt gctttccgct gcgggcaaga aggtatcgtc acaagtagca gcatcatgtc
      481 gactggggac agttttgaga ctcggtttga aaaaatcgac aacctgctgc gggatcccaa
      541 atcggaagtg aattcagatt gtttgctgga tggattggat gccctggttt atgatttgga
      601 ttttcctgcc ttaagaaaaa acaaaaatat tgacaacttt ctaagcagat ataaagacac
      661 aataaataaa attagagatt tacggatgaa agcagaagat tatgaagtgg taaaggtaat
      721 cggcagaggt gcatttggag aagttcaatt ggtgaggcat aaatccacta ggaaggttta
      781 tgctatgaag ctgctcagca aatttgaaat gattaagaga tcggattctg cttttttctg
      841 ggaagaaagg gacatcatgg cgtttgccaa tagtccttgg gttgttcagc ttttttatgc
      901 attccaagat gaccggtatc tctacatggt gatggagtac atgcctggcg gagaccttgt
      961 caacctgatg agcaactatg acgtgcctga aaaatgggca agattctata ctgcagaagt
     1021 agttcttgca ttggatgcaa tccattccat gggttttatt catagagatg taaagcctga
     1081 taacatgctg ctggataagt ctggacattt gaagttagca gattttggta cttgtatgaa
     1141 gatgaataag gaaggtatgg tacgatgtga cacagcagtt ggaacacctg attatatctc
     1201 acccgaagta ttaaaatccc aaggcggtga tggctattat ggacgagagt gtgactggtg
     1261 gtcagttggg gtatttctat atgaaatgct cgtaggtgac acacctttct atgcagattc
     1321 tttggttggg acttacagta aaattatgaa ccataaaaat tcacttactt tccctgatga
     1381 taatgacata tcaaaagagg caaaaaatct catttgtgcc ttccttacag acagagaagt
     1441 gagattgggc agaaatggtg tagaggaaat caaacgtcat ctcttcttca aaaatgatca
     1501 gtgggcttgg gaaacgctcc gagacactgt agcaccagtt gtgcctgatt taagtagtga
     1561 cattgatact agtaattttg atgacttaga agaagataaa ggagatgaag aaacatttcc
     1621 tattccaaaa gcttttgttg gcaatcagct accttttgta ggatttacat attatagcaa
     1681 tcgtagatac ttaccttcag caaatgccag tgagaacaga tctagctcca atgtggataa
     1741 aagcttgcag gaaagtttac agaaaacaat ctacaagctt gaagagcaac tgcataatga
     1801 aatgcaatta aaagatgaaa tggagcagaa atgcagaact tcaaacttaa aactagacaa
     1861 gataatgaaa gaattggatg aagaggggaa tcaaagaaga aatctagaat ctgcagtgtc
     1921 tcaaattgag aaagaaaaga tgttgctaca acatagaatt aatgagtacc aaagaaaagt
     1981 ggaacaggaa aatgagaaga gaagaaatat agaaaatgaa gtttctacac taaaggacca
     2041 gttagaagac ttacggaaag caagtcagac ctcacagctt gctaatgaga agctgacaca
     2101 gttacagaag cagttagaag aagcgaatga cttacttagg acagaatcag acacagctgt
     2161 aagattaagg aagagtcaca cagagatgag caagtcaatt agtcagctag agtccctgaa
     2221 cagagaatta caggaaagaa acagaatttt agagaattcc aagtcacaag cagacaagga
     2281 ttactaccag ctgcaagctg tattggaagc tgagcgaaga gacagagggc atgattctga
     2341 gatgattgga gaccttcaag cacgaattac atctttacaa gaagaagtga aacatctcaa
     2401 acataatctt gaaagagtgg aaggagaaag aaaagaggct caagacatgc ttaatcattc
     2461 agaaaaggaa aagaataatt tggagataga tttgaattac aagctcaagt ctatacaaca
     2521 gcggttagaa caagaagtaa atgaacataa agtcaccaaa gcacgcctaa ctgacaagca
     2581 ccaatctatc gaagaggcaa agtctgttgc catgtgtgaa atggaaaaaa agctgaagga
     2641 agagagagaa gctcgagaga aggcagaaaa tagagttgtt gagactgaga aacaatgttc
     2701 catgctagat gttgacctga aacagtctca gcagaagcta gaacatttga ccgaaaataa
     2761 agaaaggatg gaggatgaag ttaagaatct cgccctgcag ctggaacagg aatcaaataa
     2821 acggctcttg ttacagaatg aattgaagac tcaagcattt gaagcagaca atttaaaagg
     2881 tttagaaaaa cagatgaaac aggaaataaa tactttattg gaagcaaaga gattgttaga
     2941 atttgagtta gctcagctta caaagcaata taggggaaat gaagggcaaa tgcgggagtt
     3001 acaagatcaa cttgaagctg agcagtattt ctctacactt tataaaaccc aagtaaagga
     3061 gcttaaagaa gaaattgaag aaaaaaaccg agaaaattta aggaaaatac aggaactgca
     3121 aagtgaaaaa gaaactctct ctactcagtt ggatttagca gaaacaaaag ctgagtctga
     3181 gcagctggcg cgagggattc tggaagaaca gtattttgag ttgactcagg aaagcaagaa
     3241 agctgcttca agaaatagac aagagattac agataaagat catactgtta gtcggcttga
     3301 agaaacaaac agtgtgctaa ccaaagatat tgaaatgcta agaaaagaaa atgaagagct
     3361 aaatgaaaga atgaggacag cagaagaaga atataaattg aagaaggagg aagaaataaa
     3421 taatcttaag gctgcttttg aaaagaatat cagtaccgaa cggaccctta aaacacaggc
     3481 tgttaacaag ttggcagaaa taatgaatcg caaagatttt aaaattgatc gaaagaaagc
     3541 taatacacaa gatttaagaa aaaaagaaaa ggaaaataga aagctacaac tggaacttaa
     3601 ccaagagaga gaaaaattta accaaatggt ggtgaaacac cagaaggagc tgaatgacat
     3661 gcaagcgcaa ttggtagaag aatgtacaca tagaaatgaa cttcaaatgc agttggctag
     3721 caaagagagt gatattgagc agttgcgggc aaaacttttg gacctttcgg attcaactag
     3781 tgttgctagt tttcctagtg cagatgaaac tgatggaaac cttccagagt caagaattga
     3841 aggttggctt tctgtaccaa atagaggaaa tatcaaaaga tatggctgga agaaacagta
     3901 tgttgtggta agcagcaaaa agatcttgtt ctataatgat gaacaagata aggaacaatc
     3961 cagtccatct atggtgttag acatagataa attgtttcat gtccgacctg taacccaagg
     4021 agatgtgtac agagcagaaa ctgaagaaat tcctaaaata ttccagatac tatatgcaaa
     4081 tgaaggtgaa tgtagaaaag atatagaagt ggaaccggtt caacaaggtg aaaaaactaa
     4141 tttccagaat cacaaaggcc atgaattcat tcctaccctc taccactttc ctgccaactg
     4201 tgaggcctgt gccaaacctt tgtggcatgt ctttaagcca ccacctgccc tagagtgtcg
     4261 aagatgccat gttaagtgcc acagagacca tctagacaag aaagaggact tgatttcccc
     4321 gtgcaaagta agttacgatg taacatcagc aagagatatg ctgctgttag catgttctca
     4381 ggatgaacaa aaaaagtggg ttactcatct agtaaagaag attcctaaga acccaccatc
     4441 tggctttgtc cgtgcctctc ctcgaacgct gtcaacaaga tccactgcaa atcagtcttt
     4501 ccgcaaagta gtcaaaaata catctggaaa aactagttaa ccatgtgacc tactgctgtg
     4561 ttggaatcat gtgggatgct acctgataaa ccgagctgtt taaccatgtg gaacagacag
     4621 gctgtttctt ttgacacaaa taccacaggc ttttcagggt taagattgct gttattctgt
     4681 ccttgttttg gcacaaaaag cacactgagg attgtctttt ttttctgttg tttttttttt
     4741 tttttttcct tgcgggtttg cctacaggta gattagatta attattacta tgtaatgcaa
     4801 gtacagttgg ggaaagcttt gctagatatt ttttttaagg tgctgccttt taaatttatt
     4861 agaaaatgcc tgtcagtcat gatagaaccg ttttcctcgt atgaacaaga ggaaggaact
     4921 ttcactttca gtggaatggc catcactatc aagatcagat cgtggaagga gtaaagaaaa
     4981 tatctcaaaa tgagacaagt ttttctgttt tgttttgttt ttttaataac taagtttttt
     5041 gtgctcttgc aaaactattc agaactgttt taagaacaca gtgatgtcac tttaagctca
     5101 gtgtccttac tgtagaatta aaagccttac tgtcgattgc ccacagtggg ctctgtggag
     5161 aaattaaata tcttacatta tgctttacaa aatattgtat atgtttcagc aactttgtag
     5221 attgggaact gggagaagag gaaagaatta catttaatct atgcattttt gccaagccat
     5281 attgagttat tttactacta gagacataac taactgtaca agagaaccaa gtttaaaagc
     5341 attttgtggg atacatcatt tctgtaatta tataatgtat ttctttgtgg ttttaagtga
     5401 aaagacatta agttaacaaa catataaaaa tgtatgcact gtttgaaatg taaattattc
     5461 ttagaatatt ttcagtggaa gttgcattac cctattagtg ccttaatttg agagaatttt
     5521 tttactgcca taaatacaga cttttcagaa aacagatttt acaaaaaatt atgtgttttt
     5581 ttcattggta attggtttaa tttaaaatat agaggtttgt cagattttta taaattgagt
     5641 acaacctttg taccaaacta cctgctacaa taatgaaact atctgcaaaa acatatacag
     5701 ttacaccagt agtaaagaat tatgaaatat atccatgatg ttttccagtt aacataggaa
     5761 ttaccatata aatactgttc aactctcctc tggtaacaag agttgatgtg tatgggcagt
     5821 gtgatttatt gtttattttt ttaaccaaat acctcctcag taatttataa tggctttgca
     5881 gtaatgtgta tcaaataagc actggaaaac cgatcttctc tagggtgata tgcatgtttc
     5941 aagtggtatt gaaagccgca ctgatggata tgtagtaata aacatatctg ttattaatat
     6001 gctaatgact ctgtgctcat ttaatgagaa ataaaataat ttatggatag atacttttaa
     6061 tattgactac tatagtattt tctcatggct ggaatgaata gatggcatac taaaaattat
     6121 tcagtgattg tatacaaatg tttgctaaat tttgtgaata gattaaaatt attttttaaa
     6181 gataaaa
//
